NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Board on Life Sciences; Division on Earth and Life Studies; Committee on Science, Technology, and Law; Policy and Global Affairs; Board on Health Sciences Policy; National Research Council; Institute of Medicine. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington (DC): National Academies Press (US); 2015 Apr 13.
![Cover of Potential Risks and Benefits of Gain-of-Function Research](/https/www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nap21666-lrg.png)
Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop.
Show details- Atlas R. Potential Benefits. National Academy of Sciences; Washington, DC: Dec 16, 2014. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=vyFoJNfUmxg&list =UUBeoZcQRZ800s3bP2yJrFEw . - Baric R. No Approved Vaccines or Therapeutics for SARS-Cov or Mers-CoV in the Midst of an Ongoing MERS-CoV Outbreak. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=Aw-nR6-4kQQ . - Baric R. Research: Coronaviruses, Noroviruses and Flaviviruses, Host-Susceptibility Gene Mapping, Cross Species Transmission, Pathogenesis, Animal Model Development, Vaccine Design. National Academy of Sciences; Washington, DC: Dec 16, 2014. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=jfUTwoe7SvE . - Borse R, Shrestha SS, Fiore AE, Atkins CY, Singleton JA, Furlow C, Meltzer MI. Effects of Vaccine Program Against Pandemic Influenza A (H1N1) Virus, United States, 2009-2010. 2013. http://wwwnc
.cdc.gov /eid/article/19/3/12-0394_article . [PMC free article: PMC3647645] [PubMed: 23622679] - Charo A. Policy Implications. National Academy of Sciences; Washington, DC: Dec 16, 2014. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=vyFoJNfUmxg&list =UUBeoZcQRZ800s3bP2yJrFEw . - Deng X. A Chimeric Virus-Mouse Model System for Evaluating Function and Inhibition of Papain-like Proteases of Emerging Coronaviruses. J. Virol. 2014;88(20):11825–11833. [PMC free article: PMC4178736] [PubMed: 25100850]
- Denison M. GoF Studies in MERS and SARS Countermeasures. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=Aw-nR6-4kQQ . - Dormitzer P. Synthetic Generation of Influenza Vaccine Viruses for Rapid Response to Pandemics. 2013. http://stm
.sciencemag .org/content/5/185/185ra68 . [PubMed: 23677594] - Fineberg H. Opening Remarks at the Symposium on Risks and Benefits of Gain-of-Function Research. National Academy of Sciences; Washington, DC: Dec 15, 2014. https://www
.youtube.com /watch?v=vyFoJNfUmxg&list =UUBeoZcQRZ800s3bP2yJrFEw . - Fischhoff B. What Can Risk/Benefit Assessment Do and What Can It Not Do? What have we learned from the past about strategies, pitfalls, and limitations of risk and benefit assessments? Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research. National Academy of Sciences; Washington, DC: Dec 16, 2014a. https://www
.youtube.com /watch?v=vyFoJNfUmxg&list =UUBeoZcQRZ800s3bP2yJrFEw . - Fischoff B. Considerations/challenges for analysis of potential risks and benefits to inform broader assessments. National Academy of Sciences; Washington, DC: Dec 16, 2014b. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=vyFoJNfUmxg&list =UUBeoZcQRZ800s3bP2yJrFEw . - Fischhoff B, Kadvany J. Risk: A Very Short Introduction. Oxford, UK: Oxford University Press; 2011.
