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Clinical MedicineImmunologyInflammation Free access | 10.1172/JCI129301
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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de Jesus, A.
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Hou, Y. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Brooks, S.
in:
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Malle, L.
in:
JCI
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PubMed
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Google Scholar
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Huang, Y. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Calvo, K. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Marrero, B. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Moir, S.
in:
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Oler, A.
in:
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Deng, Z. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Montealegre Sanchez, G. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Ahmed, A. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Allenspach, E.
in:
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Google Scholar
|
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Arabshahi, B. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Behrens, E.
in:
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Benseler, S. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Bezrodnik, L. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Bout-Tabaku, S. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Brown, D. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Burnham, J. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Caldirola, M. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Carrasco, R. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Chan, A.
in:
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Cimaz, R. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Dancey, P.
in:
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Dare, J.
in:
JCI
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PubMed
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Google Scholar
|
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by DeGuzman, M. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Dimitriades, V.
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Ferguson, I. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Ferguson, P. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Finn, L. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Gattorno, M. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Grom, A. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Hashkes, P. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Herzog, R. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Horneff, G. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Jerath, R. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Kessler, E. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Kingsbury, D. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Laxer, R. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Lee, P. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Lee-Kirsch, M. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Lewandowski, L. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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Li, S.
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Lilleby, V. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Mammadova, V. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Moorthy, L. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Nasrullayeva, G. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by O’Neil, K. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Onel, K. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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Ozen, S.
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Pan, N. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Pillet, P. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Piotto, D. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Punaro, M. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Reiff, A. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Reinhardt, A. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Rider, L.
in:
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PubMed
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Google Scholar
|
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Rivas-Chacon, R. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Ronis, T.
in:
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PubMed
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Google Scholar
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Rösen-Wolff, A. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Roth, J. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Ruth, N. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Schmeling, H. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Schulert, G.
in:
JCI
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Scott, C.
in:
JCI
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PubMed
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Google Scholar
|
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Seminario, G. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Shulman, A. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Sivaraman, V. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Stepanovskiy, Y. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Stringer, E. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Taber, S. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Terreri, M.
in:
JCI
|
PubMed
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Google Scholar
|
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Tifft, C.
in:
JCI
|
PubMed
|
Google Scholar
|
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Torgerson, T.
in:
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by
Tosi, L.
in:
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Van Royen-Kerkhof, A. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Wampler Muskardin, T. in: JCI | PubMed | Google Scholar
1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
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1Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
2Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
3Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
4Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
6Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
7Computational Systems Biology Section,
8Laboratory of Immunoregulation, and
9Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
10The Autoinflammatory Diseases Consortium,
11Levine Children’s Hospital, Charlotte, North Carolina, USA.
12Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
13Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
14Division of Rheumatology, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
15Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada.
16Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
17Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
18Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
19Division of Rheumatology, Children’s Hospital Los Angeles & USC, Los Angeles, California, USA.
20Pediatric Rheumatology, Dell Children’s Medical Center of Central Texas, Austin, Texas, USA.
21Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
22Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
23Division of Rheumatology, Janeway Children’s Hospital & Rehabilitation Centre, Saint John’s, Newfoundland and Labrador, Canada.
24Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, Arkansas, USA.
25Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
26Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
27Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
28Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
29Pathology Department, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA.
30Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
31Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
32Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
33Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
34Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool, United Kingdom.
35Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
36Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
37Augusta University Medical Center, Augusta, Georgia, USA.
38Division of Rheumatology, Children’s Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
39Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
40Randall Children’s Hospital at Legacy Emanuel, Portland, Oregon, USA.
41Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
42Division of Allergy, Immunology and Rheumatology, Boston Children’s Hospital, Boston, Massachusetts, USA.
43Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
44Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
45Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
46Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
47Azerbaijan Medical University, Baku, Azerbaijan.
48Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
49Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
50Hacettepe University, Department of Pediatrics, Ankara, Turkey.
51Children Hospital Pellegrin-Enfants, Bordeaux, France.
52Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
53Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
54Division of Rheumatology, Children’s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
55University of Nebraska Medical Center/Children’s Hospital and Medical Center, Omaha, Nebraska, USA.
56Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
57Department of Pediatric Rheumatology, Nicklaus Children’s Hospital, Miami, Florida, USA.
58Division of Pediatric Rheumatology, Children’s National Health System, Washington, DC, USA.
59Division of Pediatric Dermatology and Rheumatology, Children’s Hospital of Eastern Ontario, Ottawa, Canada.
60Medical University of South Carolina, Charleston, South Carolina, USA.
61Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
62University of Cape Town, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa.
63Pediatric Rheumatology, Children’s Hospital of Orange County, UC Irvine, Irvine, California, USA.
64Section of Rheumatology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
65Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA.
66Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
67IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
68Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
69Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
70Bone Health Program, Children’s National Health System, Washington, DC, USA.
71Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital Utrecht, Utrecht, Netherlands.
72New York University School of Medicine, New York, New York, USA.
73Children’s Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Find articles by Goldbach-Mansky, R. in: JCI | PubMed | Google Scholar
Published December 24, 2019 - More info
In this episode, Raphaela Goldbach-Mansky, Adriana de Jesus, and colleagues use a comprehensive approach to identify autoinflammatory diseases that present with elevated interferon signature.
BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.
METHODS. Sixty-six consecutively referred USAID patients underwent underwent screening for the presence of an interferon signature using a standardized type-I IFN-response-gene score (IRG-S), cytokine profiling, and genetic evaluation by next-generation sequencing.
RESULTS. Thirty-six USAID patients (55%) had elevated IRG-S. Neutrophilic panniculitis (40% vs. 0%), basal ganglia calcifications (46% vs. 0%), interstitial lung disease (47% vs. 5%), and myositis (60% vs. 10%) were more prevalent in patients with elevated IRG-S. Moderate IRG-S elevation and highly elevated serum IL-18 distinguished 8 patients with pulmonary alveolar proteinosis (PAP) and recurrent macrophage activation syndrome (MAS). Among patients with panniculitis and progressive cytopenias, 2 patients were compound heterozygous for potentially novel LRBA mutations, 4 patients harbored potentially novel splice variants in IKBKG (which encodes NF-κB essential modulator [NEMO]), and 6 patients had de novo frameshift mutations in SAMD9L. Of additional 12 patients with elevated IRG-S and CANDLE-, SAVI- or Aicardi-Goutières syndrome–like (AGS-like) phenotypes, 5 patients carried mutations in either SAMHD1, TREX1, PSMB8, or PSMG2. Two patients had anti-MDA5 autoantibody–positive juvenile dermatomyositis, and 7 could not be classified. Patients with LRBA, IKBKG, and SAMD9L mutations showed a pattern of IRG elevation that suggests prominent NF-κB activation different from the canonical interferonopathies CANDLE, SAVI, and AGS.
CONCLUSIONS. In patients with elevated IRG-S, we identified characteristic clinical features and 3 additional autoinflammatory diseases: IL-18–mediated PAP and recurrent MAS (IL-18PAP-MAS), NEMO deleted exon 5–autoinflammatory syndrome (NEMO-NDAS), and SAMD9L-associated autoinflammatory disease (SAMD9L-SAAD). The IRG-S expands the diagnostic armamentarium in evaluating USAIDs and points to different pathways regulating IRG expression.
TRIAL REGISTRATION. ClinicalTrials.gov NCT02974595.
FUNDING. The Intramural Research Program of the NIH, NIAID, NIAMS, and the Clinical Center.
