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Sattar, N. , Lee, M. M.Y. and McGuire, D. K. (2024) What the SELECT trial of semaglutide means for clinicians. Nature Medicine, 30(7), pp. 1830-1831. (doi: 10.1038/s41591-024-03013-7) (PMID:38796654)
Kondo, T. et al. (2024) A hierarchical kidney outcome using win statistics in patients with heart failure from the DAPA-HF and DELIVER trials. Nature Medicine, 30(5), pp. 1432-1439. (doi: 10.1038/s41591-024-02941-8) (PMID:38710952) (PMCID:PMC11108780)
Alivernini, S., Cañete, J. D., Bacardit, J. and Kurowska-Stolarska, M. (2024) Using explainable artificial intelligence to predict and forestall flare in rheumatoid arthritis. Nature Medicine, (doi: 10.1038/s41591-024-02818-w) (PMID:38361121) (Early Online Publication)
Fizazi, K. et al. (2024) Publisher Correction: First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial. Nature Medicine, 30, (doi: 10.1038/s41591-024-02835-9)
Fizazi, K. et al. (2023) First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: The phase 3 TALAPRO-2 trial. Nature Medicine, 30, pp. 257-264. (doi: 10.1038/s41591-023-02704-x) (PMID:38049622) (PMCID:PMC10803259)
Vardeny, O. et al. (2023) Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial. Nature Medicine, 29(12), p. 3269. (doi: 10.1038/s41591-023-02302-x) (PMID:36932245)
Lam, C. S.P., Docherty, K. F. , Ho, J. E., McMurray, J. J.V. , Myhre, P. L. and Omland, T. (2023) Recent successes in heart failure treatment. Nature Medicine, 29(10), pp. 2424-2437. (doi: 10.1038/s41591-023-02567-2) (PMID:37814060)
Taquet, M. et al. (2023) Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization. Nature Medicine, (doi: 10.1038/s41591-023-02525-y) (PMID:37653345) (Early Online Publication)
Borlaug, B. A. et al. (2023) Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial. Nature Medicine, 29(9), pp. 2358-2365. (doi: 10.1038/s41591-023-02526-x) (PMID:37635157) (PMCID:PMC10504076)
Barnes, E. et al. (2023) SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. Nature Medicine, 29(7), pp. 1760-1774. (doi: 10.1038/s41591-023-02414-4) (PMID:37414897) (PMCID:PMC10353927)
van der Klaauw, A. A. et al. (2023) Accelerated waning of the humoral response to COVID-19 vaccines in obesity. Nature Medicine, 29(5), pp. 1146-1154. (doi: 10.1038/s41591-023-02343-2) (PMID:37169862) (PMCID:PMC10202802)
Allerton, F., Jamieson, C., Aggarwal, R., Barker, A., Work, M., Cooper, D. and Ramsey, I. (2023) An antibiotic amnesty can be a One Health tool to tackle antimicrobial resistance. Nature Medicine, 29, pp. 1046-1047. (doi: 10.1038/s41591-023-02334-3) (PMID:37147502)
Al-Sawaf, O. et al. (2023) Body composition and lung cancer-associated cachexia in TRACERx. Nature Medicine, 29(4), pp. 846-858. (doi: 10.1038/s41591-023-02232-8) (PMID:37045997) (PMCID:PMC7614477)
Karasaki, T. et al. (2023) Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nature Medicine, 29(4), pp. 833-845. (doi: 10.1038/s41591-023-02230-w) (PMID:37045996) (PMCID:PMC7614478)
Shields, B. M., Angwin, C. D., Shepherd, M. H., Britten, N., Jones, A. G., Sattar, N. , Holman, R., Pearson, E. R. and Hattersley, A. T. (2023) Patient preference for second- and third-line therapies in type 2 diabetes: a prespecified secondary endpoint of the TriMaster study. Nature Medicine, 29(2), pp. 384-391. (doi: 10.1038/s41591-022-02121-6) (PMID:36477734) (PMCID:PMC7614215)
