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Ganguly, A. et al. (2023) G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions. Journal of Biological Chemistry, 299(10), 105218. (doi: 10.1016/j.jbc.2023.105218) (PMID:37660910) (PMCID:PMC10520886)
Ji, Z., Nagar, R., Duncan, S. M., Sampaio Guther, M. L. and Ferguson, M. A.J. (2023) Identification of the glycosylphosphatidylinositol-specific phospholipase A2 (GPI-PLA2) that mediates GPI fatty acid remodeling in Trypanosoma brucei. Journal of Biological Chemistry, 299(8), 105016. (doi: 10.1016/j.jbc.2023.105016) (PMID:37414151) (PMCID:PMC10457582)
Butler, L., Locatelli, C., Allagioti, D., Lousa, I., Lemonidis, K. , Tomkinson, N. C.O., Salaun, C. and Chamberlain, L. H. (2022) S-Acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction. Journal of Biological Chemistry, 299(1), 102754. (doi: 10.1016/j.jbc.2022.102754) (PMID:36442513) (PMCID:PMC9800311)
van Gijsel-Bonnello, M. et al. (2022) Salt Inducible Kinase 2 regulates fibrosis during bleomycin-induced lung injury. Journal of Biological Chemistry, 298(12), 102644. (doi: 10.1016/j.jbc.2022.102644) (PMID:36309093) (PMCID:PMC9706632)
Mukundan, A., Byeon, C.-H., Hinck, C. S., Cunningham, K. , Campion, T., Smyth, D. J. , Maizels, R. M. and Hinck, A. P. (2022) Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-ß to its receptors, TßRI and TßRII. Journal of Biological Chemistry, 298(6), 101994. (doi: 10.1016/j.jbc.2022.101994) (PMID:35500648) (PMCID:PMC9163516)
Marsango, S. et al. (2022) Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. Journal of Biological Chemistry, 298(5), 101932. (doi: 10.1016/j.jbc.2022.101932) (PMID:35427647) (PMCID:PMC9118924)
Divorty, N., Jenkins, L. , Ganguly, A., Butcher, A. J., Hudson, B. D. , Schulz, S., Tobin, A. B. , Nicklin, S. A. and Milligan, G. (2022) Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor. Journal of Biological Chemistry, 298(3), 101655. (doi: 10.1016/j.jbc.2022.101655) (PMID:35101446) (PMCID:PMC8892012)
Duncan, S. M., Nagar, R., Damerow, M., Yashunsky, D. V., Buzzi, B., Nikolaev, A. V. and Ferguson, M. A.J. (2021) A Trypanosoma brucei β3 glycosyltransferase superfamily gene encodes a β1-6 GlcNAc-transferase mediating N-glycan and GPI anchor modification. Journal of Biological Chemistry, 297(4), 101153. (doi: 10.1016/j.jbc.2021.101153) (PMID:34478712) (PMCID:PMC8477195)
Cvetko, F., Caldwell, S. T. , Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C. , Dinkova-Kostova, A. and Murphy, M. P. (2021) Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. Journal of Biological Chemistry, 296, 100169. (doi: 10.1074/jbc.RA120.016551) (PMID:33298526) (PMCID:PMC7948991)
Ward, R. J., Pediani, J. D. , Marsango, S., Jolly, R., Stoneman, M. R., Biener, G., Handel, T. M., Raicu, V. and Milligan, G. (2021) Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. Journal of Biological Chemistry, 296, 100139. (doi: 10.1074/jbc.RA120.016612) (PMID:33268380)
Palor, M. et al. (2020) Cholesterol sensing by CD81 is important for hepatitis C virus entry. Journal of Biological Chemistry, 295(50), pp. 16931-16948. (doi: 10.1074/jbc.RA120.014761) (PMID:32900848) (PMCID:PMC7863897)
Mitxitorena, I., Somma, D. , Mitchell, J. P., Lepistö, M., Tyrchan, C., Smith, E. L., Kiely, P. A., Walden, H. , Keeshan, K. and Carmody, R. J. (2020) The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits. Journal of Biological Chemistry, 295(33), pp. 11754-11763. (doi: 10.1074/jbc.RA120.014113) (PMID:32587091) (PMCID:PMC7450122)
Zoltner, M. et al. (2020) Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. Journal of Biological Chemistry, 295(24), pp. 8331-8347. (doi: 10.1074/jbc.ra120.012355) (PMID:32354742) (PMCID:PMC7294092)
Lochhead, M. R., Brown, A. D., Kirlin, A. C., Chitayat, S., Munro, K., Findlay, J. E., Baillie, G. S. , LeBrun, D. P., Langelaan, D. N. and Smith, S. P. (2020) Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A. Journal of Biological Chemistry, 27, pp. 4303-4315. (doi: 10.1074/jbc.RA119.011078) (PMID:32098872)
Albuquerque-Wendt, A. , Jacot, D., Dos Santos Pacheco, N., Seegers, C., Zarnovican, P., Buettner, F. F.R., Bakker, H., Soldati-Favre, D. and Routier, F. H. (2020) C-Mannosylation of Toxoplasma gondii proteins promotes attachment to host cells and parasite virulence. Journal of Biological Chemistry, 295(4), pp. 1066-1076. (doi: 10.1074/jbc.ra119.010590) (PMID:31862733) (PMCID:PMC6983843)
Robinson, P. J. , Kanemura, S., Cao, X. and Bulleid, N. J. (2020) Protein secondary structure determines the temporal relationship between folding and disulfide formation. Journal of Biological Chemistry, 295(8), pp. 2438-2448. (doi: 10.1074/jbc.RA119.011983) (PMID:31953323) (PMCID:PMC7039548)
Dutton, L. R. , O'Neill, C. L., Medina, R. J. and Brazil, D. P. (2019) No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells. Journal of Biological Chemistry, 294(48), pp. 18041-18045. (doi: 10.1074/jbc.AC119.010148) (PMID:31604823) (PMCID:PMC6885617)
Patel, A., Sibbet, G. J. and Huang, D. T. (2019) Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B~ubiquitin complex. Journal of Biological Chemistry, 294, pp. 1240-1249. (doi: 10.1074/jbc.RA118.006045) (PMID:30523153) (PMCID:PMC6349121)
Liu, Y. and Sumpter, D. J.T. (2018) Mathematical modeling reveals spontaneous emergence of self-replication in chemical reaction systems. Journal of Biological Chemistry, 293(49), pp. 18854-18863. (doi: 10.1074/jbc.ra118.003795) (PMID:30282809) (PMCID:PMC6295724)
Maziarz, M., Broselid, S., DiGiacomo, V., Park, J.-C., Luebbers, A., Garcia-Navarrete, L., Blanco-Canosa, J. B., Baillie, G. S. and Garcia-Marcos, M. (2018) A biochemical and genetic discovery pipeline identifies PLCδ4b as a non-receptor activator of heterotrimeric G proteins. Journal of Biological Chemistry, 293(44), pp. 16964-16983. (doi: 10.1074/jbc.RA118.003580) (PMID:30194280) (PMCID:PMC6222092)
Marciano, G., Da Vela, S., Tria, G., Svergun, D. I., Byron, O. and Huang, D. T. (2018) Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones. Journal of Biological Chemistry, 293(26), pp. 10071-10083. (doi: 10.1074/jbc.RA117.000994) (PMID:29764934) (PMCID:PMC6028955)
Fazakerley, D. J. et al. (2018) Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Journal of Biological Chemistry, 293(19), pp. 7315-7328. (doi: 10.1074/jbc.RA117.001254) (PMID:29599292) (PMCID:PMC5950018)
Schnabel, J., Hombach, P., Waksman, T., Guiriani, G., Petersen, J. and Christie, J. M. (2018) A chemical genetic approach to engineer phototropin kinases for substrate labeling. Journal of Biological Chemistry, 293(15), pp. 5613-5623. (doi: 10.1074/jbc.RA118.001834) (PMID:29475950) (PMCID:PMC5900772)
Shams, K., Kurowska-Stolarska, M. , Schütte, F., Burden, A. D., McKimmie, C. S. and Graham, G. J. (2018) MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2. Journal of Biological Chemistry, 293(8), pp. 3003-3012. (doi: 10.1074/jbc.M117.809780) (PMID:29279330) (PMCID:PMC5827444)
Clayton, S. A., Jones, S. W., Kurowska-Stolarska, M. and Clark, A. R. (2018) The role of microRNAs in glucocorticoid action - literature review. Journal of Biological Chemistry, 293(6), pp. 1865-1874. (doi: 10.1074/jbc.R117.000366) (PMID:29301941) (PMCID:PMC5808749)
Lemonidis, K., MacLeod, R., Baillie, G. S. and Chamberlain, L. H. (2017) Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase. Journal of Biological Chemistry, 292(42), pp. 17190-17202. (doi: 10.1074/jbc.M117.799650)
Petersen, J., Inoue, S.-i., Kelly, S. M. , Sullivan, S. , Kinoshita, T. and Christie, J. M. (2017) Functional characterization of a constitutively active kinase variant of Arabidopsis phototropin 1. Journal of Biological Chemistry, 292(33), pp. 13843-13852. (doi: 10.1074/jbc.M117.799643) (PMID:28663371) (PMCID:PMC5566536)
Plain, F., Congreve, S. D., Yee, R. S. Z., Kennedy, J., Howie, J., Kuo, C.-W., Fraser, N. J. and Fuller, W. (2017) An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger. Journal of Biological Chemistry, 292(25), pp. 10745-10752. (doi: 10.1074/jbc.M116.773945) (PMID:28432123) (PMCID:PMC5481580)
Arndt, S. et al. (2017) Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA. Journal of Biological Chemistry, 292(19), pp. 7761-7773. (doi: 10.1074/jbc.M117.784678) (PMID:28320864) (PMCID:PMC5427258)
Robinson, P. J. , Pringle, M. A. , Woolhead, C. A. and Bulleid, N. J. (2017) Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation. Journal of Biological Chemistry, 292(17), pp. 6978-6986. (doi: 10.1074/jbc.M117.780742) (PMID:28298446) (PMCID:PMC5409466)
Alvarez-Curto, E. , Inoue, A., Jenkins, L. , Raihan, S. Z., Prihandoko, R., Tobin, A. B. and Milligan, G. (2016) Targeted elimination of G proteins and arrestins defines their specific contributions to both intensity and duration of G protein-coupled receptor signalling. Journal of Biological Chemistry, 291(53), pp. 27147-27159. (doi: 10.1074/jbc.M116.754887) (PMID:27852822) (PMCID:PMC5207144)
Bandara, M. , Corey, R. A., Martin, R., Skehel, J. M., Blocker, A. J., Jenkinson, H. F. and Collinson, I. (2016) Composition and activity of the non-canonical gram-positive SecY2 complex. Journal of Biological Chemistry, 291(41), pp. 21474-21484. (doi: 10.1074/jbc.m116.729806) (PMID:27551046) (PMCID:PMC5076819)
Valinsky, W. C., Jolly, A., Miquel, P., Touyz, R. M. and Shrier, A. (2016) Aldosterone upregulates transient receptor potential melastatin 7 (TRPM7). Journal of Biological Chemistry, 291(38), pp. 20163-20172. (doi: 10.1074/jbc.M116.735175) (PMID:27466368) (PMCID:PMC5025699)
Sanchez, M. A., Tran, K. D., Valli, J., Hobbs, S., Johnson, E., Gluenz, E. and Landfear, S. M. (2016) KHARON Is an essential cytoskeletal protein involved in the trafficking of flagellar membrane proteins and cell division in African trypanosomes. Journal of Biological Chemistry, 291(38), pp. 19760-19773. (doi: 10.1074/jbc.M116.739235) (PMID:27489106) (PMCID:PMC5025667)
Bolognini, D. et al. (2016) A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias. Journal of Biological Chemistry, 291, pp. 18915-18931. (doi: 10.1074/jbc.M116.736157) (PMID:27385588) (PMCID:PMC5009265)
Pediani, J. D. , Ward, R. J., Godin, A. G., Marsango, S. and Milligan, G. (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. Journal of Biological Chemistry, 291, pp. 13132-13146. (doi: 10.1074/jbc.M115.712562) (PMID:27080256) (PMCID:PMC4933229)
Dyer, D. P. , Salanga, C. L., Johns, S. C., Valdambrini, E., Fuster, M. M., Milner, C. M., Day, A. J. and Handel, T. M. (2016) The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine:glycosaminoglycan interactions. Journal of Biological Chemistry, 291, pp. 12627-12640. (doi: 10.1074/jbc.M116.720953) (PMID:27044744) (PMCID:27044744)
Vodnala, M., Ranjbarian, F., Pavlova, A., de Koning, H. P. and Hofer, A. (2016) Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine. Journal of Biological Chemistry, 291(22), pp. 11717-11726. (doi: 10.1074/jbc.M116.715615) (PMID:27036940) (PMCID:PMC4882440)
McLuskey, K., Grewal, J. S., Das, D., Godzik, A., Lesley, S. A., Deacon, A. M., Coombs, G. H., Elsliger, M.-A., Wilson, I. A. and Mottram, J. C. (2016) Crystal structure and activity studies of the C11 cysteine peptidase from Parabacteroides merdae in the human gut microbiome. Journal of Biological Chemistry, 291, pp. 9482-9491. (doi: 10.1074/jbc.M115.706143) (PMID:26940874) (PMCID:PMC4850288)
Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)
Butcher, A. J. et al. (2016) An antibody biosensor establishes the activation of the M1 muscarinic acetylcholine receptor during learning and memory. Journal of Biological Chemistry, 291(17), pp. 8862-8875. (doi: 10.1074/jbc.M115.681726) (PMID:26826123) (PMCID:PMC4861454)
Baratchian, M., Davis, C. A. , Shimizu, A., Escors, D., Bagnéris, C., Barrett, T. and Collins, M. K. (2016) Distinct activation mechanisms of NF-κB regulator inhibitor of NF-κB kinase (IKK) by isoforms of the cell death regulator cellular FLICE-like inhibitory protein (cFLIP). Journal of Biological Chemistry, 291(14), pp. 7608-7620. (doi: 10.1074/jbc.M116.718122) (PMID:26865630) (PMCID:PMC4817188)
Lefoulon, C., Boeglin, M., Moreau, B., Véry, A.-A., Szponarski, W., Dauzat, M., Michard, E., Gaillard, I. and Chérel, I. (2016) The Arabidopsis AtPP2CA protein phosphatase inhibits the GORK K+ efflux channel and exerts a dominant suppressive effect on phosphomimetic-activating mutations. Journal of Biological Chemistry, 291(12), pp. 6521-6533. (doi: 10.1074/jbc.M115.711309) (PMID:26801610)