The discovery of Mendelian defects that cause immune-dysregulatory and autoinflammatory diseases rapidly expanded our ability to diagnose pediatric patients with systemic sterile inflammation and provided insights into pathogenic mechanisms that cause organ inflammation and damage. Furthermore, pathogenesis and treatment studies in autoinflammatory diseases converge on confirming a key role of proinflammatory cytokines in amplifying abnormal immune responses, which have become effective targets for treatments (1).
Mutations in IL-1–activating inflammasomes (including NLRP3 and pyrin) and their remarkable response to IL-1–inhibiting therapies suggest a central role for IL-1 in their pathogenesis (1). More recently, 2 diseases with systemic inflammation, one caused by gain-of-function mutations in the viral sensor STING1/TMEM173 (STING) causing STING-associated vasculopathy with onset in infancy (SAVI), and another by additive loss-of-function mutations in proteasome genes causing the proteasome-associated autoinflammatory syndromes (PRAAS) (also, chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures [CANDLE]), presented with chronically elevated interferon (IFN) signatures, suggesting a pathogenic role for type-I IFN in autoinflammatory diseases (2, 3). Type-I IFN was first discovered as a soluble antiviral factor over 50 years ago, and a role in sterile inflammation was proposed in patients with systemic lupus erythematosus (4). However, the discovery of genetic mutations that cause the autoinflammatory type-I interferonopathies CANDLE (2, 5), SAVI (3, 6–8), and Aicardi-Goutières syndrome (AGS) (9, 10) have shed light on pathomechanisms that drive chronic IFN signaling, and recent studies blocking IFN signaling validate a critical role for type-I IFNs (11). AGS-causing loss-of-function mutations in nucleases impair self–nucleic acid homeostasis, SAVI-causing gain-of-function mutations in STING1/TMEM173 lead to chronic predominantly IFN-β production, and PRAAS-causing loss-of-function mutations in proteasome genes cause an elevated IFN signature that is independent of nucleic acids and viral sensor activation and points to additional intracellular mechanisms that trigger an IFN signature.
A link between autoinflammation and type-II IFN (IFN-γ) was recently established via the discovery of gain-of-function mutations in NLRC4 (12, 13). Patients demonstrate chronically and extremely high levels of serum IL-18, as well as evidence for IFN-γ activity during flares (14). Highly elevated serum IL-18 levels emerged as risk factors for developing macrophage activation syndrome (MAS) and have been associated with the development of MAS in systemic juvenile idiopathic arthritis and adult-onset Still’s disease (15, 16). The disease-causing NLRC4 mutations have associated the NLRC4 inflammasome but not the other inflammasomes with very high IL-18 activation (15). Mutations in XIAP (17) and CDC42 (18) are other monogenic autoinflammatory syndromes with high IL-18 levels that predispose to the development of MAS, thus providing genetically defined disease models to study the role of IL-18 in MAS. The presence of free IL-18 in these patients with ultrahigh serum IL-18 levels may modify the synergy with IL-12 in promoting the production of the type-II IFN, IFN-γ (19), which emerges as the critical factor in leading to the hyperinflammatory state of MAS (14).
Emerging data from interventional studies targeting the type-I IFN and IL-18/type-II IFN pathways have shown benefit in patients with these diseases and treatment also might benefit patients who currently have no genetic diagnosis but evidence of immune dysregulation in the respective inflammatory pathways. Patients with chronically elevated IFN signatures may clinically respond to treatments that block type-I IFN signaling (11). Likewise, patients with high serum IL-18 levels and an MAS predisposition might respond to treatments that target IL-18 (20) and/or the type-II IFN, IFN-γ (21).
Comprehensive clinical phenotyping of undifferentiated systemic autoinflammatory disease (USAID) patients and screening for an IFN signature by using a standardized type-I IFN response gene score (IRG-S), a targeted cytokine profile, and by genomic evaluation, led to the identification of 3 additional autoinflammatory diseases, IL-18–associated pulmonary alveolar proteinosis (PAP) and MAS syndrome (IL-18PAP-MAS), NEMO deleted exon 5–autoinflammatory syndrome (NEMO-NDAS), and SAMD9L-associated autoinflammatory disease (SAMD9L-SAAD). The preferential elevation of IFN-response genes (IRGs) with STAT-1 and NF-κB binding sites in patients with NEMO-NDAS, LPS-responsive beige-like anchor protein (LRBA) deficiency, and SAMD9L-SAAD suggests a prominent role for both NF-κB and IFN signaling, which is distinct from CANDLE, SAVI, and AGS.
Screening by using a validated IFN response gene score (IRG-S) identifies distinct clinical features in patients with elevated IRG-S compared with patients with normal IRG-S. IRG expression is low in healthy controls and untreated patients with the IL-1–mediated disease, neonatal-onset multisystem inflammatory disease (NOMID), and elevated in patients with PRAAS/CANDLE and SAVI. Of 65 patients tested for IRG-S elevation (see workflow in Figure 1), 36 (55%) had elevated IRG-S with an active disease flare and 29 patients were negative (Figure 2A). Four of the 29 patients with a normal IRG-S at the time of testing were later included in one of the disease groups of patients with an elevated IRG-S during disease flares (Table 1 and Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI129301DS1). Clinical and laboratory features varied in patients with and without elevated IRG-S and a significantly earlier disease onset was observed in patients with elevated IRG-S (Figure 2, B–G, Table 1, and Supplemental Table 1). Panniculitis was present in 22 patients (54%) included in disease groups with an elevated IRG-S, compared with no patient with a normal IRG-S (P < 0.0001). Similarly, basal ganglia calcifications were present in 12 out of 26 patients (46%) with elevated IRG-S who had either CTs or MRIs compared with none of 14 patients with normal IRG-S (P < 0.01). Other clinical features that were more frequent in patients with elevated IRG-S included interstitial lung disease (47% vs. 5% in patients with normal IRG-S), myositis (60% vs. 10% with normal IRG-S), arterial hypertension (30% vs. 4% with normal IRG-S), and liver enzyme elevation (61% vs. 12% with normal IRG-S) (Table 1).
Study overview, patient allocation and diagnosis. All patients were screened for elevation of an IFN-response-gene score (IRG-S) except for 1 patient (G4-P5), who was diagnosed postmortem based on WES with SAMD9L-SAAD. Patients were characterized based on presence or absence of an elevated IRG-S. All patients underwent clinical phenotyping, cytokine analyses, and genetic testing (WES/WGS or Sanger sequencing). Negative–IRG-S patients were clinically grouped (see supplement). Positive–IRG-S patients were grouped as CANDLE-like, SAVI-like, and AGS-like disease. Cytokine analyses and genetic analyses allowed for the characterization of patients with 3 additional diseases: IL-18PAP-MAS, NEMO-NDAS, and SAMD9L-SAAD (in red); and 2 patients had LRBA deficiency. Three patients had CANDLE, 1 AGS5, and 2 had anti-MDA5 autoantibody positive juvenile dermatomyositis. Seven patients with an elevated IRG-S and 7 patients with negative IRG-S could not be further classified. *No monogenic candidate gene. **Negative–IRG-S patients were classified as CRMO/CRMO-like (n = 5), CAPS/CAPS-like (n = 4), periodic fever syndrome (n = 6), Still’s-like disease and MAS (n = 3); 7 patients could not be classified. ***Two patients (G1-P5 and G4-P6) only had one sample, 1 patient (G4-P3) had a bone marrow transplant (BMT) and no pre-BMT sample available, and 1 patient (G1-P3) had 3 negative samples.
