A team of researchers led by Professor Patrick Hsu has discovered the first DNA recombinase that is programmable, allowing the user to specify any desired genomic target sequence and any donor DNA molecule to be inserted. The bridge recombinase mechanism promises to expand genome editing beyond CRISPR and RNA interference (RNAi) to offer a unified mechanism for programmable DNA rearrangements. Bioengineering graduate student Nicholas Perry is also a lead author of the study, along with other researchers from the Arc Institute.