- Fischhoff B, Brewer NT, Downs JS. Communicating Risks and Benefits: An Evidence-Based User’s Guide. Silver Spring, MD: U.S. Food and Drug Administration; 2011. http://www
.fda.gov/AboutFDA /ReportsManualsForms /Reports/ucm268078.htm . - Fouchier RAM. Letter to the Editor: Studies on Influenza Virus Transmission between Ferrets; the Public Health Risks Revisited. 2014. (MBio 6:1 02560-13). [PMC free article: PMC4323420] [PubMed: 25616377] [CrossRef]
- Fraser C. Modelling of Potential Pandemics. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=mkS65OsYSzg . - Frieman M, Yount B, Agnihothram S, Page C, Donaldson E, Roberts A, Vogel L, Woodruff B, Scorpio D, Subbarao K, Baric RS. Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease. 2012. http://www
.ncbi.nlm.nih .gov/pubmed/22072787 . [PMC free article: PMC3255850] [PubMed: 22072787] - Ge X. Isolation and Characterization of a Bat SARS-like Coronavirus That Uses the ACE2 Receptor. 2013. http://www
.nature.com /nature/journal/v503 /n7477/full/nature12711.html . [PMC free article: PMC5389864] [PubMed: 24172901] - Groesch M. Charge to the Academies. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Haas C. Risk. National Academy of Sciences; Washington, DC: Dec 16, 2014. (Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Haynes AB. New England Journal of Medicine. 5. Vol. 360. 2009. A surgical safety checklist to reduce morbidity and mortality in a global population; pp. 491–499. [PubMed: 19144931]
- Hebbeler AM. Current U.S. Government Policy on Gain-of-Function Research. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Henkel RD, Miller T, Weyant RS. Monitoring Select Agent Theft, Loss and Release Reports in the United States – 2004, 2010. 2012. http://www
.absa.org/abj /abj/121704FAHenkel.pdf . - Holdren PJ, Monaco L. Enhancing Biosafety and Biosecurity in the United States. Aug 18, 2014. http://www
.whitehouse .gov/sites/default/files /microsites/ostp /enhancing_biosafety _and_biosecurity_19aug2014_final.pdf . - Huntley-Fenner G. The Role of Human Factors. National Academy of Sciences; Washington, DC: Dec 16, 2014. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, Shinya K, Zhong G, Hanson A, Katsura H, Watanabe S, Li C, Kawakami E, Yamada S, Kiso M, Suzuki Y, Maher E, Neumann G, Kawaoka Y. Experimental Adaptation of an Influenza H5 HA Confers Respiratory Droplet Transmission to a Reassortant H5 HA/H1N1 Virus in Ferrets. 2012. http://www
.nature.com /nature/journal/v486 /n7403/full/nature10831.html . [PMC free article: PMC3388103] [PubMed: 22722205] - Johnson B. Global Biosafety Considerations and Gain-of-Function Research. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Kawaoka Y. Influenza GoF Research. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=z5BJ5yBjShQ . - Koblentz G. Assessing the Risk of Bioterrorism and Implications for Dual-Use Research. National Academy of Sciences; Washington, DC: Dec 15, (Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Langlois RR, Albrecht A, Kimble B, Sutton T, Shapiro JS, Finch C, Angel M, Chua MA, Gonzalez-Reiche AS, Xu K, Perez D, Garcia-Sastre A, tenOever BR. MicroRNA-Based Strategy to Mitigate the Risk of Gain-of-Function Influenza Studies. 2013. (Nature Biotechnology). http://www
.nature.com /nbt/journal/v31/n9/full/nbt.2666.html . [PMC free article: PMC3808852] [PubMed: 23934176] - Linden C. Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research. National Academy of Sciences; Washington, DC: Dec 15, 2014. https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Lipsitch M. Presentation at the Symposium on Risks and Benefits of Gain-of-Function Research. National Academy of Sciences; Washington, DC: Dec 15, 2014. https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Lipsitch M, Galvani AP. Ethical Alternatives to Experiments with Novel Potential Pandemic Pathogens. May 20, 2014. http://www
.plosmedicine .org/article/info%3Adoi%2F10 .1371%2Fjournal .pmed.1001646#s3 . [PMC free article: PMC4028196] [PubMed: 24844931] - Lipsitch M, Inglesby TV. Moratorium on Research Intended to Create Novel Potential Pandemic Pathogens. 2014. http://mbio
.asm.org/content /5/6/e02366-14.full . [PMC free article: PMC4271556] [PubMed: 25505122] - Mertl M. Deriving an Ethical Code for Scientists: An Interview with Joseph Rotblat. 2000. (Science Careers). http:
//sciencecareers .sciencemag.org/career_magazine /previous_issues /articles/2000_05_12/nodoi .13488436328346697892 . - National Institutes of Health (NIH). NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules. http://osp
.od.nih.gov /office-biotechnology-activities /biosafety/nih-guidelines . - National Research Council (NRC). Risk Assessment in the Federal Government: Managing the Process. Washington, DC: National Academy Press; 1983. [PubMed: 25032414]
- NRC. Science and Judgment in Risk Assessment. Washington, DC: National Academy Press; 1994.