Shared clinical features and different cytokine profiles in patients with and without elevated IFN scores. (A) An elevated IFN-response gene score (IRG-S) distinguishes 36 patients during active disease from 29 patients who had normal IFN scores during bouts of active disease. Nonparametric (Kruskal-Wallis) test was used for multiple comparisons of IFN or Non-IFN groups with healthy controls (HC) or with CANDLE and SAVI patients combined. Depicted in the graph are the statistical significances (Kruskal-Wallis test) from the comparisons of each group (NOMID, IFN, and Non-IFN groups) with CANDLE and SAVI patients combined. Each individual patient is represented by a different symbol shape. ****P < 0.0001; NS, not significant. Bars and error lines indicate median and interquartile range, respectively; dotted line indicates the 28-gene IFN score cutoff (48.9) previously described (34). Multiple comparisons of each group (NOMID, CANDLE, and SAVI combined; IFN and Non-IFN) with HC (not depicted): NOMID P = 0.5004, CANDLE + SAVI P < 0.0001, IFN P < 0.0001, Non-IFN P = 0.2986. For HC, NOMID, and non-IFN groups, the same symbol is used for different individuals, as only 1 sample per patient is included. For CANDLE, SAVI, and IFN groups, each patient is represented by a different symbol. (B–G) Characteristic clinical features that were present only in patients with elevated IFN scores included panniculitis with lipoatrophy (B), neutrophilic vasculitis (C), erythematous macular rash (D), Gottron’s papules (E), interstitial lung disease (F), and basal ganglia calcifications (G). Four patients (per groups defined in Table 2; Group 1 – patient 3 [G1-P3] and G1-P5, G4-P2 and G4-P5) had negative IRG-S but were later added to the respective groups when a clinical or genetic diagnosis was made (not depicted).
On laboratory evaluation (Supplemental Table 2), lymphopenia (with low B cell and NK cell counts) and thrombocytopenia were present in 24%–31% of patients with elevated IRG-S compared with none with normal IRG-S; patients with high IRG-S were more frequently anemic (36% vs. 8%). Antinuclear antibodies were present in patients with and without an elevated IRG-S (33% vs. 11%, P = nonsignificant) but were more prevalent in patients with an elevated IRG-S; anti-dsDNA antibodies and anti-neutrophil antibodies (anti-PR3 and anti-MPO) were low positive in 1 or 2 patients with an elevated IRG-S each. In contrast, autoantibodies against endothelial lipoproteins (anti-cardiolipin, lupus anticoagulant) were equally positive in patients with and without elevated IRG-S. Serum IgA and IgM levels were higher in patients with elevated IRG-S (Supplemental Table 2).
Mortality within the study period was high in patients with positive IRG-S: 8 out of 41 (19.5%) expired within the study period (2014 to 2018); all patients with normal IRG-S are alive (Table 1). The IRG-S elevation was thought to be associated with active disease, although absence of infection could not always be excluded as a contributing factor to the increased IRG-S.
Of the 41 patients in the disease groups with elevated IRG-S, 18 were diagnosed with additional diseases based on clinical phenotype, cytokine and/or genetic analyses, and are described in groups 1 to 4 (G1–G4). Eight patients with PAP and recurrent MAS were grouped into G1. Twelve patients with CANDLE-like features had relatively lower IRG-S with disease flares than patients with CANDLE and were later genetically classified with distinct diseases: LRBA deficiency (G2, n = 2), NEMO-NDAS (G3, n = 4), and SAMD9L-SAAD (G4, n = 6). Several patients with high IRG-S resembled AGS (G5, n = 4) and one of them had a known mutation in SAMHD1. Two patients with high IRG-S, interstitial lung disease, soft tissue calcifications, and myositis had elevated anti-MDA5 autoantibodies, consistent with anti-MDA5 autoantibody–positive juvenile dermatomyositis (JDM) (G6, n = 2). Of the remaining patients in the disease groups with positive IRG-S, 3 had mutation-positive CANDLE and 3 had CANDLE-like features and were grouped in group 7 (G7, n = 6). Of the 3 CANDLE patients, 1 had a known mutation (n = 1), and 1 had a potentially novel mutation (n = 1) in the CANDLE-causing gene PSMB8. The third patient was compound heterozygous for mutations in a potentially novel CANDLE-causing gene, PSMG2 (n = 1). Two patients with SAVI-like features did not have disease-causing mutations and are described in G8 (SAVI-like)(n = 2) (see Supplemental Methods for definition of disease categories, Supplemental Methods A). Seven patients, each with clinical features unlike any other patient, could not be grouped or classified (G9, n = 7).
We assessed 48 cytokines in 53 patients with available serum samples (Supplemental Figure 1). The median IP-10 levels were significantly higher in patients with an elevated IRG-S (n = 20) compared with those with a normal IRG-S (n = 25) (7,369 [range 404.1–25,884] vs. 622.1 [191.4–3,185] pg/mL, P < 0.0001). Other cytokines that were significantly elevated include MIG/CXCL9 (2,890 [range 441.9–43,205] vs. 737.5 [83.4–1,272] pg/mL, P = 0.0001), SCF/KITLG (38.9 [4.3–209.8] vs. 20.9 [3.5–107.2] pg/mL, P = 0.0156), GROα/CXCL1 (251.6 [74.9–1,696] vs. 161.7 [24.9–314.8] pg/mL, P = 0.0043), and TRAIL (94.8 [18.1–633.3] vs. 47.9 [10.7–290.0] pg/mL, P = 0.0277).
Highly elevated serum IL-18 levels, PAP, and recurrent MAS characterize a defined clinical syndrome. Eight patients with a history of recurrent MAS, PAP, and nail clubbing (Figure 3, A–C) had ultrahigh elevations of serum IL-18 levels (Figure 3, D and E). Three were repeatedly tested for the entire cytokine panel and had significantly increased expression of a 12-cytokine signature nearly identical to that seen in patients with an NLRC4 gain-of-function mutation and recurrent MAS (NLRC4-MAS), which includes hematopoietic growth factors/cytokines like M-CSF, SCF, and IL-3 (12) (Figure 3D). However, whole-exome sequencing (WES) did not reveal definitive candidate mutations and no patient had NLRC4 mutations. The distinct clinical presentation with PAP, the very high IL-18 levels (Figure 3E), an IL-18/CXCL9 ratio similar to patients with NLRC4-MAS (14) (Figure 3F), and a cytokine signature previously associated with recurrent MAS clinically suggest a previously unrecognized disease, that is subsequently referred to as IL-18–associated PAP and MAS syndrome (IL-18PAP-MAS). These patients are combined in G1. Of the 8 patients, 7 had active disease at the time of assessment and 6 had an elevated IRG-S with active disease, although elevations were significantly lower than in CANDLE and SAVI (P = 0.0002 and P = 0.0003, respectively) (Figure 4A). In 1 patient with inactive disease and a normal C-reactive protein (CRP) at the time of blood draw, serum IL-18 levels had dropped from 430,423 pg/mL during active disease to 2,506 pg/mL (normal <500 pg/mL) and the IRG-S was normal. This patient was included in G1 due to the clinical phenotype of IL-18PAP-MAS and the ultrahigh IL-18 levels at the time of active disease. Supplemental Table 3 includes the clinical features and treatments for the IL-18PAP-MAS group.
