Lipid pneumonia: Difference between revisions
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'''Lipoid pneumonia''' is a specific form of lung inflammation ([[pneumonia]]) that develops when [[lipids]] enter the bronchial tree. The disorder is sometimes called [[cholesterol]] pneumonia in cases where that lipid is a factor.<ref>{{cite journal | vauthors=Pelz L, Hobusch D, Erfurth F, Richter K | title=[Familial cholesterol pneumonia] | journal=Helv Paediatr Acta | year=1972 | pages=371–9 | volume=27 | issue=4 | pmid=4644274}}</ref> |
'''Lipoid pneumonia''' is a specific form of lung inflammation ([[pneumonia]]) that develops when [[lipids]] enter the bronchial tree. The disorder is sometimes called [[cholesterol]] pneumonia in cases where that lipid is a factor.<ref>{{cite journal | vauthors=Pelz L, Hobusch D, Erfurth F, Richter K | title=[Familial cholesterol pneumonia] | journal=Helv Paediatr Acta | year=1972 | pages=371–9 | volume=27 | issue=4 | pmid=4644274}}</ref> |
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Sources of such lipids could be either exogenous or endogenous.<ref name="urlPulmonary Pathology">{{cite web |url=http://library.med.utah.edu/WebPath/LUNGHTML/LUNG026.html |title=Pulmonary Pathology |access-date=21 November 2008}}</ref> |
Sources of such lipids could be either exogenous or endogenous.<ref name="urlPulmonary Pathology">{{cite web |url=http://library.med.utah.edu/WebPath/LUNGHTML/LUNG026.html |title=Pulmonary Pathology |access-date=21 November 2008}}</ref> |
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=== Exogenous === |
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From outside the body. For example, inhaled nose drops with an oil base, or accidental inhalation of cosmetic oil. [[Amiodarone]] is an anti-arrythmic known to cause this condition. [[Oil pulling]] has also been shown to be a cause.<ref>{{cite journal |vauthors=Kim JY, Jung JW, Choi JC, Shin JW, Park IW, Choi BW |title=Recurrent lipoid pneumonia associated with oil pulling |journal=The International Journal of Tuberculosis and Lung Disease |volume=18 |issue=2 |pages=251–2 | date=February 2014 |pmid=24429325 |doi=10.5588/ijtld.13.0852}}</ref> [[Fire breather's pneumonia]] from the inhalation of hydrocarbon fuel is a specific variant. At risk populations include the elderly, developmentally delayed or persons with [[gastroesophageal reflux]]. Switching to water-soluble alternatives may be helpful in some situations.<ref name="CFP" /> |
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==== Tuberculosis ==== |
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A [[secondary tuberculosis]] in humans often begins as a lipid pneumonia.<ref name=":0">{{Cite journal |last1=Rl |first1=Hunter |last2=Mr |first2=Olsen |last3=C |first3=Jagannath |last4=Jk |first4=Actor |date=2006 |title=Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease |url=https://pubmed.ncbi.nlm.nih.gov/17127724/ |journal=Annals of Clinical and Laboratory Science |language=en |volume=36 |issue=4 |pages=371–386 |issn=0091-7370 |pmid=17127724}}</ref> This may be due to high content of [[mycolic acid]], [[cord factor]], and Wax-D in the cell wall of ''M. tuberculosis,'' that has long been speculated to be a [[virulence factor]] of the mycobacteria.<ref name=":0" /> |
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=== Endogenous === |
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| ⚫ | From the body itself, for example, when an airway is obstructed, it is often the case that distal to the obstruction, [[Lipid-laden alveolar macrophage|lipid-laden macrophages]] and [[giant cell]]s fill the lumen of the disconnected airspace.<ref name="pmid25103284">{{cite journal |vauthors=Antoon JW, Hernandez ML, Roehrs PA, Noah TL, Leigh MW, Byerley JS |title=Endogenous lipoid pneumonia preceding diagnosis of pulmonary alveolar proteinosis |journal=The Clinical Respiratory Journal |year=2014 |volume=10 |issue=2 |pages=246–249 |pmid=25103284 |doi=10.1111/crj.12197 |s2cid=205037400 }}</ref> |
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==Appearance== |
==Appearance== |
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The gross appearance of a lipid pneumonia is that in which there is an ill-defined, pale yellow area on the lung. This yellow appearance explains the colloquial term "golden" pneumonia. |
The gross appearance of a lipid pneumonia is that in which there is an ill-defined, pale yellow area on the lung. This yellow appearance explains the colloquial term "golden" pneumonia.<ref>{{cite book |last1=Zander |first1=Dani S. |last2=Farver |first2=Carol F. |title=Pulmonary Pathology E-Book: A Volume in Foundations in Diagnostic Pathology Series |date=14 December 2016 |publisher=Elsevier Health Sciences |isbn=978-0-323-46119-1 |page=517 |url=https://books.google.com/books?id=6Ze_DQAAQBAJ&dq=lipid+pneumonia+gross+pathology&pg=PA517 |access-date=19 December 2022 |language=en}}</ref> |
