- Leonardo DiCaprio
- Howard Hughes, Producer
- Cate Blanchett
- Katharine Hepburn
- Kate Beckinsale
- Ava Gardner
- John C. Reilly
- Noah Dietrich
- Alec Baldwin
- Juan Trippe
- Alan Alda
- Sen. Ralph Owen Brewster
- Ian Holm
- Professor Fitz
- Danny Huston
- Jack Frye
- Gwen Stefani
- Jean Harlow
- Jude Law
- Errol Flynn
- Adam Scott
- Johnny Meyer
- Matt Ross
- Glenn Odekirk
- Kelli Garner
- Faith Domergue
- Frances Conroy
- Katharine Martha Houghton Hepburn
- Brent Spiner
- Robert Gross
- Stanley DeSantis
- Louis B. Mayer
- Edward Herrmann
- Joseph Breen
- Willem Dafoe
- Tabloid editor
- Kenneth Welsh
- Dr. Thomas Norval Hepburn
- J.C. MacKenzie
- Ludlow Ogden Smith
- Josie Maran
- Thelma
- Vincent Laresca
- Jorge
- Sam Hennings
- Frank
- Chris Ufland
- Engineer
- Justin Shilton
- Test pilot
- Martin Scorsese
- Director
- Michael Mann
- Producer
- John Logan
- Screenwriter
- Chris Brigham
- Executive Producer, Producer
- Howard Shore
- Original Music
- Robert Richardson
- Cinematographer
- Thelma Schoonmaker
- Film Editing
- Ellen Lewis
- Casting
- Dante Ferretti
- Production Design
- Martin Gendron
- Art Director
- Alice Baker
- Set Decoration
- Sandy Climan
- Producer
- Leonardo DiCaprio
- Howard Hughes, Producer
- Charles Evans Jr.
- Producer
- Graham King
- Producer
- Francesca Lo Schiavo
- Set Decoration
- Sandy Powell
- Costume Design
