- Research
- Open access
- Published:
Dietary caffeine intake is associated with favorable metabolic profile among apparently healthy overweight and obese individuals
BMC Endocrine Disorders volume 23, Article number: 227 (2023)
Abstract
Background
Recent studies have revealed some conflicting results about the health effects of caffeine. These studies are inconsistent in terms of design and population and source of consumed caffeine. In the current study, we aimed to evaluate the possible health effects of dietary caffeine intake among overweight and obese individuals.
Methods
In this cross-sectional study, 488 apparently healthy individuals with overweight and obesity were participated. Dietary intake was assessed by a Food Frequency Questionnaire (FFQ) and the amount of dietary caffeine was calculated. Body composition was determined by bioelectrical impedance analysis (BIA). Enzymatic methods were used to evaluate serum lipid, glucose, and insulin concentrations.
Results
Those at the highest tertile of dietary caffeine intake had lower percentage of fat mass, higher fat free mass and appetite score (P < 0.05). Also, lower total cholesterol (TC) and low density lipoprotein cholesterol (LDL-c) was observed in higher tertiles of dietary caffeine intake compared with lower tertiles. In multinomial adjusted models, those at the second tertile of dietary caffeine intake were more likely to have higher serum insulin (P = 0.04) and lower homeostatic model assessment of insulin resistance (HOMA-IR) values compared with first tertile (P = 0.03) in crude model. While, in the age, body mass index (BMI), sex, physical activity, socio-economic status (SES) and energy intake –adjusted model (Model III), those at the third tertile of dietary caffeine intake were more likely to have low serum LDL concentrations [odds ratio (OR) = 0.957; CI = 0.918–0.997; P = 0.04]. With further adjustment to dietary vegetable, fiber and grain intake, those at the third tertile of dietary caffeine intake were more likely to have low systolic blood pressure (SBP), LDL and high HDL levels compared with those at the first tertile (P < 0.05).
Conclusion
High intakes of dietary caffeine was associated with lower LDL, SBP, insulin resistance and higher HDL concentrations among overweight and obese individuals. However, due to observational design of the study, causal inference is impossible and further studies are warranted to confirm our findings.
Introduction
Caffeine (3,7-dihydro-13,7-trimethyl-1H-purine-2,6-dione), is the most studied pharmacologically active substance in coffee, tea and soft drinks, cola, chocolate and cocoa [1]. From the caffeine dietary sources, coffee, is the most important source of caffeine and it is one of the world’s most popular beverages; it is estimated that four hundred billion cups of coffee are consumed each and every year [2]. Also, tea drinking is a common, popular social habit in Saudi Arabia [3]. In a systematic review of 472 articles, it was established that during the coronavirus pandemic, tea consumption clearly increased (70% versus 30%) while no clear trend in coffee consumption was observed (7 of 13 studies indicated an increase, accounting for 53.8%) [4]. Caffeine is well-known for its stimulant effects and numerous evidence has established its effects on wellbeing, happiness, energy, alertness, and sociability [5]. However, other health effects of caffeine consumption toward cardiovascular health, metabolic disorders and neurological problems have also been revealed in some of the previous studies; moderate caffeine consumption was associated with reduced risk of all-cause and cardiovascular mortality in elderly hypertensive patients [1]. Also, in a previous follow-up study, after 6 years follow-up, a 42% lower incidence of cardiovascular diseases was observed in coffee drinkers, compared to non-drinkers [hazard ratio (HR) = 0.58, 95% CI = 0.36–0.93; P trend = 0.023) [6]. Also, in previous meta-analysis, coffee and caffeine intake were significantly associated with reduced incidence of type 2 diabetes mellitus (T2DM) [7]. In a cross-sectional study by Kim K et al. [8], habitual coffee consumption was associated with reduced risk of metabolic syndrome among Korean adults [8]. Similarly, in a meta-analysis by Shen H et al [9], total caffeine consumption was not associated with the prevalence or hepatic fibrosis of non-alcoholic fatty liver disease (NAFLD), but, regular coffee consumption significantly reduced hepatic fibrosis in patients with NAFLD. Although numerous studies regarding the health effects of caffeine on metabolic parameters are available, but, most of these studies are focused on coffee consumption and the isolate effects of dietary caffeine on metabolic parameters is evaluated in a very limited number of studies. Caffeine is consumed not only in coffee but also in soft drinks and tea and other kinds of