- Has 3 children with husband Josh Kelley: two adopted daughters, Nancy Leigh Mi-Eun Kelley (b.November 23, 2008) and Adalaide Marie Hope Kelley (b.April 3, 2012), and one biological son Joshua Bishop Kelley (b.December 20, 2016).
- Best friend of her Grey's Anatomy (2005) co-star T.R. Knight, who was a groomsman at her wedding.
- Publicly criticized her two most successful projects. After Knocked Up (2007) was released, she said that the film presented its female characters in a sexist way; Seth Rogen and Judd Apatow both responded curtly that Heigl had not expressed any problems during filming. Later, Heigl stated that she had not received Emmy-worthy writing for her character during a recent season of Grey's Anatomy (2005) and she should not be nominated for an Emmy (she wasn't). The ties between Heigl and show creator Shonda Rhimes were frayed afterwards, and Heigl's Izzie Stevens was reduced in the show's focus before Heigl asked to be written off the series and Rhimes agreed to do so.
- A lifelong animal lover, Katherine owns 8 dogs, 4 cats, 9 horses, 2 donkeys, 2 goats and 8 chickens (2014).
- Has two older brothers, Holt and John; and an older sister, Meg Heigl-Beltran. Brother Jason died from head injuries, suffered in a car accident, when she was very young.
- Admits that one of her worst vices is being a smoker.
- Was engaged to co-actor Jason Behr during their time together on the set of Roswell (1999).
- Followed through on plans to marry fiancé Josh Kelley, on December 23, 2007, in Utah where she has a ranch property, including a tribute to her late brother, Jason, at the ceremony [July 18, 2007].
- Played the cello in High School.
- Her "Just One" foundation is involved with dog adoption.
- Started her career as a child model with Wilhelmina Models.
- Met husband-to-be singer-songwriter Josh Kelley when she appeared in his music video "Only You" (2005).
- Lives in Utah.
- Gave birth to her 3rd child (1st biological child) at age 38, a son Joshua Bishop Kelley Jr. on December 20, 2016. Child's father is her husband, Josh Kelley.
- Auditioned for all 3 female leads on Roswell (1999) before being cast as Isabel.
- Has played a character with the name of "Isabel" or "Isobel" three times. Grey's Anatomy (2005), Roswell (1999) and Wuthering Heights (2003).
- Her last name is pronounced "HI guhl."
- In Judd Apatow's film, The 40-Year-Old Virgin (2005), the FHM "100 Sexiest Women in the World 2005" special supplement with Katherine on the cover is shown in close-up during a scene on the extended version DVD. Katherine plays the lead in Apatow's follow-up, Knocked Up (2007).
- Katherine's paternal grandfather was of half German and half Swiss-German descent, and Katherine's paternal grandmother was the daughter of Irish parents. Katherine's mother is of German descent.
- Auditioned for the role of Felicity Porter in the TV series Felicity (1998), but lost out to Keri Russell. She also auditioned for the roles of Sydney Bristow and Lauren Reed on Alias (2001), but lost out to Jennifer Garner and Melissa George, respectively.
- Voted as #1 in 2008's Askmen.com "Top 99 sexiest women in the world" poll. (2008).
- Starred in a video on the Shelter Me website to encourage dog adoption.
- Beat out Alicia Silverstone for the lead role in My Father the Hero (1994).
- June 2006: Engaged to musician Josh Kelley.
- Has an American pit-bull named Apollo.
- Fan of Glee (2009).
- Summer 2016: Can be seen as a pet therapist in Cat's Pride cat litter commercial.
- Graduated from New Canaan High School in 1996.
- Ranked #14 on the Maxim magazine Hot 100 of 2007 list.
- 2005: She was October on FHM magazine's 2005 pin-up calendar.
- Sister-in-law of Charles Kelley.
- Was named one of Entertainment Weekly's Top 25 Entertainers Of The Year (2007).
- Ranked #72 in Stuff magazine's "102 Sexiest Women In The World" (2002)
- Is related to actress Amber Perkins.
- Cut & dyed her hair for season 3 of Roswell (1999).
- 2006: Named #19 in FHM magazine's "100 Sexiest Women in the World 2006" supplement.
- Daughter of Nancy Heigl and Paul Heigl.
- Ranked as #55 in FHM's "100 Sexiest Women in the World 2005" special supplement. (2005)
- Her publicists are Jill Fritzo and Catherine Olim.
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