Wu, X. et al. (2023) [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial. Nature Medicine, 29(1), pp. 190-202. (doi: 10.1038/s41591-022-02114-5) (PMID:36646800)
Mentzer, A. J. et al. (2023) Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection. Nature Medicine, 29(1), pp. 147-157. (doi: 10.1038/s41591-022-02078-6) (PMID:36228659) (PMCID:PMC9873562)
Stamatakis, E., Ahmadi, M. N., Gill, J. M. R. , Thøgersen-Ntoumani, C., Gibala, M. J., Doherty, A. and Hamer, M. (2022) Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality. Nature Medicine, 28, pp. 2521-2529. (doi: 10.1038/s41591-022-02100-x) (PMID:36482104) (PMCID:PMC9800274)
Vardeny, O. et al. (2022) Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial. Nature Medicine, 28(12), pp. 2504-2511. (doi: 10.1038/s41591-022-02102-9) (PMID:36522606) (PMCID:PMC9800271)
Jhund, P. S. et al. (2022) Dapagliflozin across the range of ejection fraction in patients with heart failure: a patient-level, pooled meta-analysis of DAPA-HF and DELIVER. Nature Medicine, 28(9), pp. 1956-1964. (doi: 10.1038/s41591-022-01971-4) (PMID:36030328) (PMCID:PMC9499855)
Robertson, N. A. et al. (2022) Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects. Nature Medicine, 28(7), pp. 1439-1446. (doi: 10.1038/s41591-022-01883-3) (PMID:35788175) (PMCID:PMC9307482)
Routen, A., Akbari, A., Banerjee, A., Katikireddi, S. V. , Mathur, R., McKee, M., Nafilyan, V. and Khunti, K. (2022) Strategies to record and use ethnicity information in routine health data. Nature Medicine, 28(7), pp. 1338-1342. (doi: 10.1038/s41591-022-01842-y) (PMID:35641824)
Morrow, A. J. et al. (2022) A multisystem, cardio-renal investigation of post-COVID-19 illness. Nature Medicine, 28(6), pp. 1303-1313. (doi: 10.1038/s41591-022-01837-9) (PMID:35606551) (PMCID:PMC9205780)
Wei, J. et al. (2022) Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines. Nature Medicine, 28(5), pp. 1072-1082. (doi: 10.1038/s41591-022-01721-6) (PMID:35165453) (PMCID:PMC9117148)
Cerqueira-Silva, T. et al. (2022) Vaccine effectiveness of heterologous CoronaVac plus BNT162b2 in Brazil. Nature Medicine, 28(4), pp. 838-843. (doi: 10.1038/s41591-022-01701-w) (PMID:35140406) (PMCID:PMC9018414)
Stock, S. J. et al. (2022) SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland. Nature Medicine, 28(3), pp. 504-512. (doi: 10.1038/s41591-021-01666-2) (PMID:35027756)
Sattar, N. , McGuire, D. K., Pavo, I., Weerakkody, G. J., Nishiyama, H., Wiese, R. J. and Zoungas, S. (2022) Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis. Nature Medicine, 28(3), pp. 591-598. (doi: 10.1038/s41591-022-01707-4) (PMID:35210595) (PMCID:PMC8938269)
McMurray, J. J.V. (2022) Can an implanted minipump deliver for diabetes patients? Nature Medicine, 28(1), pp. 27-28. (doi: 10.1038/s41591-021-01628-8) (PMID:34903896)
Pouwels, K. B. et al. (2021) Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK. Nature Medicine, 27(12), pp. 2127-2135. (doi: 10.1038/s41591-021-01548-7) (PMID:34650248) (PMCID:PMC8674129)
Patone, M. et al. (2021) Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection. Nature Medicine, 27(12), pp. 2144-2153. (doi: 10.1038/s41591-021-01556-7) (PMID:34697502) (PMCID:PMC8629105)
