Amir Shahein
Metropolregion Lausanne
1830 Follower:innen
500+ Kontakte
Info
My personal philosophy is that despite how it may seem, we don't know very much, and we…
Aktivitäten
-
The Baker Lab’s latest Nature paper introduces protein assemblies that change shape on demand. This includes nano-sized containers that open and…
The Baker Lab’s latest Nature paper introduces protein assemblies that change shape on demand. This includes nano-sized containers that open and…
Beliebt bei Amir Shahein
Berufserfahrung
-
sota.bio
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Ausbildung
Veröffentlichungen
-
Automancer
Github
https://www.adaptyvbio.com/blog/automancer
-
A workcell 1.0 for programmable and controlled operation of multiple fluidic chips in parallel
biorxiv
https://www.youtube.com/watch?v=OZv7OxHxxOs&ab_channel=AmirShahein
https://www.biorxiv.org/content/10.1101/2023.04.16.536594v1
A.S. conceived of, designed the workcell, and directed the work. A.S. and C.N. assembled and characterized the system, designed the animation, developed the workcell CAD files and manufacturing thereof. G.B. performed all experiments using the platform, and conducted wafer and chip-fabrication. A.S. developed the chip designs and CAD files for photolithography…https://www.youtube.com/watch?v=OZv7OxHxxOs&ab_channel=AmirShahein
https://www.biorxiv.org/content/10.1101/2023.04.16.536594v1
A.S. conceived of, designed the workcell, and directed the work. A.S. and C.N. assembled and characterized the system, designed the animation, developed the workcell CAD files and manufacturing thereof. G.B. performed all experiments using the platform, and conducted wafer and chip-fabrication. A.S. developed the chip designs and CAD files for photolithography. A.S. and G.B. wrote experiment protocols, optimized system performance and designed the automated cleaning circuit. C.N. programmed the programmable logic controller and the animation. S.L. wrote the core software application including the user-interface, and L.H. wrote the image analysis pipeline with support from A.S. A.S. wrote the paper with review from all authors. -
Cell-Free Synthetic Biology (Textbook)
Frontiers
Contributed to a section on bottom-up engineering of complex biological systems.
-
Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance
Nature Communications
A.S. performed all in vitro experiments, data analysis and modeling used in this manuscript. M.L. performed all in vivo experiments, M.L. and A.S. performed data analysis. I.I. and S.J.M. designed the initial iMITOMI method which was further refined by A.S. I.I. and S.J.M. designed the Pho4 target library. A.S. and S.J.M. designed the Zif268 target library. I.I. designed the recombinant proteins and cloned the expression plasmids. I.I. and A.S. generated the recombinant proteins. I.I. collected…
A.S. performed all in vitro experiments, data analysis and modeling used in this manuscript. M.L. performed all in vivo experiments, M.L. and A.S. performed data analysis. I.I. and S.J.M. designed the initial iMITOMI method which was further refined by A.S. I.I. and S.J.M. designed the Pho4 target library. A.S. and S.J.M. designed the Zif268 target library. I.I. designed the recombinant proteins and cloned the expression plasmids. I.I. and A.S. generated the recombinant proteins. I.I. collected and analyzed preliminary Pho4 data. E.O. supported I.I. and A.S. with development of the iMITOMI method, modeling, and data analysis. S.C., M.L., and A.S. generated the yeast strains. A.S. and S.J.M. wrote the manuscript with input from all authors. S.J.M. conceived and directed the study.
-
Bottom-Up Construction of Complex Biomolecular Systems With Cell-Free Synthetic Biology
Frontiers in Bioengineering
Cell-free systems offer a promising approach to engineer biology since their open nature allows for well-controlled and characterized reaction conditions. In this review, we discuss the history and recent developments in engineering recombinant and crude extract systems, as well as breakthroughs in enabling technologies, that have facilitated increased throughput, compartmentalization, and spatial control of cell-free protein synthesis reactions. Combined with a deeper understanding of the…
Cell-free systems offer a promising approach to engineer biology since their open nature allows for well-controlled and characterized reaction conditions. In this review, we discuss the history and recent developments in engineering recombinant and crude extract systems, as well as breakthroughs in enabling technologies, that have facilitated increased throughput, compartmentalization, and spatial control of cell-free protein synthesis reactions. Combined with a deeper understanding of the cell-free systems themselves, these advances improve our ability to address a range of scientific questions. By mastering control of the cell-free platform, we will be in a position to construct increasingly complex biomolecular systems, and approach natural biological complexity in a bottom-up manner.
Auszeichnungen/Preise
-
Venture Kick Grant
Venture Kick
Prize awarded to help scale our company Adaptyv Biosystems
-
Innogrant Awardee
FIT | Fondation pour l’Innovation Technologique
100K CHF grant awarded for the development of a nanofluidic antibody discovery platform and experimental process.
-
Chess Medalist: Placed 3rd in Ontario (U18)
Chess Federation of Canada (CFC)
-
Governor General's Academic Medal
Government of Canada
Awarded to the student graduating with the highest grade point average from a high school.
-
J.W. McConnell Scholarship
McGill University
Awarded by McGill University for outstanding academic performance.
-
Sir Isaac Newton Physics Competition Award
University of Waterloo
Sprachen
-
English
Muttersprache oder zweisprachig
-
French
Fließend
-
Computer
Muttersprache oder zweisprachig
Weitere Aktivitäten von Amir Shahein
-
Good news: our EU-Korea semiconductor ENERGIZE project, aiming to develop brain-like circuits using two-dimensional materials to create energy…
Good news: our EU-Korea semiconductor ENERGIZE project, aiming to develop brain-like circuits using two-dimensional materials to create energy…
Beliebt bei Amir Shahein
-
I'm very happy to finally share what I've been working on for the past year with my friend and co-founder Ashwin Gopinath as Biostate AI comes out of…
I'm very happy to finally share what I've been working on for the past year with my friend and co-founder Ashwin Gopinath as Biostate AI comes out of…
Beliebt bei Amir Shahein
-
News on the EPFL front page about our latest work out in Nature Nanotechnology (http://rdcu.be/dMvnR): A 2D device for quantum cooling…
News on the EPFL front page about our latest work out in Nature Nanotechnology (http://rdcu.be/dMvnR): A 2D device for quantum cooling…
Beliebt bei Amir Shahein
-
Enhance productivity with the TM AI cobot paired with a Brother SPEEDIO machine. This powerful combination is ideal for customers seeking efficiency…
Enhance productivity with the TM AI cobot paired with a Brother SPEEDIO machine. This powerful combination is ideal for customers seeking efficiency…
Beliebt bei Amir Shahein
-
Gideon , an #NVIDIAInception partner, is set to transform warehouse operations and enhance efficiency. Learn more about their announcement ⬇
Gideon , an #NVIDIAInception partner, is set to transform warehouse operations and enhance efficiency. Learn more about their announcement ⬇
Beliebt bei Amir Shahein
-
While this is a very small M&A deal — up to $50 million — GSK's acquisition of Elsie Biotechnologies speaks to a far larger ambition of the British…
While this is a very small M&A deal — up to $50 million — GSK's acquisition of Elsie Biotechnologies speaks to a far larger ambition of the British…
Beliebt bei Amir Shahein
Weitere ähnliche Profile
Weitere Mitglieder, die Amir Shahein heißen
Es gibt auf LinkedIn 1 weitere Person, die Amir Shahein heißt.
Weitere Mitglieder anzeigen, die Amir Shahein heißen