Hafver, T. L. et al. (2016) Protein phosphatase 1c associated with the cardiac sodium calcium exchanger 1 regulates its activity by dephosphorylating serine 68-phosphorylated phospholemman. Journal of Biological Chemistry, 291(9), pp. 4561-4579. (doi: 10.1074/jbc.M115.677898) (PMID:26668322) (PMCID:PMC4813481)
Hover, S. et al. (2016) Modulation of potassium channels inhibits bunyavirus infection. Journal of Biological Chemistry, 291(7), pp. 3411-3422. (doi: 10.1074/jbc.M115.692673) (PMID:26677217) (PMCID:PMC4751384)
Sergeev, E. , Hansen, A. H., Pandey, S. K., MacKenzie, A. E., Hudson, B. D. , Ulven, T. and Milligan, G. (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. Journal of Biological Chemistry, 291, pp. 303-317. (doi: 10.1074/jbc.M115.687939) (PMID:26518871) (PMCID:PMC4697166)
Miles, J. A., Frost, M. G., Carroll, E., Rowe, M. L., Howard, M. J., Sidhu, A., Chaugule, V. K., Alpi, A. F. and Walden, H. (2015) The Fanconi Anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL. Journal of Biological Chemistry, 290(34), pp. 20995-21006. (doi: 10.1074/jbc.M115.675835) (PMID:26149689) (PMCID:PMC4543658)
Collins, P. E., Grassia, G., Colleran, A., Kiely, P. A., Ialenti, A., Maffia, P. and Carmody, R. J. (2015) Mapping the interaction of B cell Leukemia 3 (BCL-3) and nuclear factor κB (NF-κB) p50 identifies a BCL-3-mimetic anti-inflammatory peptide. Journal of Biological Chemistry, 290(25), pp. 15687-15696. (doi: 10.1074/jbc.M115.643700) (PMID:25922067) (PMCID:PMC4505479)
Marsango, S., Caltabiano, G., Pou, C., Varela Liste, M. J. and Milligan, G. (2015) Analysis of human dopamine D3 receptor quaternary structure. Journal of Biological Chemistry, 290, pp. 15146-15162. (doi: 10.1074/jbc.M114.630681) (PMID:25931118) (PMCID:PMC4463457)
Aslanoglou, D., Alvarez-Curto, E. , Marsango, S. and Milligan, G. (2015) Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers. Journal of Biological Chemistry, 290(23), pp. 14785-14796. (doi: 10.1074/jbc.M115.649079) (PMID:25918156) (PMCID:PMC4505543)
Ward, R. J., Pediani, J. D. , Godin, A. G. and Milligan, G. (2015) Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. Journal of Biological Chemistry, 290(20), pp. 12844-12857. (doi: 10.1074/jbc.M115.644724) (PMID:25825490) (PMCID:PMC4432300)
Choi, J.-Y., Duraisingh, M. T., Marti, M. , Ben Mamoun, C. and Voelker, D. R. (2015) From protease to decarboxylase: the molecular metamorphosis of phosphatidylserine decarboxylase. Journal of Biological Chemistry, 290(17), pp. 10972-10980. (doi: 10.1074/jbc.M115.642413) (PMID:25724650) (PMCID:PMC4409258)
Hudson, G. M., Watson, P. J., Fairall, L., Jamieson, A. G. and Schwabe, J. W.R. (2015) Insights into the recruitment of class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR transcriptional repression complex. Journal of Biological Chemistry, 290(29), pp. 18237-18244. (doi: 10.1074/jbc.M115.661058) (PMID:26055705) (PMCID:PMC4505066)
Bishop, P., Rubin, P., Thomson, A. R. , Rocca, D. and Henley, J. M. (2014) The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons. Journal of Biological Chemistry, 289(52), pp. 36140-36149. (doi: 10.1074/jbc.M114.557124) (PMID:25326379) (PMCID:PMC4276877)
Hock, A. K., Vigneron, A. M. and Vousden, K. H. (2014) Ubiquitin-specific Peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity. Journal of Biological Chemistry, 289(50), pp. 34862-34870. (doi: 10.1074/jbc.M114.589267)
Bonvin, P., Dunn, S. M., Rousseau, F., Dyer, D. P. , Shaw, J., Power, C. A., Handel, T. M. and Proudfoot, A. E.I. (2014) Identification of the pharmacophore of the CC chemokine-binding proteins evasin-1 and -4 using phage display. Journal of Biological Chemistry, 289(46), pp. 31846-31855. (doi: 10.1074/jbc.M114.599233) (PMCID:PMC4231662)
Yadav, T., Carrasco, B., Serrano, E. and Alonso, J. C. (2014) Roles of bacillus subtilis Dpra and Ssba in RecA-mediated genetic recombination. Journal of Biological Chemistry, 289(40), pp. 27640-27652. (doi: 10.1074/jbc.M114.577924) (PMID:25138221) (PMCID:PMC4183802)
Evans, S., Burgess, K. E.V. and Gray, J. V. (2014) Recovery from Rapamycin: drug-insensitive activity of yeast target of rapamycin complex 1 (torc1) supports residual proliferation that dilutes rapamycin among progeny cells. Journal of Biological Chemistry, 289(38), pp. 26554-26565. (doi: 10.1074/jbc.M114.589754) (PMID:25104356) (PMCID:PMC4176226)
Liefhebber, J. M.P., Hague, C. V., Zhang, Q., Wakelam, M. J.O. and McLauchlan, J. (2014) Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus. Journal of Biological Chemistry, 289(31), pp. 21276-21288. (doi: 10.1074/jbc.M114.582999)
Hudson, B. D. , Shimpukade, B., Milligan, G. and Ulven, T. (2014) The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120). Journal of Biological Chemistry, 289, pp. 20345-20358. (doi: 10.1074/jbc.M114.561449) (PMID:24860101) (PMCID:PMC4106347)
Butcher, A. J., Hudson, B. D. , Shimpukade, B., Alvarez-Curto, E. , Prihandoko, R., Ulven, T., Milligan, G. and Tobin, A. B. (2014) Concomitant action of structural elements and receptor phosphorylation determine arrestin-3 interaction with the free fatty acid receptor FFA4. Journal of Biological Chemistry, 289, pp. 18451-18465. (doi: 10.1074/jbc.M114.568816) (PMID:24817122) (PMCID:PMC4140278)
Fjaere, E. et al. (2014) Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. Journal of Biological Chemistry, 289(23), pp. 16032-16045. (doi: 10.1074/jbc.M113.525220)
Hewit, K. D., Fraser, A., Nibbs, R. J.B. and Graham, G. J. (2014) The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding. Journal of Biological Chemistry, 289(18), pp. 12330-12342. (doi: 10.1074/jbc.M113.534545)
Collins, P. E., Kiely, P. A. and Carmody, R. J. (2014) Inhibition of transcription by B cell leukaemia 3 (Bcl-3) requires interaction with nuclear factor (NF)-κB p50. Journal of Biological Chemistry, 289(10), pp. 7059-7067. (doi: 10.1074/jbc.M114.551986)
Cao, Z., Subramaniam, S. and Bulleid, N. J. (2014) Lack of an efficient endoplasmic reticulum-localized recycling system protects peroxiredoxin IV from hyperoxidation. Journal of Biological Chemistry, 289(9), pp. 5490-5498. (doi: 10.1074/jbc.M113.529305)
Muller, P. A.J., Trinidad, A. G., Caswell, P. T., Norman, J. C. and Vousden, K. H. (2014) Mutant p53 regulates dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. Journal of Biological Chemistry, 289(1), pp. 122-132. (doi: 10.1074/jbc.M113.502138)
Salanga, C. L., Dyer, D. P. , Kiselar, J. G., Gupta, S., Chance, M. R. and Handel, T. M. (2014) Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine. Journal of Biological Chemistry, 289(21), pp. 14896-14912. (doi: 10.1074/jbc.M114.547737) (PMID:24727473) (PMCID:PMC4031540)
Higman, V. A. et al. (2014) A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function. Journal of Biological Chemistry, 289(9), pp. 5619-5634. (doi: 10.1074/jbc.M113.542357) (PMID:24403066) (PMCID:PMC3937638)
Baldwin, H.M., Pallas, K., King, V., Jamieson, T., McKimmie, C.S., Nibbs, R.J.B. , Carballido, J.M., Jaritz, M., Rot, A. and Graham, G.J. (2013) Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice. Journal of Biological Chemistry, 288(51), pp. 36473-36483. (doi: 10.1074/jbc.M113.491563)
Fan, J., Kamphorst, J.J. , Rabinowitz, J.D. and Shlomi, T. (2013) Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux. Journal of Biological Chemistry, 288(43), pp. 31363-31369. (doi: 10.1074/jbc.M113.502740) (PMID:24030823) (PMCID:PMC3829450)
Keenholtz, R.A., Mouw, K.W., Boocock, M.R., Li, N.-S., Piccirilli, J.A. and Rice, P.A. (2013) Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage. Journal of Biological Chemistry, 288(40), pp. 29206-29214. (doi: 10.1074/jbc.M113.508028)
Kaan, H.Y.K., Major, J., Tkocz, K., Kozielski, F. and Rosenfeld, S.S. (2013) "Snapshots" of Ispinesib-induced conformational changes in the mitotic kinesin Eg5. Journal of Biological Chemistry, 288(25), pp. 18588-18598. (doi: 10.1074/jbc.M113.462648)
Hudson, B.D. et al. (2013) Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. Journal of Biological Chemistry, 288(24), pp. 17296-17312. (doi: 10.1074/jbc.M113.455337)
Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. and Fuller, W. (2013) A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump. Journal of Biological Chemistry, 288(19), pp. 13808-13820. (doi: 10.1074/jbc.M113.460956) (PMID:23532852) (PMCID:PMC3650417)
Sommerville, C., Richardson, J.M., Williams, R.A.M., Mottram, J.C. , Roberts, C.W., Alexander, J. and Henriquez, F.L. (2013) Biochemical and immunological characterization of toxoplasma gondii macrophage migration inhibitory factor. Journal of Biological Chemistry, 288(18), pp. 12733-12741. (doi: 10.1074/jbc.M112.419911)
Lek, H.S., Morrison, V.L. , Conneely, M., Campbell, P.A., McGloin, D., Kliche, S., Watts, C., Prescott, A. and Fagerholm, S.C. (2013) The spontaneously adhesive leukocyte function-associated antigen-1 (lfa-1) integrin in effector t cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow. Journal of Biological Chemistry, 288(21), pp. 14698-14708. (doi: 10.1074/jbc.M112.430918) (PMID:23585567) (PMCID:PMC3663495)
Williams, R.A.M., Mottram, J.C. and Coombs, G.H. (2013) Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major. Journal of Biological Chemistry, 288(5), pp. 3678-3690. (doi: 10.1074/jbc.M112.415372)
Spender, L.C., Carter, M.J., O'Brien, D.I., Clark, L.J., Yu, J., Michalak, E.M., Happo, L., Cragg, M.S. and Inman, G.J. (2013) Transforming growth factor- directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas. Journal of Biological Chemistry, 288(7), pp. 5198-5209. (doi: 10.1074/jbc.M112.410274) (PMID:23243310) (PMCID:PMC3576124)
Choi, C.-H., Thomason, P.A., Zaki, M., Insall, R.H. and Barber, D.D.L. (2013) Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in dictyostelium. Journal of Biological Chemistry, 288(4), pp. 2464-2474. (doi: 10.1074/jbc.M112.435313)
Winter, A., McCormack, G., Myllyharju, J. and Page, A. (2013) Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi. Journal of Biological Chemistry, 288(3), pp. 1750-1761. (doi: 10.1074/jbc.M112.397604) (PMID:23223450) (PMCID:PMC3548485)
Ramirez-Peinado, S., Leon-Annicchiarico, C. L., Galindo-Moreno, J., Iurlaro, R., Caro-Maldonado, A., Prehn, J. H.M., Ryan, K. M. and Munoz-Pinedo, C. (2013) Glucose-starved cells do not engage in prosurvival autophagy. Journal of Biological Chemistry, 288(42), pp. 30387-30398. (doi: 10.1074/jbc.M113.490581)
Moreno, J.L. et al. (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A{middle dot}mGlu2) receptor heteromerization and its psychoactive behavioral function. Journal of Biological Chemistry, 287(53), pp. 44301-44319. (doi: 10.1074/jbc.M112.413161)
Grinter, R., Roszak, A.W., Cogdell, R.J. , Milner, J.J. and Walker, D. (2012) The crystal structure of the lipid II-degrading bacteriocin syringacin M suggests unexpected evolutionary relationships between colicin M-like bacteriocins. Journal of Biological Chemistry, 287(46), pp. 38876-38888. (doi: 10.1074/jbc.M112.400150)
Greaves, J., Lemonidis, K., Gorleku, O. A., Cruchaga, C., Grefen, C. and Chamberlain, L. H. (2012) Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. Journal of Biological Chemistry, 287(44), pp. 37330-37339. (doi: 10.1074/jbc.M112.389098)
Hudson, B.D. , Tikhonova, I.G., Pandey, S.K., Ulven, T. and Milligan, G. (2012) Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. Journal of Biological Chemistry, 287(49), pp. 41195-41209. (doi: 10.1074/jbc.M112.396259)
Denisova, O. V. et al. (2012) Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. Journal of Biological Chemistry, 287(42), pp. 35324-35332. (doi: 10.1074/jbc.M112.392142)
Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P.C.F., Patterson-Kane, J., Arthur, J.S.C. and Cohen, P. (2012) Pellino1 is required for interferon production by viral double-stranded RNA. Journal of Biological Chemistry, 287(41), pp. 34825-34835. (doi: 10.1074/jbc.M112.367557)
Christie, J.M. , Hitomi, K., Arvai, A.S., Hartfield, K.A., Mettlen, M., Pratt, A.J., Tainer, J.A. and Getzoff, E.D. (2012) Structural tuning of the fluorescent protein iLOV for improved photostability. Journal of Biological Chemistry, 287(26), pp. 22295-22304. (doi: 10.1074/jbc.M111.318881)
Meir, A., Bayer, E. A. and Livnah, O. (2012) Structural adaptation of a thermostable biotin-binding protein in a psychrophilic environment. Journal of Biological Chemistry, 287(22), pp. 17951-17962. (doi: 10.1074/jbc.M112.357186) (PMID:22493427) (PMCID:PMC3365750)
Cunningham, M. R., McIntosh, K. A., Pediani, J. D. , Robben, J., Cooke, A. E., Nilsson, M., Gould, G. W. , Mundell, S., Milligan, G. and Plevin, R. (2012) Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4). Journal of Biological Chemistry, 287(20), pp. 16656-16669. (doi: 10.1074/jbc.M111.315911)
