Oryl Photonics

And it is a wrap! EFMC-ISMC 2024 has come to an end.   While dissolving ourselves in the Roman heat with Italian coffee ☕ we had the opportunity to present our laboratory instrument and measurement service to many people. It is great to feel the strong interest and need for better solubility measurement in the field.   Next stop will be at home with Ilmac in Lausanne ! #symposium #Rome #solubility #aggregation ------------------------- 📨 𝘋𝘰 𝘺𝘰𝘶 𝘸𝘢𝘯𝘵 𝘵𝘰 𝘬𝘯𝘰𝘸 𝘮𝘰𝘳𝘦 𝘢𝘣𝘰𝘶𝘵 𝘰𝘶𝘳 𝘮𝘦𝘢𝘴𝘶𝘳𝘦𝘮𝘦𝘯𝘵 𝘴𝘦𝘳𝘷𝘪𝘤𝘦 𝘰𝘳 𝘩𝘰𝘸 𝘰𝘶𝘳 𝘪𝘯𝘴𝘵𝘳𝘶𝘮𝘦𝘯𝘵 𝘸𝘰𝘳𝘬𝘴? 𝘚𝘦𝘯𝘥 𝘶𝘴 𝘢 𝘮𝘦𝘴𝘴𝘢𝘨𝘦! 

>> Meet us at EFMC-ISMC 2024 in Rome 🇮🇹 We will be in Rome next week from September 1st to 5th at the International Symposium on Medicinal Chemistry organized by EFMC - European Federation for Medicinal Chemistry and Chemical Biology. You can meet Nathan Dupertuis and Orly Tarun for more information on our new instrument to measure solubility and aggregation of compounds in various solvents. #symposium #solubility #aggregation #laboratoryinstrument ------------------------- 🔔 𝘐𝘧 𝘺𝘰𝘶 𝘸𝘢𝘯𝘵 𝘵𝘰 𝘧𝘰𝘭𝘭𝘰𝘸 𝘸𝘩𝘢𝘵 𝘸𝘦 𝘥𝘰, 𝘴𝘶𝘣𝘴𝘤𝘳𝘪𝘣𝘦 𝘵𝘰 𝘰𝘶𝘳 𝘓𝘪𝘯𝘬𝘦𝘥𝘐𝘯 𝘱𝘢𝘨𝘦! 📨 𝘐𝘧 𝘺𝘰𝘶 𝘸𝘢𝘯𝘵 𝘵𝘰 𝘬𝘯𝘰𝘸 𝘮𝘰𝘳𝘦 𝘰𝘯 𝘰𝘶𝘳 𝘚𝘰𝘭𝘷𝘦𝘯𝘵 𝘙𝘦𝘥𝘪𝘴𝘵𝘳𝘪𝘣𝘶𝘵𝘪𝘰𝘯 𝘮𝘦𝘵𝘩𝘰𝘥 𝘰𝘳 𝘵𝘰 𝘨𝘦𝘵 𝘢 𝘥𝘦𝘮𝘰𝘯𝘴𝘵𝘳𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘸𝘩𝘢𝘵 𝘸𝘦 𝘥𝘰, 𝘳𝘦𝘢𝘤𝘩 𝘰𝘶𝘵 𝘵𝘰 𝘶𝘴!