beverages and since coffee also contains many other ingredients, caffeine and coffee cannot be considered the same [1, 10]. In obesity, most of the studies focused on the weight-reducing effects of caffeine in interventional designs and reported its positive effects on weight loss and body fat reduction [11,12,13,14]. Whereas, obesity, as a major growing health problem, is associated with numerous cardio-metabolic risk factors like dyslipidemia, metabolic syndrome, hyperglycemia and increased blood pressure [15,16,17,18]. Therefore, it is worthy to evaluate the possible beneficial effects of total dietary caffeine intake and cardio metabolic risk factors in obesity. The health effects of coffee and caffeine consumption is dose-dependent and the beneficial effects are observed in habitual and moderate consumptions but not in heavy consumption [19, 20]; it is established that caffeine intake in moderate dosages (200–300 mg) for adults is associated with reduced risk of chronic diseases like obesity and T2DM. Also, consumption of up to 400 mg of caffeine per day for adults and children, and 200 mg per day for pregnant and lactating women are considered safe [21, 22]. However, using more than safe doses is known to be associated with hypertension, cardiovascular disease’ risks and anxiety [21, 23]. Reduced heart rate and reduced blood pressure are reported in consumption of moderate doses of caffeine [24], while in high doses, caffeine increases the risk of hypertension [25, 26]. About physical functions, it has been shown that higher coffee consumption is strongly associated with improved physical functioning outcomes like weakness, physical frailty and muscle wasting [27,28,29]. Coffee consumption has been shown to reduce the prevalence of low muscle mass among 2085 adults aged 40–87 years in WASEDA’S Health Study [30]. Although, there are some discrepancies regarding this association [31]. Considering the conflicting results about the health effects of caffeine, and lack of an organized study about the possible association of the dietary caffeine intake with obesity-related metabolic parameters, in the current cross-sectional study, we aimed to evaluate the association between dietary caffeine intake and metabolic risk factors including anthropometric features, body composition, serum lipids and glycemic markers among obese individuals.
Materials and methods
Study population
In the present cross-sectional study, 488 randomly chosen volunteers who were overweight or obese [body mass index (BMI) > 25 kg/m2] and between the ages of 20 and 50 were invited by public announcements. Sampling was performed in the Nutrition and Diet centers of Riyadh Clinics. The age range was chosen to remove the possible confounding effect of menopause of women on the study variables (e.g. serum lipids, blood pressure, glycemic markers [32,33,34]. We excluded women who were pregnant, breast-feeding, or post menopause. Also, those who underwent bariatric surgeries, or had different types of cancer, cardiovascular diseases and diabetes mellitus were excluded.
Demographic and dietary assessments
Demographic information were gathered through questionnaires and interviews. Data of education, employment, family size and occupation were used to estimate socio-economic status. Using the Arabic version of Depression, Anxiety, and Stress Scale (DASS)-21, the frequency of depression, anxiety, and stress-related symptoms were evaluated [35]. Visual analogue scale (VAS) was used to assess the state of the appetite [36]. Physical activity was assessed by international physical activity questionnaire (IPAQ) [37, 38].
A validated, semi-quantitative food frequency questionnaire (FFQ) with 140 food items, with acceptable validity and reliability, that was adapted for the Saudi’s general population was used to obtain data of dietary consumptions [39]. The Saudi’s household manual’s recommendations for dietary food amounts cooking yields and portion sizes were used to ask subjects about their food and beverage consumption and were converted to gram. Participants were questioned about frequency of drinking coffee or tea in the preceding year, considering a given portion size (cups per day or week or month). Caffeine intake was calculated as mg/day, from the sum of caffeine content in tea, coffee, soft drinks and chocolates.
Anthropometric measurements
Weight and height were measured to the nearest 0.1 in kg and 0.1 cm, respectively, without shoes and with light clothes. WC was measured to the nearest 0.1 cm at the midpoint between the lowest rib margin and the iliac crest. The bioelectrical impedance analysis (BIA) method was employed by Tanita, BC-418 MA (Tanita Corporation, Tokyo, Japan) to provide detailed body composition data through the use of 8 polar electrodes in less than thirty seconds. The results of BIA includes fat mass (FM), fat free mass (FFM), and muscle mass.
