Toronto Research Chemicals

𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫 𝐭𝐡𝐞 𝐤𝐞𝐲 𝐭𝐨 𝐞𝐧𝐬𝐮𝐫𝐢𝐧𝐠 𝐝𝐫𝐮𝐠 𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐜𝐨𝐦𝐩𝐥𝐢𝐚𝐧𝐜𝐞 𝐰𝐢𝐭𝐡 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐰𝐡𝐢𝐭𝐞 𝐩𝐚𝐩𝐞𝐫 𝐨𝐧 𝐟𝐨𝐫𝐜𝐞𝐝 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧 𝐬𝐭𝐮𝐝𝐢𝐞𝐬! This essential guide integrates industry insights, scientific literature, and regulatory guidelines to help you design effective stress testing protocols. Learn how to identify real-world degradation pathways, create robust stability-indicating methods, and enhance drug approval and formulation processes. Enhance your pharmaceutical testing and development with our white paper: https://okt.to/nHMXrm #Pharmaceutical #stresstesting #ImpurityStandards #impurities #APIs #ReferenceStandards

The World Health Organisation has released draft guidelines to combat the presence of potentially carcinogenic nitrosamine impurities in medicines. These guidelines, building on the efforts of the FDA and EMA, offer detailed advice on Good Manufacturing Practices, risk assessment, root cause analysis, and analytical procedures. This critical update aims to enhance the safety of drug products by ensuring rigorous identification and control of nitrosamine impurities, thereby maintaining the global supply of essential medicines. Read the article to learn more: https://okt.to/nWCKxV #pharma #Nitrosamines #WHOGuidelines #drugmanufacturing

𝗡𝗮𝗻𝗼𝗽𝗮𝗿𝘁𝗶𝗰𝗹𝗲-𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝗲𝗱, 𝗨𝗩-𝗔𝗰𝘁𝗶𝘃𝗮𝘁𝗲𝗱 𝗖𝗵𝗲𝗺𝗼𝘁𝗵𝗲𝗿𝗮𝗽𝘆 𝗘𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗶𝗻 𝗕𝗿𝗲𝗮𝘀𝘁 𝗖𝗮𝗻𝗰𝗲𝗿 𝗠𝗼𝗱𝗲𝗹𝘀 Breast cancer, a disease affecting millions worldwide, often requires chemotherapy, which can cause serious side effects due to off-target toxicity. Improved, targeted drug delivery technologies aim to enhance efficacy and reduce toxicity by precisely targeting tumours, thereby improving outcomes and minimizing side effects. We're excited to share a study using our TRC research chemicals to develop a gold nanoparticle system for delivering the chemotherapy drug doxycycline, which can be activated at the tumour site using UV light. Recently published by Turkish scientists at Hacettepe University, these preclinical studies show promising progress. Read on at https://okt.to/GLo102. 💡 TRC supports you from target identification to drug development and toxicology, view our extensive range at https://okt.to/08Kbw4 #ProductCitation #ResearchChemicals #CancerReseacrch

Nanotechnology is revolutionising drug delivery by tackling the key challenges in solubility and bioavailability that significantly impact drug efficacy. Some of the most promising nano drug delivery systems currently being studied are metal-organic frameworks (MOFs), carbon nanotubes (CNTs), mesoporous silica nanoparticles (MSNs), nanoemulsions, and solid lipid nanoparticles. Read our latest blog post to explore the key issues and trends in nano drug delivery techniques at https://okt.to/EqIG3M #nanotechnology #nanoparticles #DrugDelivery #pharma #SILS

𝗡𝗮𝗻𝗼𝗽𝗮𝗿𝘁𝗶𝗰𝗹𝗲𝘀 𝗦𝘂𝗰𝗰𝗲𝘀𝘀𝗳𝘂𝗹𝗹𝘆 𝗗𝗲𝗹𝗶𝘃𝗲𝗿 𝗔𝗻𝘁𝗶𝗿𝗲𝘁𝗿𝗼𝘃𝗶𝗿𝗮𝗹 (𝗔𝗥𝗧) 𝗗𝗿𝘂𝗴𝘀 𝘁𝗼 𝘁𝗵𝗲 𝗕𝗿𝗮𝗶𝗻 The progress in HIV/AIDS treatment, with many patients achieving undetectable virus levels through effective antiretroviral therapy (ART) regimens, showcases the success of modern drug discovery. However, HIV can invade the brain as early as eight days post-infection, residing in white blood cells. The limited ability of ART to cross the blood-brain barrier presents a significant challenge, leading to numerous HIV-associated brain disorders. Improvements in drug formulation and targeting are needed to meet these clinical needs. We’re delighted to learn about the use of our darunavir research chemical in a study that developed polymer-coated nanoparticles to deliver ART drugs into mice brains. Published recently in Pharmaceutics, these findings offer hope for a clinical breakthrough for HIV-related CNS infections. Learn more about the research chemical and related product citations at https://okt.to/qiYUAP #ProductCitation #antiretroviral #nanoparticles #ResearchChemicals

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Happy Canada Day! We hope you all enjoy the long weekend and have a wonderful time with family and friends.

Targeting all KRAS oncogenic variants: a viable path to tangible therapeutic impact? KRAS was at one time considered undruggable. However, persistent efforts led to the approval of two KRAS mutant inhibitors. Here we review further KRAS inhibition strategies and consider their enormous therapeutic potential. Read our white paper today: https://okt.to/xo5Ggv #KRAS #Oncology #OncologyResearch #CancerResearch #Inhibitors

Recently, researchers have explored the potential benefits of ayahuasca. This Amazonian plant medicine contains the psychedelic compound DMT and harmine alkaloids and is believed to offer therapeutic effects for patients with affective and mental health disorders. However, the way ayahuasca is processed in the body causes problems for clinical use. We are thrilled to share that our TRC research chemicals were used to support a study in which researchers have developed an enhanced formulation currently in clinical trials. Read the findings in the journal Frontiers in Pharmacology: https://okt.to/C0o24j #ProductCitation #pharmacology #neuroscience #ResearchChemicals

From kinase inhibitors, apoptosis inducers and cytokine modulators to isotopes and synthetic chemistry building blocks, TRC supports you from drug discovery through to drug development and toxicology. Explore our comprehensive range of cancer research chemicals at: https://okt.to/7QtTdP #ScienceForaSaferWorld #ResearchChemicals #DrugDiscovery #Pharma #oncology