Robert F. Siegmund, PhD MBA
Metropolregion Basel
15.148 Follower:innen
500+ Kontakte
Info
I have worked successfully in the areas of cancer research, market research, market…
Artikel von Robert F. Siegmund, PhD MBA
-
BioPharma Short-Term Forecasting Methods
BioPharma Short-Term Forecasting Methods
Von Robert F. Siegmund, PhD MBA
-
Principles And Pitfalls Of Forecasting
Principles And Pitfalls Of Forecasting
Von Robert F. Siegmund, PhD MBA
-
Biopharma Long-Term Product Forecasting
Biopharma Long-Term Product Forecasting
Von Robert F. Siegmund, PhD MBA
Beiträge
Aktivitäten
-
Looking forward to representing SAI MedPartners LLC at PharmaCI 2024 in four weeks! If you are attending, I would love to chat with you about our…
Looking forward to representing SAI MedPartners LLC at PharmaCI 2024 in four weeks! If you are attending, I would love to chat with you about our…
Beliebt bei Robert F. Siegmund, PhD MBA
-
If you are at #ISPEAnnual2024 this week, check out this TriNetX co-authored poster on using #RWD to compare the effectiveness of bebtelovimab with…
If you are at #ISPEAnnual2024 this week, check out this TriNetX co-authored poster on using #RWD to compare the effectiveness of bebtelovimab with…
Beliebt bei Robert F. Siegmund, PhD MBA
-
Congratulations Pasi Korhonen!
Congratulations Pasi Korhonen!
Geteilt von Robert F. Siegmund, PhD MBA
Berufserfahrung
Ausbildung
-
MIT Sloan Executive Education
–
Insights into the various AI-based techniques impacting and improving upon traditional health care structures, including natural language processing, data analytics, and machine learning.
-
Ph. D. thesis entitled "Analysis of the Transcription Factors SBF and MBF Required for Entry into the Cell Cycle in Saccharomyces Cerevisae".
-
Master's Thesis entitled "Assessment of a Specific Case of Synergy Between the Diagnostics and Pharmaceutical Divisions of a Pharmaceutical Company."
-
Activities and Societies: President of the Biochemistry Students Association.
Master thesis entitled "Isolation of mRNA 3' ends by use of the polymerase chain reaction".
-
Veröffentlichungen
-
Shining a light on a hidden disease.
Poster presented at EphMRA conference 2011 in Basel
Results of an international survey of Niemann-Pick type C patients and carers. Niemann-Pick type C is a very rare (ultra-orphan) lysosomal storage disease. The poster was presented at the annual conference of the European Pharmaceutical Market Research Association (EphMRA) in Basel in June 2011.
Andere Autor:innenVeröffentlichung anzeigen -
The Saccharomyces cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6.
Molecular and Cellular Biology
At a point in late G1 termed Start, yeast cells enter S phase, duplicate their spindle pole bodies, and form buds. These events require activation of Cdc28 kinase by G1 cyclins. Swi4 associates with Swi6 to form the SCB-binding factor complex which activates G1 cyclin genes CLN1 and CLN2 in late G1. In G2 and M phases, the transcriptional activity of SCB-binding factor is repressed by the mitotic Clb2/Cdc28 kinase. Mbp1, a transcription factor related to Swi4, forms the MCB- binding factor…
At a point in late G1 termed Start, yeast cells enter S phase, duplicate their spindle pole bodies, and form buds. These events require activation of Cdc28 kinase by G1 cyclins. Swi4 associates with Swi6 to form the SCB-binding factor complex which activates G1 cyclin genes CLN1 and CLN2 in late G1. In G2 and M phases, the transcriptional activity of SCB-binding factor is repressed by the mitotic Clb2/Cdc28 kinase. Mbp1, a transcription factor related to Swi4, forms the MCB- binding factor complex with Swi6, which activates DNA synthesis genes and S-phase cyclin genes CLB5 and CLB6 in late G1. Clb2/Cdc28 kinase is not required for the repression of MCB-binding factor transcriptional activity in G2 and M phase. We show here that the Swi4 carboxy terminus is sufficient for interaction with Swi6 in vitro. A carboxy-terminal domain of Swi6 is required and sufficient for interaction with Swi4. The carboxy terminus of Mbp1 is sufficient for interaction with Swi6, and the carboxy terminus of Swi6 is required for interaction with Mbp1. By coimmunoprecipitation, we show that Swi4 but not Mbp1 interacts with Clb2/Cdc28 kinase in vivo during the G2 and M phases of the cell cycle. We demonstrate that the ankyrin repeats of Swi4 mediate the interaction with Clb2/Cdc28 kinase. The ankyrin repeats constitute a domain by which a cell cycle-specific transcription factor can interact with cyclin-dependent kinase complexes, thus enabling it to link its transcriptional activity to cell cycle progression.
Andere Autor:innen -
Sprachen
-
English
Verhandlungssicher
-
German
Muttersprache oder zweisprachig
-
Spanish
Gute Kenntnisse
-
Polish
Grundkenntnisse
Organisationen
-
European Pharmaceutical Market Research Association (EphMRA)
Ethics Committee Member
–Heute -
Pharma Competitive Intelligence Conference Europe
Advisory Board Member and Key Note Speaker
–HeuteRecognized thought-leader in competitive intelligence as an advisory board member and keynote speaker. The Pharma CI Conference is the best-in-class conference for pharmaceutical, biotechnology, medical device, and diagnostic competitive intelligence executives
-
Society of Competitive Intelligence Professionals (SCIP)
Member
–Heute
Erhaltene Empfehlungen
-
LinkedIn Mitglied
29 Personen haben Robert F. Siegmund, PhD MBA empfohlen
Jetzt anmelden und ansehenWeitere Aktivitäten von Robert F. Siegmund, PhD MBA
-
Nova Magazin Gracija je u prodaji, već na svim kioscima u Crnoj Gori! U njoj ćete pročitati i moj intervju, vjerovatno najbolji do sada! Hvala na…
Nova Magazin Gracija je u prodaji, već na svim kioscima u Crnoj Gori! U njoj ćete pročitati i moj intervju, vjerovatno najbolji do sada! Hvala na…
Beliebt bei Robert F. Siegmund, PhD MBA