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NHS leaders have said the service is expecting "major disruption" as a result of the hot weather and the junior doctors' strike.
Yellow heat health alerts are in place for many parts of the country until 5pm on Thursday, when medics will down tools and pick up placards.
It will be the eleventh walkout by junior doctors from the British Medical Association (BMA) in England, as the bitter dispute over pay continues.
While the weather will cool slightly during the five-day industrial action, NHS bosses say that the current warm spell has already put strain on the service.
And concerns have been raised about the impact that the strike will have on hospitals affected by a cyber attack earlier this month.
Major hospitals Guys' and St Thomas' and King's in London are still running at reduced capacity after the incident, which saw Russian hackers publish patient names, dates of birth and blood test data.
But the BMA announced that some junior doctors would be given permission to work at the hospitals during the walkouts to "prevent dangerous delays to cancer care".
Posting on X, formerly Twitter, it said: "To prevent dangerous delays to cancer care, we are granting a derogation for surgical registrars working on high-risk upper GI, head and neck, and lung cancers at three hospital trusts: Lewisham and Greenwich, Guys & St Thomas' and King's College Hospital.
"This will help patients who have experienced dangerous delays to their care due to the difficulties of mitigation against the unplanned and malicious cyber attack.
"We thank NHS England for raising their concerns with us in the interest of patient safety.
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"The derogation only applies to surgical registrars in upper GI, head and neck, and lung cancer services at the three trusts listed.
"All other junior doctors, including at these trusts, still can and should strike."
Asked about the impact of the cyber attack and the weather, BMA chairman of council, Professor Philip Banfield, said: "When the junior doctors go on strike, it doesn't empty the hospital out of doctors, you re-provide what junior doctors are doing with more experienced doctors.
"So you've got our SAS colleagues, consultants, so it is a more senior workforce in place, those gaps are not quite what you would expect.
"The cyber attack, they [the hospitals] are not able to do as much of the elective work anyway - that's going across a six-week period.
"So if you put a strike on to that, they've already got a mechanism for doing the work that they can cope with.
"In any heatwave warning, if you end up going to emergency departments because of heat, you will be treated as you would on any normal day, you don't suddenly end up bringing in lots of doctors.
"If any [hospital] finds that there is a cluster of incidents that need doctors to go back into work, then the junior doctors will go back into work.
"So for example, if there was something big that happened at an event like Glastonbury and ended up with tonnes of people being admitted to the hospital, what does the NHS England do?
"It comes and tells us what the situation is, and we say 'Fair, you need two people to go back'."
'DANGEROUS DELAYS'
On the request for some doctors to continue working during the walkout, Prof Banfield added: "Safe patient care has always been a priority for the BMA during the rounds of industrial action; ensured by giving trusts plenty of notice of the planned strikes, so that more senior doctors provide cover across the strike periods.
"This is why we have agreed with NHS England that a limited number of doctors will be able to work at six sites across London where the recent cyber attack crippled access to lifesaving surgery.
"The doctors who are at hospitals in the Lewisham and Greenwich, Guy's and St Thomas and King's College Trusts, will look after patients who have experienced potentially dangerous delays to their care due to this malicious attack.
"NHS England raised concerns with us about patient safety at these hospitals, and we are pleased that we have been able to come to an agreement which means this group of patients will not suffer any further delays during the strike action."
Earlier this week, charity Age UK urged people to look out for older friends and neighbours, saying that certain medical conditions can be exacerbated during a heatwave.
NHS England said that it expects the strike to cause "widespread disruption to routine care and difficulties with discharging patients", despite extensive preparations.
Junior doctors make up half of the medical workforce and their last walkout in February led to 91,048 appointments, procedures and operations being cancelled.
Similar, if not higher, numbers are expected this time around.
The strike starts at 9am on June 27 and ends on July 2, just two days before voters go to the polls.
The cumulative effect for patients, staff and the NHS as a whole is enormous
Professor Sir Stephen Powis
NHS England's national medical director, Professor Sir Stephen Powis, said: "This new round of strike action will again hit the NHS very hard, with almost all routine care likely to be affected, and services put under significant pressure.
"While the warmer weather can lead to additional pressure on services at a time when demand for services is already high.
"As ever, we are working to ensure urgent and emergency care is prioritised for patients, but there is no doubt that it becomes harder each time to bring routine services back on track following strikes, and the cumulative effect for patients, staff and the NHS as a whole is enormous.
"People should continue to use 999 in life-threatening emergencies and NHS 111 - on the NHS app, online, or by phone - for other health concerns.
"GP services and pharmacies are also available for patients and can be accessed in the normal way, and patients who haven't been contacted or informed that their planned appointment has been postponed are also urged to attend as normal."
Junior doctors have said that they will call off the strike if Prime Minister Rishi Sunak makes a credible commitment to restore their pay.
The BMA has said that junior doctors' pay has been cut by more than a quarter since 2008.
How much do junior doctors earn?
The pay received by junior doctors is dependent on experience.
In 2023/24, the basic annual pay for a first-year junior doctor in England is £32,397.
This was after the government also announced a pay rise for junior doctors of 6% plus £1,250 each.
This began to be paid in autumn 2023, backdated to April.
This works out at a basic pay of £15.53 per hour for most junior doctors.
However, the average junior doctor is not in their first year and therefore earns much more than basic pay.
According to the NHS Digital workforce and earnings data, the average full-time junior doctor in September 2023 earned a basic pay of £44,5000.
This figure also does not include any extra earnings, which comes from working extra hours.
A doctor beginning their specialist training will earn between £40,257 to £53,398 a year.
The average salary is about £50,000 per year.
If you are a specialist grade doctor you'll earn a basic salary of £83,945 to £92,275.
Matthew Taylor, chief executive of the NHS Confederation, said: "While we fully understand the genuine grievances junior doctors have over their pay, conditions and training, NHS leaders will still be frustrated that they will yet again be taking to the picket lines.
"Holding strikes in the middle of an election campaign when no political party is in a position to bring the dispute to a close is a bitter pill to swallow for staff who have to plug the gaps and patients who will have their appointments cancelled or delayed.
"The BMA should also explain what allowances they will be making for organisations and patients affected by the recent serious cyber attacks.
"With both main parties pledging to restart negotiations immediately upon forming a new government, there is no reason for these strikes to go ahead.
"We would urge the BMA to wait for a new government to be formed and try to find a compromise."
Age UK's charity director, Caroline Abrahams, said: "We are anxious about the risk strikes pose to older people's health.
"We know that the NHS is under considerable pressure and older people really value the care and support they receive from their doctors, but ongoing industrial action is simply unsustainable for NHS services and patients alike.
"Older people should not be left in pain as appointments and operations are cancelled or delayed once again and possible illnesses go undetected.
"Every strike action poses a potential risk to patients, among whom older people form the biggest group.
"There needs to be a settlement and we would urge the next Government to make this a day-one priority - in the meantime we would urge junior doctors to call off the strike action and hold tight until then."
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About 1.5million appointments have been postponed since the current wave of industrial action began in the NHS in England in December 2022, which has included walkouts by junior doctors, consultants, paramedics, physiotherapists and other staff groups
It is estimated that strikes have cost the NHS an estimated £3billion.