„I recently had the pleasure of attending two workshops co-hosted by Daniel Gau and Tilo Senger. The first workshop, "Project Management in Action," was a very informative and interactive workshop that gave participants with little background knowledge (like me) not only the theory and tools used for effective project management, but also hands-on experience that we can already apply to our current projects. Having enjoyed the interactive teaching style of the first workshop, I signed up for the next workshop "Career Paths in Pharma." This is also a very worthwhile course for anyone who is considering a career in industry, or a change in career. It was useful to have a small group of people who were at various stages in their career development attend the workshop, because this allowed for a broader discussion that delved into aspects that would not have been addressed with a strictly PhD student or post-doc group. Daniel and Tilo ran the workshop very well and I appreciated that it was tailored to the needs and interests of those in attendance. I also valued the careful attention Daniel and Tilo gave to individual students' questions and constructive feedback provided in both workshops.“
Info
Passionate intrapreneur with versatile experience in R&D and CMC, focusing on ATMPs…
Aktivitäten
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🚀 The IZB - Innovation and Start-up Center Biotechnology as the Global Village of Biotechnology in Germany! 🌍 IZB Managing Director Christian Gnam…
🚀 The IZB - Innovation and Start-up Center Biotechnology as the Global Village of Biotechnology in Germany! 🌍 IZB Managing Director Christian Gnam…
Beliebt bei Daniel Gau
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☀From Summer Silence to Post-Holiday Buzz at IZB👙 As August fades into September, the usually lively IZB has quieted down as summer draws to a…
☀From Summer Silence to Post-Holiday Buzz at IZB👙 As August fades into September, the usually lively IZB has quieted down as summer draws to a…
Beliebt bei Daniel Gau
Berufserfahrung
Ausbildung
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Université Louis Pasteur (Strasbourg I)
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Bescheinigungen und Zertifikate
Veröffentlichungen
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Evaluation of ultrasound velocity measurements for estimating protease activities using casein as substrate.
Biotechnol Lett.
Ultrasonic resonator technology (URT) was compared with the well established UV-Vis/ninhydrin assay to estimate protease activities in defined buffer systems. Hydrolysis of casein was measured using subtilisin, trypsin, halophilic protease from Haloferax mediterranei and Bacillus lentus alkaline protease. Sensitivity, reproducibility, working range as well as the limit of detection and the limit of quantification were comparable for both methods. Salt concentrations (0.5 M NaCl) interfered with…
Ultrasonic resonator technology (URT) was compared with the well established UV-Vis/ninhydrin assay to estimate protease activities in defined buffer systems. Hydrolysis of casein was measured using subtilisin, trypsin, halophilic protease from Haloferax mediterranei and Bacillus lentus alkaline protease. Sensitivity, reproducibility, working range as well as the limit of detection and the limit of quantification were comparable for both methods. Salt concentrations (0.5 M NaCl) interfered with the URT method. The quantification of protease activity by URT was possible when the product concentration measured by the UV-Vis/ninhydrin assay was correlated to the corresponding ultrasonic velocity signals.
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Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth.
Genes Dev.
Mice carrying a hepatocyte-specific inactivation of the glucorticoid receptor (GR) gene show a dramatic reduction in body size. Growth hormone signaling mediated by the Stat5 transcription factors is impaired. We show that Stat5 proteins physically interact with GR and GR is present in vivo on Stat5-dependent IGF-I and ALS regulatory regions. Interestingly, mice with a DNA-binding-deficient GR but an unaltered ability to interact with STAT5 (GR(dim/dim)) have a normal body size and normal…
Mice carrying a hepatocyte-specific inactivation of the glucorticoid receptor (GR) gene show a dramatic reduction in body size. Growth hormone signaling mediated by the Stat5 transcription factors is impaired. We show that Stat5 proteins physically interact with GR and GR is present in vivo on Stat5-dependent IGF-I and ALS regulatory regions. Interestingly, mice with a DNA-binding-deficient GR but an unaltered ability to interact with STAT5 (GR(dim/dim)) have a normal body size and normal levels of Stat5-dependent mRNAs. These findings strongly support the model in which GR acts as a coactivator for Stat5-dependent transcription upon GH stimulation and reveal an essential role of hepatic GR in the control of body growth.