Cleland, J. G.F. , Pellicori, P. and González, A. (2021) A novel treatment for heart failure targets myocardial fibrosis. Nature Medicine, 27(8), pp. 1343-1344. (doi: 10.1038/s41591-021-01457-9) (PMID:34385705)
Simpson, C.R. et al. (2021) First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland. Nature Medicine, 27(7), pp. 1290-1297. (doi: 10.1038/s41591-021-01408-4) (PMID:34108714) (PMCID:PMC8282499)
Powles, T. et al. (2021) An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer. Nature Medicine, 27(5), pp. 793-801. (doi: 10.1038/s41591-021-01317-6) (PMID:33941921)
Andrade, C. M. et al. (2020) Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season. Nature Medicine, 26, pp. 1929-1940. (doi: 10.1038/s41591-020-1084-0) (PMID:33106664)
Uwimana, A. et al. (2020) Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda. Nature Medicine, 26(10), pp. 1602-1608. (doi: 10.1038/s41591-020-1005-2) (PMID:32747827) (PMCID:PMC7541349)
Gill, J. M.R. (2020) Linking volume and intensity of physical activity to mortality. Nature Medicine, 26, pp. 1332-1334. (doi: 10.1038/s41591-020-1019-9) (PMID:32807932)
Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)
AbdulJabbar, K. et al. (2020) Geospatial immune variability illuminates differential evolution of lung adenocarcinoma. Nature Medicine, 26(7), pp. 1054-1062. (doi: 10.1038/s41591-020-0900-x) (PMID:32461698)
Sattar, N. , Gill, J. M.R. and Alazawi, W. (2020) Improving prevention strategies for cardiometabolic disease. Nature Medicine, 26(3), pp. 320-325. (doi: 10.1038/s41591-020-0786-7) (PMID:32152584)
Lees, J. S. et al. (2019) Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nature Medicine, 25, pp. 1753-1760. (doi: 10.1038/s41591-019-0627-8) (PMID:31700174) (PMCID:PMC6858876)
Chemi, F. et al. (2019) Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine, 25(10), pp. 1534-1539. (doi: 10.1038/s41591-019-0593-1) (PMID:31591595) (PMCID:PMC6986897)
Rothwell, D. G. et al. (2019) Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study. Nature Medicine, 25(5), pp. 738-743. (doi: 10.1038/s41591-019-0380-z) (PMID:31011204)
Gammage, P. A. et al. (2018) Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo. Nature Medicine, 24(11), pp. 1691-1695. (doi: 10.1038/s41591-018-0165-9) (PMID:30250142) (PMCID:PMC6225988)
Binnewies, M. et al. (2018) Understanding the tumor immune microenvironment (TIME) for effective therapy. Nature Medicine, 24(5), pp. 541-550. (doi: 10.1038/s41591-018-0014-x) (PMID:29686425) (PMCID:PMC5998822)
Zhang, B. et al. (2018) Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia. Nature Medicine, 24, pp. 450-462. (doi: 10.1038/nm.4499) (PMID:29505034) (PMCID:PMC5965294)
Mowat, A. M., Scott, C. L. and Bain, C. C. (2017) Barrier-tissue macrophages: functional adaptation to environmental challenges. Nature Medicine, 23(11), pp. 1258-1270. (doi: 10.1038/nm.4430) (PMID:29117177)
Kuntz, E. M., Baquero, P., Michie, A. M. , Dunn, K., Tardito, S. , Holyoake, T. L., Helgason, G. V. and Gottlieb, E. (2017) Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells. Nature Medicine, 23(10), pp. 1234-1240. (doi: 10.1038/nm.4399) (PMID:28920959) (PMCID:PMC5657469)
West, N. R. et al. (2017) Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease. Nature Medicine, 23(5), pp. 579-589. (doi: 10.1038/nm.4307) (PMID:28368383) (PMCID:PMC5420447)