>> Upcoming events and conferences   Do you want to meet us?   We were already present this year at: 🇨🇭 The Swiss Biotech Day in Basel 🇩🇪 analytica in Munich 🇨🇭 Basel Campus' Seminar in Basel 🇨🇭The Pharma Sustainability Days in Geneva 🇨🇭 BOS|Basel24 in Basel  🇨🇭 Future Labs Live in Basel   We will be at the following events conferences and fairs: 🇮🇹 EFMC-ISMC in Rome (01/09) 🇨🇭 Ilmac in Lausanne (18/09) 🏴󠁧󠁢󠁥󠁮󠁧󠁿 Drug Discovery 2024 in London (02-03/10) 🇮🇹 CPHI Europe in Milan (08-10/10) 🇨🇭Festival of Biologics in Basel (15-17/10)    ------------------------- 🔔 𝘐𝘧 𝘺𝘰𝘶 𝘸𝘢𝘯𝘵 𝘵𝘰 𝘧𝘰𝘭𝘭𝘰𝘸 𝘸𝘩𝘢𝘵 𝘸𝘦 𝘥𝘰, 𝘴𝘶𝘣𝘴𝘤𝘳𝘪𝘣𝘦 𝘵𝘰 𝘰𝘶𝘳 𝘓𝘪𝘯𝘬𝘦𝘥𝘐𝘯 𝘱𝘢𝘨𝘦! 📨 𝘐𝘧 𝘺𝘰𝘶 𝘸𝘢𝘯𝘵 𝘵𝘰 𝘬𝘯𝘰𝘸 𝘮𝘰𝘳𝘦 𝘰𝘯 𝘰𝘶𝘳 𝘚𝘰𝘭𝘷𝘦𝘯𝘵 𝘙𝘦𝘥𝘪𝘴𝘵𝘳𝘪𝘣𝘶𝘵𝘪𝘰𝘯 𝘮𝘦𝘵𝘩𝘰𝘥 𝘰𝘳 𝘵𝘰 𝘨𝘦𝘵 𝘢 𝘥𝘦𝘮𝘰𝘯𝘴𝘵𝘳𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘸𝘩𝘢𝘵 𝘸𝘦 𝘥𝘰, 𝘳𝘦𝘢𝘤𝘩 𝘰𝘶𝘵 𝘵𝘰 𝘶𝘴! #startup #conference #event #pharmaceuticals

🇨🇭Bonne Fête Nationale Suisse !🇨🇭 🇨🇭Fröhe Schweizer Bundesfeier !🇨🇭 🇨🇭Buona Festa Nazionale Svizzera !🇨🇭 🇨🇭Bun Festa Naziunala Svizra !🇨🇭 ... Happy Swiss National Holiday! 🎉🎇 #suisse #schweiz #svizzera #svizra #switzerland

🐶 💊 Your pet also needs good drugs! Did you know that there is a whole field of pharmacology centered on animal health? Last week we had the chance to be invited by Bouvier Jacques in Saint-Blaise, Neuchâtel, for a visit of the headquarters of Invenesis. Invenesis is a Swiss 🇨🇭 CRO (Contract Research Organisation) helping pharmaceutical companies in their development of drugs. They have drug discovery services for 👨 human health and 🌾 crop protection, but their key expertise is 𝐚𝐧𝐢𝐦𝐚𝐥 𝐡𝐞𝐚𝐥𝐭𝐡. They have many 🔬 screening assays with parasites and other model species 🕷 🦗 🐝 . It allows them to meet the needs of their customers. And guess what: one of the challenges they are facing is the 𝐬𝐨𝐥𝐮𝐛𝐢𝐥𝐢𝐭𝐲 of their compounds and how to measure it! We gathered a lot of insights, especially on the sample preparation. A warm thank you to Bouvier Jacques and Yves Desaules for the visit and the extensive discussions! #animalhealth #drugdiscovery #solubility

>> New grant A significant milestone: together with our partners of the FASS – Fast and Accurate Solubility for Sustainability project, we were awarded the prestigious EIC Transition grant amounting € 2.5 M.   This highly competitive grant is a direct follow-up to our previous ERC Proof of concept grant. Its aim is to bring to the market our laboratory instrument for the measurement of the solubility of drug molecules. 🔬 💊   Our consortium is led by EU-OPENSCREEN, the European research infrastructure for early drug discovery and chemical biology. It includes also the Fachhochschule Nordwestschweiz FHNW and ALPhANOV. We are excited to work with this excellent team!   The project is funded by the European Commission 🇪🇺 and the Secrétariat d’Etat à la formation, à la recherche et à l’innovation SEFRI🇨🇭. We would like to thank the Euresearch team, especially Eva Servoli, for their tremendous help during and after the application process.   If you want to know more, send us a message! 📨   #solubility #laboratoryinstrument #grant #sustainability #pharmaceutical

