Otis Chandler's Reviews > The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race

Walter Isaacson is a true storyteller, and this book yet another compelling, fast to read, educational, biography. He goes deep into the fascinating and burgeoning world of CRISPR to explain it and its origins. And it's clear that CRISPR is changing the world, and will be something we are all familiar with in the decades to come.

The moral dilemmas CRISPR brings are large, and the book appropriately spends a lot of time on them. So far, most scientists and governments have approached it from the perspective that horrible genetic diseases (eg sickle cell) should be cured, but we shouldn't use it it for other purposes. So, Gattaca and designer babies are possible, but nobody is working on it. However, as the rogue scientist in China showed when he successfully birthed human babies after removing their HIV susceptible genes, it's only a matter of time before other rogue scientists show up. Eg, who knows what's happening in Russia right now...

I really enjoyed the story of how CRISPR was discovered. Isaacson puts a lot of onus on the trait of curiosity across all his biologies (Steve Jobs, Leonardo Da Vinci, etc). And Jennifer Doudna was only a pioneer and discoverer of CRISPR's uses because she was being curious and exploring the bounds of science.

"In the history of science, there are few real eureka moments, but this came pretty close. “It wasn’t just some gradual process where it slowly dawned on us,” Doudna says. “It was an oh-my-God moment.” When Jinek showed Doudna his data demonstrating that you could program Cas9 with different guide RNAs to cut DNA wherever you desired, they actually paused and looked at each other. “Oh my God, this could be a powerful tool for gene editing,” she declared. In short, they realized that they had developed a means to rewrite the code of life."

Very interesting too to learn that lots of animal breeders, cattle farmers, etc are using CRISPR and see lot's of opportunities to use it more.

The drama between scientists discovering CRISPR and the patent wars was an interesting peek inside a world I knew little about. It added to the story, but maybe could have been condensed slightly. OTOH, I get it, he was covering a space not just a person, and needed to tread carefully, which I think he did.