Measurement of blood biomarkers and blood pressure assessments
A trained physician used a standard mercury sphygmomanometer with an inflatable cuff (OMRON M6) to measure the subject’s blood pressure. Ten ml blood samples were obtained from all of the participants. Serum lipids and fasting blood glucose were measured with commercial kits. Serum LDL was calculated with the Friedewald Eqs. [40, 41]. Enzyme-linked immunosorbent assay (ELISA) kit was used to determine serum insulin levels (Bioassay Technology Laboratory, Shanghai Korean Biotech, Shanghai City, China). Homeostatic model assessment for insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) were estimated [42].
Statistical analysis
The Statistical Package for Social Sciences (version 23.0; SPSS Inc, Chicago IL) was used for statistical analysis. Discrete and continuous variables were reported as frequency (%), and mean ± SD. The Chi-square test and one-way analysis of variance (ANOVA) were used to assess the differences in discrete and continuousvariables across different tertiles of dietary caffeine intake, respectively. In addition, four multivariable-adjusted models of multinomial logistic regression were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the association between biochemical risk factors in different tertiles of dietary caffeine intake.
Results
General demographic characteristics of study population are presented in Table 1. As shown, lower percentage of fat mass, higher fat free mass, appetite score and basal metabolic rate (BMR) were observed in higher tertiles of dietary caffeine intake (P < 0.05). No significant difference was observed for other parameters like DASS scale and socio-economic status between different tertiles of dietary caffeine intake. Table 2, represents dietary intake of calorie, macronutrients and food groups among study population. As shown, significantly higher energy, vegetable, fiber and grains consumption was observed in higher tertiles of dietary caffeine intake compared with lower tertiles (P < 0.05). No significant difference was observed for other dietary ingredients. The comparison of biochemical variables in different tertiles of dietary caffeine intake is presented in Table 3. In one way ANOVA, lower TC and LDL were observed in higher tertiles of dietary caffeine intake (P = 0.049 and P = 0.013 respectively). Although, SBP and insulin levels were reduced and HDL was increased within tertiles of dietary caffeine intake, but these changes were not statistically significant (P > 0.05). In the crude model of multinomial logistic regression (Table 4), those at the second tertile of dietary caffeine intake were more likely to have higher serum insulin (P = 0.04) and lower HOMA-IR values compared with those at the first tertile (P = 0.03). While, in the age, BMI, sex, physical activity, SES and energy intake –adjusted model (Model III), those at the third tertile of dietary caffeine intake were more likely to have low serum LDL concentrations [odds ratio (OR) = 0.957; CI = 0.918–0.997; P = 0.04]. In the fourth model, when we further adjusted the third model for dietary intake of vegetable, fiber and grain intake, being at the third tertile of dietary caffeine intake was associated with lower SBP (OR = 0.95; CI = 0.91-1.0; P = 0.05), LDL (OR = 0.95; CI = 0.90–0.99; P = 0.03) and higher HDL (OR = 1.02; CI = 1.01–1.03; P = 0.03) concentrations compared with reference category. No significant difference for other variables was observed.
Discussion
In the current study, we observed lower body fat mass and higher fat free mass, better glycemic status and lower LDL cholesterol in higher tertiles of dietary caffeine intake. Lower fat mass and higher fat free mass in those with the highest dietary caffeine intake without any difference in BMI is attributed to the health effects of caffeine in weight regulation include increased energy expenditure and fat oxidation, inhibits phosphordiesterase [43], increase thermogenesis and fat oxidation [43, 44], reduced hormone-sensitive lipase activity [45] and increases fat oxidation via malonyl CoA and carnitine palmitoyltransferase 1 [46, 47]. Several studies have revealed the beneficial effects of caffeine on reduced fat mass accumulation; in a three phase study in adipocyte, human and animal model that was performed by Arceneaux III et al. [48], caffeine enhanced lipolysis in cultured adipocytes and acute treatment of humans with caffeine increased resting metabolic rate. There was also an increased lean mass gain concurrent with decreased fat mass gain with caffeine in the animal model that was more pronounced when it was combined with albuterol. In a randomized double blinded trial conducted by Liu AG et al. [49], the authors suggested caffeine as “a modestly effective weight loss agent that produces significant reductions in fat mass”. Although in their study, caffeine was administered as a combined 200 mg caffeine/20 mg ephedrine. It seems that dietary intake of caffeine in habitual consumption of its main sources will have weaker effects on body weight; in the study by Larsen SC et al. among 2128 participants from the Danish part of the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) cohort, no association was observed between baseline coffee consumption and 6-year changes in adiposity measurements. However, over a 6-year period, increased coffee consumption was significantly associated with reduced weight gain; although these associations were weak [31]. We observed a low TC and LDL in highest tertiles of dietary caffeine intake; the association for LDL remained significant even after adjustment for multiple confounders. Previous studies have revealed the possible role of dietary fiber, vegetable and grains in lowering serum lipids, blood pressure and glycemic markers [50, 51]; high fruit and vegetable consumption has been shown to reduce odds of high LDL concentrations to 1.00, 0.88, 0.81, and 0.75 (P for trend < 0.01) after adjusting for multiple confounders among apparently healthy population [51]; some of the studies have revealed that some of the water-soluble fibers, can decrease serum total cholesterol and LDL by 19% and 22% respectively [50]. Since there was a significant difference in dietary vegetable, fiber and grain intake between different categories of dietary caffeine intake in our study, we further adjusted our regression model to these variables, and while LDL reduction in the third tertile remained significant, also a reduction in SBP and an increase in HDL in the third tertile versus first tertile was observed. In fact, it seems that higher intake of dietary caffeine (e.g. 333.94–412.12 mg in our study) can have beneficial effects against serum lipids.
