The world’s first TCR-T therapy for solid tumors has received approval by the FDA! This is an enormous milestone for the field and for patients suffering from cancer. The approval demonstrates the promise of TCR-T therapies and their potential to become an important part of cancer treatment in the future. It also sets the benchmark for the development of future generations of TCR-T therapies. Congratulations to Adaptimmune on this remarkable achievement! Read more about the FDA approval here: https://lnkd.in/dUy7-qqW and listen to our CEO Selwyn Ho's interview with Cormac Sheridan to learn more about this exciting field: https://lnkd.in/eVfycfpB #tcr #biotech #platform2patient
Info
Medigene AG (FSE: MDG1) is a leading immuno-oncology platform company dedicated to developing T-cell therapies to effectively eliminate cancer. Its end-to-end technology platform is built on multiple proprietary exclusive product development and product enhancement technologies, and allows Medigene to create best-in-class differentiated, T cell receptor engineered T cell (TCR-T) therapies for multiple solid tumor indications that are optimized for both safety and efficacy. This platform provides product candidates for both its in-house therapeutics pipeline and partnering. For more information, please visit www.medigene.com
- Website
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http://www.medigene.com
Externer Link zu Medigene AG
- Branche
- Biotechnologieforschung
- Größe
- 51–200 Beschäftigte
- Art
- Kapitalgesellschaft (AG, GmbH, UG etc.)
- Gegründet
- 1994
- Spezialgebiete
- Immunotherapies und T Cell receptors TCR
Orte
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Primär
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Lochhamer Strasse 11
Planegg, BY 82152, DE
Beschäftigte von Medigene AG
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Pamela Keck
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Tristan Holland
Team Leader - Senior Scientist at Medigene AG | Medigene Immunotherapies GmbH | Pre-Clinical Development of Cellular Immunotherapies (TCR-Ts)
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Julia Heilmann-Brohl
Senior Scientist bei MediGene AG
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Dolores J. Schendel
Chief Scientific Officer at Medigene AG
Updates
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With the decision on the FDA approval of the first autologous TCR-T therapy expected within the next few days, our CEO Selwyn Ho talked to Cormac Sheridan about the development of TCR-T therapies and their future potential. Exciting times ahead for this promising treatment modality! 🎧 Listen to the podcast here: https://lnkd.in/eVfycfpB #TCRT #Medigene #platform2patient
Episode 3.9 The slow rise of TCR-T therapy Listen here: https://lnkd.in/eVfycfpB When the first chimeric antigen receptor T-cell (CAR-T) therapy was approved in 2017, there was a general expectation that T-cell receptor T-cell (TCR-T) therapies would follow shortly afterwards and would greatly expand the range of addressable antigens. Despite considerable efforts, CAR-T therapies are still limited to haematological cancers expressing extracellular antigens, such as CD19 or B-cell maturation antigen (BCMA). Autologous TCR-T therapies can be engineered to target intracellular as well as extracellular peptide antigens presented on the cell surface by human leukocyte antigens (HLAs) and can be more readily used in solid tumors as well as in haematological cancers. Progress has been slow, however, given the complexities involved in both product design and process development. A decade ago, the field grappled with the issue of toxic and sometimes fatal cross-reactions between epitopes present in proteins expressed in healthy tissue and those contained in the targeted tumor antigens. More recently, the great challenge has been to ensure that engineered TCR-T cells are healthy enough to expand and persist once transferred back into patients. This year marks an important milestone for the field, as the FDA is due to grant – or deny – approval of Adaptimmune’s T-cell receptor (TCR) T-cell (TCR-T) therapy Afamitresgene autoleucel (afami-cel) for treating melanoma by 4 August 4. In this episode, we trace the development of the TCR-T technology and sketch out its future possibilities with Selwyn Ho, CEO of TCR-T therapy developer Medigene. © S & S #BIOTECH #BIOTECHNEWS #DRUGDISCOVERY #TCRTtherapy #immunotherapy #celltherapy
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Medigene AG will present at ESMO Congress 2024 taking place from September 13-17, 2024 in Barcelona, Spain. Read here the PR: https://lnkd.in/dNpaF_aD More details on the conference here: https://www.esmo.org/ #ESMO, #Platform2Patient, #TCR, #TCRT
