Santhosh Thomas Kallivalappil
Winnipeg, Manitoba, Canada
830 followers
500+ connections
About
Entrepreneur scientist, Experienced Synthetic Biologist, Genetic Engineering & Gene Therapy, Stem cell reprogramming, Stem cell transplantation, nanoparticles, and controlled release of biologically active materials.
Activity
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Looking forward to presenting our research at this important meeting
Looking forward to presenting our research at this important meeting
Liked by Santhosh Thomas Kallivalappil
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Does the integrity of your plasmid DNA keep you up at night? If not, maybe it should. A recent Nature article highlights results from a large-scale…
Does the integrity of your plasmid DNA keep you up at night? If not, maybe it should. A recent Nature article highlights results from a large-scale…
Liked by Santhosh Thomas Kallivalappil
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I am very proud of you, Scott Dyck, PhD, for your remarkable achievements during your PhD in my lab including the 2017 Most Promising Bioscience…
I am very proud of you, Scott Dyck, PhD, for your remarkable achievements during your PhD in my lab including the 2017 Most Promising Bioscience…
Liked by Santhosh Thomas Kallivalappil
Experience
Education
Volunteer Experience
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Local organizing committee member
International Brain Research Organization
- 5 months
Science and Technology
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Executive committee member
Society for Biotechnologists India
- 1 year
Science and Technology
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General Secretary, University Union
Cochin University of Science & Technology
- 1 year
Social Services
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Chairman
College Students Union
- Present 22 years 6 months
Social Services
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Vice President
Malayali Association of Manitoba Inc
- 4 years
Social Services
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President
Malayali Association of Manitoba Inc
- 2 years 1 month
Social Services
Publications
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Thromboxane receptor hyper-responsiveness in hypoxic pulmonary hypertension requires serine 324.
British Journal of Pharmacology
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Regulation of GPCR-mediated Smooth Muscle Contraction: Implications for Asthma and Pulmonary Hypertension
Pulmonary Pharmacology and Therapeutics
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Milrinone Attenuates Thromboxane Receptor-Mediated Hyper-responsiveness in Hypoxic Pulmonary Artery
British Journal of Pharmacology
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Potent suppressive effect of green tea polyphenols on tobacco-induced mutagenesity
Journal of Phytomedicine
Courses
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Anesthesia Wetlab
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Animal user training course- Biomedical
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Blood collection and injection wetlab
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Surgery and post operative care wet lab
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The Radiation Safety Program
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Projects
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Stem cell transplantation and use of PLGA based nano particles for controlled and sustained drug delivery
PLGA based nano particles encapsulated with drug of interest was prepared. Duration and release rate was optimized based on the requirement. Nanoparticles were fully characterized and specific tissue compatability was tested. These particles were injected into the stem cell transplantation area to protect the transplanted cells from adverse tissue environments (Injured Spinal Cord, Infracted myocardium etc..) and facilitate differentiation of stem cells into appropriate lineage to replace the…
PLGA based nano particles encapsulated with drug of interest was prepared. Duration and release rate was optimized based on the requirement. Nanoparticles were fully characterized and specific tissue compatability was tested. These particles were injected into the stem cell transplantation area to protect the transplanted cells from adverse tissue environments (Injured Spinal Cord, Infracted myocardium etc..) and facilitate differentiation of stem cells into appropriate lineage to replace the lost cell type in tissue.
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Synthesis and evaluation of biodegradable and biocompatible nanoparticles loaded with protein/drug of interest for the sustained delivery of drugs in to tissues.
- Present
Biodegradable PLGA based nano and micro particles loaded with protein drugs of interest is synthesized. These drug loaded particles were characterized for its physical properties such as size shape. In vitro and in vivo release of functional protein is measured. Toxicity of the nano and micro-particles are studied in vitro and in vivo models. These particles are used for the continuous delivery of the protein drugs in to CNS tissues.
Other creators -
Identification of target gene switches for Neuronal Progenitor Cell (NPC) differentiation
Identification of gene switches for neuronal stem cell differentiation. DsiRNA mediated down regulation of specific genes under differentiating conditions.
