Notice Number: NOT-GM-20-025
Key Dates
Release Date: March 25, 2020
First Available Due Date: March 25, 2020
Expiration Date: February 06, 2021
PA-18-935 Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional)
NOT-AI-20-040
NOT-AI-20-030
NOT-OD-20-118 Guide Notice of Information Highlighting Harmonization and Data Sharing Expectations for Supplement and Revision Projects Addressing Social, Behavioral, Economic and Health Impacts of the COVID-19 Public Health Emergency
Issued by
National Institute of General Medical Sciences (NIGMS)
Purpose
NIGMS is issuing this Notice of Special Interest (NOSI) to highlight the urgent need for research on SARS-CoV-2 and Coronavirus Disease 2019 (COVID-19).
Background
Coronaviruses are a diverse family of viruses that cause a range of disease in humans and animals, and there are currently no approved coronavirus vaccines or therapeutics. In January 2020, a novel coronavirus, SARS-CoV-2, was identified as the causative agent of an outbreak of viral pneumonia centered around Wuhan, Hubei Province, China. Current information regarding confirmed cases is changing daily and can be found on the Centers for Disease Control and Prevention website (https://www.cdc.gov/coronavirus/index.html) and through other sources. Transmission characteristics and the associated morbidity and mortality are not completely understood, but there is clear evidence of human-to-human transmission. Many other aspects of viral pathogenesis, natural history, and host range are poorly understood. Given this, there is an urgent public health need to better understand SARS-CoV-2, particularly to improve the predictive quality of existing models of spread, diagnostics for measurement of transmission, susceptibility and recovery, and development of therapeutic interventions.
Research Objectives
NIGMS will accept the submission of applications for Competitive Revisions to active grants to address only the following research areas of interest:
Repurposing or modification of diagnostic tools currently under development to enable rapid detection of SARS-CoV-2 infection (SBIR/STTR grants only).
Rapid development of potential therapeutic agents for COVID-19 (SBIR/STTR only).
Applications that are not responsive to the above research areas of interest will be withdrawn without review.
Application and Submission Information
Applications in response to this NOSI must be submitted to PA-18-935 "Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional)", which is intended to provide funds for NIH grantees applying to expand the scope of their active grant. The activity code will be the same as that of the parent award.
Competitive revision applications to PA-18-935 must use the application form package with the Competition ID of NOT-GM-20-025-FORMS-E." This FOA will be reissued with a NOT-GM-20-025-FORMS-F package on May 25, 2020. Submissions to PA-18-935 must be completed by June 25, 2020. Submissions to the reissued FOA will be accepted on or after May 25, 2020 through the expiration date of this Notice.
Applications will be accepted on a rolling basis from March 25, 2020 to February 5, 2021 by 5:00 PM local time of the applicant organization. This NOSI expires on February 6, 2021 . An application submitted in response to this NOSI that is received on/after the expiration date will be withdrawn.
When developing applications in response to this NOSI, all instructions in the SF424 (R&R) Application Guide and PA-18-935 must be followed, with the following additions:
Review Process
Applications will be evaluated for scientific and technical merit by an appropriate internal review panel convened by NIGMS staff, in accordance with the review criteria specified in the FOA as well as these additional review criteria:
Investigators planning to submit an application in response to this NOSI are strongly encouraged to contact the relevant program officer listed below to discuss the proposed project in the context of the parent award
Inquiries
Please direct all inquiries related to predictive models of virus transmission to:
Daniel E. Janes, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Email: [email protected]
Please direct all inquiries related to SBIR and STTR applications to:
Dmitriy Krepkiy, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Email: [email protected]