The health effects of caffeine on serum lipids is also investigated before; and the results are conflicting; caffeine consumption more than 200 mg per day was associated with increased serum cholesterol among women [52]. In another study, coffee consumption was in a negative association with serum TG and in a positive association with serum TC and LDL concentration [53]. In the study by Chen S et al. [1], no significant difference was observed in serum TC or TG concentrations between different categories of caffeine consumers while those with caffeine consumption greater than 200 mg/day had relatively lower HDL concentrations. A study revealed that only caffeine intake from coffee was associated with higher serum cholesterol level and this association was not observed for other dietary caffeine sources [54]. These conflicting results are due to the difference in the source of the consumed caffeine, type of it or studying the dietary caffeine or coffee consumption in different populations. Coffee consumption will exert different health effects compared with caffeine; it has been suggested that it is coffee prepared by boiling rather than other methods that has a hyper-cholesterolemic effect [55]. The suggested mechanisms are inhibition of nuclear factor-kappa B and consequent up-regulation of lipid-metabolizing enzymes, diminishing fat absorption via inhibition of gastric and pancreatic lipases, inhibition of the glucose transporters GLUT4 and SGLT1 and reduced carbohydrate oxidation [56] that could partly explain the favorable effects of dietary caffeine intake on cholesterol and glycemic markers.
Coffee and caffeine consumption are associated with reduced incident T2DM in a meta-analysis of prospective studies [7]. In the Japan Public Health Center-based Prospective Diabetes study, high coffee consumption was associated with reduced fasting plasma glucose among Japanese population. The possible mechanisms of the beneficial effects of caffeine on glycemic status are increased insulin sensitivity [57] and increased adiponectin levels [58]. Intakes of caffeinated and decaffeinated coffee and caffeine were found each inversely associated with C-peptide concentration, a marker of insulin secretion in the Nurses’ Health Study [59]. In addition, caffeine might also protect against T2DM incidence through increasing metabolic rate and thermogenesis, stimulating fat oxidation and free fatty acid release from peripheral tissues and mobilizing glycogen in muscles [60,61,62]. Although, in our study, only in the crude model, the moderate intake of dietary caffeine (e.g. 156.43–168.04 mg) can reduce insulin resistance while this effect disappeared after adjustment for multiple confounders. Some of the mechanistic pathways are summarized in Fig. 1.
Graphical abstract of the possible mechanisms of caffeine in body fat, serum lipids and glycemic status. CPT-1, Carnitine palmitoyl transferase I; TG, triglycerides; HSL, hormone-sensitive lipase; FFAs, Free fatty acids; FM, fat mass; FFM, fat free mass, NF-κB, nuclear factor-kappa B; GLUT-4, glucose transporter 4; SGLT1, Sodium/glucose co-transporter 1
In the current study, we used a validated FFQ adopted for use in Saudi Arabia [39] and also the amounts of dietary caffeine is exactly measured according no caffeine intake from not only coffee but also the caffeine content in tea, soft drinks and chocolates, therefore, the results can directly be generalized into Saudi’s overweight and obese population.
The current study has some limitations; due to cross-sectional design of the current study, the causality cannot be inferred from our results. Also, we measured body composition with BIA that was not the gold standard and this may limit the interpretation of our results.