>> What are we developing? A machine, a device, or an instrument?   Here are the differences:   🎰 𝐃𝐞𝐯𝐢𝐜𝐞: it is a piece of equipment made for a defined purpose (usually it is a tool or an instrument). It ranges from a screwdriver to a more complex smartphone. ⚙ 𝐌𝐚𝐜𝐡𝐢𝐧𝐞: it is an apparatus powered by some external energy and made of several parts combined together. Each part has a specific function, and the whole assembly performs a particular task. There is an intrinsic dimension of converting energy (from the external power into a new energy or action). All machines are designed for a purpose, hence they fall in the device category. 🔬 𝐈𝐧𝐬𝐭𝐫𝐮𝐦𝐞𝐧𝐭: it is a subclass of device/machine, but more specific. An instrument is a tool used for 𝘥𝘦𝘭𝘪𝘤𝘢𝘵𝘦 𝘰𝘳 𝘱𝘳𝘦𝘤𝘪𝘴𝘪𝘰𝘯 𝘸𝘰𝘳𝘬 (surgery instrument, music instrument). In some context it means a device/machine used to measure a physical quantity (e.g. laboratory instrument).   At Oryl Photonics, we are developing the latest: a laboratory instrument to measure the solubility of drugs.   >> Why does it matter?   This choice of word has an important impact on our communication. When we are discussing with people (customers, scientists, investors, etc) we have a limited amount of time to introduce us. The audience should be able to understand immediately what we do and our context. It sets expectations, but also avoids misunderstandings.   One example is the 'medical device' class. These are devices intended for medical purposes, meaning that it is in contact with a patient or is used for a treatment. Hence they are heavy regulated by the health authorities like Swiss medic to prevent any harm being done to the patient. At Oryl Photonics we do not fall in this category as our instrument is used for measurements in R&D much earlier in drug development.     We hope this gives you a bit more clarity on our work. We have now developed advanced prototypes of our instrument, that are 𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐥𝐞 𝐟𝐨𝐫 𝐯𝐢𝐬𝐢𝐭𝐬 𝐢𝐧 𝐋𝐚𝐮𝐬𝐚𝐧𝐧𝐞 𝐚𝐧𝐝 𝐁𝐚𝐬𝐞𝐥. Commercialisation will happen in the future, but 𝐰𝐞 𝐚𝐥𝐫𝐞𝐚𝐝𝐲 𝐨𝐟𝐟𝐞𝐫 𝐒𝐌𝐚𝐚𝐒 – 𝐒𝐨𝐥𝐮𝐛𝐢𝐥𝐢𝐭𝐲 𝐌𝐞𝐚𝐬𝐮𝐫𝐞𝐦𝐞𝐧𝐭 𝐚𝐬 𝐚 𝐒𝐞𝐫𝐯𝐢𝐜𝐞 to researchers and companies who would like to test and benefit from our technology.   #laboratoryinstrument #instrument #solubility #lexicon ------------------------- 📨 𝘞𝘰𝘶𝘭𝘥 𝘺𝘰𝘶 𝘭𝘪𝘬𝘦 𝘵𝘰 𝘬𝘯𝘰𝘸 𝘮𝘰𝘳𝘦 𝘰𝘳 𝘵𝘰 𝘨𝘦𝘵 𝘢 𝘥𝘦𝘮𝘰𝘯𝘴𝘵𝘳𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘸𝘩𝘢𝘵 𝘸𝘦 𝘥𝘰? 𝘙𝘦𝘢𝘤𝘩 𝘰𝘶𝘵 𝘵𝘰 𝘶𝘴!