- NRC. Understanding Risk: Informing Decisions in a Democratic Society. Washington, DC: National Academy Press; 1996.
- NRC. Biotechnology Research in an Age of Terrorism. Washington, DC: National Academies Press; 2004. [PubMed: 25057686]
- NRC. Public Participation in Environmental Assessment and Decision Making. Washington, DC: National Academies Press; 2008.
- NRC. Science and Decisions: Advancing Risk Assessment. Washington, DC: National Academies Press; 2009. [PubMed: 25009905]
- NRC. Perspectives on Research with H5N1 Avian Influenza: Scientific Inquiry, Communication, Controversy. Washington, DC: National Academies Press; 2013. [PubMed: 24901200]
- National Science Advisory Board for Biosecurity (NSABB). Proposed Framework for the Oversight of Dual Use Life Sciences Research. 2007. http://osp
.od.nih.gov /sites/default/files /resources/Framework %20for%20transmittal %20duplex%209-10-07.pdf . - Palese P, Zheng H, Engelhardt OG, Pleschka S, Garcia-Sastre A. Negative-Strand RNA Viruses: Genetic Engineering and Applications. 1996. http://www
.pnas.org/content/93/21/11354 .abstract . [PMC free article: PMC38061] [PubMed: 8876139] - Presidential/Congressional Commission on Risk Assessment and Risk Management. Framework for Environmental Health Risk Management. 1997. http://www
.risk-world .com/Nreports/nr7me001.htm . - Proceedings of the National Academy of Sciences of the United States of America. 2012 Sackler Colloquium papers on The Science of Science Communication. Supplement 3. Vol. 110. Aug 20, 2013. pp. 14031–14109. www
.pnas.org/content/110/Supplement_3 . - Proceedings of the National Academy of Sciences of the United States of America. 2013 Sackler Colloquium papers on The Science of Science Communication II. Supplement 4. Vol. 111. Sep 16, 2014. http://www
.pnas.org/content /111/Supplement_4 .toc#ColloquiumPapersfreeonline . - Quinn SC, Kumar S, Freimuth VS. Racial disparities in exposure, susceptibility, and access to health care in the U.S. H1N1 influenza pandemic. Am J Public Health. 2011;101(2):285–293. [PMC free article: PMC3020202] [PubMed: 21164098]
- Relman D. What Are the Key Issues on Risks That Need to Be Addressed in the Assessments the NIH Will Undertake? Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research. National Academy of Sciences; Washington, DC: Dec 15, 2014. https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Roberts A, Derning D, Paddock CD, Cheng A, Yount B, Vogel L, Herman BD, Sheahan T, Heise M, Genrich GL, Zaki SR, Baric R, Subbarao K. A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice. 2007. http://www
.plospathogens .org/article/info%3Adoi%2F10 .1371%2Fjournal.ppat.0030005 . [PMC free article: PMC1769406] [PubMed: 17222058] - Russell CA, Kasson PM, Donis RO, Riley S, Dunbar J, Rambaut A, Asher J, Burke S, Davis CT, Garten RJ, Gnanakaran S, Hay SI, Herfst S, Lewis NS, Lloyd-Smith JO, Macken CA, Maurer-Stroh S, Neuhaus E, Parrish CR, Pepin KM, Shepard SS, Smith DL, Suarez DL, Trock SC, Widdowson M, George DB, Lipsitch M, Bloom JD. Improving pandemic influenza risk assessment. 2014. (eLife 2014;3:e03883). [PMC free article: PMC4199076] [PubMed: 25321142] [CrossRef]
- Russell C, Fonville JM, Brown AEX, Burke DF, Smith DL, James SL, Herfst S, van Boheemen S, Linster M, Schrauwen EJ, Katzelnick L, Mosterin A, Kuiken T, Maher E, Neumann GA, Osterhaus DME, Kawaoka Y, Fouchier RAM, Smith DJ. The Potential for Respiratory Droplet-Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host. 2012. http://www
.sciencemag .org/content/336/6088/1541 . [PMC free article: PMC3426314] [PubMed: 22723414] - Russell C. Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research. National Academy of Sciences; Washington, DC: Dec 15, 2014. https://www
.youtube.com /watch?v=mkS65OsYSzg . - Schoch-Spana M. Public archetypes in U.S. counter-bioterrorist policy. In: Durmaz H, Sevinc B, Yayla AS, Ekici S, editors. Understanding and Responding to Terrorism. Amsterdam: IOS Press; 2007. pp. 364–375.