Clinical features and cytokine dysregulation in patients with IL-18PAP-MAS (n = 8). (A) Nail clubbing. (B) Interstitial and alveolar lung disease. (C) Histologic features characteristic of pulmonary alveolar proteinosis (PAP). Original magnification, ×20. (D) Heatmap of 22 out of 48 analytes tested. The 12-cytokine signature includes SDF-1α/CXCL12, IFN-α2, MCP-3/CCL7, β-NGF, TRAIL, SCF, IL-16, IL-3, IL-18, IL-12p40, TNF-β/Ltα, and M-CSF. The 12-cytokine signature upregulation tracks with ultrahigh IL-18 levels that are also seen in patients with recurrent macrophage activation syndrome (MAS) and gain-of-function mutations in NLRC4 (12). Two other patients with the 12-cytokine signature (*) had MAS but no pulmonary disease. (E) Serum IL-18 levels in patients with IL-18PAP-MAS and healthy and disease controls. HC, healthy controls; IL-18PAP-MAS, G1 patients with PAP and recurrent MAS (n = 8); NLRC4/MAS, patients with monogenic NLRC4-mediated MAS (n = 5); NOMID, neonatal-onset multisystem inflammatory disease (n = 8); SAVI, STING-associated vasculopathy with onset in infancy (n = 5); CANDLE, chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (n = 8). (F) IL-18/CXCL9 ratio has previously been described to a cutoff of 2.3 (15), which is indicated with a gray horizontal line. IL-18PAP-MAS (n = 7); NLRC4/MAS, patients with monogenic NLRC4-mediated MAS (n = 5). In E and F, nonparametric test (Kruskal-Wallis) was performed for multiple comparisons and all significant differences are shown. In E, populations in brackets share the same significance pattern. *P < 0.05; **P < 0.01; ****P < 0.0001.
IFN score by disease group and clinical and genetic characteristics of SAMD9L-mediated autoinflammatory disease (SAMD9L-SAAD). (A) Twenty-eight–gene IFN scores by disease group. Nonparametric tests were used for multiple comparisons (Kruskal-Wallis) or individual group comparisons (Mann-Whitney). Each patient in groups 1 to 9 (G1 to G9) is represented by a different symbol shape. Depicted in the graph are the statistical significances (Kruskal-Wallis test) from the comparisons of each group (healthy controls [HC], NOMID, G1 to G4 combined, G5, G6, G7, G8, G9, and Non-IFN groups) with CANDLE and SAVI patients combined. *P = 0.0259; ****P < 0.0001; NS, not significant. Bars and error lines indicate median and interquartile range, respectively; dotted line indicates the 28-gene IFN score cutoff (48.9) previously described (34). For the control groups, HC and NOMID, the same symbol is used for different individuals, as only 1 sample per patient is included. For all other disease groups including CANDLE and SAVI, each patient is represented by a different symbol. (B) Clinical manifestations of SAMD9L-associated autoinflammatory disease (SAMD9L-SAAD) include nodular panniculitis and lipoatrophy (patient 1), interstitial lung disease (patient 6), and basal ganglia calcifications (patient 5). (C) SAMD9L domains and variant localization. SAM (blue), sterile α motif domain; AlbA/PPR (orange/yellow), DNA-binding domain; SIR2 (light blue), silent mating-type information regulator 2; P-loop NTPase (green), P-loop–containing NTP hydrolase; TPR (purple), tetratricopeptide repeat domain; OB (gray), oligonucleotide-binding fold domain; AA, amino acid; P1–P6, patient 1 to patient 6. Variants identified in SAMD9L-SAAD are in red, variants associated with ataxia-pancytopenia syndrome (APS) are in blue, and variants associated with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) are in green. Variants associated with either APS or MDS/AML are shown in purple.
Genetic analyses of 12 patients with CANDLE-like clinical phenotypes including panniculitis, but also progressive B cell lymphopenia, and low/intermediate IRG-S revealed potentially novel mutations in LRBA, potentially novel splice variants in IKBKG/NEMO, and truncating mutations in SAMD9L. Twelve patients with CANDLE-like phenotypes who were negative for known CANDLE-causing mutations had low/intermediate IRG-S and all developed progressive cytopenias. WES identified 2 patients with potentially novel or very rare compound heterozygous LRBA mutations (22). One of the LRBA-deficiency patients (G2-P2) had severe lipoatrophy, hepatomegaly, and type 2 insulin-resistant diabetes (DM type 2). A de novo mutation in IRS-1 (c.3632T>G; p.L1211R), encoding the insulin receptor substrate 1 previously associated with DM type 2 (23, 24), may have contributed to this phenotype but was not formally evaluated. Upon leptin replacement, the patient’s profound DM type 2 and hepatosplenomegaly resolved (25). The patient subsequently developed transverse myelitis and septic arthritis and underwent a bone marrow transplant. The other patient (G2-P1) had recurrent neutrophilic panniculitis in predominantly lower extremities and granulomatous hepatitis (Supplemental Table 4). Both patients were combined in G2 based on their biallelic LRBA mutations, reduced surface expression of CTLA4, and reduced number of regulatory T cells, consistent with previous findings in patients with LRBA deficiency (26) (data not shown).
One patient with lymphohistiocytic panniculitis and chorioretinitis (G3-P1) had conical teeth reminiscent of the ectodermal dysplasia found in NEMO deficiency syndrome, which prompted targeted sequencing of IKBKG (the causative gene in NEMO deficiency), the gamma subunit of the IκB kinase complex that regulates NF-κB activation. This patient, 2 other males, and 1 girl with panniculitis, progressive B cell lymphopenia, and hypogammaglobulinemia all had de novo splice-site variants that lead to deletion of exon 5 of IKBKG (G3-P1 to G3-P4) and are listed under G3 (Supplemental Table 4).
Genetic evaluation of 6 other patients revealed 3 tightly clustered de novo frameshift mutations in SAMD9L. All patients were clinically diagnosed as CANDLE due to the prominent neutrophilic panniculitis that was clinically and histologically indistinguishable from CANDLE. However, 4 patients also had early-onset, severe interstitial lung disease, a clinical feature that is not seen in CANDLE (Figure 4B). These patients had lower IRG-S in the context of high CRPs than CANDLE patients and developed progressive isolated B cell and NK cell cytopenias (Supplemental Table 4). One patient, who succumbed from respiratory failure at the age of 2 months, was included postmortem; she and 2 other patients had the identical de novo frameshift mutations in SAMD9L. Two patients with SAMD9L mutations (G4-P1 and G4-P4) had elevated IRG-S. Of the other 3 patients tested, 2 (G4-P3 and G4-P5) had negative IRG-S and the third patient (G4-P2) had 4 samples tested, 3 with negative IRG-S, and 1 sample, obtained during a rhinovirus induced disease flare, had an elevated IRG-S. Two patients received bone marrow transplants: G4-P3 had received a sibling-matched bone marrow transplant at the age of 20 months, and a second patient (G4-P6) received an allogeneic bone marrow transplant at the age of 9 months.
The highly similar clinical presentation, progressive B cell lymphopenia, and genetic findings (frameshift mutations all within 13 amino acids of each other, absent from public databases, and in a conserved protein domain) support their classification as a previously unrecognized autoinflammatory disease, referred to as SAMD9L-SAAD (G4) (Figure 4, A–C, and Supplemental Table 4).