Xu, T.-R., Ward, R. J., Pediani, J. D. and Milligan, G. (2012) Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. Journal of Biological Chemistry, 287, pp. 14937-14949. (doi: 10.1074/jbc.M111.334300)
Malik, P., Tabarraei, A., Kehlenbach, R. H., Korfali, N., Iwasawa, R., Graham, S. and Schirmer, E. C. (2012) Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways. Journal of Biological Chemistry, 287(15), pp. 12277-12292. (doi: 10.1074/jbc.M111.331777)
Haag, A. F. , Kerscher, B., Dall'Angelo, S., Sani, M., Longhi, R., Baloban, M., Wilson, H. M., Mergaert, P., Zanda, M. and Ferguson, G. P. (2012) Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide. Journal of Biological Chemistry, 287(14), pp. 10791-10798. (doi: 10.1074/jbc.M111.311316) (PMID:22351783) (PMCID:PMC3322895)
Podar, D., Scherer, J., Noordally, Z., Herzyk, P. , Nies, D. and Sanders, D. (2012) Metal selectivity determinants in a family of transition metal transporters. Journal of Biological Chemistry, 287(5), pp. 3185-3196. (doi: 10.1074/jbc.M111.305649)
Sampels, V., Hartmann, A., Dietrich, I., Coppens, I., Sheiner, L. , Striepen, B., Herrmann, A., Lucius, R. and Gupta, N. (2012) Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii. Journal of Biological Chemistry, 287(20), pp. 16289-16299. (doi: 10.1074/jbc.M112.347138)
Galian, C., Bjorkholm, P., Bulleid, N. and von Heijne, G. (2012) Efficient Glycosylphosphatidylinositol (GPI) modification of membrane proteins requires a C-terminal anchoring signal of marginal hydrophobicity. Journal of Biological Chemistry, 287(20), pp. 16399-16409. (doi: 10.1074/jbc.M112.350009)
Pou, C., Mannoury la Cour, C., Stoddart, L.A., Millan, M.J. and Milligan, G. (2012) Functional homomers and heteromers of dopamine D2L and D3 receptors co-exist at the cell surface. Journal of Biological Chemistry, 287(12), pp. 8864-8878. (doi: 10.1074/jbc.M111.326678)
Herod, M. R., Jones, D. M., McLauchlan, J. and McCormick, C. J. (2012) Increasing rate of cleavage at boundary between non-structural proteins 4B and 5A inhibits replication of Hepatitis C virus. Journal of Biological Chemistry, 287(1), pp. 568-580. (doi: 10.1074/jbc.M111.311407) (PMID:22084249) (PMCID:PMC3249110)
Carta, E. et al. (2012) Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease. Journal of Biological Chemistry, 287(34), pp. 28975-28985. (doi: 10.1074/jbc.M112.372094)
Su, T., Chapin, S. J., Bryant, D. M. , Shewan, A. M., Young, K. and Mostov, K. E. (2011) Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. Journal of Biological Chemistry, 286(52), pp. 44921-44925. (doi: 10.1074/jbc.M111.296731)
Cao, Z., Tavender, T.J., Roszak, A.W., Cogdell, R.J. and Bulleid, N.J. (2011) Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle. Journal of Biological Chemistry, 286(49), pp. 42257-42266. (doi: 10.1074/jbc.M111.298810)
Proto, W. R., Castanys-Munoz, E., Black, A., Tetley, L., Moss, C. X., Juliano, L., Coombs, G. H. and Mottram, J. C. (2011) Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor. Journal of Biological Chemistry, 286(46), pp. 39914-39925. (doi: 10.1074/jbc.M111.292334)
Ward, R. J., Pediani, J. D. and Milligan, G. (2011) Heteromultimerization of cannabinoid CB1 receptor and orexin OX1 receptor generates a unique complex in which both protomers are regulated by orexin A. Journal of Biological Chemistry, 286(43), pp. 37414-37428. (doi: 10.1074/jbc.M111.287649)
Antolikova, E., Zakova, L., Turkenburg, J.P., Watson, C.J., Hanclova, I., Sanda, M., Cooper, A., Kraus, T., Brzozowski, A.M. and Jiracek, J. (2011) Non-equivalent role of inter- and intramolecular hydrogen bonds in the insulin dimer interface. Journal of Biological Chemistry, 286(42), pp. 36968-36977. (doi: 10.1074/jbc.M111.265249)
Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J. and Fuller, W. (2011) The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. Journal of Biological Chemistry, 286(41), pp. 36020-36031. (doi: 10.1074/jbc.M111.282145) (PMID:21868384) (PMCID:PMC3195638)
Hodson, C., Cole, A. R., Lewis, L. P. C., Miles, J. A., Purkiss, A. and Walden, H. (2011) Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway. Journal of Biological Chemistry, 286(37), pp. 32628-32637. (doi: 10.1074/jbc.M111.244632) (PMID:21775430) (PMCID:PMC3173227)
Waardenberg, A.J. et al. (2011) Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure. Journal of Biological Chemistry, 286(35), pp. 30837-46. (doi: 10.1074/jbc.M111.271684)
Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286(34), pp. 29922-29931. (doi: 10.1074/jbc.M111.233858) (PMID:21724850) (PMCID:PMC3191033)
Haag, A. , Wehmeier, S., Muszynski, A., Kerscher, B., Fletcher, V., Berry, S. H., Hold, G. L., Carlson, R. W. and Ferguson, G. P. (2011) Biochemical characterization of Sinorhizobium meliloti mutants reveals gene products involved in the biosynthesis of the unusual lipid a very long-chain fatty acid. Journal of Biological Chemistry, 286(20), pp. 17455-17466. (doi: 10.1074/jbc.M111.236356) (PMID:21454518) (PMCID:PMC3093819)
Ross, F. A. et al. (2011) Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase. Journal of Biological Chemistry, 286(14), pp. 11929-11936. (doi: 10.1074/jbc.M110.189779) (PMID:21209098) (PMCID:PMC3069395)
Heyes, D. J., Levy, C., Sakuma, M., Robertson, D. L. and Scrutton, N. S. (2011) A twin-track approach has optimized proton and hydride transfer by dynamically coupled tunneling during the evolution of protochlorophyllide oxidoreductase. Journal of Biological Chemistry, 286(13), pp. 11849-11854. (doi: 10.1074/jbc.M111.219626) (PMID:21317291) (PMCID:PMC3064235)
Schmidt, J. et al. (2011) Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. Journal of Biological Chemistry, 286(12), pp. 10628-10640. (doi: 10.1074/jbc.M110.210872)
Christian, F. et al. (2011) Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. Journal of Biological Chemistry, 286(11), pp. 9079-9096. (doi: 10.1074/jbc.M110.160614) (PMID:21177871) (PMCID:PMC305896)
Redelinghuys, P., Antonopoulos, A., Liu, Y., Campanero-Rhodes, M.A., McKenzie, E., Haslam, S.M., Dell, A., Feizi, T. and Crocker, P.R. (2011) Early murine t-lymphocyte activation is accompanied by a switch from n-glycolyl- to n-acetyl-neuraminic acid and generation of ligands for siglec-e. Journal of Biological Chemistry, 286(40), pp. 34522-34532. (doi: 10.1074/jbc.M111.243410) (PMID:21835922) (PMCID:PMC3186437)
Richard, D., Bartfai, R., Volz, J., Ralph, S.A., Muller, S., Stunnenberg, H.G. and Cowman, A.F. (2011) A genome-wide chromatin-associated nuclear peroxiredoxin from the malaria parasite Plasmodium falciparum. Journal of Biological Chemistry, 286(13), pp. 11746-11755. (doi: 10.1074/jbc.M110.198499)
Mohamed, T.M.A. et al. (2011) Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain. Journal of Biological Chemistry, 286(48), pp. 41520-41529. (doi: 10.1074/jbc.M111.290411)
de Wet, B., Zech, T., Salek, M., Acuto, O. and Harder, T. (2011) Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses. Journal of Biological Chemistry, 286(6), pp. 4072-4080. (doi: 10.1074/jbc.M110.165415)
Reijns, M.A.M., Bubeck, D., Gibson, L.C.D., Graham, S.C., Baillie, G.S. , Jones, E.Y. and Jackson, A.P. (2011) The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease. Journal of Biological Chemistry, 286(12), pp. 10530-10539. (doi: 10.1074/jbc.M110.177394)
Kean, M. J. et al. (2011) Structure-Function Analysis of Core STRIPAK Proteins: A SIGNALING COMPLEX IMPLICATED IN GOLGI POLARIZATION. Journal of Biological Chemistry, 286(28), pp. 25065-25075. (doi: 10.1074/jbc.M110.214486)
Anand, P.K., Tait, S.W.G. , Lamkanfi, M., Amer, A.O., Nunez, G., Pages, G., Pouyssegur, J., McGargill, M.A., Green, D.R. and Kanneganti, T.-D. (2011) TLR2 and RIP2 pathways mediate autophagy of listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. Journal of Biological Chemistry, 286(50), pp. 42981-42991. (doi: 10.1074/jbc.M111.310599)
McLuskey, K., Paterson, N. G., Bland, N. D., Isaacs, N. W. and Mottram, J. C. (2010) Crystal structure of leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. Journal of Biological Chemistry, 285(50), pp. 39249-39259. (doi: 10.1074/jbc.M110.156679)
Diskar, M. et al. (2010) Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit αH-α1 LOOP. Journal of Biological Chemistry, 285(46), pp. 35910-35918. (doi: 10.1074/jbc.M110.155150)
Rampersad, S. N., Ovens, J. D., Huston, E. , Umana, M. B., Wilson, L. S., Netherton, S. J., Lynch, M. J., Baillie, G. S. , Houslay, M. D. and Maurice, D. H. (2010) Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability. Journal of Biological Chemistry, 285(44), pp. 33614-33622. (doi: 10.1074/jbc.M110.140004)
Jeffries, O., Geiger, N., Rowe, I. C. M. , Tian, L., McClafferty, H., Chen, L., Bi, D., Knaus, H. G., Ruth, P. and Shipston, M. J. (2010) Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels. Journal of Biological Chemistry, 285(43), pp. 33307-33314. (doi: 10.1074/jbc.M110.153940) (PMID:20693285) (PMCID:PMC2963414)
Naula, C.M. , Logan, F.M., Wong, P.E., Barrett, M.P. and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285(39), pp. 29721-29728. (doi: 10.1074/jbc.M110.106815)
Garcia-Mata, C., Wang, J., Gajdanowicz, P., Gonzalez, W., Hills, A., Donald, N., Riedelsberger, J., Amtmann, A. , Dreyer, I. and Blatt, M.R. (2010) A minimal cysteine motif required to activate the SKOR K+ channel of arabidopsis by the reactive oxygen species H2O2. Journal of Biological Chemistry, 285(38), pp. 29286-29294. (doi: 10.1074/jbc.M110.141176) (PMID:20605786) (PMCID:PMC2937961)
Harrington, J. M., Widener, J., Stephens, N., Johnson, T., Francia, M., Capewell, P. , MacLeod, A. and Hajduk, S. L. (2010) The plasma membrane of bloodstream-form African trypanosomes confers susceptibility and specificity to killing by hydrophobic peptides. Journal of Biological Chemistry, 285(37), pp. 28659-28666. (doi: 10.1074/jbc.M110.151886) (PMID:20615879) (PMCID:PMC2937892)
Alvarez-Curto, E., Ward, R. J., Pediani, J. D. and Milligan, G. (2010) Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET. Journal of Biological Chemistry, 285(30), pp. 23318-23330. (doi: 10.1074/jbc.M110.122184) (PMID:20489201) (PMCID:PMC2906324)
Chen, L., Jeffries, O., Rowe, I. C. M. , Liang, Z., Knaus, H.-G., Ruth, P. and Shipston, M. J. (2010) Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker. Journal of Biological Chemistry, 285(30), pp. 23265-23275. (doi: 10.1074/jbc.M110.139758) (PMID:20479001) (PMCID:PMC2906319)
Harris, H. J. et al. (2010) Claudin association with CD81 defines hepatitis C virus entry. Journal of Biological Chemistry, 285(27), pp. 21092-21102. (doi: 10.1074/jbc.M110.104836) (PMID:20375010) (PMCID:PMC2898367)
Ma, J., Benz, C., Grimaldi, R., Stockdale, C., Wyatt, P., Frearson, J. and Hammarton, T. C. (2010) Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei. Journal of Biological Chemistry, 285(20), pp. 15356-15368. (doi: 10.1074/jbc.M109.074591)
Hundsrucker, C. et al. (2010) Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. Journal of Biological Chemistry, 285(8), pp. 5507-5521. (PMID:20007971) (PMCID:PMC2820779)
Jones, D.M. and McLauchlan, J. (2010) Hepatitis C virus: assembly and release of virus particles. Journal of Biological Chemistry, 285(30), pp. 22733-22739. (doi: 10.1074/jbc.R110.133017) (PMID:20457608) (PMCID:PMC2906262)
Poleshko, A., Einarson, M.B., Shalginskikh, N., Zhang, R., Adams, P.D., Skalka, A.M. and Katz, R.A. (2010) Identification of a functional network of human epigenetic silencing factors. Journal of Biological Chemistry, 285, 422 -433. (doi: 10.1074/jbc.M109.064667)
Chambers, J.E., Tavender, T.J., Oka, O.B.V. , Warwood, S., Knight, D. and Bulleid, N.J. (2010) The reduction potential of the active site disulfides of human protein disulfide isomerase limits oxidation of the enzyme by Ero1. Journal of Biological Chemistry, 285(38), pp. 29200-29207. (doi: 10.1074/jbc.M110.156596)
Diskar, M. et al. (2010) Regulation of cAMP-dependent Protein Kinases: The human protein kinase x (prkx) reveals the role of the catalytic subunit h- i loop. Journal of Biological Chemistry, 285(46), pp. 35910-35918. (doi: 10.1074/jbc.M110.155150)
Arlehamn, C.S.L., Petrilli, V., Gross, O., Tschopp, J. and Evans, T.J. (2010) The role of potassium in inflammasome activation by bacteria. Journal of Biological Chemistry, 285(14), pp. 10508-10518. (doi: 10.1074/jbc.M109.067298)
