Robert F. Siegmund, PhD MBA

Robert F. Siegmund, PhD MBA

Metropolregion Basel
15.148 Follower:innen 500+ Kontakte

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I have worked successfully in the areas of cancer research, market research, market…

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Beiträge

Aktivitäten

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Berufserfahrung

  • Life Code GmbH Grafik

    Life Code GmbH

    Basel Metropolitan Area

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    Basel Metropolitan Area

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    Basel Metropolitan Area

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    Basel Metropolitan Area

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    Lucerne, Switzerland

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    Munich, Bavaria, Germany

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    Vienna, Austria

Ausbildung

  • MIT Sloan Executive Education Grafik

    MIT Sloan Executive Education

    Insights into the various AI-based techniques impacting and improving upon traditional health care structures, including natural language processing, data analytics, and machine learning.

  • Ph. D. thesis entitled "Analysis of the Transcription Factors SBF and MBF Required for Entry into the Cell Cycle in Saccharomyces Cerevisae".

  • Master's Thesis entitled "Assessment of a Specific Case of Synergy Between the Diagnostics and Pharmaceutical Divisions of a Pharmaceutical Company."

  • Activities and Societies: President of the Biochemistry Students Association.

    Master thesis entitled "Isolation of mRNA 3' ends by use of the polymerase chain reaction".

Veröffentlichungen

  • Shining a light on a hidden disease.

    Poster presented at EphMRA conference 2011 in Basel

    Results of an international survey of Niemann-Pick type C patients and carers. Niemann-Pick type C is a very rare (ultra-orphan) lysosomal storage disease. The poster was presented at the annual conference of the European Pharmaceutical Market Research Association (EphMRA) in Basel in June 2011.

    Andere Autor:innen
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  • The Saccharomyces cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6.

    Molecular and Cellular Biology

    At a point in late G1 termed Start, yeast cells enter S phase, duplicate their spindle pole bodies, and form buds. These events require activation of Cdc28 kinase by G1 cyclins. Swi4 associates with Swi6 to form the SCB-binding factor complex which activates G1 cyclin genes CLN1 and CLN2 in late G1. In G2 and M phases, the transcriptional activity of SCB-binding factor is repressed by the mitotic Clb2/Cdc28 kinase. Mbp1, a transcription factor related to Swi4, forms the MCB- binding factor…

    At a point in late G1 termed Start, yeast cells enter S phase, duplicate their spindle pole bodies, and form buds. These events require activation of Cdc28 kinase by G1 cyclins. Swi4 associates with Swi6 to form the SCB-binding factor complex which activates G1 cyclin genes CLN1 and CLN2 in late G1. In G2 and M phases, the transcriptional activity of SCB-binding factor is repressed by the mitotic Clb2/Cdc28 kinase. Mbp1, a transcription factor related to Swi4, forms the MCB- binding factor complex with Swi6, which activates DNA synthesis genes and S-phase cyclin genes CLB5 and CLB6 in late G1. Clb2/Cdc28 kinase is not required for the repression of MCB-binding factor transcriptional activity in G2 and M phase. We show here that the Swi4 carboxy terminus is sufficient for interaction with Swi6 in vitro. A carboxy-terminal domain of Swi6 is required and sufficient for interaction with Swi4. The carboxy terminus of Mbp1 is sufficient for interaction with Swi6, and the carboxy terminus of Swi6 is required for interaction with Mbp1. By coimmunoprecipitation, we show that Swi4 but not Mbp1 interacts with Clb2/Cdc28 kinase in vivo during the G2 and M phases of the cell cycle. We demonstrate that the ankyrin repeats of Swi4 mediate the interaction with Clb2/Cdc28 kinase. The ankyrin repeats constitute a domain by which a cell cycle-specific transcription factor can interact with cyclin-dependent kinase complexes, thus enabling it to link its transcriptional activity to cell cycle progression.

    Andere Autor:innen
    • and Kim Nasmyth
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Sprachen

  • English

    Verhandlungssicher

  • German

    Muttersprache oder zweisprachig

  • Spanish

    Gute Kenntnisse

  • Polish

    Grundkenntnisse

Organisationen

  • European Pharmaceutical Market Research Association (EphMRA)

    Ethics Committee Member

    –Heute
  • Pharma Competitive Intelligence Conference Europe

    Advisory Board Member and Key Note Speaker

    –Heute

    Recognized thought-leader in competitive intelligence as an advisory board member and keynote speaker. The Pharma CI Conference is the best-in-class conference for pharmaceutical, biotechnology, medical device, and diagnostic competitive intelligence executives

  • Society of Competitive Intelligence Professionals (SCIP)

    Member

    –Heute

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