Allumiqs

Navigating the complexities of biological systems requires more than just data. It demands a comprehensive approach. Each multiomics project is customized to meet your unique research goals, using cutting-edge mass spectrometry technology. The process starts with meticulous sample preparation, from extracting metabolites and lipids to protein digestion. Then comes an in-depth quantification of molecules using tried and tested LCMS methods ensuring that each type of omics data is of the highest quality. But it doesn’t stop there. The omics data is integrated with advanced bioinformatics and can be merged with other datasets like metadata or genomics studies. This holistic approach uncovers insights that might otherwise remain hidden, helping you answer the most challenging biological questions. ⬇ Learn more about our multiomics capabilities ⬇ https://lnkd.in/e_e_WWhm #Multiomics #MassSpectrometry #Bioinformatics #BoldScience

Plasma biomarker discovery experiments are at the forefront of drug development efforts. However, this matrix's very high dynamic range of protein concentration can make it challenging to analyze using mass spectrometry. With the #Proteograph ™ from Seer in combination with DIA mass spectrometry, we are reliably and reproducibly quantifying thousands of proteins per sample for our customers. Not to mention one of the most interesting aspects of this workflow that allows us to access post-translational modifications (PTMs), pQTLs, isoforms, and more as the readings are done on the protein themselves, and not the nucleic acid or fluorescent reporters. Looking for new ways to advance your drug development or want to take the Proteograph™ for test drive? Let’s connect to chat about our plasma biomarker discovery solutions enabled by the Proteograph™. https://lnkd.in/e6gpieUc #PlasmaBiomarkers #Proteomics #DrugDevelopment #MassSpectrometry

Metabolic abnormalities often disrupt key pathways, leading to significant health challenges. The accumulation or deficiency of specific metabolites is a hallmark of many diseases, providing crucial clues for diagnosis, prognosis, and treatment strategies. Small molecule metabolomics has emerged as a vital tool in the discovery of metabolic biomarkers and pathway analysis. With untargeted metabolomics, it's possible to identify up to 60,000 features in a sample, narrowing down to the most relevant 100s with high potential for biomarker discovery. On the other hand, targeted approaches offer precise quantification of selected molecules, using internal standards for accuracy. By leveraging retention time and MS/MS ion-ratio to commercially available identified standards, we can achieve accurate metabolite identification and uncover structural features, enhancing our understanding of disease mechanisms.  ⬇Learn more about our capabilities here ⬇  https://lnkd.in/dSPtTDij #UntargetedMetabolomics #MetabolicBiomarkerDiscovery #OmicsScience

Protein phosphorylation plays a crucial role in cellular signaling and the regulation of cellular networks. However, due to the dynamic nature of phosphorylation and the low abundance of phosphoproteins, mapping and analyzing these modifications is a challenging task. MagReSyn® beads are specifically designed to bind and enrich phosphopeptides, providing a reliable matrix for their isolation. These phosphopeptides are then ready for detailed analysis using mass spectrometry, enabling deeper insights into phosphorylation patterns within your samples. MagReSyn® Ti-IMAC microparticles feature a flexible linker that reduces steric hindrance, allowing the Ti4+ ions to effectively bind the phosphonate groups on phosphopeptides. Once bound, the phosphopeptides are isolated using a magnet, allowing the remaining proteins to be washed away. These microparticles can be used alone or in combination with MagReSyn® TiO2, Zr-IMAC, and/or ZrO2 to maximize phosphoproteome coverage. For even greater performance, the new High Performance (HP) versions of Zr-IMAC and Ti-IMAC offer increased yield and enhanced sample coverage, making phosphopeptide enrichment more effective than ever. ⬇ Explore MagReSyn® beads here ⬇ https://lnkd.in/dS_SmZjc #MagReSyn #Enrichment #BoldScience

Working with complex biological matrices like serum, plasma, urine, CSF, and cell cultures can be challenging. That’s why we’re proud to distribute MagReSyn® SAX beads—high-capacity magnetic microparticles designed for the efficient purification of proteins, peptides, enzymes, and antibodies. MagReSyn® SAX is a powerful anionic exchanger that excels at fractionating complex biological samples. For example, when introduced to plasma, these beads bind negatively charged extracellular vesicles (EVs), which are then immobilized with a magnet, allowing abundant plasma proteins to be washed away without losing your target molecules. The bound particles are lysed directly on the beads, with proteins reduced and alkylated to ensure optimal preparation for enzymatic digestion with trypsin. Post-digestion, the peptides are collected and analyzed via LC-MS/MS, revealing insights into EV proteins and their biology. ⬇ Learn more about the MagResyn Technology here ⬇ https://lnkd.in/eFEpTu3W #Proteomics #MagReSyn #Biotech #ResearchInnovation

We're proud to be the first certified lab partner of biocrates life sciences ag in North America, marking a new era in targeted metabolomics analysis. Our collaboration is set to redefine what's possible in metabolite research, enhancing both accessibility and quality of data insights. Utilizing the cutting-edge Absolute IDQ® p400 HR kit, our workflows are designed for precision and efficiency. This powerful tool allows us to quantify over 400 key metabolites and lipids from 11 crucial compound classes, all vital to understanding central metabolic pathways. What sets us apart? Our capabilities extend to high-throughput analysis, allowing us to process up to 240 metabolites weekly with a minimal sample requirement of just 10ul for most biofluids, ensuring that even limited sample volumes yield significant data. Additionally, our methodologies are refined to deliver consistent, reliable results every time, underlining our commitment to reproducibility and precision. Our goal is to empower researchers and innovators by providing deep, actionable insights into the metabolic processes that drive biological systems. Whether you’re studying disease mechanisms or exploring new therapeutics, our targeted metabolomics services are here to accelerate your research and enhance your outcomes. #Allumiqs #Metabolomics #MassSpectrometry #InnovationInResearch

Targeted protein degradation (TPD) offers a novel approach to drug development by eliminating specific proteins within cells. PROTACs are designed to selectively degrade disease-causing proteins, offering promising therapeutic potential. Our advanced high-throughput proteomics, powered by Zeno SWATH DIA, provides a robust platform for PROTAC screening. This not only confirms target protein degradation but also uncovers potential off-target effects and identifies surrogate biomarkers, helping to refine and accelerate your drug discovery process. Learn more about the process in the SCIEX Webinar: High-throughput Proteomics in Drug Development with Zeno SWATH DIA for PROTAC Screening and CRISPR Validation Applications given by our CSO Hugo Gagnon #TargetedProteinDegradation #PROTACs #DrugDevelopment #Proteomics https://lnkd.in/eHGxxCZg

We're #hiring a new Chef de projet in Sherbrooke, Quebec. Apply today or share this post with your network.

Are you looking for ways to optimize your time-to-biomarker? Our team can help.  Using our data-driven approach in combination with powerful SWATH/DIA LC-MS/MS technology we deliver fast, precise, and reliable insights, empowering our customers to make informed decisions in the identification of valuable biomarkers. https://lnkd.in/e6gpieUc #ReliableInsights #DataDrivenApproach #BiomarkerDiscovery #LCMS #MassSpectrometry

Are you passionate about LC-MS technology and data analysis? Exciting news - we're #hiring! Allumiqs is looking for a dedicated individual to join our team as an LC-MS Specialist at our Sherbrooke, QC location. In this role, you will be instrumental in delivering customer solutions, maintaining our technology platform, and conducting data acquisition activities. For more details, take a look at our job posting ⬇️ https://lnkd.in/eNUh9dqH #LifeSciences #JoinOurTeam #CRO #JobOpportunity