Costa, R. L., Gadelha, L., D'arc, M., Ribeiro-Alves, M., Robertson, D. L. , Schwartz, J.-M., Soares, M. A. and Porto, F. (2024) HIHISIV: a database of gene expression in HIV and SIV host immune response. BMC Bioinformatics, 25, 125. (doi: 10.1186/s12859-024-05740-7) (PMID:38519883) (PMCID:PMC10958971)
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Abstract
In the battle of the host against lentiviral pathogenesis, the immune response is crucial. However, several questions remain unanswered about the interaction with different viruses and their influence on disease progression. The simian immunodeficiency virus (SIV) infecting nonhuman primates (NHP) is widely used as a model for the study of the human immunodeficiency virus (HIV) both because they are evolutionarily linked and because they share physiological and anatomical similarities that are largely explored to understand the disease progression. The HIHISIV database was developed to support researchers to integrate and evaluate the large number of transcriptional data associated with the presence/absence of the pathogen (SIV or HIV) and the host response (NHP and human). The datasets are composed of microarray and RNA-Seq gene expression data that were selected, curated, analyzed, enriched, and stored in a relational database. Six query templates comprise the main data analysis functions and the resulting information can be downloaded. The HIHISIV database, available at https://hihisiv.github.io , provides accurate resources for browsing and visualizing results and for more robust analyses of pre-existing data in transcriptome repositories.
Item Type: | Articles |
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Additional Information: | Open Access funding enabled and organized by Projekt DEAL. This work has been supported by CAPES (Coorde‑ nação de Aperfeiçoamento de Pessoal de Nível Superior), CNPq (Conselho Nacional de Desenvolvimento Científco e Tecnológico) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) as part of GHGA – The German Human Genome-Phenome Archive (www.ghga.de, Grant Number 441914366 (NFDI 1/1)). |
Keywords: | SIV, Immune response, Animals, Disease Progression, Immunity, Humans, HIV-1, Simian Acquired Immunodeficiency Syndrome - genetics, HIV, Simian Immunodeficiency Virus - genetics, High-throughput gene expression data, Gene Expression, HIV Infections |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Robertson, Professor David |
Creator Roles: | Robertson, D.Methodology, Conceptualization, Writing – original draft, Writing – review and editing, Supervision |
Authors: | Costa, R. L., Gadelha, L., D'arc, M., Ribeiro-Alves, M., Robertson, D. L., Schwartz, J.-M., Soares, M. A., and Porto, F. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | BMC Bioinformatics |
Publisher: | Biomed Central |
ISSN: | 1471-2105 |
ISSN (Online): | 1471-2105 |
Copyright Holders: | Copyright: © The Author(s) 2024 |
First Published: | First published in BMC Bioinformatics 25(125) |
Publisher Policy: | Reproduced under a Creative Commons licence |
Related URLs: | |
Data DOI: | 10.5281/zenodo.7093185 |
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