Potentially novel and known mutations in PRAAS/CANDLE- and AGS-causing genes characterize patients with high IRG-S and suggestive clinical features. Of 4 patients summarized in G5 with neurologic disease manifestations, 2 had spastic quadriplegia and were wheelchair bound (G5-P2 and G5-P3); patient 2 expired in the context of a presumed infection. One patient (G5-P1) who suffered a stroke at the age of 7 years had Moya-Moya–like vasculopathy and was later found to have a previously described (27) homozygous SAMHD1 deletion. Patient G5-P3 had spastic quadriplegia and peripheral vasculitis. Her father had a very high IRG-S and extensive basal ganglia calcifications during workup of “muscle weakness” and was subsequently included as a patient (G5-P4).
Two patients who suffered from digital ulcerations, interstitial lung disease, and myositis were initially thought to have an autoinflammatory disease, but the presence of anti-MDA5 autoantibodies was consistent with a diagnosis of anti-MDA5 autoantibody–positive JDM. No obvious candidate gene was identified, and these patients (G6-P1 and G6-P2) were grouped together in G6.
Six patients with CANDLE-like features, who had no cytopenias but high IRG-S, were included in G7. Of these, 3 had disease-causing CANDLE mutations (G7-P4 through G7-P6). Patient G7-P4 was homozygous for a known PSMB8 mutation (p.T75M). Patient G7-P5 was compound heterozygous for 2 potentially novel PSMB8 mutations (p.S118P and p.Q55*) and patient G7-P6 harbored potentially novel compound heterozygous mutations in the proteasome assembly gene, PSMG2 (PAC2), that were recently confirmed to be pathogenic (28). Patient G7-P3 had severe localized panniculitis, localized lipoatrophy, and basal ganglia calcifications without white matter disease, and harbored a de novo somatic mutation (~26% allele fraction) in TREX1 that was previously associated with autosomal dominant AGS1 as a germline mutation (29). Four G7 patients (G7-P3, G7-P4, G7-P5, and G7-P6) were treated with JAK inhibitors with partial or good responses. Patient G7-P4 died due to severe pulmonary hypertension, which developed before initiation of JAK inhibitor treatment (30). Two siblings, G7-P1 and G7-P2, have no genetic diagnosis. G8 includes 2 patients with SAVI-like disease (G8-P1 and G8-P2) who presented with chilblains lesions and systemic inflammation but carried no obvious candidate mutations (Table 2 and Supplemental Table 5).
Diagnoses of patients with elevated type-1 IFN score (IRG-S), including genetic and immune evaluation
G9 includes 7 patients with elevated IRG-S who could not be grouped on a clinical, immunological, or genetic basis (Supplemental Table 6).
Patients with negative–IFN-S can be grouped according to clinical phenotype, genotype, and cytokine profile. The findings of the 25 patients with negative IRG-S are described in Supplemental Table 7; these patients could be classified into 4 subgroups (GN1 to GN-4). Five patients had chronic recurrent multifocal osteomyelitis (CRMO) (GN1, n = 5). GN1-P2 and GN1-P5 had exclusive jaw involvement and the others had long bone and spine involvement; no unifying genetic hypothesis was found. Four patients had cryopyrin-associated periodic syndrome–like (CAPS-like) disease (GN2, n = 4). Interestingly, all had a rare variant of unknown significance in NLRP3 that was inherited from a parent. All patients in GN2 had complete or partial responses to IL-1–blocking treatment, strengthening the concept that selected low-penetrance variants may predispose to the development of CAPS-like disease (31). No unifying genetic hypothesis was found for 6 patients with periodic fever syndromes (GN3, n = 6). Three patients with systemic juvenile idiopathic arthritis–like (sJIA-like) disease and MAS (GN4, n = 3) had all high serum IL-18 levels between 9,878 pg/mL and 24,200 pg/mL and IL-18/CXCL9 ratios greater than 1 that have previously been associated with increased risk for the development of MAS (15). Seven patients could not be grouped (GN5, n = 7).
Distinct gene expression patterns in 3 NF-κB–coregulated IRGs distinguish disease groups with both NF-κB and IFN signaling for potential leveraging of the diversity in IRG regulation for diagnostic purposes. Though all disease groups had elevated IRG-S compared with negative controls (healthy controls and NOMID), the mean IRG-S elevation was significantly lower in patients with IL-18PAP-MAS (G1), LRBA deficiency (G2), NEMO-NDAS (G3), and SAMD9L-SAAD (G4). Normalized gene expression for 25 of the 28 IRGs in our assay was significantly higher in CANDLE, SAVI, and disease groups G5–G8 compared with groups G1–G4 except for normalized gene expression in 3 genes, CXCL10, GBP1, and SOCS1, which was equal or higher in groups G1–G4 compared with CANDLE and SAVI (Supplemental Figure 2 and Supplemental Figure 3A).
We hypothesized that the differential expression of these genes may be due to regulation by different transcription factors (TFs). We therefore assessed TF binding sites (TFBSs) in the 28 genes in our IFN score. As expected, all 28 genes have TFBSs for STAT1 and other TFs activated by type-I IFNs. The 3 genes with relatively high expression compared with CANDLE and SAVI in patient groups G1–G4 have additional TFBSs for NF-κB1 (CXCL10, GBP1, and SOCS1) and/or NF-κB2 (CXCL10) (Supplemental Figure 3B), thus suggesting that NF-κB–dependent activation of these IRGs may be relatively high in patients in G1–G4 compared with STAT1-dependent activation, which differs in patients with CANDLE and SAVI. To validate a role of NF-κB in driving their expression, we used whole blood RNA-seq data to correlate the expression level of the 3 genes (CXCL10, GBP1, and SOCS1) with that of 11 genes that have NF-κB but no STAT1 TFBSs, by calculating summary Z scores, a “3-gene NF-κB/STAT1 score,” and an “11-gene NF-κB–only validation score” (Supplemental Methods and Supplemental Figures 3 and 4). The 3-gene NF-κB/STAT1 score did not correlate with the 11-gene NF-κB–only validation score in healthy controls who have no IFN score elevation nor in CANDLE, and SAVI, where we expected predominant type-I IFN/STAT1 inflammation. However, the 11-gene NF-κB–only validation score highly correlated with the 3-gene NF-κB/STAT1 score in patients with LRBA deficiency (G2, r = 0.82, P = 0.02), NEMO-NDAS (G3, r = 0.72, P = 0.03), and SAMD9L-SAAD (G4, r = 0.99, P = 0.002) (Supplemental Figure 5). A “25-gene STAT1-only score” of genes expressing only STAT1 but no NF-κB TFBSs did not correlate with the 11-gene NF-κB–only validation score in any disease group with elevated IRG-S. Interestingly, in the IL-18PAP-MAS patients, neither the 3-gene NF-κB/STAT1 score nor the 25-gene STAT1-only score correlated with the 11-gene NF-κB–only score (G1) (Supplemental Figure 5B). TFs that are activated by recombinant IL-18 (including FOS, ATF2, JUN, and ATF3) (32) were present in the regulatory domains of many of the IRGs in the 28-gene IRG-S (data not shown). In support of the notion that free IL-18 may coregulate the expression of IRGs in patients with IL-18PAP-MAS, we correlated total serum IL-18 levels, which correlates with free IL-18 levels (15), with the IRG-S and found that only serum levels of IL-18 but not IL-18BP and CXCL9 correlated weakly with the 28-gene IRG-S (r = 0.3, P = 0.06; Supplemental Figure 6A).