Long, J. S., Fujiwara, Y., Edwards, J. , Tannahill, C.L., Tigyi, G., Pyne, S. and Pyne, N. J. (2010) Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells. Journal of Biological Chemistry, 285(46), pp. 35957-35966. (doi: 10.1074/jbc.M110.117945)
Westrop, G. D., Georg, I. and Coombs, G. H. (2009) The mercaptopyruvate sulfurtransferase of Trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide. Journal of Biological Chemistry, 284(48), pp. 33485-33494. (doi: 10.1074/jbc.M109.054320)
Tardito, S. , Isella, C., Medico, E., Marchiò, L., Bevilacqua, E., Hatzoglou, M., Bussolati, O. and Franchi-Gazzola, R. (2009) The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. Journal of Biological Chemistry, 284(36), pp. 24306-24319. (doi: 10.1074/jbc.M109.026583) (PMID:19561079) (PMCID:PMC2782024)
Reininger, L., Tewari, R., Fennell, C., Holland, Z., Goldring, D., Ranford-Cartwright, L.C. , Billker, O. and Doerig, C. (2009) An essential role for the plasmodium nek-2 NIMA-related protein kinase in the sexual development of malaria parasites. Journal of Biological Chemistry, 284(31), pp. 20858-20868. (doi: 10.1074/jbc.M109.017988)
Kiely, P. A., Baillie, G. S. , Barrett, R., Buckley, D. A., Adams, D. R., Houslay, M. D. and O'Connor, R. (2009) Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for IGF-I-mediated regulation of focal adhesion kinase (FAK). Journal of Biological Chemistry, 284, pp. 20263-20274. (doi: 10.1074/jbc.M109.017640) (PMID:19423701) (PMCID:PMC2740452)
Smith, N.J., Stoddart, L.A., Devine, N.M., Jenkins, L. and Milligan, G. (2009) The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1. Journal of Biological Chemistry, 284(26), pp. 17527-17539. (doi: 10.1074/jbc.M109.012849) (PMID:19398560) (PMCID:PMC2719392)
Borland, G., Bird, R. J., Palmer, T. M. and Yarwood, S. J. (2009) Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. Journal of Biological Chemistry, 284(26), pp. 17391-17403. (doi: 10.1074/jbc.M109.015370) (PMID:19423709) (PMCID:PMC2719379)
Thein, M. C., Winter, A. D., Stepek, G., McCormack, G., Stapleton, G., Johnstone, I. L. and Page, A. P. (2009) Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans. Journal of Biological Chemistry, 284(26), pp. 17549-17563. (doi: 10.1074/jbc.M900831200)
Li, X., Baillie, G. S. and Houslay, M. D. (2009) Mdm2 directs the ubiquitination of β-arrestin-sequestered cAMP phosphodiesterase-4D5. Journal of Biological Chemistry, 284(24), pp. 16170-16182. (doi: 10.1074/jbc.M109.008078)
Ippel, J.H., de Haas, C.J.C., Bunschoten, A., van Strijp, J.A.G., Kruijtzer, J.A.W., Liskamp, R.M.J. and Kemmink, J. (2009) Structure of the tyrosine-sulfated C5a receptor N terminus in complex with chemotaxis inhibitory protein of Staphylococcus aureus. Journal of Biological Chemistry, 284(18), pp. 12363-12372. (doi: 10.1074/jbc.M808179200)
Meng, D., Lynch, M. J., Huston, E. , Beyermann, M., Eichhorst, J., Adams, D. R., Klusmann, E., Houslay, M. D. and Baillie, G. S. (2009) MEK1 binds directly to βArrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. Journal of Biological Chemistry, 284(17), pp. 11425-11435. (doi: 10.1074/jbc.M806395200) (PMID:19153083) (PMCID:PMC2670148)
Terrenoire, C., Houslay, M. D., Baillie, G. S. and Kass, R. S. (2009) The Cardiac IKs Potassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3. Journal of Biological Chemistry, 284(14), pp. 9140-9146. (doi: 10.1074/jbc.M805366200)
Teertstra, W.R., van der Velden, G.J., de Jong, J.F., Kruijtzer, J.A.W., Liskamp, R.M.J. , Kroon-Batenburg, L.M.J., Muller, W.H., Gebbink, M.F.B.G. and Wosten, H.A.B. (2009) The filament-specific Rep1-1 repellent of the phytopathogen ustilago maydis forms functional surface-active amyloid-like fibrils. Journal of Biological Chemistry, 284(14), pp. 9153-9159. (doi: 10.1074/jbc.M900095200)
Ning, K., Miller, L. C., Laidlaw, H. A., Watterson, K. R., Gallagher, J., Sutherland, C. and Ashford, M. L.J. (2009) Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels. Journal of Biological Chemistry, 284(14), pp. 9331-9340. (doi: 10.1074/jbc.M806774200) (PMID:19208634) (PMCID:PMC2666585)
Jessop, C.E., Tavender, T.J., Watkins, R.H., Chambers, J.E. and Bulleid, N.J. (2009) Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin. Journal of Biological Chemistry, 284(4), pp. 2194-2202. (doi: 10.1074/jbc.M808054200)
Spender, L. C. and Inman, G. J. (2009) TGF-β Induces growth arrest in Burkitt lymphoma cells via transcriptional repression of E2F-1. Journal of Biological Chemistry, 284(3), pp. 1435-1442. (doi: 10.1074/jbc.m808080200) (PMID:19022773)
Lamb, D., Mirsaliotis, A., Kelly, S.M. and Brighty, D.W. (2009) Basic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry. Journal of Biological Chemistry, 284(10), pp. 6575-6584. (doi: 10.1074/jbc.M806725200)
Roohvand, F. et al. (2009) Initiation of hepatitis C virus infection requires the dynamic microtubule network: role of the viral nucleocapsid protein. Journal of Biological Chemistry, 284(20), pp. 13778-13791. (doi: 10.1074/jbc.M807873200) (PMID:19269968) (PMCID:PMC2679479)
Gray, C. H., McGarry, L. C., Spence, H. J., Riboldi-Tunnicliffe, A. and Ozanne, B. W. (2009) Novel -Propeller of the BTB-Kelch Protein Krp1 Provides a Binding Site for Lasp-1 That Is Necessary for Pseudopodial Extension. Journal of Biological Chemistry, 284(44), pp. 30498-30507. (doi: 10.1074/jbc.M109.023259)
Collar, C.J., Al Salabi, M.I., Stewart, M.L., Barrett, M.P. , Wilson, W.D. and de Koning, H.P. (2009) Predictive computational models of substrate binding by a nucleoside transporter. Journal of Biological Chemistry, 284(49), pp. 34028-34035. (doi: 10.1074/jbc.M109.049726)
Kiely, P. A., Baillie, G. S. , Lynch, M. J., Houslay, M. D. and O'Connor, R. (2008) Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and {beta}1 integrin and for tumor cell proliferation and migration. Journal of Biological Chemistry, 283(34), pp. 22952-22961. (doi: 10.1074/jbc.M800802200)
Scorah, J., Dong, M.-Q., Yates, J.R., Scott, M. , Gillespie, D. and McGowan, C.H. (2008) A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function. Journal of Biological Chemistry, 283(25), pp. 17250-17259. (doi: 10.1074/jbc.M800369200)
Coustou, V., Biran, M., Breton, M., Guegan, F., Riviere, L., Plazolles, N., Nolan, D., Barrett, M.P. , Franconi, J.M. and Bringaud, F. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. Journal of Biological Chemistry, 283(24), pp. 16342-16354. (doi: 10.1074/jbc.M709592200)
Jacquet, S., Nishino, Y., Kumphune, S., Sicard, P., Clark, J. E., Kobayashi, K. S., Flavell, R. A., Eickhoff, J., Cotten, M. and Marber, M. S. (2008) The role of RIP2 in p38 MAPK activation in the stressed heart. Journal of Biological Chemistry, 283(18), pp. 11964-11971. (doi: 10.1074/jbc.m707750200) (PMID:18310079) (PMCID:PMC3774113)
Canals Buj, M. and Milligan, G. (2008) Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors. Journal of Biological Chemistry, 283(17), pp. 11424-11434. (doi: 10.1074/jbc.M710300200)
Boyle, J. G., Logan, P. J., Ewart, M.-A., Reihill, J. A., Ritchie, S. A., Connell, J. M.C., Cleland, S. J. and Salt, I. P. (2008) Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase. Journal of Biological Chemistry, 283(17), pp. 11210-11217. (doi: 10.1074/jbc.M710048200)
Keskiaho, K., Kukkola, L., Page, A. P., Winter, A. D., Vuoristo, J., Sormunen, R., Nissi, R., Riihimaa, P. and Myllyharju, J. (2008) Characterization of a novel Caenorhabditis elegans prolyl 4-hydroxylase with a unique substrate specificity and restricted expression in the pharynx and excretory duct. Journal of Biological Chemistry, 283(16), pp. 10679-10689. (doi: 10.1074/jbc.M800972200)
Holmstrom, T.H. et al. (2008) c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. Journal of Biological Chemistry, 283(11), pp. 7046-7053. (doi: 10.1074/jbc.M709613200)
Yarwood, S.J., Borland, G., Sands, W.A. and Palmer, T.M. (2008) Identification of CCAAT/Enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene. Journal of Biological Chemistry, 283(11), pp. 6843-6853. (doi: 10.1074/jbc.M710342200)
Raggatt, L. J., Qin, L., Tamasi, J., Jefcoat, Jr, S. C., Shimizu, E., Selvamurugan, N., Liew, F. Y., Bevelock, L., Feyen, J. H. M. and Partridge, N. C. (2008) Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions. Journal of Biological Chemistry, 283(11), pp. 6790-6798. (doi: 10.1074/jbc.M709909200)
Chambers, J.E., Jessop, C.E. and Bulleid, N.J. (2008) Formation of a major histocompatibility complex class I tapasin disulfide indicates a change in spatial organization of the peptide-loading complex during assembly. Journal of Biological Chemistry, 283(4), pp. 1862-1869. (doi: 10.1074/jbc.M708196200)
Hale, B.G. , Batty, I.H., Downes, C.P. and Randall, R.E. (2008) Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85beta suggests a novel mechanism for phosphoinositide 3-kinase activation. Journal of Biological Chemistry, 283(3), pp. 1372-1380. (doi: 10.1074/jbc.M708862200)
Ferguson, B. J. et al. (2008) AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity. Journal of Biological Chemistry, 283(3), pp. 1723-1731. (doi: 10.1074/jbc.M707211200)
Dixon, D. P., Lapthorn, A. , Madesis, P., Mudd, E. A., Day, A. and Edwards, R. (2008) Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases. Journal of Biological Chemistry, 283(29), pp. 20268-20276. (doi: 10.1074/jbc.M802026200)
Stoddart, L. A., Smith, N. J., Jenkins, L. , Brown, A. J. and Milligan, G. (2008) Conserved Polar Residues in Transmembrane Domains V, VI, and VII of Free Fatty Acid Receptor 2 and Free Fatty Acid Receptor 3 Are Required for the Binding and Function of Short Chain Fatty Acids. Journal of Biological Chemistry, 283(47), pp. 32913-32924. (doi: 10.1074/jbc.M805601200) (PMID:18801738)
Lionaki, E., de Marcos Lousa, C., Baud, C., Vougioukalaki, M., Panayotou, G. and Tokatlidis, K. (2008) The essential function of Tim12 in vivo is ensured by the assembly interactions of its C-terminal domain. Journal of Biological Chemistry, 283(23), pp. 15747-15753. (doi: 10.1074/jbc.M800350200)
Targett-Adams, P., Hope, G., Boulant, S. and McLauchlan, J. (2008) Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production. Journal of Biological Chemistry, 283(24), pp. 16850-16859. (doi: 10.1074/jbc.M802273200) (PMID:18424431)
McCulloch, C., Morrow, V., Milasta, S., Comerford, I., Milligan, G. , Graham, G. , Isaacs, N. and Nibbs, R. (2008) Multiple roles for the C-terminal tail of the chemokine scavenger D6. Journal of Biological Chemistry, 283(12), pp. 7972-7982. (doi: 10.1074/jbc.M710128200)
Erridge, C., Kennedy, S. , Spickett, C.M. and Webb, D.J. (2008) Oxidised phospholipid inhibition of toll-like receptor (TLR) signalling is restricted to TLR2 and TLR4 - roles for CD14, LPS-binding protein and MD2 as targets for specificity of inhibition. Journal of Biological Chemistry, 283(36), pp. 24748-24759. (doi: 10.1074/jbc.M800352200)
Stevens, C., Lin, Y., Harrison, B., Burch, L., Ridgway, R. A., Sansom, O. and Hupp, T. (2008) Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling. Journal of Biological Chemistry, 284(1), pp. 334-344. (doi: 10.1074/jbc.M805165200)
Goldshmidt, H., Sheiner, L. , Butikofer, P., Roditi, I., Uliel, S., Gunzel, M., Engstler, M. and Michaeli, S. (2008) Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei. Journal of Biological Chemistry, 283(46), pp. 32085-32098. (doi: 10.1074/jbc.M801499200)
Shavinskaya, A., Boulant, S., Penin, F., McLauchlan, J. and Bartenschlager, R. (2007) The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly. Journal of Biological Chemistry, 282(51), pp. 37158-37169. (doi: 10.1074/jbc.M707329200) (PMID:17942391)
Winter, A. D., Eschenlauer, S. C. P., McCormack, G. and Page, A. P. (2007) Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality in caenorhabditis elegans. Journal of Biological Chemistry, 282(17), pp. 12813-12821. (doi: 10.1074/jbc.M700274200)
Zhang, X., Boot-Handford, R. P., Huxley-Jones, J., Forse, L. N., Mould, A. P., Robertson, D. L. , Li, L., Athiyal, M. and Sarras, M. P. (2007) The collagens of hydra provide insight into the evolution of metazoan extracellular matrices. Journal of Biological Chemistry, 282(9), pp. 6792-802. (doi: 10.1074/jbc.M607528200) (PMID:17204477)
Jones, M. A. , Feeney, K. A., Kelly, S. M. and Christie, J. M. (2007) Mutational analysis of phototropin 1 provides insights into the mechanism underlying LOV2 signal transmission. Journal of Biological Chemistry, 282(9), pp. 6405-6414. (doi: 10.1074/jbc.M605969200) (PMID:17164248)
Rich, T. (2007) AIRE's card revealed; A new structure for central tolerance provokes transcriptional plasticity. Journal of Biological Chemistry, 283(3), pp. 1723-1731.
