BHFF

BHFF
Identifiers
	IUPAC name 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone;
CAS Number	123557-91-5 ;
PubChem CID	4332683;
ChemSpider	3537035 ;
UNII	K3W3822BMV;
CompTox Dashboard (EPA)	DTXSID50402030 ;
ECHA InfoCard	100.229.838
Chemical and physical data
Formula	C17H21F3O3
Molar mass	330.347 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)C2(O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1OC2=O;
	InChI InChI=1S/C17H21F3O3/c1-14(2,3)9-7-10(15(4,5)6)12-11(8-9)16(22,13(21)23-12)17(18,19)20/h7-8,22H,1-6H3 ; Key:RVNOANDLZIIFHB-UHFFFAOYSA-N ;
	(verify)

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BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABA_B receptor. It has anxiolytic effects in animal studies, and good oral bioavailability.^[1]

References

^ Malherbe P, Masciadri R, Norcross RD, Knoflach F, Kratzeisen C, Zenner MT, et al. (June 2008). "Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors". British Journal of Pharmacology. 154 (4): 797–811. doi:10.1038/bjp.2008.135. PMC 2439845. PMID 18536733.

External links

Media related to BHFF at Wikimedia Commons

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[1] Malherbe P, Masciadri R, Norcross RD, Knoflach F, Kratzeisen C, Zenner MT, et al. (June 2008). "Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors". British Journal of Pharmacology. 154 (4): 797–811. doi:10.1038/bjp.2008.135. PMC 2439845. PMID 18536733.

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