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Protein Transduction - for the functional recovery of Spinal Code neuronal cells and stem cell proliferation
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Role of Thromboxane receptors and downstream signalling on hypoxia induced persistent pulmonary hypertension
Role of Thromboxane receptors and downstream signalling on hypoxia induced persistent pulmonary hypertension was studied using molecular biological approach. Techniques such as point mutation, transient transfection, calcium imaging. second messanger signallings such as IP3 and cAMP was studied. Developed a method for the assay for adenyl cyclase enzyme assay.
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Role of dopaminergic neurons on pancreatic islets cell proliferation.
Dopamin D2 receptor signalling on central nervous system was studied. Effect of specific dopaminergic neuronal stimulation on pancreatic islets cell proliferation was studied.
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Effect of traumatic Brain Injury on long born healing.
Long born in human seems to be healing quickly with the patients with traumatic brain injury. The reason was not well understood. Bone callus from patients with or without traumatic brain injury was studied for its growth pattern and changes in mitogenic factors.
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Potent Suppressive effect of green tea polyphenols on transplanted tumors
Green Tea polyphenols were extracted, its composition was identified using HPLC. its effect on transplanted toumors were assessed.
Honors & Awards
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12th Annual Child Health Research Day - Research competition
Chrildren's Hospital Research Institute of Manitoba
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Annual Child Health Research Day Symposium Presentation Award
Manitoba Institute of Child Health
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Manitoba poster competition Award
University of Manitoba
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Best Poster Award Presentation Award
ICRH Young Investigators forum
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Dean of Medicine Poster Award
Manitoba poster competition, University of Manitoba
Languages
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English
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More activity by Santhosh Thomas
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Circular RNA: Vaccines, therapeutics and biomarkers could be revolutionised. CircRNA is still in very early days of development, but it is expected…
Circular RNA: Vaccines, therapeutics and biomarkers could be revolutionised. CircRNA is still in very early days of development, but it is expected…
Liked by Santhosh Thomas Kallivalappil
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Want to learn about World's only non E.coli bacterial platform that does not suffer from low productivity, sequence rearrangement, truncation and…
Want to learn about World's only non E.coli bacterial platform that does not suffer from low productivity, sequence rearrangement, truncation and…
Liked by Santhosh Thomas Kallivalappil
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Struggling with plasmid yield, endotoxin levels or E. coli rearrangements? Come talk to us! Stay up-to-date with us, follow our Page.
Struggling with plasmid yield, endotoxin levels or E. coli rearrangements? Come talk to us! Stay up-to-date with us, follow our Page.
Liked by Santhosh Thomas Kallivalappil
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Researchers from the Rady Faculty of Health Sciences have been awarded more than $8.3 million in the latest round of Canadian Institutes of Health…
Researchers from the Rady Faculty of Health Sciences have been awarded more than $8.3 million in the latest round of Canadian Institutes of Health…
Liked by Santhosh Thomas Kallivalappil
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Ever send out for plasmid synthesis of a complex lentiviral or AAV construct only to be disappointed with the effort and service level? Ever send…
Ever send out for plasmid synthesis of a complex lentiviral or AAV construct only to be disappointed with the effort and service level? Ever send…
Liked by Santhosh Thomas Kallivalappil
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Yesterday was an emotional day for me. My former PhD candidate, Dr. Javad Alizadeh has successfully done his oral PhD and examination and graduated…
Yesterday was an emotional day for me. My former PhD candidate, Dr. Javad Alizadeh has successfully done his oral PhD and examination and graduated…
Liked by Santhosh Thomas Kallivalappil
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Beyond excited and extremely grateful to receive a 5-year @CIHR_IRSC Project Grant on its first submission with high ranking. Thanks to reviewers for…
Beyond excited and extremely grateful to receive a 5-year @CIHR_IRSC Project Grant on its first submission with high ranking. Thanks to reviewers for…
Liked by Santhosh Thomas Kallivalappil
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I am pleased to inform you that I have taken on the role of guest editor for the journal "Mini-Reviews in Organic Chemistry." I extend an invitation…
I am pleased to inform you that I have taken on the role of guest editor for the journal "Mini-Reviews in Organic Chemistry." I extend an invitation…
Liked by Santhosh Thomas Kallivalappil
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Happy New year from the Smith Family! May 2024 bring you and your family new opportunities, hope and success. #manzanillo #newyear #happynewyear…
Happy New year from the Smith Family! May 2024 bring you and your family new opportunities, hope and success. #manzanillo #newyear #happynewyear…
Liked by Santhosh Thomas Kallivalappil
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