Borland, G., Edkins, A., Acharya, M., Matheson, J., White, L., Allen, J., Bonnefoy, J., Ozanne, B. and Cushley, W. (2007) alpha v beta 5 integrin sustains growth of human pre-B cells through an RGD-independent interaction with a basic domain of the CD23 protein. Journal of Biological Chemistry, 282, pp. 27315-27326. (doi: 10.1074/jbc.M609335200)
Muddasani, P., Norman, J. , Ellman, M., van Wijnen, A. and Im, H. (2007) Basic fibroblast growth factor activates the MAPK and NF kappa B pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. Journal of Biological Chemistry, 282(43), pp. 31409-31421. (doi: 10.1074/jbc.M706508200)
Willoughby, D., Baillie, G. , Lynch, M., Ciruela, A., Houslay, M. and Cooper, D. (2007) Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta(2)-adrenoceptor and prostanoid receptor cAMP signaling. Journal of Biological Chemistry, 282, pp. 34235-34249. (doi: 10.1074/jbc.M706765200)
Winter, A., Eschenlauer, S., McCormack, G. and Page, A. (2007) Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality and associate extracellular matrix defects in the nematode Caenorhabditis elegans. Journal of Biological Chemistry, 282, pp. 12813-12821. (doi: 10.1074/jbc.M700274200)
Sithu, S., English, W., Olson, P., Krubasik, D., Baker, A., Murphy, G. and D'Souza, S. (2007) Membrane-type 1-matrix metalloproteinase regulates intracellular adhesion molecule-1 (ICAM-1)-mediated monocyte transmigration. Journal of Biological Chemistry, 282, pp. 25010-25019. (doi: 10.1074/jbc.M611273200)
Ayscough, K., Thevissen, K., Aerts, A., Du, W.,, Brucker, K., Meert, E., Awsna, J., Borges, M., Carnmue, B. and Francois, I. (2007) Miconazole induces changes in actin cytoskeleton prior to reactive oxygen species induction in yeast. Journal of Biological Chemistry, 282(30), pp. 21592-21597. (doi: 10.1074/jbc.M608505200)
Meissner, J., Chang, K., Kubis, H., Nebreda, A., Gros, G. and Scheibe, R. (2007) The p38 alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes. Journal of Biological Chemistry, 282, pp. 7265-7275. (doi: 10.1074/jbc.M609076200)
Walker, D., Moshbahi, K., Vankemmelbeke, M., James, R. and Kleanthous, C. (2007) The role of electrostatics in colicin nuclease domain translocation into bacterial cells. Journal of Biological Chemistry, 282, pp. 31389-31397. (doi: 10.1074/jbc.M705883200)
Garcia-Saez, I., DeBonis, S., Lopez, R., Trucco, F., Rousseau, B., Thuery, P. and Kozielski, F. (2007) Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration. Journal of Biological Chemistry, 282(13), pp. 9740-9747. (doi: 10.1074/jbc.M608883200)
Borland, G., Edkins, A.L., Acharya, M., Matheson, J., White, L.J., Allen, J.M., Bonnefoy, J.-Y., Ozanne, B. W. and Cushley, W. (2007) vbeta5 Integrin Sustains Growth of Human Pre-B Cells through an RGD-independent Interaction with a Basic Domain of the CD23 Protein. Journal of Biological Chemistry, 282(37), pp. 27315-27326. (doi: 10.1074/jbc.M609335200)
Guil, S., Rodríguez-Castro, M., Aguilar, F., Villasevil, E. M., Antón, L. C. and Del Val, M. (2006) Need for tripeptidyl-peptidase II in major histocompatibility complex class I viral antigen processing when proteasomes are detrimental. Journal of Biological Chemistry, 281(52), pp. 39925-39934. (doi: 10.1074/jbc.M608522200) (PMID:17088258)
Ellis, J., Pediani, J.D. , Canals Buj, M., Milasta, S. and Milligan, G. (2006) Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. Journal of Biological Chemistry, 281(25), pp. 38812-38824. (doi: 10.1074/jbc.M602494200)
Castelló, A. , Alvarez, E. and Carrasco, L. (2006) Differential cleavage of eIF4GI and eIF4GII in mammalian cells: effects on translation. Journal of Biological Chemistry, 281(44), pp. 33206-33216. (doi: 10.1074/jbc.m604340200) (PMID:16959778)
Brennan, J. P., Bardswell, S. C., Burgoyne, J. R., Fuller, W. , Schröder, E., Wait, R., Begum, S., Kentish, J. C. and Eaton, P. (2006) Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. Journal of Biological Chemistry, 281(31), pp. 21827-21836. (doi: 10.1074/jbc.M603952200) (PMID:16754666)
Boulant, S., Montserret, R., Hope, R. G., Ratinier, M., Targett-Adams, P., Lavergne, J.-P., Penin, F. and McLauchlan, J. (2006) Structural determinants that target the hepatitis C virus core protein to lipid droplets. Journal of Biological Chemistry, 281(31), pp. 22236-22247. (doi: 10.1074/jbc.M601031200) (PMID:16704979)
Smolle, M., Prior, A.E., Brown, A.E., Cooper, A., Byron, O. and Lindsay, J.G. (2006) A new level of architectural complexity in the human pyruvate dehydrogenase complex. Journal of Biological Chemistry, 281(28), pp. 19772-19780. (doi: 10.1074/jbc.M601140200)
Eckert, M., Meek, S. E.M. and Ball, K. L. (2006) A novel repressor domain is required for maximal growth inhibition by the IRF-1 tumor suppressor. Journal of Biological Chemistry, 281(32), pp. 23092-23102. (doi: 10.1074/jbc.M512589200)
Smith, B.O., Picken, N.C., Westrop, G.D., Bromek, K., Mottram, J.C. and Coombs, G.H. (2006) The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors. Journal of Biological Chemistry, 281, pp. 5821-5828. (doi: 10.1074/jbc.M510868200)
Smyth, D. J. , Glanfield, A., McManus, D. P., Hacker, E., Blair, D., Anderson, G. J. and Jones, M. K. (2006) Two isoforms of a divalent metal transporter (DMT1) in Schistosoma mansoni suggest a surface-associated pathway for iron absorption in schistosomes. Journal of Biological Chemistry, 281(4), pp. 2242-2248. (doi: 10.1074/jbc.M511148200) (PMID:16267047) (PMCID:PMC1459476)
Lamb, H., Mee, C., Xu, W., Liu, L., Blond, S., Cooper, A., Charles, I. and Hawkins, A. (2006) The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP. Journal of Biological Chemistry, 281, pp. 8796-8805. (doi: 10.1074/jbc.M503964200)
Westrop, G., Goodall, G., Mottram, J. and Coombs, G. (2006) Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine. Journal of Biological Chemistry, 281, pp. 25062-25075. (doi: 10.1074/jbc.M600688200)
Terhzaz, S. , Southall, T. D., Lilley, K. S., Kean, L., Allan, A. K., Davies, S. A. and Dow, J. A.T. (2006) Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Journal of Biological Chemistry, 281, pp. 18849-18858. (doi: 10.1074/jbc.M603002200) (PMID:16670086)
Besteiro, S., Williams, R., Morrison, L., Coombs, G. and Mottram, J. (2006) Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major. Journal of Biological Chemistry, 281, pp. 11384-11396. (doi: 10.1074/jbc.M512307200)
Felton-Edkins, Z., Kondrashov, A., Karali, D., Fairley, J., Dawson, C., Arrand, J., Young, L. and White, R. (2006) Epstein-Barr virus induces cellular transcription factors to allow active expression of EBER genes by RNA polymerase III. Journal of Biological Chemistry, 281, pp. 33871-33880. (doi: 10.1074/jbc.M600468200)
McMillan, P.J., Arscott, L.D., Ballou, D.P., Becker, K., Williams, C.H. and Muller, S. (2006) Identification of acid-base catalytic residues of high-M-r thioredoxin reductase from Plasmodium falciparum. Journal of Biological Chemistry, 281, pp. 32967-32977. (doi: 10.1074/jbc.M601141200)
Francke, F., Ward, R., Jenkins, L., Kellett, E., Richter, D., Milligan, G. and Bachner, D. (2006) Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization. Journal of Biological Chemistry, 281, pp. 32496-32507. (doi: 10.1074/jbc.M602889200)
Skoufias, D., DeBonis, S., Saoudi, Y., Lebeau, L., Crevel, I., Cross, R., Wade, R., Hackney, D. and Kozielski, F. (2006) S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression. Journal of Biological Chemistry, 281(26), pp. 17559-17569. (doi: 10.1074/jbc.M511735200)
Targett-Adams, P., Schaller, T., Hope, R.G., Lanford, R.E., Lemon, S.M., Martin, A. and McLauchlan, J. (2006) Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivo. Journal of Biological Chemistry, 281(39), pp. 29221-29227. (doi: 10.1074/jbc.M605373200) (PMID:16882659)
Pettigrew, D.M., Williams, D.T., Kerrigan, D., Evans, D.J., Lea, S.M. and Bhella, D. (2006) Structural and functional insights into the interaction of echoviruses and decay-accelerating factor. Journal of Biological Chemistry, 281, pp. 5169-5177. (doi: 10.1074/jbc.M510362200)
Canals, M., Jenkins, L., Kellett, E. and Milligan, G. (2006) Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of G(q)/G(11) by MAS. Journal of Biological Chemistry, 281, pp. 16757-16767. (doi: 10.1074/jbc.M601121200)
Gengenbacher, M., Fitzpatrick, T., Raschle, T., Flicker, K., Sinning, I., Muller, S., Macheroux, P., Tews, I. and Kappes, B. (2006) Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum - Biochemical and structural insights. Journal of Biological Chemistry, 281, pp. 3633-3641. (doi: 10.1074/jbc.M508696200)
McCarty, O. J. T. et al. (2005) Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. Journal of Biological Chemistry, 280(47), pp. 39474-39484. (doi: 10.1074/jbc.M504672200) (PMID:16195235) (PMCID:PMC1395485)
Dias-Gunasekara, S., Gubbens, J., van Lith, M., Dunne, C., Williams, J.A.G., Kataky, R., Scoones, D., Lapthorn, A., Bulleid, N.J. and Benham, A.M. (2005) Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1β. Journal of Biological Chemistry, 280, pp. 33066-33075. (doi: 10.1074/jbc.M505023200)
Collins, M. O., Yu, L., Coba, M. P., Husi, H., Campuzano, I., Blackstock, W. P., Choudhary, J. S. and Grant, S. G.N. (2005) Proteomic analysis of in vivo phosphorylated synaptic proteins. Journal of Biological Chemistry, 280(7), pp. 5972-5982. (doi: 10.1074/jbc.M411220200) (PMID:15572359)
Barnes, W., Reiter, E., Violin, J., Ren, X., Milligan, G. and Lefkowitz, R. (2005) beta-arrestin 1 and G(alpha q/11) coordinately activate RhoA and stress fiber formation following receptor stimulation. Journal of Biological Chemistry, 280, pp. 8041-8050. (doi: 10.1074/jbc.M412924200)
Marquez, R. (2005) BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. Journal of Biological Chemistry, 280(20), pp. 19472-19479.
Federici, L., Du, D.J., Walas, F., Matsumura, H., Fernandez-Recio, J., McKeegan, K.S., Borges-Walmsley, M.I., Luisi, B.F. and Walmsley, A.R. (2005) The crystal structure of the outer membrane protein VceC from the bacterial pathogen Vibrio cholerae at 1.8 angstrom resolution. Journal of Biological Chemistry, 280, pp. 15307-15314. (doi: 10.1074/jbc.M500401200)
Wilson, S., Wilkinson, G. and Milligan, G. (2005) The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities. Journal of Biological Chemistry, 280, pp. 28663-28674. (doi: 10.1074/jbc.M413475200)
Sansom, O. , Reed, K., van de Wetering, M., Muncan, V., Winton, D., Clevers, H. and Clarke, A. (2005) Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine. Journal of Biological Chemistry, 280(31), pp. 28463-28467. (doi: 10.1074/jbc.M500191200)
Ewart, M.-A., Clarke, M. , Kane, S., Chamberlain, L.H. and Gould, G.W. (2005) Evidence for a role of the exocyst in insulin-stimulated Glut4 trafficking in 3T3-L1 adipocytes. Journal of Biological Chemistry, 280, pp. 3812-3816. (doi: 10.1074/jbc.M409928200) (PMID:15550383)
Price, N., Price, N., Kelly, S. and McDonnell, J. (2005) The key role of protein flexibility in modulating IgE interactions. Journal of Biological Chemistry, 280, pp. 2324-2330. (doi: 10.1074/jbc.M409458200)
Salaun, C., Gould, G. and Chamberlain, L. (2005) Lipid raft association of SNARE proteins regulates exocytosis in PC12 cells. Journal of Biological Chemistry, 280, pp. 19449-19453. (doi: 10.1074/jbc.M501923200)
Tsuboi, T., Ravier, M.A., Xie, H., Ewart, M.-A., Gould, G.W., Baldwin, S.A. and Rutter, G.A. (2005) Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. Journal of Biological Chemistry, 280(27), pp. 25565-25570. (doi: 10.1074/jbc.M501674200)
Gupta, M. and Yarwood, S. (2005) MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion. Journal of Biological Chemistry, 280, pp. 8109-8116. (doi: 10.1074/jbc.M413697200)
Reininger, L. et al. (2005) A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites. Journal of Biological Chemistry, 280, pp. 31957-31964. (doi: 10.1074/jbc.M504523200)
Murdoch, H., Feng, G., Bachner, D., Ormiston, L., White, J., Richter, D. and Milligan, G. (2005) Periplakin interferes with g protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail. Journal of Biological Chemistry, 280, pp. 8208-8220. (doi: 10.1074/jbc.M405215200)
Akerman, S. and Muller, S. (2005) Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii. Journal of Biological Chemistry, 280, pp. 564-570. (doi: 10.1074/jbc.M406367200)
Lamour, N., Riviere, L., Coustou, V., Coombs, G., Barrett, M. and Bringaud, F. (2005) Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. Journal of Biological Chemistry, 280, pp. 11902-11910. (doi: 10.1074/jbc.M414274200)
Bradley, P. et al. (2005) Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii. Journal of Biological Chemistry, 280, pp. 34245-34258. (doi: 10.1074/jbc.M504158200)
Pang, J.H., Kraemer, A., Stehbens, S.J., Frame, M.C. and Yap, A.S. (2005) Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function. Journal of Biological Chemistry, 280(4), pp. 3043-3050.
Lynch, M., Baillie, G. , Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G. and Houslay, M. (2005) RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta(2)-adrenergic receptor to activation of ERK in HEK293B2 cells. Journal of Biological Chemistry, 280, pp. 33178-33189. (doi: 10.1074/jbc.M414316200)
Salaun, C., Gould, G. and Chamberlain, L. (2005) The SNARE proteins SNAP-25 and SNAP-23 display different affinities for lipid rafts in PC12 cells - Regulation by distinct cysteine-rich domains. Journal of Biological Chemistry, 280, pp. 1236-1240. (doi: 10.1074/jbc.M410674200)
Acosta-serrano, A. (2005) Structural characterization of NETNES, a novel glycoconjugate in Trypanosoma cruzi epimastigotes. Journal of Biological Chemistry, 280(13), pp. 12201-12211.
Acosta-serrano, A. (2005) The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number. Journal of Biological Chemistry, 280(20), pp. 19728-19736.
