Spinal cord injury (SCI) and spinal infarction lead to neurological complications and
eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major …

The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

Traumatic spinal cord injury (SCI) elicits an acute inflammatory response which comprises
numerous cell populations. It is driven by the immediate response of macrophages and …

Background and Objectives Randomization, allocation concealment, and blind outcome
assessment have been shown to reduce bias in human studies. Authors from the …

Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

Scientists who perform major survival surgery on laboratory animals face a dual welfare and
methodological challenge: how to choose surgical anesthetics and post-operative …

Acute spinal cord injury (SCI) is one of the serious central nervous system injuries, which
can lead to significant neurological impairments and a reduction in quality of life with loss in …

Acute traumatic spinal cord injury (SCI) can result in severe, lifelong neurological deficits.
After SCI, Rho activation contributes to collapse of axonal growth cones, failure of axonal …