Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

HIV type 1 genetic diversity and genotypic drug susceptibility in the Republic of Moldova.

Author information

Affiliations

  • 1. Virology and Pathology Laboratories, School of Medicine, Gr. T. Popa University of Iasi, Romania.
      Authors
    • Pandrea I 1
    (1 author)

ORCIDs linked to this article

AIDS Research and Human Retroviruses, 01 Sep 2001, 17(13):1297-1304
https://doi.org/10.1089/088922201750461375 PMID: 11559431 

Abstract 

HIV-1 genetic diversity and, for the first time, genotypic drug susceptibility was investigated for strains circulating in the Republic of Moldova (of the former Soviet Union). Eighty-three samples from adults recently infected by intravenous drug use (IDU) (n = 60), heterosexual contact (n = 8), and from blood donors (n = 15) that tested positive from 1997 to 1998, and originating from different regions of Moldova were serotyped. By group-specific and subtype-specific peptide ELISA, patients were infected by serotype A (n = 65), serotype B (n = 1), or were nontypable (n = 17). Heteroduplex mobility assay (HMA) confirmed 11 subtype A and the one subtype B infection. Analyses of pol and env sequences for six of the IDUs confirmed that they were infected with subtype A strain. These strains clustered tightly with subtype A strains isolated from the former Soviet Union in phylogenetic analysis. No mutations associated with drug resistance were detected. The Republic of Moldova is culturally more closely related to Romania (where subtype F dominates the epidemic), but depends economically on Russia (where subtype A is established among IDUs). Thus, our results suggest that the spread of HIV in this region is driven by drug networks rather than being due to cultural similarities.

Full text links 

Read article at publisher's site: https://doi.org/10.1089/088922201750461375

References 

Articles referenced by this article (20)

Show 10 more references (10 of 20)

Citations & impact 

Impact metrics

20
Citations
Jump to Citations
20
Data citations
Jump to Data

Citations of article over time

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1089/088922201750461375

Supporting
Mentioning
Contrasting
2
13
0

Article citations

Go to all (20) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.