Jessop, C.E. and Bulleid, N.J. (2004) Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells. Journal of Biological Chemistry, 279(53), pp. 55341-55347. (doi: 10.1074/jbc.M411409200)
Paling, N.R.D., Wheadon, H. , Bone, H.K. and Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi: 10.1074/jbc.M406467200)
Theodossis, A., Walden, H. , Westwick, E. J., Connaris, H., Lamble, H. J., Hough, D. W., Danson, M. J. and Taylor, G. L. (2004) The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus. Journal of Biological Chemistry, 279(42), pp. 43886-43892. (doi: 10.1074/jbc.M407702200) (PMID:15265860)
Chakravarthi, S. and Bulleid, N.J. (2004) Glutathione is required to regulate the formation of native disulfide bonds within proteins entering the secretory pathway. Journal of Biological Chemistry, 279(38), pp. 39872-39879. (doi: 10.1074/jbc.M406912200)
Spagnolo, L. , Törö, I., D'Orazio, M., O'Neill, P., Pedersen, J. Z., Carugo, O., Rotilio, G., Battistoni, A. and Djinović-Carugo, K. (2004) Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site. Journal of Biological Chemistry, 279(32), pp. 33447-33455. (doi: 10.1074/jbc.M404699200) (PMID:15155722)
Douglas, M.W., Diefenbach, R.J., Homa, F.L., Miranda-Saksena, M., Rixon, F.J., Vittone, V., Byth, K. and Cunningham, A.L. (2004) Herpes Simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. Journal of Biological Chemistry, 279(27), pp. 28522-28530. (doi: 10.1074/jbc.M311671200)
Zhang, M., MacDonald, A. I., Hoyt, M. A. and Coffino, P. (2004) Proteasomes begin ornithine decarboxylase digestion at the C terminus. Journal of Biological Chemistry, 279(20), pp. 20959-20965. (doi: 10.1074/jbc.M314043200) (PMID:15016805)
Lu, H., Allen, S., Wardleworth, L., Savory, P. and Tokatlidis, K. (2004) Functional TIM10 chaperone assembly is redox-regulated in vivo. Journal of Biological Chemistry, 279(18), pp. 18952-18958. (doi: 10.1074/jbc.M313045200)
Fraser, C. S., Lee, J. Y., Mayeur, G. L., Bushell, M. , Doudna, J. A. and Hershey, J. W.B. (2004) The j-Subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. Journal of Biological Chemistry, 279(10), pp. 8946-8956. (doi: 10.1074/jbc.M312745200) (PMID:14688252)
Eickhoff, J. et al. (2004) RICK activates a NF-κB-dependent anti-human cytomegalovirus response. Journal of Biological Chemistry, 279(10), pp. 9642-9652. (doi: 10.1074/jbc.m312893200) (PMID:14670961)
Coombs, G., Westrop, G., Suchan, P., Puzova, G., Hirt, R., Embley, T., Mottram, J. and Muller, S. (2004) The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system. Journal of Biological Chemistry, 279, pp. 5249-5256. (doi: 10.1074/jbc.M304359200)
MacPherson, M., Lohmann, S. and Davies, S. (2004) Analysis of Drosophila cGMP-dependent protein kinases and assessment of their in vivo roles by targeted expression in a renal transporting epithelium. Journal of Biological Chemistry, 279, pp. 40026-40034. (doi: 10.1074/jbc.M405619200)
Ibrahim, F.B.M., Melendez Romero, A.J. and Pang, S.J. (2004) Anaphylatoxin signaling in human neutrophils - A key role for sphingosine kinase. Journal of Biological Chemistry, 279(43), pp. 44802-44811. (doi: 10.1074/jbc.M403977200)
Kukkola, L., Koivunen, P., Pakkanen, O., Page, A. and Myllyharju, J. (2004) Collagen prolyl 4-hydroxylase tetramers and dimers show identical decreases in K-m values for peptide substrates with increasing chain length - Mutation of one of the two catalytic sites in the tetramer inactivates the enzyme by more than half. Journal of Biological Chemistry, 279, pp. 18656-18661. (doi: 10.1074/jbc.M401514200)
Meek, S. E.M., Lane, W. S. and Piwnica-Worms, H. (2004) Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. Journal of Biological Chemistry, 279(31), pp. 32046-32054. (doi: 10.1074/jbc.M403044200)
Mosbahi, K., Walker, D., Lea, E., Moore, G., James, R. and Kleanthous, C. (2004) Destabilization of the colicin E9 endonuclease domain by interaction with negatively charged phospholipids - Implications for colicin translocation into bacteria. Journal of Biological Chemistry, 279, pp. 22145-22151. (doi: 10.1074/jbc.M400402200)
Im, J., Yu, K., Illarionov, P., LeClair, K., Storey, J., Kennedy, M. , Besra, G. and Porcelli, S. (2004) Direct measurement of antigen binding properties of CD1 proteins using fluorescent lipid probes. Journal of Biological Chemistry, 279, pp. 299-310. (doi: 10.1074/jbc.M308803200)
Broderick, K., Kean, L., Dow, J. , Pyne, N. and Davies, S. (2004) Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. Journal of Biological Chemistry, 279, pp. 8159-8168. (doi: 10.1074/jbc.M304679200)
Malik, P., Blackbourn, D.J. and Clements, J.B. (2004) The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor. Journal of Biological Chemistry, 279, pp. 33001-33011. (doi: 10.1074/jbc.M313008200)
Griffiths, G.J. et al. (2004) Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-x(L) and increases oxaliplatin- and Fas-induced apoptosis. Journal of Biological Chemistry, 279, pp. 46113-46121. (doi: 10.1074/jbc.M408550200)
Melendez Romero, A.J. and Tay, H.K. (2004) Fc gamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA(2) but not cPLA(2) in human monocytic cells. Journal of Biological Chemistry, 279(21), pp. 22505-22513. (doi: 10.1074/jbc.M308788200)
Thomas, D., Blakqori, G., Wagner, V., Banholzer, M., Kessler, N., Elliott, R.M., Haller, O. and Weber, F. (2004) Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist. Journal of Biological Chemistry, 279, pp. 31471-31477. (doi: 10.1074/jbc.M400938200)
Mark, L., Lee, W., Spiller, O.B., Proctor, D., Blackbourn, D.J., Villoutreix, B.O. and Blom, A.M. (2004) The Kaposi's sarcoma-associated herpesvirus complement control protein mimics human molecular mechanisms for inhibition of the complement system. Journal of Biological Chemistry, 279, pp. 45093-45101. (doi: 10.1074/jbc.M407558200)
James, D., Salaun, C., Brandie, F., Connell, J. and Chamberlain, L. (2004) Neomycin prevents the wortmannin inhibition of insulin-stimulated glut4 translocation and glucose transport in 3T3-L1 adipocytes. Journal of Biological Chemistry, 279, pp. 20567-20570. (doi: 10.1074/jbc.C400096200)
McCarron, J.G., MacMillan, D., Bradley, K.N., Chalmers, S. and Muir, T.C. (2004) Origin and mechanisms of Ca2+ waves in smooth muscle as revealed by localized photolysis of caged inositol 1,4,5-trisphosphate. Journal of Biological Chemistry, 279, pp. 8417-8427. (doi: 10.1074/jbc.M311797200)
Melino, G., Bernassola, F., Ranalli, M., Yee, K., Zong, W., Corazzari, M., Knight, R., Green, D., Thompson, C. and Vousden, K. (2004) p73 induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. Journal of Biological Chemistry, 279, pp. 8076-8083. (doi: 10.1074/jbc.M307469200)
Bate, C., Reid, S. and Williams, A. (2004) Phospholipase A(2) inhibitors or platelet-activating factor antagonists prevent prion replication. Journal of Biological Chemistry, 279, pp. 36405-36411. (doi: 10.1074/jbc.M404086200)
Werner, A.B., Tait, S.W.G. , de Vries, E., Eldering, E. and Borst, J. (2004) Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens. Journal of Biological Chemistry, 279(27), pp. 28771-28780. (doi: 10.1074/jbc.M400268200)
Canning, M., Boutell, C.J. , Parkinson, J. and Everett, R.D. (2004) A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. Journal of Biological Chemistry, 279(37), pp. 38160-38168. (doi: 10.1074/jbc.M402885200)
Bate, C., Salmona, M., Diomede, L. and Williams, A. (2004) Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. Journal of Biological Chemistry, 279, pp. 14983-14990. (doi: 10.1074/jbc.M313061200)
Smith, B. (2004) Structural analysis of the complement control protein (CCP) modules of GABAB receptor 1a: only one of the two ccp modules is compactly folded. Journal of Biological Chemistry, 279(46), pp. 48292-48306. (doi: 10.1074/jbc.M406540200)
Bhella, D. , Goodfellow, I.G., Roversi, P., Pettigrew, D., Chaudhry, Y., Evans, D.J. and Lea, S.M. (2004) The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55). Journal of Biological Chemistry, 279, pp. 8325-8332. (doi: 10.1074/jbc.M311334200)
Acosta-serrano, A. (2004) Transposon mutagenesis of Trypanosoma brucei identifies glycosylation mutants resistant to concanavalin A. Journal of Biological Chemistry, 279(28), pp. 28979-28988.
Hammarton, T. , Engstler, M. and Mottram, J. (2004) The Trypanosoma brucei cyclin, CYC2, is required for cell cycle progression through G(1) phase and for maintenance of procyclic form cell morphology. Journal of Biological Chemistry, 279, pp. 24757-24764. (doi: 10.1074/jbc.M401276200)
Dalley, J.A. and Bulleid, N.J. (2003) The endoplasmic eeticulum (ER) translocon can differentiate between hydrophobic sequences allowing signals for glycosylphosphatidylinositol anchor addition to be fully translocated into the ER lumen. Journal of Biological Chemistry, 278(51), pp. 51749-51757. (doi: 10.1074/jbc.M303978200)
Brewer, L., Corzett, M., Lau, E.Y. and Balhorn, R. (2003) Dynamics of protamine 1 binding to single DNA molecules. Journal of Biological Chemistry, 278(43), pp. 42403-42408. (doi: 10.1074/jbc.M303610200)
Allen, S., Lu, H., Thornton, D. and Tokatlidis, K. (2003) Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. Journal of Biological Chemistry, 278(40), pp. 38505-38513. (doi: 10.1074/jbc.M306027200)
Singh, S., Powell, D. W., Rane, M. J., Millard, T. H., Trent, J. O., Pierce, W. M., Klein, J. B., Machesky, L. M. and McLeish, K. R. (2003) Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis. Journal of Biological Chemistry, 278(38), pp. 36410-36417. (doi: 10.1074/jbc.M306428200) (PMID:12829704)
Nada, S., Shima, T., Yanai, H., Husi, H., Grant, S. G.N., Okada, M. and Akiyama, T. (2003) Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn. Journal of Biological Chemistry, 278(48), pp. 47610-47621. (doi: 10.1074/jbc.M303873200) (PMID:13129934)
Dyall, S.D., Agius, S.C., De Marcos Lousa, C., Trézéguet, V. and Tokatlidis, K. (2003) The dynamic dimerization of the yeast ADP/ATP carrier in the iunner mitochondrial membrane is affected by conserved cysteine residues. Journal of Biological Chemistry, 278(29), pp. 26757-26764. (doi: 10.1074/jbc.M302700200)
Marti, M. , Regös, A., Li, Y., Schraner, E. M., Wild, P., Müller, N., Knopf, L. G. and Hehl, A. B. (2003) An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis. Journal of Biological Chemistry, 278(27), pp. 24837-24848. (doi: 10.1074/jbc.M302082200) (PMID:12711599)
Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M. and Lapthorn, A.J. (2003) Structures of Shikimate dehydrogenase AroE and its paralog YdiB: a common structural framework for different activities. Journal of Biological Chemistry, 278, pp. 19463-19472. (doi: 10.1074/jbc.M300794200)
Longhi, S., Receveur-Bréchot, V., Karlin, D., Johansson, K., Darbon, H., Bhella, D. , Yeo, R., Finet, S. and Canard, B. (2003) The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein. Journal of Biological Chemistry, 278(20), pp. 18638-18648. (doi: 10.1074/jbc.M300518200)
Garofalo, A., Rowlinson, M.C., Amambua, N.A., Hughes, J.M., Kelly, S.M. , Price, N.C., Cooper, A., Watson, D.G., Kennedy, M.W. and Bradley, J.E. (2003) The FAR protein family of the nematode Caenorhabditis elegans - Differential lipid binding properties, structural characteristics, and developmental regulation. Journal of Biological Chemistry, 278, pp. 8065-8074. (doi: 10.1074/jbc.M206278200)
Oda, A. et al. (2003) CrkL directs ASAP1 to peripheral focal adhesions. Journal of Biological Chemistry, 278(8), pp. 6456-6460. (doi: 10.1074/jbc.M210817200) (PMID:12522101)
Williams, R., Kelly, S., Mottram, J. and Coombs, G. (2003) 3-mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism. Journal of Biological Chemistry, 278, pp. 1480-1486. (doi: 10.1074/jbc.M209395200)
Bolger, G., Peden, A., Steele, M., MacKenzie, C., McEwan, D., Wallace, D., Huston, E., Baillie, G. and Houslay, M. (2003) Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. Journal of Biological Chemistry, 278, pp. 33351-33363. (doi: 10.1074/jbc.M303269200)
Peterson, J.H., Woolhead, C.A. and Bernstein, H.D. (2003) Basic amino acids in a distinct subset of signal peptides promote interaction with the signal recognition particle. Journal of Biological Chemistry, 278(46), pp. 46155-46162. (doi: 10.1074/jbc.M309082200)
Most, P. et al. (2003) The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers. Journal of Biological Chemistry, 278(29), pp. 26356-26364. (doi: 10.1074/jbc.M303338200)
Eschenlauer, S. and Page, A. (2003) The Caenorhabditis elegans ERp60 homolog protein disulfide isomerase-3 has disulfide isomerase and transglutaminase-like cross-linking activity and is involved in the maintenance of body morphology. Journal of Biological Chemistry, 278, pp. 4227-4237. (doi: 10.1074/jbc.M210510200)
Kolch, W. (2003) Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. Journal of Biological Chemistry, 278(42), pp. 41173-41181. (doi: 10.1074/jbc.M302644200)
Burchmore, R. , Wallace, L., Candlish, D., Al-Salabi, M., Beal, P., Barrett, M. , Baldwin, S. and de Koning, H. (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278(26), pp. 23502-23507. (doi: 10.1074/jbc.M301252200)
Gotthardt, M., Granzier, H., Hammer, R.E., Herz, J., Hubner, N., Labeit, S., McNabb, M., Monti, J., Richardson, J.A. and Witt, C.C. (2003) Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. Journal of Biological Chemistry, 278(8), pp. 6059-6065.