>> Measuring solubility: with rapidity   💊 Measuring solubility of a drug in a liquid is important for the pharmaceutical R&D (as well as in other fields). However you are often facing a problem of scale. There is a lot of potential compounds to study (especially at early stage of the research pipeline) or many experimental conditions to test (different pH, solvents, excipients etc). Therefore you need to ponder when and how to measure solubility (restraining your research).   At Oryl Photonics, we have developed a new technique that measures solubility very rapidly. It is called the 𝘚𝘰𝘭𝘷𝘦𝘯𝘵 𝘙𝘦𝘥𝘪𝘴𝘵𝘳𝘪𝘣𝘶𝘵𝘪𝘰𝘯 (𝘚𝘙) 𝘮𝘦𝘵𝘩𝘰𝘥.   𝐒𝐢𝐧𝐜𝐞 𝐢𝐭 𝐢𝐬 𝐛𝐚𝐬𝐞𝐝 𝐨𝐧 𝐚 𝐯𝐞𝐫𝐲 𝐞𝐟𝐟𝐢𝐜𝐢𝐞𝐧𝐭 𝐟𝐨𝐫𝐦 𝐨𝐟 𝐥𝐢𝐠𝐡𝐭 𝐬𝐜𝐚𝐭𝐭𝐞𝐫𝐢𝐧𝐠, 𝐭𝐡𝐞 𝐒𝐑 𝐦𝐞𝐭𝐡𝐨𝐝 𝐦𝐞𝐚𝐬𝐮𝐫𝐞𝐬 𝐫𝐚𝐩𝐢𝐝𝐥𝐲 𝐚 𝐥𝐢𝐪𝐮𝐢𝐝 𝐬𝐚𝐦𝐩𝐥𝐞 𝐚𝐧𝐝 𝐜𝐚𝐧 𝐛𝐞 𝐜𝐨𝐧𝐟𝐢𝐠𝐮𝐫𝐞𝐝 𝐚𝐧𝐝 𝐚𝐮𝐭𝐨𝐦𝐚𝐭𝐞𝐝 𝐟𝐨𝐫 𝐡𝐢𝐠𝐡-𝐭𝐡𝐫𝐨𝐮𝐠𝐡𝐩𝐮𝐭: 1️⃣ We typically prepare a dilution series of the compounds in standard well-plates. An acoustic liquid dispenser (Labcyte, Echo platform) is used to directly transfer the stock solution with the compound into well-plates with increasing concentration. Then we add the solvent with a peristaltic liquid dispenser. 2️⃣ We measure then the solubility by shining infrared light on the sample in each well sequentially, while recording the scattered intensity through the transparent bottom of the wellplate. The analysis is performed automatically with our software.   ⏱ The sample preparation can be done in less than 10 minutes while a full scan of a 384 well-plate using Oryl’s instrument is done in less than 15 minutes (read time per well of 1-100 ms). Thus, it is now feasible to perform solubility screening for hundreds of thousands of compounds and experimental conditions within a reasonable amount of time. We wrote an application note with more details (see link in first comment👇).   In the end, our SR method provides a unique sensitivity and accuracy 🎯, saves valuable compounds 💊 and reduces the time needed for a measurement ⏱. 𝐂𝐨𝐦𝐛𝐢𝐧𝐞𝐝 𝐭𝐨𝐠𝐞𝐭𝐡𝐞𝐫, 𝐭𝐡𝐞𝐬𝐞 𝐚𝐝𝐯𝐚𝐧𝐭𝐚𝐠𝐞𝐬 𝐮𝐧𝐥𝐨𝐜𝐤 𝐬𝐨𝐥𝐮𝐛𝐢𝐥𝐢𝐭𝐲 𝐦𝐞𝐚𝐬𝐮𝐫𝐞𝐦𝐞𝐧𝐭 𝐚𝐭 𝐬𝐜𝐚𝐥𝐞.   #rapidity #laboratoryinstrument #solubility #aggregation #scattering   ------------------------- 📨 𝘞𝘰𝘶𝘭𝘥 𝘺𝘰𝘶 𝘭𝘪𝘬𝘦 𝘵𝘰 𝘬𝘯𝘰𝘸 𝘮𝘰𝘳𝘦 𝘰𝘯 𝘰𝘶𝘳 𝘚𝘰𝘭𝘷𝘦𝘯𝘵 𝘙𝘦𝘥𝘪𝘴𝘵𝘳𝘪𝘣𝘶𝘵𝘪𝘰𝘯 𝘮𝘦𝘵𝘩𝘰𝘥 𝘰𝘳 𝘵𝘰 𝘨𝘦𝘵 𝘢 𝘥𝘦𝘮𝘰𝘯𝘴𝘵𝘳𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘸𝘩𝘢𝘵 𝘸𝘦 𝘥𝘰? 𝘙𝘦𝘢𝘤𝘩 𝘰𝘶𝘵 𝘵𝘰 𝘶𝘴!