A ratio of the 3-gene NF-κB/STAT1 score and the 25-gene STAT1-only score (3:25 ratio) to reflect the relative contribution of NF-κB versus STAT1/IFN–mediated inflammation was very low in CANDLE, SAVI, AGS, AGS-like disease (G5), anti-MDA5 autoantibody–positive JDM (G6), CANDLE/CANDLE-like disease (G7), and SAVI-like disease (G8) (Figure 5A) as well as in childhood systemic lupus erythematosus (SLE) and other JDM (Supplemental Figure 7). A ratio less than 0.07 or greater than 0.15 distinguished the canonical interferonopathies (SAVI or CANDLE) and patients with LRBA deficiency (G2) and with NEMO-NDAS (G3) from healthy controls and NOMID patients, respectively (Figure 5B). The 3:25 ratio was normal in IL-18PAP-MAS. Although most of the 28 IRGs assessed in the IFN score are strongly triggered by type I IFNs, 9 genes are also significantly activated by type II IFN (IFN-γ). Interestingly, a ratio of IFN-γ– and IFN-α– regulated genes over all genes was higher in the IL-18PAP-MAS than in CANDLE and SAVI (Supplemental Figure 6B).
Ratios of 3-gene score (CXCL10 + GBP1 + SOCS1) over 25-gene score (3:25 gene ratio). (A) A ratio between 3 IFN-response genes with NF-κB transcription binding sites (CXCL10, GBP1, and SOCS1) and the 25 IFN genes with no NF-κB binding sites (3:25 ratio) was calculated. Depicted in the graph are the statistical significances (nonparametric Kruskal-Wallis test) from the comparisons of each group with CANDLE and SAVI patients combined: healthy controls (HC) and NOMID combined P < 0.0001, G1 P = 0.0017, G2 P = 0.0003, G3 P < 0.0001, G4 P = 0.0027, G5 P = 0.9271, G6 P = 0.6055, G7 P = 0.1499, G8 P = 0.8684, G9 P = 0.0083, Non-IFN P < 0.0001. NS, not significant. Bars and error lines indicate median and interquartile range, respectively. Red shaded area indicates a high 3:25 gene ratio, blue shaded area indicates low ratio, and white area indicates normal ratio. Cutoffs were calculated in panel B. For the control groups (HC and NOMID) the same symbol is used for different individuals, as only one sample per patient is included. In all other groups, including CANDLE and SAVI, each patient is represented by a different symbol. (B) Two receiver operating characteristic (ROC) curves for the 3:25 gene ratio to distinguish HC and NOMID from patients with NDAS (G3) and LRBA deficiency (G2) (ROC-1) and CANDLE and SAVI from HC and NOMID (ROC-2) are shown. A black arrow indicates the optimal cutoff (listed under each graph). AUC, area under the curve; SEN, sensitivity; SPE, specificity. The cutoffs for the ROC curves were marked in panel A with black arrows on the y axis. A list of genes in the IFN-gene score is published in ref. 34. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.
Preliminary outcomes in patients who received treatment with a JAK inhibitor. Although this study was not conducted to collect treatment outcomes, we report preliminary observations to increase available data on these very rare diseases to improve management (Supplemental Table 8). A total of 15 patients have received treatment with JAK inhibitors. Five patients received baricitinib in the context of a compassionate-use study (NCT01724580), and the other 10 patients received a JAK inhibitor through commercial sources: 7 received tofacitinib, 2 ruxolitinib, and 1 baricitinib (Supplemental Table 8). Two patients expired during the period of this study. One patient had anti-MDA5–antibody JDM and received ruxolitinib while on a ventilator for worsening lung disease. The other patient, a CANDLE patient, had severe primary pulmonary hypertension before starting tofacitinib (30). One patient with a psoriasiform dermatitis and scarring skin fibrosis had no response to 9 months of treatment and discontinued baricitinib treatment (G9-P1). Two additional CANDLE patients (G7-P5 and G7-P6) (28) and 1 patient with CANDLE-like disease and a somatic TREX1 mutation (G7-P3) had complete responses to JAK inhibition and continue on treatment. One patient with AGS5 (G5-P1) was previously reported (33) and has stable disease on baricitinib. Two patients with AGS-like disease had partial to minimal responses to baricitinib and tofacitinib (G5-P3 and G5-P4), respectively, with ongoing significant steroid requirement in 1 patient (G5-P3). Another patient with anti-MDA5 antibody–positive JDM (G6-P1) had a partial response to low dose of tofacitinib with progressive soft tissue and cardiac calcifications. Of the patients in G1–G4 who were treated with a JAK inhibitor, the patient with IL-18PAP-MAS had a partial response with no progression of lung disease and decreasing serum IL-18 levels (G1-P7), and the patient with LRBA deficiency has had partial responses with resolving cytopenias and rashes, and lower steroid requirements (G2-P1). One patient with NEMO-NDAS (G3-P4) had a suboptimal response and discontinued tofacitinib. Finally, 1 patient with SAMD9L-SAAD (G4-P1) had a partial response with ongoing skin disease and steroid requirements. Based on our findings, we suggest disease criteria to diagnose patients with and without an elevated IRG-S (Supplemental Table 9).
Mendelian autoinflammatory interferonopathies present with chronic elevation of an IRG-S (summarized in ref. 34). Clinical benefit in patients treated with JAK inhibitors who have CANDLE (11), SAVI (11, 35, 36), or AGS (37, 38) are encouraging, and the correlation of treatment responses with suppression of the IRG-S (34) suggests that the IRG-S is useful in diagnosis and as a biomarker in monitoring treatment responses. In this study, a strategy for screening patients with undifferentiated autoinflammatory diseases that included assessment of IRG-S, cytokine profiling, clinical phenotyping, and genomics led to characterization of additional disease groups of patients with both chronic and temporary IRG-S elevations, and to the development of a ratio of differentially regulated IRGs that were included in a 28-gene score that distinguishes the additional conditions from the canonical interferonopathies, CANDLE, SAVI, and AGS.
Compared with patients with a negative IRG-S, which included patients with osteomyelitis, CAPS-like disease, periodic fever syndromes, and sJIA-like disease with MAS flares and high IL-18 levels, most of which responded to IL-1–blocking treatments, patients with elevated IRG-S had more severe disease and higher mortality, thus underlining the unmet need to find better treatments.
The characterization of patients with clinical phenotypes that resemble CANDLE/PRAAS, who had overall lower IRG-S and developed progressive B cell cytopenias and/or hypogammaglobulinemia, led to the recognition of 3 distinct, monogenic conditions that underline the importance of assessing these mutations in patients suspected to have CANDLE/PRAAS and who are negative for mutations in genes that encode proteasome components. Two patients with CANDLE/PRAAS-like phenotypes had loss-of-function mutations in LRBA causing LRBA deficiency (39). Both patients (G2-P1 and G2-P2) had panniculitis and lower CTLA4 surface expression on CD4+ T cells than controls (data not shown), which confirm that the mutations impact CTLA4 recycling (26). However, both patients carry other mutations that may affect IFN signaling (Supplemental Table 4). It therefore remains to be determined whether the IFN signature is a characteristic part of the immune dysregulation of patients with LRBA deficiency (22) or is associated with other rare variants in those patients. Patient G2-P1 is partially responding to JAK inhibition with concomitant decrease in IRG-S after previously unsatisfactory responses to sirolimus and abatacept (Supplemental Table 4), suggesting a possible pathogenic role of increased IFN signaling.
