The US EPA reports the LC50 value is very toxic to aquatic life.
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high
|
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
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European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
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some
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EU Ecolabel: Detergents Ingredients Database
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The US EPA reports this substance is a skin sensitizer.
|
some
|
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
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NIOSH reports that this substance is a skin sensitizer.
|
some
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Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
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The US EPA reports this substance causes skin irritation.
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some
|
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
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A Cosmetic Ingredient Review Expert Panel found that methylchloroisothiazinolinone causes allergic contact dermatitis.
|
some
|
Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. 2010. Final report of the safety assessment of methylisothiazolinone. International journal of toxicology 29(4 Suppl), 187S-213S.
|
A Cosmetic Ingredient Review Expert Panel found that methylchloroisothiazinolinone is a skin sensitizer.
|
some
|
Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. 2010. Final report of the safety assessment of methylisothiazolinone. International journal of toxicology 29(4 Suppl), 187S-213S.
|
A review article reports that this substance causes contact allergies.
|
some
|
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
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A review article reports that this substance is a skin sensitizer.
|
some
|
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
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NIOSH reports that this substance is a skin irritant.
|
some
|
Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
|
A peer-reviewed study reports this substance causes dermatitis.
|
some
|
Robert Willi, Florian Pfab, Thomas Zilker, Jeroen Buters, Peter Schalock, Johannes Huss-Marp, Antonia Todorova, Johannes Ring & Ulf Darsow. 2011. Danger from the workplace: allergic contact dermatitis from the first exposure to isothiazolinones. Contact dermatitis 64(6), 361-2.
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A peer-reviewed study reports that this substance causes allergic contact dermatitis.
|
some
|
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
|
A peer-reviewed study reports that this substance is a skin sensitizer.
|
some
|
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
|
A peer-reviewed study reports that this substance is a skin sensitizer.
|
some
|
D. A. Basketter, R. Rodford, I. Kimber, I. Smith & J. E. Wahlberg. 1999. Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. Contact dermatitis 40(3), 150-4.
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The US EPA reports it is unknown if this substance is carcinogenic.
|
low
|
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
|
The European Union Ecolabel program reports this substance in inherently biodegradable.
|
low
|
EU Ecolabel: Detergents Ingredients Database
|
The US EPA reports this substance is unlikely to accumulate in fish at a significant level.
|
low
|
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
|