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On [[computed tomography|CT]], lipoid pneumonia appears as a "crazy paving" pattern, characterized by grounglass opacities with interspersed interlobular septal thickening.<ref>{{cite journal |last1=Betancourt |first1=SL |last2=Martinez-Jimenez |first2=S |last3=Rossi |first3=SE |last4=Truong |first4=MT |last5=Carrillo |first5=J |last6=Erasmus |first6=JJ |title=Lipoid pneumonia: spectrum of clinical and radiologic manifestations. |journal=AJR. American Journal of Roentgenology |date=January 2010 |volume=194 |issue=1 |pages=103–9 |doi=10.2214/AJR.09.3040 |pmid=20028911}}</ref> |
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==Diagnosis== |
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[[File:Lipid pneumonia, exogenous, chronic Case 203 (6970200736).jpg|thumb|right|250px|Lipid pneumonia-exogenous]] |
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In terms of the evaluation of Lipid pneumonia we find the following:<ref name=sta/> |
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*Chest X-ray |
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*[[CT scan]] |
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*Arterial blood gas (pH) |
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*[[Bronchoscopy]] (histological sample) |
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==Management== |
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There are no specific guidelines for the treatment of the disease. Limited evidence suggest that the [[corticosteroids]] and possibly intravenous [[antibody|immunoglobulins]] may improve condition but in the case of exogenous type the stopping of the offending agent is the step that should be taken first.<ref name="sta">{{cite book |last1=Beck |first1=Lauren R. |last2=Landsberg |first2=David |title=StatPearls |date=2022 |publisher=StatPearls Publishing |url=https://www.ncbi.nlm.nih.gov/books/NBK554577/ |access-date=19 December 2022 |chapter=Lipoid Pneumonia|pmid=32119464 }}</ref> |
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Treatment is with [[corticosteroids]] and possibly intravenous [[antibody|immunoglobulins]]. |
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==Prognosis== |
==Prognosis== |
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==Epidemiology== |
==Epidemiology== |
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Lipid pneumonia has been known to occur in underwater divers after breathing poorly filtered air supplied by a surface compressor lubricated by mineral oil.<ref name="Kizer and Golden 1987" /> |
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{{empty section}} |
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{{expand section|date=September 2022}} |
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==History== |
==History== |
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Laughlen first described lipid pneumonia in 1925 with infants that inhaled oil droplets.<ref name=" |
Laughlen first described lipid pneumonia in 1925 with infants that inhaled oil droplets.<ref name="Kizer and Golden 1987">{{cite journal |vauthors=Kizer KW, Golden JA |title=Lipoid pneumonitis in a commercial abalone diver |journal=Undersea Biomedical Research |volume=14 |issue=6 |pages=545–52 |date=November 1987 |pmid=3686744 |url=http://archive.rubicon-foundation.org/2451 |archive-url=https://archive.today/20130415184538/http://archive.rubicon-foundation.org/2451 |url-status=usurped |archive-date=15 April 2013 |access-date=2013-04-02}}</ref> It is a condition that has been seen as an occupational risk for [[commercial diving]] operations but documented cases are rare.<ref name="Kizer and Golden 1987"/> |
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==References== |
==References== |
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== External links == |
== External links == |
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{{Medical resources |
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| ICD9 = {{ICD9|516.8}} |
| ICD9 = {{ICD9|516.8}} |
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| OMIM = 215030 |
| OMIM = 215030 |
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Latest revision as of 06:32, 19 September 2023
| Lipoid pneumonia | |
|---|---|
| Other names | Lipoid pneumonia, cholesterol pneumonia |
.jpg) | |
| Lipid pneumonia, exogenous Case 108 | |
| Specialty | Pulmonology  |
Lipoid pneumonia is a specific form of lung inflammation (pneumonia) that develops when lipids enter the bronchial tree. The disorder is sometimes called cholesterol pneumonia in cases where that lipid is a factor.[1]
Signs and symptoms
[edit]The pneumonia presents as a foreign body reaction causing cough, dyspnea, and often fever. Hemoptysis has also been reported.[2]
Causes
[edit]Sources of such lipids could be either exogenous or endogenous.[3]
Exogenous