Four patients harbor potentially novel splice variants inIKBKG/NEMO, the gamma subunit of the IκB kinase complex that activates NF-κB. In contrast with patients deficient in the NEMO protein who exhibit immunodeficiency, patients with the NEMO spliced mutant who lack only exon 5 (NEMOΔexon5) do not present with severe immunodeficiency but with systemic inflammation panniculitis and elevated IRG-S. Hanson et al. recently explored the molecular mechanisms that coactivate NF-κB and IRGs in these patients and called the disease NEMO-NDAS and found that NEMOΔexon5 stabilizes the TBK1/IKKi complex and facilitates IRF3 phosphorylation, IFNB1 transcription, and concomitant NF-κB activation. These evaluations provide a potential mechanistic explanation for the type-I IFN–associated “autoinflammatory” clinical features and the concomitant NF-κB nuclear translocation in this previously unrecognized inflammatory syndrome (40).
A severe perinatal-onset inflammatory disease was seen in 6 patients with frameshift mutations in SAMD9L that is phenotypically distinct from 2 diseases previously associated with heterozygous missense mutations in SAMD9L (41–44). One of the diseases, pancytopenia and ataxia syndrome (41, 44), presents later in life with concomitant cerebellar atrophy and risk of myelodysplasia. Other somatic and selective germline SAMD9L mutations can cause pediatric early-onset myelodysplastic syndrome (MDS) (43). The 6 patients reported here harbor potentially novel, de novo frameshift mutations that are in close proximity to each other. The mutations cause immune dysregulation characterized by nodular panniculitis similar to CANDLE/PRAAS, and early-onset interstitial lung disease in most patients (unlike CANDLE/PRAAS), and severe infection-associated myelosuppression/cytopenias. Genetic reversion that is described in pancytopenia and ataxia syndrome (41) and in pediatric MDS (43) was also seen in 1 patient before bone marrow transplant. The inflammatory disease manifestations suggest that these heterozygous SAMD9L frameshift mutations confer a gain of function through mechanisms that need to be further investigated. Furthermore, the positive outcome of bone marrow transplantation in 2 of the 6 patients, and the high mortality in patients who have severe concomitant lung disease, point to the importance of distinguishing these patients from CANDLE by making the diagnosis of SAMD9L-SAAD early.
Eight patients uniformly presented with recurrent MAS-like episodes and developed PAP/lipoid pneumonia and clubbing of their distal phalanges. They were diagnosed clinically as having a previously unrecognized disease that is referred to as IL-18PAP-MAS. These patients’ histological findings of PAP are distinct from the interstitial fibrosis of SAVI, and are not seen in patients with NLRC4-associated MAS despite comparably high serum IL-18 levels (12, 15). Similarly, elevated IL-18 levels are also seen in some patients with sJIA and adult Still’s disease, and are now recognized as factors predisposing to the development of MAS (15, 17, 45–47). Some of these patients are included in a publication that highlights a larger spectrum of sJIA patients who develop a heterogeneous spectrum of lung diseases that include PAP and interstitial lung fibrosis and are referred to as sJIA-LD (48). Patients with IL-18PAP-MAS share a cytokine signature linked to high expression of IL-18 and originally described in NLRC4-MAS (12), which includes hematopoietic growth factors/cytokines like M-CSF, SCF, and IL-3. Interestingly, humanized mice with transgenic expression of human SCF, IL-3, and GM-CSF develop spontaneous MAS directly mediated by myeloid cells (49), raising questions whether IL-18 promotes the production of these growth factors. These mechanisms may synergize with the known function of the role of IL-18 as IFN-γ–stimulating factor in infections and may provide further potential mechanisms by which IL-18 confers MAS susceptibility. The presence of PAP suggests alveolar macrophage dysfunction in clearing surfactant from the alveoli, as is seen in patients with genetic or autoimmune GM-CSF deficiency (50). Whether treatment aimed at blocking IL-18, or IFN-γ signaling, or treatments aimed at modifying phagocytosis and processing of surfactant by alveolar macrophages are viable treatment strategies needs further exploration. Genetic analyses have so far not been conclusive in the IL-18PAP-MAS patients nor the other sJIA-LD patients (48).
Interestingly, the magnitude and pattern of the IRG elevation differed between these 4 conditions (LRBA deficiency, NEMO-NDAS, SAMD9L-SAAD, and IL-18PAP-MAS) versus CANDLE and SAVI. The expression of 3 IRGs that contain both NF-κB and STAT1 TFBSs (CXCL10, GBP1, and SOCS1) correlated with IFN-independent NF-κB–induced gene expression in LRBA deficiency and NEMO-NDAS, and in SAMD9L-SAAD during flares when IRG-S was elevated, suggesting a relatively large effect of NF-κB signaling, compared with the canonical interferonopathies (CANDLE, SAVI, and AGS) and some autoimmune interferonopathies. Although preliminary, our data suggest that patients with IL-18PAP-MAS, LRBA deficiency, NEMO-NDAS, and SAMD9L-SAAD may have more variable responses to JAK inhibition than CANDLE patients, consistent with the observation that the inflammatory response is complex. The partial response to JAK inhibition would be expected in this scenario and may suggest treatment combinations that target the IFN-mediated and NF-κB–mediated dysregulation. In the IL-18PAP-MAS patients, IRGs induced by IFN-α and IFN-γ relative to those induced by predominantly IFN-α were higher in IL-18PAP-MAS than in the other diseases. The pattern of IRGs did not correlate with NF-κB–induced genes, but correlated weakly with the patients’ highly elevated total serum IL-18 levels (often >200,000 pg/mL, whereas normal levels are <500 pg/mL) (15). As any of the IRGs in the 28-gene IRG-S have TFs in their respective regulatory domains that are activated by recombinant IL-18, the correlation of IL-18 levels with the IRG-S suggests that free IL-18 may coregulate the expression of IRGs in patients with IL-18PAP-MAS. IL-18 induces IFN-γ (51), which emerges as a critical downstream mediator of the pathogenesis of MAS (15). Whether and how free IL-18 drives the IRG-S, directly via coregulating expression of IRGs or via promoting IFN-γ needs to be evaluated. Pathomechanisms underlying the promising results with JAK inhibition in MAS and hemophagocytic lymphohistiocytosis (52–54) may be partially attributable to IFN-γ receptor signaling blockade (21), but treatments targeting the IL-18/IFN-γ axis are promising (55).
Overall, this study establishes the value of screening for an interferon signature and for high serum IL-18 levels and expands the diagnostic armamentarium that supports the challenging evaluation of patients with undifferentiated autoinflammatory diseases. The diagnosis of IL-18PAP-MAS, NEMO-NDAS, SAMD9L-SAAD, and LRBA deficiency needs to be considered in patients presenting with elevated IRG-S and clinically suggestive features. A high ratio of 3:25 differentially regulated IRGs identified NEMO-NDAS, LRBA deficiency, and a normal ratio was seen in the SAMD9L-SAAD patients. These diseases mimic CANDLE/PRAAS clinically but higher 3:25 ratios suggest a relatively increased NF-κB signaling distinct from CANDLE/PRAAS and SAVI. Future investigations are necessary to determine whether the 3:25 ratio will be useful in predicting response to IFN-targeted monotherapy, versus the need for additional treatments.
