Chemi, F. et al. (2019) Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine, 25(10), pp. 1534-1539. (doi: 10.1038/s41591-019-0593-1) (PMID:31591595) (PMCID:PMC6986897)
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Abstract
Approximately 50% of patients with early-stage non-small-cell lung cancer (NSCLC) who undergo surgery with curative intent will relapse within 5 years1,2. Detection of circulating tumor cells (CTCs) at the time of surgery may represent a tool to identify patients at higher risk of recurrence for whom more frequent monitoring is advised. Here we asked whether CellSearch-detected pulmonary venous CTCs (PV-CTCs) at surgical resection of early-stage NSCLC represent subclones responsible for subsequent disease relapse. PV-CTCs were detected in 48% of 100 patients enrolled into the TRACERx study3, were associated with lung-cancer-specific relapse and remained an independent predictor of relapse in multivariate analysis adjusted for tumor stage. In a case study, genomic profiling of single PV-CTCs collected at surgery revealed higher mutation overlap with metastasis detected 10 months later (91%) than with the primary tumor (79%), suggesting that early-disseminating PV-CTCs were responsible for disease relapse. Together, PV-CTC enumeration and genomic profiling highlight the potential of PV-CTCs as early predictors of NSCLC recurrence after surgery. However, the limited sensitivity of PV-CTCs in predicting relapse suggests that further studies using a larger, independent cohort are warranted to confirm and better define the potential clinical utility of PV-CTCs in early-stage NSCLC.
Item Type: | Articles |
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Additional Information: | Correction to: Nature Medicine https://doi.org/10.1038/s41591-019-0593-1, published online 7 October 2019. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Miller, Professor Crispin |
Authors: | Chemi, F., Rothwell, D. G., McGranahan, N., Gulati, S., Abbosh, C., Pearce, S. P., Zhou, C., Wilson, G. A., Jamal-Hanjani, M., Birkbak, N., Pierce, J., Kim, C. S., Ferdous, S., Burt, D. J., Slane-Tan, D., Gomes, F., Moore, D., Shah, R., Al Bakir, M., Hiley, C., Veeriah, S., Summers, Y., Crosbie, P., Ward, S., Mesquita, B., Dynowski, M., Biswas, D., Tugwood, J., Blackhall, F., Miller, C., Hackshaw, A., Brady, G., Swanton, C., Dive, C., and TRACERx Consortium, . |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Nature Medicine |
Publisher: | Nature Research |
ISSN: | 1078-8956 |
ISSN (Online): | 1546-170X |
Published Online: | 07 October 2019 |
Copyright Holders: | Copyright © 2019, Springer Nature |
First Published: | First published in Nature Medicine 25(10):1534-1539 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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