[edit]From outside the body. For example, inhaled nose drops with an oil base, or accidental inhalation of cosmetic oil. Amiodarone is an anti-arrythmic known to cause this condition. Oil pulling has also been shown to be a cause.[4] Fire breather's pneumonia from the inhalation of hydrocarbon fuel is a specific variant. At risk populations include the elderly, developmentally delayed or persons with gastroesophageal reflux. Switching to water-soluble alternatives may be helpful in some situations.[2]
Tuberculosis
[edit]A secondary tuberculosis in humans often begins as a lipid pneumonia.[5] This may be due to high content of mycolic acid, cord factor, and Wax-D in the cell wall of M. tuberculosis, that has long been speculated to be a virulence factor of the mycobacteria.[5]
Endogenous
[edit]From the body itself, for example, when an airway is obstructed, it is often the case that distal to the obstruction, lipid-laden macrophages and giant cells fill the lumen of the disconnected airspace.[6]
Appearance
[edit]The gross appearance of a lipid pneumonia is that in which there is an ill-defined, pale yellow area on the lung. This yellow appearance explains the colloquial term "golden" pneumonia.[7]
At the microscopic scale foamy macrophages and giant cells are seen in the airways, and the inflammatory response is visible in the parenchyma.[citation needed]
On CT, lipoid pneumonia appears as a "crazy paving" pattern, characterized by grounglass opacities with interspersed interlobular septal thickening.[8]
Diagnosis
[edit].jpg)
In terms of the evaluation of Lipid pneumonia we find the following:[9]
- Chest X-ray
- CT scan
- Arterial blood gas (pH)
- Bronchoscopy (histological sample)
Management
[edit]There are no specific guidelines for the treatment of the disease. Limited evidence suggest that the corticosteroids and possibly intravenous immunoglobulins may improve condition but in the case of exogenous type the stopping of the offending agent is the step that should be taken first.[9]
Prognosis
[edit]Endogenous lipoid pneumonia and non-specific interstitial pneumonitis has been seen prior to the development of pulmonary alveolar proteinosis in a child.[6]
Epidemiology
[edit]Lipid pneumonia has been known to occur in underwater divers after breathing poorly filtered air supplied by a surface compressor lubricated by mineral oil.[10]
![[icon]](/https/en.wikipedia.org/wiki/File:Wiki_letter_w_cropped.svg){kind=small} | This section needs expansion. You can help by adding to it. (September 2022) |
History
[edit]Laughlen first described lipid pneumonia in 1925 with infants that inhaled oil droplets.[10] It is a condition that has been seen as an occupational risk for commercial diving operations but documented cases are rare.[10]
References
[edit]- ^ Pelz L, Hobusch D, Erfurth F, Richter K (1972). "[Familial cholesterol pneumonia]". Helv Paediatr Acta. 27 (4): 371–9. PMID 4644274.
- ^ a b Moe Bell, Marvin (2015). "Lipoid pneumonia: An unusual and preventable illness in elderly patients". Canadian Family Physician. 61 (9): 775–777. PMC 4569110. PMID 26371101.
- ^ "Pulmonary Pathology". Retrieved 21 November 2008.
- ^ Kim JY, Jung JW, Choi JC, Shin JW, Park IW, Choi BW (February 2014). "Recurrent lipoid pneumonia associated with oil pulling". The International Journal of Tuberculosis and Lung Disease. 18 (2): 251–2. doi:10.5588/ijtld.13.0852. PMID 24429325.
- ^ a b Rl, Hunter; Mr, Olsen; C, Jagannath; Jk, Actor (2006). "Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease". Annals of Clinical and Laboratory Science. 36 (4): 371–386. ISSN 0091-7370. PMID 17127724.
- ^ a b Antoon JW, Hernandez ML, Roehrs PA, Noah TL, Leigh MW, Byerley JS (2014). "Endogenous lipoid pneumonia preceding diagnosis of pulmonary alveolar proteinosis". The Clinical Respiratory Journal. 10 (2): 246–249. doi:10.1111/crj.12197. PMID 25103284. S2CID 205037400.
- ^ Zander, Dani S.; Farver, Carol F. (14 December 2016). Pulmonary Pathology E-Book: A Volume in Foundations in Diagnostic Pathology Series. Elsevier Health Sciences. p. 517. ISBN 978-0-323-46119-1. Retrieved 19 December 2022.
- ^ Betancourt, SL; Martinez-Jimenez, S; Rossi, SE; Truong, MT; Carrillo, J; Erasmus, JJ (January 2010). "Lipoid pneumonia: spectrum of clinical and radiologic manifestations". AJR. American Journal of Roentgenology. 194 (1): 103–9. doi:10.2214/AJR.09.3040. PMID 20028911.
- ^ a b Beck, Lauren R.; Landsberg, David (2022). "Lipoid Pneumonia". StatPearls. StatPearls Publishing. PMID 32119464. Retrieved 19 December 2022.
- ^ a b c Kizer KW, Golden JA (November 1987). "Lipoid pneumonitis in a commercial abalone diver". Undersea Biomedical Research. 14 (6): 545–52. PMID 3686744. Archived from the original on 15 April 2013. Retrieved 2 April 2013.
{{cite journal}}: CS1 maint: unfit URL (link)
Further reading
[edit]- Spickard, Anderson; Hirschmann, JV (28 March 1994). "Exogenous Lipoid Pneumonia". Archives of Internal Medicine. 154 (6): 686–92. doi:10.1001/archinte.1994.00420060122013. PMID 8129503.
- Betancourt, SL; Martinez-Jimenez, S; Rossi, SE; Truong, MT; Carrillo, J; Erasmus, JJ (January 2010). "Lipoid pneumonia: spectrum of clinical and radiologic manifestations". AJR. American Journal of Roentgenology. 194 (1): 103–9. doi:10.2214/ajr.09.3040. PMID 20028911.