Alphey, M., Williams, R., Mottram, J. , Coombs, G. and Hunter, W. (2003) The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase - A three-domain architecture with a serine protease-like triad at the active site. Journal of Biological Chemistry, 278, pp. 48219-48227. (doi: 10.1074/jbc.M307187200)
Carrillo, J., Pediani, J. and Milligan, G. (2003) Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. Journal of Biological Chemistry, 278, pp. 42578-42587. (doi: 10.1074/jbc.M306165200)
Morrow, V., Foufelle, F., Connell, J., Petrie, J. , Gould, G. and Salt, I. (2003) Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. Journal of Biological Chemistry, 278(34), pp. 31629-31639. (doi: 10.1074/jbc.M212831200)
Benians, A., Leaney, J., Milligan, G. and Tinker, A. (2003) The dynamics of formation and action of the ternary complex revealed in living cells using a G-protein-gated K+ channel as a biosensor. Journal of Biological Chemistry, 278, pp. 10851-10858. (doi: 10.1074/jbc.M212299200)
McCracken, S., Longman, D., Johnstone, I., Caceres, J. and Blencowe, B. (2003) An evolutionarily conserved role for SRm160 in 3 '-end processing that functions independently of exon junction complex formation. Journal of Biological Chemistry, 278, pp. 44153-44160. (doi: 10.1074/jbc.M306856200)
Taylor, E. R., Dornan, E. S., Boner, W. , Connolly, J. A., McNair, S., Kannouche, P., Lehmann, A.R. and Morgan, I. M. (2003) The fidelity of HPV16 E1/E2-mediated DNA replication. Journal of Biological Chemistry, 278, pp. 52223-52230. (doi: 10.1074/jbc.M308779200) (PMID:14559922)
Dixon, D., McEwen, A., Lapthorn, A. and Edwards, R. (2003) Forced evolution of a herbicide detoxifying glutathione transferase. Journal of Biological Chemistry, 278, pp. 23930-23935. (doi: 10.1074/jbc.M303620200)
Spiller, O.B., Blackbourn, D.J., Mark, L., Proctor, D.G. and Blom, A.M. (2003) Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus. Journal of Biological Chemistry, 278, pp. 9283-9289. (doi: 10.1074/jbc.M211579200)
Harris, C.L., Hughes, C.,E., Williams, A.S., Goodfellow, I., Evans, D.J., Caterson, B. and Morgan, B.P. (2003) Generation of anti-complement "prodrugs" - Cleavable reagents for specific delivery of complement regulators to disease sites. Journal of Biological Chemistry, 278, pp. 36068-36076. (doi: 10.1074/jbc.M306351200)
Boutell, C. and Everett, R.D. (2003) The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and ubiquitinates p53. Journal of Biological Chemistry, 278(38), pp. 36596-36602. (doi: 10.1074/jbc.M300776200)
Salt, I., Morrow, V., Brandie, F., Connell, J. and Petrie, J. (2003) High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser(1177) phosphorylation in human aortic endothelial cells. Journal of Biological Chemistry, 278(21), pp. 18791-18797. (doi: 10.1074/jbc.M210618200)
Winter, A., Myllyharju, J. and Page, A. (2003) A hypodermally expressed prolyl 4-hydroxylase from the filarial nematode Brugia malayi is soluble and active in the absence of protein disulfide isomerase. Journal of Biological Chemistry, 278, pp. 2554-2562. (doi: 10.1074/jbc.M210381200)
Merckx, A. et al. (2003) Identification and initial characterization of three novel cyclin-related proteins of the human malaria parasite Plasmodium falciparum. Journal of Biological Chemistry, 278, pp. 39839-39850. (doi: 10.1074/jbc.M301625200)
Sokolowski, M., Scott, J.E., Heaney, R.P., Patel, A.H. and Clements, J.B. (2003) Identification of herpes simplex virus RNAs that interact specifically with regulatory protein ICP27 in vivo. Journal of Biological Chemistry, 278, pp. 33540-33549. (doi: 10.1074/jbc.M302063200)
Borges-Walmsley, M., Beauchamp, J., Kelly, S., Jumel, K., Candlish, D., Harding, S., Price, N. and Walmsley, A. (2003) Identification of oligomerization and drug-binding domains of the membrane fusion protein EmrA. Journal of Biological Chemistry, 278, pp. 12903-12912. (doi: 10.1074/jbc.M209457200)
Targett-Adams, P., Chambers, D., Gledhill, S., Hope, R.G., Coy, J.F., Girod, A. and McLauchlan, J. (2003) Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein. Journal of Biological Chemistry, 278(18), pp. 15998-16007. (doi: 10.1074/jbc.M211289200)
Williams, P., Chaudhry, Y., Goodfellow, I.G., Billington, J., Powell, R., Spiller, O.B., Evans, D.J. and Lea, S. (2003) Mapping CD55 function - The structure of two pathogen-binding domains at 1.7 angstrom. Journal of Biological Chemistry, 278, pp. 10691-10696. (doi: 10.1074/jbc.M212561200)
Bell, J. and McCulloch, R. (2003) Mismatch repair regulates homologous recombination, but has little influence on antigenic variation, in Trypanosoma brucei. Journal of Biological Chemistry, 278, pp. 45182-45188. (doi: 10.1074/jbc.M308123200)
Lamb, H., Leslie, K., Dodds, A., Nutley, M., Cooper, A., Johnson, C., Thompson, P., Stammers, D. and Hawkins, A. (2003) The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides. Journal of Biological Chemistry, 278, pp. 32107-32114. (doi: 10.1074/jbc.M304104200)
Osterhout, J., Waheed, A., Hiol, A., Ward, R., Davey, P., Nini, L., Wang, J., Milligan, G., Jones, T. and Druey, K. (2003) Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function - II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of G(i)-coupled signaling. Journal of Biological Chemistry, 278, pp. 19309-19316. (doi: 10.1074/jbc.M210124200) (PMID:12642592)
Hiol, A., Davey, P., Osterhout, J., Waheed, A., Fischer, E., Chen, C., Milligan, G., Druey, K. and Jones, T. (2003) Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function - I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue. Journal of Biological Chemistry, 278, pp. 19301-19308. (doi: 10.1074/jbc.M210123200) (PMID:12642593)
Feng, G., Kellett, E., Scorer, C., Wilde, J., White, J. and Milligan, G. (2003) Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation. Journal of Biological Chemistry, 278, pp. 33400-33407. (doi: 10.1074/jbc.M305866200)
Derrien, A., Zheng, B., Osterhout, J., Ma, Y., Milligan, G. , Farquhar, M. and Druey, K. (2003) Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability. Journal of Biological Chemistry, 278, pp. 16107-16116. (doi: 10.1074/jbc.M210371200)
Hammarton, T. , Clark, J., Douglas, F., Boshart, M. and Mottram, J. (2003) Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin. Journal of Biological Chemistry, 278, pp. 22877-22886. (doi: 10.1074/jbc.M300813200)
Gourlay, L., Bhella, D., Kelly, S., Price, N. and Lindsay, J. (2003) Structure-function analysis of recombinant substrate protein 22 kDa (SP-22) - A mitochondrial 2-Cys peroxiredoxin organized as a decameric toroid. Journal of Biological Chemistry, 278, pp. 32631-32637. (doi: 10.1074/jbc.M303862200)
Bryant, N. (2003) Tomosyn interacts with the t-SNAREs Syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. Journal of Biological Chemistry, 278(37), pp. 35093-35101. (doi: 10.1074/jbc.M304261200)
Bolger, G., McCahill, A., Huston, E., Cheung, Y., McSorley, T., Baillie, G. and Houslay, M. (2003) The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins. Journal of Biological Chemistry, 278, pp. 49230-49238. (doi: 10.1074/jbc.M303772200)
Brewer, L., Corzett, M. and Balhorn, R. (2002) Condensation of DNA by spermatid basic nuclear proteins. Journal of Biological Chemistry, 277(41), pp. 38895-38900. (doi: 10.1074/jbc.M204755200)
Chen, H., MacDonald, A. and Coffino, P. (2002) Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. Journal of Biological Chemistry, 277(48), pp. 45957-45961. (doi: 10.1074/jbc.M206799200) (PMID:12359729)
Vial, S., Lu, H., Allen, S., Savory, P., Thornton, D., Sheerhan, J. and Tokatlidis, K. (2002) Assembly of Tim9 and Tim10 into a functional chaperone. Journal of Biological Chemistry, 277(39), pp. 36100-36108. (doi: 10.1074/jbc.M202310200)
Tasab, M., Jenkinson, L. and Bulleid, N.J. (2002) Sequence-specific recognition of collagen triple helices by the collagen-specific molecular chaperone HSP47. Journal of Biological Chemistry, 277(38), pp. 35007-35012. (doi: 10.1074/jbc.M202782200)
Wong, S.-C., Chew, W.-K., Tan, J. E.-L., Melendez, A. J., Francis, F. and Lam, K.-P. (2002) Peritoneal CD5(+) B-1 cells have signaling properties similar to tolerant B cells. Journal of Biological Chemistry, 277(34), pp. 30707-30715. (doi: 10.1074/jbc.M202460200) (PMID:12070149)
Eaton, P., Fuller, W. and Shattock, M. J. (2002) S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation. Journal of Biological Chemistry, 277(24), pp. 21189-21196. (doi: 10.1074/jbc.M200591200) (PMID:11925435)
Werner, A.B., de Vries, E., Tait, S.W.G. , Bontjer, I. and Borst, J. (2002) Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit its collaboration with pro-apoptotic Bak or Bax. Journal of Biological Chemistry, 277(25), pp. 22781-22788. (doi: 10.1074/jbc.M201469200)
Hashmi, S., Britton, C. , Liu, J., Guiliano, D., Oksov, Y. and Lustigman, S. (2002) Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans. Journal of Biological Chemistry, 277, pp. 3477-3486. (doi: 10.1074/jbc.M106117200)
Jackson, M., Baird, J., Cambray, N., Ansell, J., Forrester, L. and Graham, G. (2002) Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation. Journal of Biological Chemistry, 277(41), pp. 38683-38692.
Reid, J., Kelly, S., Watt, K., Price, N. and McEwan, I. (2002) Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation - Influence of structure-stabilizing solutes and protein-protein interactions. Journal of Biological Chemistry, 277, pp. 20079-20086. (doi: 10.1074/jbc.M201003200)
Kozma, E., Brown, E., Ellis, E. and Lapthorn, A. (2002) The crystal structure of rat liver AKR7A1 - A dimeric member of the aldo-keto reductase superfamily. Journal of Biological Chemistry, 277, pp. 16285-16293. (doi: 10.1074/jbc.M110808200)
Le Jeune, I., Shepherd, M., Van Heeke, G., Houslay, M. and Hall, I. (2002) Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells - Identification and characterization of a novel PDE4D5 promoter. Journal of Biological Chemistry, 277, pp. 35980-35989. (doi: 10.1074/jbc.M204832200)
Khaw, A.K. and Melendez Romero, A.J. (2002) Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. Journal of Biological Chemistry, 277(19), pp. 17255-17262. (doi: 10.1074/jbc.M110944200)
Wallace, L., Candlish, D. and De Koning, H. (2002) Different substrate recognition motifs of human and trypanosome nucleobase transporters - Selective uptake of purine antimetabolites. Journal of Biological Chemistry, 277, pp. 26149-26156. (doi: 10.1074/jbc.M202835200)
Rayner, T., Gray, J. and Thorner, J. (2002) Direct and novel regulation of cAMP-dependent protein kinase by Mck1p, a yeast glycogen synthase kinase-3. Journal of Biological Chemistry, 277, pp. 16814-16822. (doi: 10.1074/jbc.M112349200)
Lawrence, A. et al. (2002) A direct pyrophosphatase-coupled assay provides new insights into the activation of the secreted adenylate cyclase from Bordetella pertussis by calmodulin. Journal of Biological Chemistry, 277, pp. 22289-22296. (doi: 10.1074/jbc.M106701200)
Watterson, K., Johnston, E., Chalmers, C., Pronin, A., Cook, S., Benovic, J. and Palmer, T. (2002) Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. Journal of Biological Chemistry, 277, pp. 5767-5777. (doi: 10.1074/jbc.M110647200)
Liu, S., Carrillo, J., Pediani, J. and Milligan, G. (2002) Effective information transfer from the alpha(1b)-adrenoceptor to G alpha(11) requires both beta/gamma interactions and an aromatic group four amino acids from the C terminus of the G protein. Journal of Biological Chemistry, 277, pp. 25707-25714. (doi: 10.1074/jbc.M201015200)
Riihimaa, P., Nissi, R., Page, A. , Winter, A., Keskiaho, K., Kivirikko, K. and Myllyharju, J. (2002) Egg shell collagen formation in Caenorhabditis elegans involves a novel prolyl 4-hydroxylase expressed in spermatheca and embryos and possessing many unique properties. Journal of Biological Chemistry, 277, pp. 18238-18243. (doi: 10.1074/jbc.M200895200)
Glynne, P., Darling, K., Picot, J. and Evans, T. (2002) Epithelial inducible nitric-oxide synthase is an apical EBP50-binding protein that directs vectorial nitric oxide output. Journal of Biological Chemistry, 277, pp. 33132-33138. (doi: 10.1074/jbc.M205764200)
Li, S., Rosen, B.P., Borges-Walmsley, M.I. and Walmsley, A.R. (2002) Evidence for cooperativity between the four binding sites of dimeric ArsD, an As(III)-responsive transcriptional regulator. Journal of Biological Chemistry, 277, pp. 25992-26002. (doi: 10.1074/jbc.M201619200)
Myllyharju, J., Kukkola, L., Winter, A. and Page, A. (2002) The exoskeleton collagens in Caenorhabditis elegans are modified by prolyl 4-hydroxylases with unique combinations of subunits. Journal of Biological Chemistry, 277, pp. 29187-29196. (doi: 10.1074/jbc.M203824200)
Boner, W. , Taylor, E. R., Tsirimonaki, E., Yamane, K., Campo, M. S. and Morgan, I. M. (2002) A functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1. Journal of Biological Chemistry, 277, pp. 22297-22303. (doi: 10.1074/jbc.M202163200) (PMID:11934899)
Robinson, N., McCulloch, R., Conway, C., Browitt, A. and Barry, J. (2002) Inactivation of Mre11 does not affect VSG gene duplication mediated by homologous recombination in Trypanosoma brucei. Journal of Biological Chemistry, 277, pp. 26185-26193. (doi: 10.1074/jbc.M203205200)