In conclusion, in the current cross-sectional study, we revealed that overweight and obese individuals at the highest tertile of dietary caffeine intake, had more favorable body composition, lower SBP, serum LDL cholesterol and lower insulin resistance. Further longitudinal and interventional studies in human models can help for generalization of our results and find the behind causality.
Data Availability
The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.
References
Chen S, Li J, Gao M, Li D, Shen R, Lyu L et al. Association of caffeine intake with all-cause and cardiovascular mortality in elderly patients with hypertension. Front Nutr. 2022;9.
Spence C, Carvalho FM. The coffee drinking experience: product extrinsic (atmospheric) influences on taste and choice. Food Qual Prefer. 2020;80:103802.
Hakim IA, Alsaif MA, Alduwaihy M, Al-Rubeaan K, Al-Nuaim AR, Al-Attas OS. Tea consumption and the prevalence of coronary heart disease in saudi adults: results from a saudi national study. Prev Med. 2003;36(1):64–70.
Castellana F, De Nucci S, De Pergola G, Di Chito M, Lisco G, Triggiani V, et al. Trends in coffee and tea consumption during the COVID-19 pandemic. Foods. 2021;10(10):2458.
Hagen K, Thoresen K, Stovner LJ, Zwart J-A. High dietary caffeine consumption is associated with a modest increase in headache prevalence: results from the Head-HUNT Study. J Headache Pain. 2009;10(3):153–9.
Gaeini Z, Bahadoran Z, Mirmiran P, Azizi F. Tea, coffee, caffeine intake and the risk of cardio-metabolic outcomes: findings from a population with low coffee and high tea consumption. Nutr Metabolism. 2019;16:1–10.
Jiang X, Zhang D, Jiang W. Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. Eur J Nutr. 2014;53:25–38.
Kim K, Kim K, Park SM. Association between the prevalence of metabolic syndrome and the level of coffee consumption among korean women. PLoS ONE. 2016;11(12):e0167007.
Shen H, Rodriguez AC, Shiani A, Lipka S, Shahzad G, Kumar A, et al. Association between caffeine consumption and nonalcoholic fatty liver disease: a systemic review and meta-analysis. Therapeutic Adv Gastroenterol. 2016;9(1):113–20.
Hjazi A. The effects of Capsicum annuum supplementation on lipid profiles in adults with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2023.
Tabrizi R, Saneei P, Lankarani KB, Akbari M, Kolahdooz F, Esmaillzadeh A, et al. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2019;59(16):2688–96.
Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res. 2005;13(7):1195–204.
Bracco D, Ferrarra J-M, Arnaud MJ, Jequier E, Schutz Y. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am J Physiology-Endocrinology Metabolism. 1995;269(4):E671–E8.
Kamolthip R, Fung XC, Lin C-Y, Latner JD, O’Brien KS. Relationships among physical activity, health-related quality of life, and weight stigma in children in Hong Kong. Am J Health Behav. 2021;45(5):828–42.
Farhangi MA, Emam-Alizadeh M, Hamedi F, Jahangiry L. Weight self-stigma and its association with quality of life and psychological distress among overweight and obese women. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity. 2017;22:451-6.
Pour-Abbasi M-S, Nikrad N, Farhangi MA, Vahdat S, Jafarzadeh F. Dietary energy density, metabolic parameters, and blood pressure in a sample of adults with obesity. BMC Endocr Disorders. 2023;23(1):3.
Gallegos-Gonzalez G, Pineda-García G, Serrano-Medina A, Martinez AL, Ochoa-Ruiz E. Association between stress and metabolic syndrome and its mediating factors in university students. Am J Health Behav. 2021;45(6):1091–102.
Al-Obaidi ZMJ, Hussein YA, AL-Duhaidahawi D, Al-Aubaidy HA. Molecular docking studies and biological evaluation of luteolin on cerebral ischemic reperfusion injury. Egypt J Chem. 2022;65(6):433–40.
Bozkır Ç, Tuğgüm S, Kağan N, Nizam B, Alpsoy Ş. Caffeine intake in adults with cardiovascular diseases; a cross-sectional study. Nutr Health. 2022:02601060221105030.
Guerra ZC, Moore JR, Londoño T, Castro Y. Associations of acculturation and gender with obesity and physical activity among Latinos. Am J Health Behav. 2022;46(3):324–36.