>> Future Labs Live 2024 We are exhibiting at Future Labs Live in Basel. This event is a great occasion to meet many people interested in laboratory technologies, and to network. You can visit us at booth S218 to discuss solubility measurement with Orly Tarun and Nathan Dupertuis. Otherwise you can check our website (link in first comment 👇) #FutureLabsLive #FLABS #solubility

>> Measuring solubility: using minimal amount of compound   💊 Measuring solubility of a drug in a liquid is important at many stages of the drug development pipeline (and in other fields). However the drug compounds at disposal are often in scarce quantity and very costly (especially at earlier stages of the development pipeline). Therefore you need to ponder when and how to measure solubility, and to make difficult choices restraining your research. At Oryl Photonics, we have developed a new technique using much less compound. It is called the 𝘚𝘰𝘭𝘷𝘦𝘯𝘵 𝘙𝘦𝘥𝘪𝘴𝘵𝘳𝘪𝘣𝘶𝘵𝘪𝘰𝘯 (𝘚𝘙) 𝘮𝘦𝘵𝘩𝘰𝘥.   𝐒𝐢𝐧𝐜𝐞 𝐢𝐭 𝐢𝐬 𝐛𝐚𝐬𝐞𝐝 𝐨𝐧 𝐚 𝐯𝐞𝐫𝐲 𝐞𝐟𝐟𝐢𝐜𝐢𝐞𝐧𝐭 𝐟𝐨𝐫𝐦 𝐨𝐟 𝐥𝐢𝐠𝐡𝐭 𝐬𝐜𝐚𝐭𝐭𝐞𝐫𝐢𝐧𝐠, 𝐭𝐡𝐞 𝐒𝐑 𝐦𝐞𝐭𝐡𝐨𝐝 𝐫𝐞𝐪𝐮𝐢𝐫𝐞𝐬 𝐦𝐢𝐧𝐢𝐦𝐮𝐦 𝐚𝐦𝐨𝐮𝐧𝐭 𝐨𝐟 𝐜𝐨𝐦𝐩𝐨𝐮𝐧𝐝 💊 𝐚𝐧𝐝 𝐜𝐡𝐞𝐦𝐢𝐜𝐚𝐥𝐬 ⚗. We typically prepare a dilution series of the compounds in standard well-plates. We measure then the solubility by shining infrared light on the sample in each well sequentially, while recording the scattered intensity through the transparent bottom of the wellplate.   With standard 384 well plates (or 96 half-area well plates) using 100 µL of volume, the compound requirement is typically around 2 µL of 10 mM stock solution per solubility datapoint (target maximum concentration of 100 µM). 𝐖𝐢𝐭𝐡 𝐍=3 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐞𝐬, 𝐢𝐭 𝐢𝐬 𝐧𝐨𝐰 𝐟𝐞𝐚𝐬𝐢𝐛𝐥𝐞 𝐭𝐨 𝐨𝐛𝐭𝐚𝐢𝐧 𝐬𝐨𝐥𝐮𝐛𝐢𝐥𝐢𝐭𝐲 𝐝𝐚𝐭𝐚 𝐩𝐞𝐫 𝐜𝐨𝐦𝐩𝐨𝐮𝐧𝐝 𝐰𝐢𝐭𝐡 ~6 µ𝐋 𝐨𝐟 𝐜𝐨𝐦𝐩𝐨𝐮𝐧𝐝. This depends of course on the defined range of target screen concentration: we wrote an application note with more details (see link in first comment 👇).   The accuracy of our SR method, combined with its unique sensitivity, also reduces the time needed for a measurement. But this is something that I will discuss later.   #lesscompound #laboratoryinstrument #solubility #aggregation #scattering ------------------------- 📨 𝘞𝘰𝘶𝘭𝘥 𝘺𝘰𝘶 𝘭𝘪𝘬𝘦 𝘵𝘰 𝘬𝘯𝘰𝘸 𝘮𝘰𝘳𝘦 𝘰𝘯 𝘰𝘶𝘳 𝘚𝘰𝘭𝘷𝘦𝘯𝘵 𝘙𝘦𝘥𝘪𝘴𝘵𝘳𝘪𝘣𝘶𝘵𝘪𝘰𝘯 𝘮𝘦𝘵𝘩𝘰𝘥 𝘰𝘳 𝘵𝘰 𝘨𝘦𝘵 𝘢 𝘥𝘦𝘮𝘰𝘯𝘴𝘵𝘳𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘸𝘩𝘢𝘵 𝘸𝘦 𝘥𝘰? 𝘙𝘦𝘢𝘤𝘩 𝘰𝘶𝘵 𝘵𝘰 𝘶𝘴!