- Schoch-Spana M. Ensuring Public Engagement. National Academy of Sciences; Washington, DC: Dec 16, 2014. (Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Schultz-Cherry S. Surveillance of Emerging Influenza Viruses. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=mkS65OsYSzg . - Stevens J, Blixt O, Timpey TM, Taubenberger JK, Paulson JC, Wilson IA. Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus. 2006. http://www
.sciencemag .org/content/312/5772/404.figures-only . [PubMed: 16543414] - Stanley SL Jr. NSABB’s Role in the Gain-of-Function Deliberative Process. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - Subbarao K. Scientific and Technical Aspects of Research on Influenza, SARS and MERS. National Academy of Sciences; Washington, DC: Dec 15, 2014. (Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research). https://www
.youtube.com /watch?v=V8eMycauhhU . - Tumpey T, Maines TR, Van Hoeven N, Glaser L, Solorzano A, Pappas C, Cox NJ, Sawyne DE, Palese P, Katz JM, Garcia-Sastre A. A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission. 2007. http://www
.sciencemag .org/content/315/5812/655 . [PubMed: 17272724] - U. S. Department of Health and Human Services (HHS). A Framework for Guiding U.S. Department of Health and Human Services Funding Decisions About Research Proposals with the Potential for Generating Highly Pathogenic Avian Influenza H5N1 Viruses That Are Transmissible Among Mammals by Respiratory Droplets. 2012. http://www
.phe.gov/s3 /dualuse/Documents/funding-hpai-h5n1 .pdf . - U.S. Food and Drug Administration (FDA). FDA’s Strategic Plan for Risk Communication. 2009. http://www
.fda.gov/downloads /AboutFDA/ReportsManualsForms /Reports/UCM183683.pdf . - National Bio and Agro-Defense Facility Final Environmental Impact Statement, Appendix B: A Review of Biocontainment Lapses and Laboratory-Acquired Infections. 2008. U.S. Department of Homeland Security (DHS) http://www
.dhs.gov/xlibrary /assets/nbaf_feis_appendix_b.pdf . - High-Containment Laboratories. National Strategy for Oversight is Needed; Washington, DC: 2009. U.S. Government Accountability Office (GAO) http://www
.gao.gov/new.items/d09574.pdf . - Reactor Safety Study. An Assessment of Accident Risks in U.S. Commercial Nuclear Power Plants; Washington, DC: 1975. U.S. Nuclear Regulatory Commission (USNRC)
- Vernon HM. Industrial Fatigue and Efficiency. London, UK: George Routledge & Sons; 1921.
- Weyant R. Occupational Exposures to Biological Select Agents and Toxins in the U.S. Presentation to the Symposium on Risks and Benefits of Gain-of-Function Research. National Academy of Sciences; Washington, DC: Dec 16, 2014. https://www
.youtube.com /watch?v=6anWHbQXjjo&list =UUBeoZcQRZ800s3bP2yJrFEw&index=9 . - White House. USG Policy for Oversight of Life Sciences Dual Use Research of Concern. Mar 29, 2012. http://www
.phe.gov/s3 /dualuse/Documents/us-policydurc-032812.pdf . - White House. U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza, MERS, and SARS Viruses. 2014a. http://www
.phe.gov/s3 /dualuse/Documents/gain-of-function.pdf . - White House. USG Policy for Institutional Oversight of Life Sciences Dual Use Research of Concern. Sep 24, 2014b. http://www
.phe.gov/s3 /dualuse/Documents/durc-policy.pdf . - Zaraket H, Bridges OA, Duan S, Baranovich T, Yoon S, Reed ML, Salomon R, Webby RJ, Webster RG, Russell CJ. Increased Acid Stability of the Hemagglutinin Protein Enhances H5N1 Influenza Virus Growth in the Upper Respiratory Tract but is Insufficient for Transmission in Ferrets. 2013. http://jvi
.asm.org/content/87/17/9911 .short . [PMC free article: PMC3754100] [PubMed: 23824818]
- References - Potential Risks and Benefits of Gain-of-Function ResearchReferences - Potential Risks and Benefits of Gain-of-Function Research
Your browsing activity is empty.
Activity recording is turned off.
See more...