Gaspar S, Ramos F, Caffeine. Consumption and health effects. Academic Press; 2016. pp. 573–8.
Kumar V, Kaur J, Panghal A, Kaur S, Handa V. Caffeine: a boon or bane. Nutrition & Food Science; 2018.
Chen X, Liu Y, Jaenicke EC, Rabinowitz AN. New concerns on caffeine consumption and the impact of potential regulations: the case of energy drinks. Food Policy. 2019;87:101746.
Grant SS, Magruder KP, Friedman BH. Controlling for caffeine in cardiovascular research: a critical review. Int J Psychophysiol. 2018;133:193–201.
Chei CL, Loh JK, Soh A, Yuan JM, Koh WP. Coffee, tea, caffeine, and risk of hypertension: the Singapore Chinese health study. Eur J Nutr. 2018;57:1333–42.
Rhee JJ, Qin F, Hedlin HK, Chang TI, Bird CE, Zaslavsky O, et al. Coffee and caffeine consumption and the risk of hypertension in postmenopausal women. Am J Clin Nutr. 2016;103(1):210–7.
Mazeaud S, Castellana F, Coelho-Junior HJ, Panza F, Rondanelli M, Fassio F, et al. Coffee drinking and adverse physical outcomes in the Aging Adult Population: a systematic review. Metabolites. 2022;12(7):654.
Cardoso FB, da Silva Loureiro V, Batista WA, Bonone FM, dos Santos Carvalho A, de Lima AP, et al. Possible effects of obesity on motor development, executive functioning, and academic performance of schoolchildren from a neuropsychopedagogical perspective. Nurture. 2023;17(3):455–62.
Chen S, Zhou Z, Ren K. Influence of sports value on adolescent participation and preference of Sci-Tech experience activities. Revista de Psicología del Deporte. 2021;30(4):1.
Kawakami R, Tanisawa K, Ito T, Usui C, Ishii K, Muraoka I, et al. Coffee consumption and skeletal muscle mass: WASEDA’S Health Study. Br J Nutr. 2022;130(1):127–36.
Larsen S, Mikkelsen M-L, Frederiksen P, Heitmann B. Habitual coffee consumption and changes in measures of adiposity: a comprehensive study of longitudinal associations. Int J Obes. 2018;42(4):880–6.
Jensen J, Nilas L, Christiansen C. Influence of menopause on serum lipids and lipoproteins. Maturitas. 1990;12(4):321–31.
Staessen JA, Bulpitt CJ, Fagard R, Lijnen P, Amery A. The influence of menopause on blood pressure. Hypertens Postmenopausal Women: Springer. 1994:15–26.
Walton C, Godsland I, Proudler A, Wynn V, Stevenson J. The effects of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women. Eur J Clin Invest. 1993;23(8):466–73.
Ali AM, Ahmed A, Sharaf A, Kawakami N, Abdeldayem SM, Green J. The arabic version of the depression anxiety stress Scale-21: cumulative scaling and discriminant-validation testing. Asian J Psychiatry. 2017;30:56–8.
Flint A, Raben A, Blundell J, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes. 2000;24(1):38–48.
Washburn RA. Assessment of physical activity in older adults. Res Q Exerc Sport. 2000;71(sup2):79–87.
Zelenović M, Kontro T, Dumitru RC, Aksovic N, Bjelica B, Alexe DI et al. Leisure-time physical activity and all-cause mortality: a systematic review. Revista de Psicología del Deporte. 2022;31(1).
Gosadi IM, Alatar AA, Otayf MM, AlJahani DM, Ghabbani HM, AlRajban WA, et al. Development of a saudi food frequency questionnaire and testing its reliability and validity. Saudi Med J. 2017;38(6):636.
Rifai N. Tietz textbook of clinical chemistry and molecular diagnostics-e-book. Elsevier Health Sciences; 2017.
Kandeel M, Al-Taher A. Bioinformatics of thymidine metabolism in Trypanosoma evansi: exploring nucleoside deoxyribosyltransferase (NDRT) as a drug target. 2021.
Hyder KM, Mohan J, Varma V, Sivasankaran P, Raja D. Effects of muscle–specific exercises compared to existing interventions on insulin resistance among Prediabetes Population of South India. J Nat Sci Biology Med. 2021;12(2):230.
Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999;70(6):1040–5.
