Kenneth A Alexander, MD

Division Chief

Nemours Children's Hospital, Florida 6535 Nemours Parkway Orlando, FL 32827

Biography

Kenneth A. Alexander, M.D., Ph.D., is chief of the Division of Infectious Diseases at Nemours Children's Hospital in Orlando, Florida. Dr. Alexander completed his medical training and earned his doctoral degree at the University of Washington School of Medicine in Seattle, Washington, before moving to Boston, Massachusetts, for his pediatric residency at Boston Children's Hospital. He then completed subspecialty training in Pediatric Infectious Diseases at Duke University in Durham, North Carolina, where he served on the faculty for ten years. Dr. Alexander served as chief of Pediatric Infectious Diseases at the University of Chicago for nine years before relocating to Nemours Children's Hospital in 2014. Dr. Alexander's clinical interests include promoting immunization among underserved communities; he has a research laboratory at which his research team studies human papillomaviruses and Zika viruses.

Fellowship

  • Pediatric Infectious Diseases - Duke University Medical Center, 1995

Internship Residency

  • Pediatrics - Boston Childrens Hospital/Boston Medical Center, 1992

Medical/Dental School

  • MD - University of Washington, 1989
  • University of Washington, 1989

Board Certifications

  • American Board of Pediatrics/Infectious Diseases

  • Immunization
  • Infectious Diseases
  • Papillomavirus
  • Vaccination
  • Virology
  • Zika Virus

  • Sam Lawrence Katz, MD, Memorial Essay; Journal of the Pediatric Infectious Diseases Society; (2023).

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  • CD24 Expression Dampens the Basal Antiviral State in Human Neuroblastoma Cells and Enhances Permissivity to Zika Virus Infection; Viruses; (2022).

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  • Answers to common questions about COVID-19 vaccines in children with cancer; Pediatric Blood and Cancer; (2022).

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  • Subsequent malignant neoplasms in the Childhood Cancer Survivor Study: Occurrence of cancer types in which human papillomavirus is an established etiologic risk factor; Cancer; (2022).

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  • Use of community forums to increase knowledge of HPV and cervical cancer in African American communities; Journal of Community Health; (2019).

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  • Zika virus as an oncolytic treatment of human neuroblastoma cells requires CD24; PLoS ONE; (2018).

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  • Team approach: Pyomyositis; JBJS Reviews; (2017).

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  • Repeated Blood Cultures in Pediatric Febrile Neutropenia: Would Following the Guidelines Alter the Outcome?; Pediatric Blood and Cancer; (2016).

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  • Common and frustrating patient management problems; Pediatric Annals; (2016).

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  • Should pediatric practices have policies to not care for children with vaccine-hesitant parents?; Pediatrics; (2016).

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  • Taxi Drivers: A Target Population for the Prevention of Transmissible Disease?; Journal of Community Health; (2016).

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  • Infectious diseases; Pediatric Annals; (2015).

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  • Challenges to school-located vaccination: Lessons learned; Pediatrics; (2014).

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  • Neonate with respiratory distress and shock; NeoReviews; (2014).

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  • An unusual cause of respiratory distress in a 17-year-old boy; Pediatric Annals; (2014).

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  • Adolescent sexual activity and cancer risk: Physicians' duty to inform?; Current Medical Research and Opinion; (2014).

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  • Pneumonia With chest wall invasion in a school-aged child; Journal of the Pediatric Infectious Diseases Society; (2014).

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  • Oral cavity tumors in younger patients show a poor prognosis and do not contain viral RNA; Oral Oncology; (2013).

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  • Recommendations for a national agenda to substantially reduce cervical cancer; Cancer Causes and Control; (2013).

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  • Safety and immunogenicity of the quadrivalent HPV vaccine in female Systemic Lupus Erythematosus patients aged 12 to 26 years; Pediatric Rheumatology; (2013).

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  • A school-located vaccination adolescent pilot initiative in Chicago: Lessons learned; Journal of the Pediatric Infectious Diseases Society; (2013).

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  • Coagulase negative staphylococci in the neonatal intensive care unit: Are we any smarter?; NeoReviews; (2013).

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  • Culture negative sepsis and systemic inflammatory response syndrome in neonates; NeoReviews; (2013).

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  • Future directions in the evaluation and management of neonatal sepsis; NeoReviews; (2012).

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  • Antibiotic Therapy and Early Onset Sepsis; NeoReviews; (2012).

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  • Antimicrobial therapy and late onset sepsis; NeoReviews; (2012).