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Sarcoma is often called the “forgotten cancer.” July marks Sarcoma Awareness Month, dedicated to raising awareness about sarcoma, a rare cancer that develops in the bones and soft tissues, including muscles, fat, blood vessels, and fibrous tissues. Let's focus on raising awareness about sarcoma and promoting research efforts for improved treatments. Medigene AG selected myxoid/round cell liposarcoma, which account for 10-20% of soft tissue sarcomas, as one of the initial clinical indications for its lead program MDG1015. More information around MDG1015: https://lnkd.in/d6k_fakE #Platform2Patient #TCR #TCRT#Sarcoma Awareness
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Medigene AG announced today that it has been granted a patent by the Chinese Patent Office for its T cell receptor targeting NY-ESO-1, complementing similar patents already issued in the United States, Japan, South Korea, Taiwan, and Australia. This optimal affinity 3S TCR along with the PD1-41BB costimulatory switch protein forms the core component of the Company's leading program MDG1015. Read here the PR: https://lnkd.in/dVvHK4GZ More information on our lead program MDG1015 here: https://lnkd.in/d6k_fakE #Platform2Patient #TCR #TCRT
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Medigene AG presented a detailed overview of its lead candidate MDG1015, a first-in-class 3rd generation TCR-T therapy at the 7th Cell and Gene Therapy In-Depth Focus Summit from June 27-28, 2024, in Beijing, China. In her presentation, Kirsty Crame - van Nierop highlighted Medigene’s lead TCR-T program, MDG1015 which targets the cancer-testis antigens NY-ESO-1 / LAGE-1a and is armored and enhanced by the Company’s PD1-41BB costimulatory switch protein. MDG1015 is scheduled for IND submission in the third quarter of 2024 and CTA submission in the fourth quarter of 2024. Read here the full PR: https://lnkd.in/dGJZN-5W Find more details on MDG1015 here: https://lnkd.in/d6k_fakE Conference details: https://lnkd.in/dv6X9dCX
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Medigene will present virtually at the 7th Cell and Gene Therapy In-Depth Focus Summit taking place from June 27-28, 2024, in Beijing, China. The presentation will feature the Company’s lead program MDG1015, a first-in-class third-generation TCR-T therapy. Read here the PR: https://lnkd.in/d5hTQufk Find out more about MDG1015 here:https://lnkd.in/d6k_fakE More details on the conference: https://lnkd.in/dv6X9dCX #Platform2Patient #TCR #TCRT
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Today Medigene AG announces lead selection for MDG2021, a TCR-T therapy targeting KRAS G12D-A*11. MDG2021 is the latest program now in preclinical development within Medigene’s library of neoantigens that comprises multiple KRAS mutations and HLAs. Read here the full PR: https://lnkd.in/dhzm-tDj Find out more about our KRAS library here: https://lnkd.in/dR-yASYw #Platform2Patient #TCR #TCRT
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Meet Medigene AG at #BIO2024! Our Senior Business Development Director Oscar Irvin-Sellers will attend BIO International Convention in San Diego from June 3-5, 2024. Feel free to directly reach out to Oscar Irvin-Sellers or connect via the BIO One-on-One Partnering system to schedule a meeting. For more information, please visit the conference website: https://lnkd.in/gMcJ49Eg
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We are excited to announce that we have submitted three patents to the European Patent Office for new proprietary technologies to further expand our End-to-End (E2E) Platform: 🔎🧫 𝗢𝘂𝗿 𝗜𝗻𝘁𝗲𝗿𝗳𝗲𝗿𝗼𝗻-𝗴𝗮𝗺𝗺𝗮 (𝗜𝗙𝗡γ) 𝗕𝗶𝗼𝘀𝗲𝗻𝘀𝗼𝗿 enables real-time monitoring and quantification of IFNγ release from cytokine-secreting cells. This provides detailed insights into immune response dynamics that are not possible using commercial tools. 💉 🔍 𝗢𝘂𝗿 𝗵𝗶𝗴𝗵 𝗽𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗧𝗖𝗥 𝘁𝗿𝗮𝗰𝗸𝗶𝗻𝗴 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝗶𝗲𝘀, 𝗨𝗻𝗶𝗧𝗼𝗽𝗲 & 𝗧𝗿𝗮𝗖𝗥, are designed to uniquely tag the #TCR and exactly track its location. This allows precise evaluation of proliferation, persistence, and localization of a TCR-guided cell therapy, both in vitro and in vivo. These 3 patents will join our group of over 20 different patent families covering Medigene’s 3S (sensitive, specific and safe) TCRs as well as its exclusive #E2E Platform technologies. Read here more: https://lnkd.in/dcb_NgYE #Platform2Patient #TCR #TCRT
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