Alquhaidan M, Kandeel M. Gene expression of multidrug-resistant ATP-binding cassette transporter (MDR1/ABCB1) in bovine mastitis. Trop J Pharm Res. 2018;17(12):2335–40.
Acheson KJ, Gremaud G, Meirim I, Montigon F, Krebs Y, Fay LB, et al. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr. 2004;79(1):40–6.
Hursel R, Westerterp-Plantenga M. Thermogenic ingredients and body weight regulation. Int J Obes. 2010;34(4):659–69.
Altaher Y, Kandeel M. Structure-Activity Relationship of Anionic and Cationic Polyamidoamine (PAMAM) Dendrimers against Staphylococcus aureus. Journal of Nanomaterials. 2022;2022.
Liu AG, Arceneaux KP III, Chu JT, Jacob G Jr, Schreiber AL, Tipton RC, et al. The effect of caffeine and albuterol on body composition and metabolic rate. Obesity. 2015;23(9):1830–5.
Liu AG, Smith SR, Fujioka K, Greenway FL. The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss. Obesity. 2013;21(10):1991–6.
Anderson JW. Dietary fiber, lipids and atherosclerosis. Am J Cardiol. 1987;60(12):G17–G22.
Mirmiran P, Noori N, Zavareh MB, Azizi F. Fruit and vegetable consumption and risk factors for cardiovascular disease. Metabolism. 2009;58(4):460–8.
Shirlow MJ, Mathers CD. Caffeine consumption and serum cholesterol levels. Int J Epidemiol. 1984;13(4):422–7.
Yamashita K, Yatsuya H, Muramatsu T, Toyoshima H, Murohara T, Tamakoshi K. Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in japanese workers: a cross-sectional study. Nutr Diabetes. 2012;2(4):e33–e.
CURB JD, REED DM, KAUTZ JA. Coffee, caffeine, and serum cholesterol in japanese men in Hawaii. Am J Epidemiol. 1986;123(4):648–55.
Salvaggio A, Periti M, Miano L, Quaglia G, Marzorati D. Coffee and cholesterol, an italian study. Am J Epidemiol. 1991;134(2):149–56.
Hursel R, Viechtbauer W, Dulloo AG, Tremblay A, Tappy L, Rumpler W, et al. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obes Rev. 2011;12(7):e573–e81.
Loopstra-Masters R, Liese A, Haffner S, Wagenknecht L, Hanley A. Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function. Diabetologia. 2011;54:320–8.
Imatoh T, Tanihara S, Miyazaki M, Momose Y, Uryu Y, Une H. Coffee consumption but not green tea consumption is associated with adiponectin levels in japanese males. Eur J Nutr. 2011;50:279–84.
Wu T, Willett WC, Hankinson SE, Giovannucci E. Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in US women. Diabetes Care. 2005;28(6):1390–6.
Van Dieren S, Uiterwaal C, Van der Schouw Y, Van Der AD, Boer J, Spijkerman A, et al. Coffee and tea consumption and risk of type 2 diabetes. Diabetologia. 2009;52(12):2561–9.
Greenberg J, Axen K, Schnoll R, Boozer C. Coffee, tea and diabetes: the role of weight loss and caffeine. Int J Obes. 2005;29(9):1121–9.
Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr. 1990;51(5):759–67.
Acknowledgements
This research was supported by the Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R259), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Funding
None.
Author information
Authors and Affiliations
Contributions
All authors approved the final version of the article. SHA and YAA designed the project, supervised it. RAB and SGA contributed in statistical analysis, and manuscript writing. NAT and SS were involved in hypothesis generation and statistical approach. RMRP and MKA were involved in manuscript revision. BMH was also involved in supervision and hypothesis generation. PR, SHA and YAA were also involved in data collection and patients’ recruitment.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Ethics approval and consent to participate
This research was supported and approved by the Princess Nourah bint Abdulrahman University Ethics Committee (Identifier: PNURSP2023R259). Written informed consent was obtained from all of the participants before participation in the study. All methods in the current research were performed in accordance with the declaration of Helsinki’s guidelines and regulations.
Consent for publication
Not applicable.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Alshahrani, S.H., Atia, Y.A., Badir, R.A. et al. Dietary caffeine intake is associated with favorable metabolic profile among apparently healthy overweight and obese individuals. BMC Endocr Disord 23, 227 (2023). https://doi.org/10.1186/s12902-023-01477-1
Received:
Accepted:
Published:
DOI: https://doi.org/10.1186/s12902-023-01477-1