Patients and healthy controls
Between 2014 and 2017, 66 consecutive patients with presumed undifferentiated autoinflammatory diseases who had no genetic diagnosis upon referral were included in an institutional review board–approved (IRB-approved) natural history study (NCT02974595). All clinical investigations were conducted according to Declaration of Helsinki principles. Written informed consent was obtained from the subjects or their parents either at the NIH or by phone consent. Blood samples were collected from patients and their unaffected family members when available. Healthy controls were recruited through the same study, NCT02974595, and were siblings or family members who have no mutations. For some assays, anonymous healthy blood donors were used.
Clinical, immunological, and genetic evaluation
We assessed 57 patients at the NIH (including physical exam, clinically indicated imaging, and a chest CT) and immunologically (T, B, NK cell count, immunoglobulins, and rheumatologic work up). Five patients passed away before an NIH visit could be arranged, and in 4 patients logistical problems precluded travel to the NIH. Samples for genetic testing were obtained from all 66 patients either at the NIH or were sent under NCT02974595. WES was performed in 19 trios, 1 duo, and 4 singletons, whole-genome sequencing (WGS) in 36 trios and 1 duo; 5 patients had Sanger sequencing of candidate genes performed only. Confirmatory targeted (Sanger) sequencing of candidate genes detected by WES or WGS was performed. Next-generation sequencing data are registered in NCBI’s dbGaP database (https://www.ncbi.nlm.nih.gov/gap/) under accession number phs001946.v1.p1.
Cytokine analysis
Serum was collected from 53 of 66 patients and 5 healthy controls. Cytokine concentrations of 48 analytes were measured using the Bio-Plex system (Bio-Rad) (3) in 2 batches. Cytokine analysis was done in 28 of the 36 patients with elevated IFN signature (presumed undifferentiated interferonopathy [UIFN]). The first batch included 45 patients, 20 with UIFN and 25 without UIFN, and 5 healthy controls, and the second batch included 8 patients with an UIFN. Due to a ceiling effect of high serum IL-18 levels in the Bio-Plex system, all samples with levels greater than 10,000 pg/mL were re-run in a dedicated ELISA assay, as previously described (15). All patients with a history of MAS had serum measurements that included IL-18, IL-18BP, and CXCL9 (MIG) as described in Weiss et al. (15).
NanoString 28-gene IRG-S
At least 1 IRG-S was obtained for 65 of 66 patients. It was not obtained from 1 patient with a SAMD9L mutation (G4-P5). As previously reported, total RNA was extracted from blood samples collected in Paxgene tubes (Qiagen). Gene expression of selected IRGs was determined by NanoString (NanoString Technologies) and an IRG-S was calculated as previously described based on healthy control data (34).
Within the 28 IRGs of the NanoString IRG-S, 3 IRGs were identified as having an NFKB1 and/or an NFKB2 TFBS. For validation and correlation of a 3-gene subscore of IRGs with STAT1 and NF-κB1 and NF-κB2 TFBSs with other genes preferentially activated by NF-κB1 and NF-κB2 that lack STAT1 binding sites, please refer to Supplemental Methods D, Supplemental Figure 3B, and Supplemental Figure 4, A and B.
Evaluation of the 3-gene to 25-gene ratio (3:25 ratio) in the various diseases. A ratio of the sum of the normalized counts of the 3 NanoString ISGs with NF-κB binding sites (CXCL10, GBP1, and SOCS1) and the sum of the normalized counts of the 25 other genes was generated and compared between diseases.
Statistics
Descriptive analyses were performed; no adjustments for multiple comparisons were made. For normally distributed data, parametric tests (unpaired 2-tailed t tests for group comparison, i.e., cytokine analysis) were used. Nonparametric tests were used for not normally distributed data (Kruskal-Wallis for multiple comparisons and Mann-Whitney test for group comparison). Pearson’s correlation was used for correlations of the 3-, 11-, and 25-gene subscores. Receiver-operating characteristic (ROC) curves were generated comparing the 3-gene/25-gene ratio in CANDLE and SAVI versus the various disease groups (G1–G9) to healthy controls and NOMID samples using the Wilson-Brown method; a confidence interval of 95% is reported. P values below 0.05 were considered statistically significant for all tests performed. All statistical analyses described above were performed using GraphPad Prism version 8.00 for Mac OS.
Study approval
The study was approved by IRBs at the NIH, NIAID. All patients were enrolled in the NIH Natural History Protocol of Autoinflammatory Diseases (NCT02974595). Patients or their parents provided written informed consent. Additional written photo consent was obtained from patients included in this paper. Most patients were evaluated at the NIH. Patients unable to come to the NIH were consented over the telephone and blood samples for RNA and DNA analysis as well as medical records were sent to the NIH.
AAJ and GAMS acquired data, oversaw the clinical aspects of the study, and analyzed data. Members of the Autoinflammatory Diseases Network referred patients and acquired and interpreted clinical data. LM, AB, YH, BM, and SM conducted experiments, and acquired and analyzed data. SC acquired and analyzed clinical and biomarker subspecialty data. AJO oversaw the statistical analyses of the study data. YH and GAMS acquired clinical data. KRC interpreted clinical and bone marrow biopsy data. SB and ZD analyzed genetic data. AAJ and RGM designed the study, analyzed the data, and wrote the first draft of the manuscript. Authors listed in the Autoinflammatory Disease Consortium (AA to TWM) provided critical patient information and phenotyping data. All authors reviewed and approved the final version of the manuscript.
We would like to thank Samantha Dill, Dawn Chapelle, and Laura Failla for excellent patient care; and Nicole Plass, Wendy Goodspeed, Michelle O’Brian, and Susan Pfeiffer for scheduling patients. We would also like to thank Jacob Mitchell and Rachel VanTries for running experiments. We further thank Paul Wakim for his review and advice on the statistical aspects of the correlation analyses. Funding was provided by the Intramural Research Program of the NIH, NIAID, NIAMS, and the Clinical Center.
Address correspondence to: Adriana A. de Jesus or Raphaela Goldbach-Mansky, Translational Autoinflammatory Diseases Section (TADS)/LCIM/NIAID, NIH, Building 10 Room 11C215 (AAJ) or Room 11C205 (RGM) MSC 1888, 10 Center Drive, Bethesda, Maryland 20892-1888, USA. Phone: 301.761.7768; Email: [email protected] (AAJ). Phone: 301.761.7553; Email: [email protected] (RGM).
Conflict of interest: RGM received investigator-initiated grants under government collaborative agreements from SOBI, Lilly, Regeneron and Novartis. SWC received grants from Novartis and AB2Bio. JAD received grants from Pfizer, Roche, and Bristol-Myers Squibb. AAG received grants from NovImmune, grants and personal fees from Ab2Bio, and grants from Novartis. RML received consultant fees from SOBI and Novartis. LGR received research support from Hope Pharmaceuticals, Bristol-Myers Squibb, and Elli Lily. GS received personal fees from Novartis. TLWM received grants from Arthritis National Research Foundation, NYU Clinical & Translational Science Institute; personal fees from Novartis; and has a patent Methods and Materials for Treating Autoimmune Conditions issued.
Copyright: © 2020, American Society for Clinical Investigation.
Reference information: J Clin Invest. 2020;130(4):1669–1682. https://doi.org/10.1172/JCI129301.