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Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock.
Neuron. 2002 Apr 11;34(2):245-53.
Biological rhythms are driven in mammals by a central circadian clock located in the suprachiasmatic nucleus (SCN). Light-induced phase shifting of this clock is correlated with phosphorylation of CREB at Ser133 in the SCN. Here, we characterize phosphorylation of CREB at Ser142 and describe its contribution to the entrainment of the clock. In the SCN, light and glutamate strongly induce CREB Ser142 phosphorylation. To determine the physiological relevance of phosphorylation at Ser142, we…
Biological rhythms are driven in mammals by a central circadian clock located in the suprachiasmatic nucleus (SCN). Light-induced phase shifting of this clock is correlated with phosphorylation of CREB at Ser133 in the SCN. Here, we characterize phosphorylation of CREB at Ser142 and describe its contribution to the entrainment of the clock. In the SCN, light and glutamate strongly induce CREB Ser142 phosphorylation. To determine the physiological relevance of phosphorylation at Ser142, we generated a mouse mutant, CREB(S142A), lacking this phosphorylation site. Light-induced phase shifts of locomotion and expression of c-Fos and mPer1 in the SCN are significantly attenuated in CREB(S142A) mutants. Our findings provide genetic evidence that CREB Ser142 phosphorylation is involved in the entrainment of the mammalian clock and reveal a novel phosphorylation-dependent regulation of CREB activity.
Sprachen
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English
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German
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French
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Spanish
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Jetzt anmelden und ansehenWeitere Aktivitäten von Daniel Gau
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Wonderful to see our team BioLabs Heidelberg today in this gem of a #German city ! #Heidelberg
Wonderful to see our team BioLabs Heidelberg today in this gem of a #German city ! #Heidelberg
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Three years ago, BioLabs Heidelberg embarked on an exciting journey and laid the foundation for its first European site in Germany. On August 16…
Three years ago, BioLabs Heidelberg embarked on an exciting journey and laid the foundation for its first European site in Germany. On August 16…
Beliebt bei Daniel Gau
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Storage, Freezing and Thawing and Biologics Drug Substance still provides challenges stability, and stability evaluation is not straight…
Storage, Freezing and Thawing and Biologics Drug Substance still provides challenges stability, and stability evaluation is not straight…
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We're looking to expand our team at DKFZ German Cancer Research Center in #Heidelberg! If you know someone passionate about office support, we have…
We're looking to expand our team at DKFZ German Cancer Research Center in #Heidelberg! If you know someone passionate about office support, we have…
Beliebt bei Daniel Gau
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Welcome, Adam Rosenberg ! Great to have you on board.
Welcome, Adam Rosenberg ! Great to have you on board.
Beliebt bei Daniel Gau
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Lufthansa! Zweieinhalb Stunden so zu sitzen ist super angenehm. Nicht! Ich bin 1,90 m groß, d.h. ich gehöre nicht zu den allerkleinsten, aber ein…
Lufthansa! Zweieinhalb Stunden so zu sitzen ist super angenehm. Nicht! Ich bin 1,90 m groß, d.h. ich gehöre nicht zu den allerkleinsten, aber ein…
Beliebt bei Daniel Gau
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📣 Selbstständig? Die Zukunftsaussichten für die gesetzliche Krankenversicherung sind alles andere als rosig, aber wer @selbständig ist, kann jetzt…
📣 Selbstständig? Die Zukunftsaussichten für die gesetzliche Krankenversicherung sind alles andere als rosig, aber wer @selbständig ist, kann jetzt…
Beliebt bei Daniel Gau
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🥳🥹 #biotech #startup #munichstartup #pitch #competition #diagnostics #dx
🥳🥹 #biotech #startup #munichstartup #pitch #competition #diagnostics #dx
Beliebt bei Daniel Gau
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Centanarian-associated SIRT6 mutant improves adipocyte function. https://lnkd.in/eDXK77ee
Centanarian-associated SIRT6 mutant improves adipocyte function. https://lnkd.in/eDXK77ee
Beliebt bei Daniel Gau
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