Kolch, W. (2002) Induction of apoptosis by protein kinase C delta is independent of its kinase activity. Journal of Biological Chemistry, 277(35), pp. 32054-32062. (doi: 10.1074/jbc.M203734200)
Knockaert, M., Wieking, K., Schmitt, S., Leost, M., Grant, K., Mottram, J. , Kunick, C. and Meijer, L. (2002) Intracellular targets of paullones - Identification following affinity purification on immobilized inhibitor. Journal of Biological Chemistry, 277, pp. 25493-25501. (doi: 10.1074/jbc.M202651200)
Conway, C., McCulloch, R., Ginger, M., Robinson, N., Browitt, A. and Barry, J. (2002) Ku is important for telomere maintenance, but not for differential expression of telomeric VSG genes, in African trypanosomes. Journal of Biological Chemistry, 277, pp. 21269-21277. (doi: 10.1074/jbc.M200550200)
Trotter, E., Kao, C., Berenfeld, L., Botstein, D., Petsko, G. and Gray, J. (2002) Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae. Journal of Biological Chemistry, 277, pp. 44817-44825. (doi: 10.1074/jbc.M204686200)
Felton-Edkins, Z. and White, R. (2002) Multiple mechanisms contribute to the activation of RNA polymerase III transcription in cells transformed by papovaviruses. Journal of Biological Chemistry, 277, pp. 48182-48191. (doi: 10.1074/jbc.M201333200)
Thomson, L., Lamont, D., Mehlert, A., Barry, J. and Ferguson, M. (2002) Partial structure of glutamic acid and alanine-rich protein, a major surface glycoprotein of the insect stages of Trypanosoma congolense. Journal of Biological Chemistry, 277, pp. 48899-48904. (doi: 10.1074/jbc.M208942200)
Poghosyan, Z., Robbins, S., Houslay, M., Webster, A., Murphy, G. and Edwards, D. (2002) Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. Journal of Biological Chemistry, 277, pp. 4999-5007. (doi: 10.1074/jbc.M107430200)
Ellis, M., Sharma, D., Hilley, J., Coombs, G. and Mottram, J. (2002) Processing and trafficking of Leishmania mexicana GP63 - Analysis using GPI8 mutants deficient in glycosylphosphatidylinositol protein anchoring. Journal of Biological Chemistry, 277, pp. 27968-27974. (doi: 10.1074/jbc.M202047200)
Inman, G. J. and Hill, C. S. (2002) Stoichiometry of active Smad-transcription factor complexes on DNA. Journal of Biological Chemistry, 277(52), pp. 51008-51016. (doi: 10.1074/jbc.m208532200) (PMID:12374795)
Radford, J., Davies, S. and Dow, J. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. Journal of Biological Chemistry, 277, pp. 38810-38817. (doi: 10.1074/jbc.M203694200)
Baillie, G. et al. (2002) TAPAS-1, a novel microdomaln within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid. Journal of Biological Chemistry, 277, pp. 28298-28309. (doi: 10.1074/jbc.M108353200)
Muller, S. (2002) Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages. Journal of Biological Chemistry, 277(29), pp. 25970-25975. (doi: 10.1074/jbc.M203539200)
Bond, M., Murphy, G., Bennett, M., Newby, A. and Baker, A. (2002) Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway. Journal of Biological Chemistry, 277, pp. 13787-13795. (doi: 10.1074/jbc.M111507200)
Werner, A.B., de Vries, E., Tait, S.W.G. , Bontjer, I. and Borst, J. (2002) TRAIL receptor and CD95 signal to mitochondria via FADD, Caspase-8/10, Bid, and Bax but differentially regulate events downstream from truncated Bid. Journal of Biological Chemistry, 277(43), pp. 40760-40767. (doi: 10.1074/jbc.M204351200)
Chamberlain, L. and Gould, G. (2002) The vesicle- and target-SNARE proteins that mediate Glut4 vesicle fusion are localized in detergent-insoluble lipid rafts present on distinct intracellular membranes. Journal of Biological Chemistry, 277, pp. 49750-49754. (doi: 10.1074/jbc.M206936200)
Kim, M., Chen, B., Hussey, R.E., Chishti, Y., Montefiori, D., Hoxie, J.A., Byron, O. , Campbell, G., Harrison, S.C. and Reinherz, E.L. (2001) The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. Journal of Biological Chemistry, 276(46), pp. 42667-42676. (doi: 10.1074/jbc.m104166200) (PMID:11544255)
Kennedy, M.W. , Heikema, A.P., Cooper, A., Bjorkman, P.J. and Sanchez, L.M. (2001) Hydrophobic ligand binding by Zn-alpha(2)-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins. Journal of Biological Chemistry, 276(37), pp. 35008-35013. (doi: 10.1074/jbc.C100301200)
Swartz, T.E., Corchnoy, S.B., Christie, J.M. , Lewis, J.W., Szundi, I., Briggs, W.R. and Bogomolni, R.A. (2001) The phocycle of a flavin-binding domain of the blue-light photoreceptor phototropin. Journal of Biological Chemistry, 276(39), pp. 36493-36500. (doi: 10.1074/jbc.M103114200)
Bushell, M. , Wood, W., Carpenter, G., Pain, V. M., Morley, S. J. and Clemens, M. J. (2001) Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4b with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages. Journal of Biological Chemistry, 276(26), pp. 23922-23928. (doi: 10.1074/jbc.M100384200) (PMID:11274152)
Rose, K. et al. (2001) hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation. Journal of Biological Chemistry, 276(26), pp. 23937-23944. (doi: 10.1074/jbc.M011564200) (PMID:11290741)
Alderton, F., Rakhit, S., Kong, K.C., Palmer, T., Sambi, B., Pyne, S. and Pyne, N.J. (2001) Tethering of the platelet-derived growth factor ß receptor to G-protein-coupled receptors - A novel platform for integrative signaling by these receptor classes in mammalian cells. Journal of Biological Chemistry, 276, pp. 28578-28585. (doi: 10.1074/jbc.M102771200)
Spurway, T.D., Dalley, J.A., High, S. and Bulleid, N.J. (2001) Early events in glycosylphosphatidylinositol anchor addition: substrate proteins associate with the transamidase subunit Gpi8p. Journal of Biological Chemistry, 276(19), pp. 15975-15982. (doi: 10.1074/jbc.M010128200)
Palmer, S., Brouillet, J.-P., Kilbey, A., Fulton, R., Walker, M., Crossley, M. and Bartholomew, C. (2001) Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins. Journal of Biological Chemistry, 276(28), pp. 25834-25840. (doi: 10.1074/jbc.M102343200)
Alderton, F., Darroch, P., Sambi, B., McKie, A.E. , Ahmed, S.I., Pyne, N. J. and Pyne, S. (2001) G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. Journal of Biological Chemistry, 276(16), pp. 13452-13460. (doi: 10.1074/jbc.M006582200) (PMID:11278307)
Christie, J.M. and Briggs, W.R. (2001) Blue light sensing in higher plants. Journal of Biological Chemistry, 276(15), pp. 11457-11460. (doi: 10.1074/jbc.R100004200)
Bonev, B. B., Gilbert, R. J.C., Andrew, P. W., Byron, O. and Watts, A. (2001) Structural analysis of the protein/lipid complexes associated with pore formation by the bacterial toxin pneumolysin. Journal of Biological Chemistry, 276(8), pp. 5714-5719. (doi: 10.1074/jbc.M005126200) (PMID:11076935)
Arrecubieta, C., Hammarton, T.C. , Barrett, B., Chareonsudjai, S., Hodson, N., Rainey, D. and Roberts, I.S. (2001) The transport of group 2 capsular polysaccharides across the peripiasmic space in Escherichia coli: roles for the KpsE and KpsD proteins. Journal of Biological Chemistry, 276(6), pp. 4245-4250. (doi: 10.1074/jbc.M008183200)
Touyz, R.M. , Mercure, C. and Reudelhuber, T.L. (2001) Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms. Journal of Biological Chemistry, 276(17), pp. 13657-13663. (doi: 10.1074/jbc.M008101200)
Campo, S. (2001) Cell transformation by the E5/E8 protein of bovine papillomavirus type 4. p27(Kip1), Elevated through increased protein synthesis is sequestered by cyclin D1-CDK4 complexes. Journal of Biological Chemistry, 276(36), pp. 33861-33868.
Carragher, N.O., Fincham, V.J., Riley, D. and Frame, M.C. (2001) Cleavage of focal adhesion kinase by different proteases during Src-reguIated transformation and apoptosis - Distinct roles for calpain and caspases. Journal of Biological Chemistry, 276(6), pp. 4270-4275. (doi: 10.1074/jbc.M008972200)
Woolhead, C.A. , Mant, A., Kim, S.J., Robinson, C. and Rodger, A. (2001) Conformation of a purified 'spontaneously' inserting thylakoid membrane protein precursor in aqueous solvent and detergent micelles. Journal of Biological Chemistry, 276(18), pp. 14607-14613. (doi: 10.1074/jbc.M009600200)
Svergun, D., Zaccai, G., Malfois, M., Wade, R., Koch, M. and Kozielski, F. (2001) Conformation of the Drosophila motor protein non-claret disjunctional in solution from x-ray and neutron scattering. Journal of Biological Chemistry, 276(27), pp. 24826-24832. (doi: 10.1074/jbc.M103618200)
Slepak, T., Webster, K., Zang, J., Prentice, H., O'Dowd, A., Hicks, M. and Bishopric, N. (2001) Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D. Journal of Biological Chemistry, 276, pp. 7575-7585.
Kantachuvesiri, S., Fleming, S., Peters, J., Peters, B., Brooker, G., Lammie, A.G., McGrath, I., Kotelevtsev, Y. and Mullins, J.J. (2001) Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease. Journal of Biological Chemistry, 276, pp. 36727-36733.
Stevens, P., Pediani, J., Carrillo, J. and Milligan, G. (2001) Coordinated agonist regulation of receptor and G protein palmitoylation and functional rescue of palmitoylation-deficient mutants of the G protein G(11)alpha following fusion to the alpha(1b)-adrenoreceptor - Palmitoylation of G(11 alpha) is not required. Journal of Biological Chemistry, 276, pp. 35883-35890.
Fotinou, C., Emsley, P., Black, I., Ando, H., Ishida, H., Kiso, M., Sinha, K., Fairweather, N. and Isaacs, N. (2001) The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. Journal of Biological Chemistry, 276, pp. 32274-32281.
Lomonte, P., Sullivan, K.F. and Everett, R.D. (2001) Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0. Journal of Biological Chemistry, 276(8), pp. 5829-5835. (doi: 10.1074/jbc.M008547200)
Baird, J. et al. (2001) Differentiating embryonal stem cells are a rich source of haemopoietic gene products and suggest erythroid preconditioning of primitive haemopoietic stem cells. Journal of Biological Chemistry, 276(12), pp. 9189-9198. (doi: 10.1074/jbc.M008354200)
Herzyk, P. (2001) The dimerization interface of the metastasis-associated protein S100A4 (Mts1) - In vivo and in vitro studies. Journal of Biological Chemistry, 276(26), pp. 24212-24222. (doi: 10.1074/jbc.M009477200)
Woolhead, C.A. , Thompson, S.J., Moore, M., Tissier, C., Mant, A., Rodger, A., Henry, R. and Robinson, C. (2001) Distinct albino3-dependent and -independent pathways for thylakoid membrane protein insertion. Journal of Biological Chemistry, 276(44), pp. 40841-40846. (doi: 10.1074/jbc.M106523200)
Smith, B. (2001) DNA recognition by the methyl-CpG binding domain of MeCP2. Journal of Biological Chemistry, 276(5), pp. 3353-3360. (doi: 10.1074/jbc.M007224200)
Flynn, E.R.M., Bradley, K.N., Muir, T.C. and McCarron, J.G. (2001) Functionally separate intracellular Ca2+ stores in smooth muscle. Journal of Biological Chemistry, 276, pp. 36411-36418.
West, K., Ito, Y., Birger, Y., Postnikov, Y., Shirakawa, H. and Bustin, M. (2001) HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome- binding proteins. Journal of Biological Chemistry, 276(28), pp. 25959-25969.
Song, Y., Ji, I., Beauchamp, J., Isaacs, N. and Ji, T. (2001) Hormone interactions to Leu-rich repeats in the gonadotropin receptors - I. Analysis of Leu-rich repeats of human luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor. Journal of Biological Chemistry, 276, pp. 3426-3435.
Song, Y., Ji, I., Beauchamp, J., Isaacs, N. and Ji, T. (2001) Hormone interactions to Leu-rich repeats in the gonadotropin receptors - II. Analysis of Leu-rich repeat 4 of human luteinizing hormone/chorionic gonadotropin receptor. Journal of Biological Chemistry, 276, pp. 3436-3442.
Zuscik, M.J. et al. (2001) Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha(1B)-adrenergic receptor. Journal of Biological Chemistry, 276(17), pp. 13738-13743. (doi: 10.1074/jbc.M008693200)
Jaiswal, R., Kao, S., Kolch, W. and Landreth, G. (2001) Identification of the mechanisms regulating the differential activation of the MAPK cascade by epidermal growth factor and nerve growth factor in PC12 cells. Journal of Biological Chemistry, 276(21), pp. 18169-18177. (doi: 10.1074/jbc.M008870200)
Mant, A., Woolhead, C.A. , Moore, M., Henry, R. and Robinson, C. (2001) Insertion of psak into the thylakoid membrane in a 'horseshoe' conformation occurs in the absence of signal recognition particle, nucleoside triphosphates, or functional albino3. Journal of Biological Chemistry, 276(39), pp. 36200-36206. (doi: 10.1074/jbc.M102914200)
Walmsley, A.R., Zhou, T.Q., Borges-Walmsley, M.I. and Rosen, B.P. (2001) A kinetic model for the action of a resistance efflux pump. Journal of Biological Chemistry, 276, pp. 6378-6391.
Lin, H.H., Stacey, M., Saxby, C., Knott, V., Chaudhry, Y., Evans, D., Gordon, S., McKnight, A.J., Handford, P. and Lea, S. (2001) Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions - Dissection of the CD97-CD55 complex. Journal of Biological Chemistry, 276, pp. 24160-24169.
McVey, M., Ramsay, D., Kellett, E., Rees, S., Wilson, S., Pope, A. and Milligan, G. (2001) Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer - The human delta-opioid receptor displays constitutive oligomerization at the cell surface, which is not regulate. Journal of Biological Chemistry, 276, pp. 14092-14099.
Kozielski, F., Svergun, D., Zaccai, G., Wade, R. and Koch, M. (2001) The overall conformation of conventional kinesins studied by small angle X-ray and neutron scattering. Journal of Biological Chemistry, 276(2), pp. 1267-1275. (doi: 10.1074/jbc.M007169200)
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