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  • Barriers to HPV immunization for African American adolescent females; Vaccine; (2012).

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  • Rationale for Reducing the Spread of Human Papillomavirus in Adolescents: Strategies to Improve Outcomes (CME Multimedia Activity); Journal of Adolescent Health; (2012).

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  • HPV—Beyond Cervical Cancer (Online Resource Center); American Journal of Medicine; (2012).

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  • Native joint septic arthritis caused by clostridium difficile in an 11-year old with hemoglobin SS disease; Pediatric Infectious Disease Journal; (2009).

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  • Paediatricians' attitudes and practices towards HPV vaccination; Acta Paediatrica, International Journal of Paediatrics; (2008).

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  • Pediatricians are more supportive of the human papillomavirus vaccine than the general public; Southern Medical Journal; (2008).

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  • Development and cardiac contractility: Cardiac troponin T isoforms and cytosolic calcium in rabbit; Pediatric Research; (2006).

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  • High potency silencing by single-stranded boranophosphate siRNA; Nucleic Acids Research; (2006).

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  • Diagnosis and management of human papillomavirus infections; Pediatric Infectious Disease Journal; (2005).

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  • RNA interference using boranophosphate siRNAs: Structure-activity relationships; Nucleic Acids Research; (2004).

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  • Identification of Peptides that Inhibit the DNA Binding, trans-Activator, and DNA Replication Functions of the Human Papillomavirus Type 11 E2 Protein; Journal of Virology; (2004).

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  • Trp<sup>2063</sup> and Trp<sup>2064</sup> in the Factor Va C2 Domain Are Required for High-Affinity Binding to Phospholipid Membranes but Not for Assembly of the Prothrombinase Complex; Biochemistry; (2004).

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  • RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells; Journal of Virology; (2003).

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  • Human TATA binding protein inhibits human papillomavirus type 11 DNA replication by antagonizing E1-E2 protein complex formation on the viral origin of replication; Journal of Virology; (2002).

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  • Infections diagnosed in the first year after pediatric stem cell transplantation; Pediatric Infectious Disease Journal; (2002).

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  • Mechanism of termination of DNA replication of Escherichia coli involves helicase-contrahelicase interaction; Proceedings of the National Academy of Sciences of the United States of America; (2001).

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  • A Single Domain of the Replication Termination Protein of Bacillus subtilis Is Involved in Arresting both DnaB Helicase and RNA Polymerase; Journal of Biological Chemistry; (2001).

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  • Bacteremia, central catheters, and neonates: When to pull the line; Pediatrics; (2001).

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  • The E1 helicase of human papillomavirus type 11 binds to the origin of replication with low sequence specificity; Virology; (2000).

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  • Recent advances in diagnosis and therapy of human papillomaviruses; Expert Opinion on Investigational Drugs; (2000).

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  • Subunit affinities and stoichiometries of the human papillomavirus type II E1:E2:DNA complex; Biochemistry; (1999).

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  • The MotA transcriptional activator of bacteriophage T4 binds to its specific DNA site as a monomer; Biochemistry; (1998).

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  • A fluorescence anisotropy study of DNA binding by HPV-11 E2C protein: A hierarchy of E2-binding sites; Biochemistry; (1996).

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  • Antiviral therapy for human papillomaviruses: Rationale and prospects; Annals of Internal Medicine; (1995).

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  • Successful treatment of abdominal wall rhizopus necrotizing cellulitis in a preterm infant; Pediatric Infectious Disease Journal; (1995).

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  • Fluorescence Energy Transfer Analysis of Calmodulin ⋅Peptide Complexes; Biochemistry; (1992).

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  • Characterization of the calmodulin binding domain of neuromodulin. Functional significance of serine 41 and phenylalanine 42; Journal of Biological Chemistry; (1991).

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  • Regulation of Free Calmodulin Levels in Neurons by Neuromodulin: Relationship to Neuronal Growth and Regeneration; Current Topics in Cellular Regulation; (1990).

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  • Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein.; The Journal of biological chemistry; (1988).

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  • Amino Acid Sequence of P-57, a Neurospecific Calmodulin-Binding Protein; Biochemistry; (1987).

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  • Regulation of calmodulin binding to P-57. A neurospecific calmodulin binding protein.; Journal of Biological Chemistry; (1987).

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  • Physicochemical and Hydrodynamic Characterization of P-57, a Neurospecific Calmodulin Binding Protein; Biochemistry; (1986).

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