ABSTRACT The Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: A
Global Perspective by the World Cancer Research Fund (WCRF) and the American Institute …

Animal experimentation helps us to understand human biology. Rodents and, in particular,
rats are among the most common animals used in animal experiments. Reporting data on …

Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …

Purpose Duloxetine (DLX) is dual serotonin and norepinephrine reuptake inhibitor suffering
from limited bioavailability (≈ 40%) due to extensive hepatic metabolism. This work aims to …

Simple Summary The value of animal research has been increasingly debated, owing to
high failure rates in drug development. A potential contributor to this situation is the lack of …

Regenerative medicine (RM) is an interdisciplinary field that aims to repair, replace or
regenerate damaged or missing tissue or organs to function as close as possible to its …

Because burn injuries are often followed by a derailed immune response and excessive
inflammation, a thorough understanding of the occurring reactions is key to preventing …

Accumulation of reactive oxygen species (ROS), especially on lipids, induces massive cell
death in neurons and oligodendrocyte progenitor cells (OPCs) and causes severe …

Background. Artemisinin and its derivatives have potential antidiabetic effects. There is no
evaluation of reported studies in the literature on the treatment of diabetic nephropathy (DN) …

Over the last two decades, awareness of the negative repercussions of flaws in the planning,
conduct and reporting of preclinical research involving experimental animals has been …