Carter, L. et al. (2017) Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nature Medicine, 23(1), pp. 114-119. (doi: 10.1038/nm.4239) (PMID:27869802)
Rath, N. and Olson, M. (2016) Regulation of pancreatic cancer aggressiveness by stromal stiffening. Nature Medicine, 22(5), pp. 462-463. (doi: 10.1038/nm.4099) (PMID:27149218)
Shiratori-Hayashi, M. et al. (2015) STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch. Nature Medicine, 21(8), pp. 927-931. (doi: 10.1038/nm.3912) (PMID:26193341)
Davis, H. et al. (2015) Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nature Medicine, 21(1), pp. 62-70. (doi: 10.1038/nm.3750) (PMID:25419707) (PMCID:PMC4594755)
Hodgkinson, C. L. et al. (2014) Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer. Nature Medicine, 20(8), pp. 897-903. (doi: 10.1038/nm.3600) (PMID:24880617)
Schett, G., Elewaut, D., McInnes, I.B. , Dayer, J.-M. and Neurath, M.F. (2013) How cytokine networks fuel inflammation: toward a cytokine-based disease taxonomy. Nature Medicine, 19(7), pp. 822-824. (doi: 10.1038/nm.3260)
Chouchani, E. T. et al. (2013) Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine, 19(6), pp. 753-759. (doi: 10.1038/nm.3212) (PMID:23708290) (PMCID:PMC4019998)
Sridhar, S., Begom, S., Bermingham, A., Hoschler, K., Adamson, W., Carman, W., Bean, T., Barclay, W., Deeks, J.J. and Lalvani, A. (2013) Cellular immune correlates of protection against symptomatic pandemic influenza. Nature Medicine, 19(10), pp. 1305-1312. (doi: 10.1038/nm.3350)
Boulter, L. et al. (2012) Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nature Medicine, 18(4), pp. 572-579. (doi: 10.1038/nm.2667)
Little, T.J., Allen, J.E., Babayan, S.A. , Matthews, K.R. and Colegrave, N. (2012) Harnessing evolutionary biology to combat infectious disease. Nature Medicine, 18(2), pp. 217-220. (doi: 10.1038/nm.2572)
Steinman, L., Merrill, J.T., McInnes, I.B. and Peakman, M. (2012) Optimization of current and future therapy for autoimmune diseases. Nature Medicine, 18(1), pp. 59-65. (doi: 10.1038/nm.2625) (PMID:22227674)
Lories, R.J. and McInnes, I.B. (2012) Primed for inflammation: enthesis-resident T cells. Nature Medicine, 18(7), pp. 1018-1019. (doi: 10.1038/nm.2854) (PMID:22772553)
Lupberger, J. et al. (2011) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nature Medicine, 17(5), pp. 589-595. (doi: 10.1038/nm.2341) (PMID:21516087) (PMCID:PMC3938446)
Nilsson, E.C. et al. (2011) The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. Nature Medicine, 17(1), pp. 105-109. (doi: 10.1038/nm.2267)
Alves Filho, J. C. et al. (2010) Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nature Medicine, 16(6), pp. 708-712. (doi: 10.1038/nm.2156)
Plantier, J.-C., Leoz, M., Dickerson, J. E., De Oliveira, F., Cordonnier, F., Lemée, V., Damond, F., Robertson, D. L. and Simon, F. (2009) A new human immunodeficiency virus derived from gorillas. Nature Medicine, 15(8), pp. 871-872. (doi: 10.1038/nm.2016) (PMID:19648927)
He, W. et al. (2009) Reply to: “Experimental aspects of copy number variant assays at CCL3L1”. Nature Medicine, 15(10), pp. 1117-1120. (doi: 10.1038/nm1009-1117)
Reynolds, A.R. et al. (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nature Medicine, 15(4), pp. 392-400. (doi: 10.1038/nm.1941)
Harnett, M. M., Harnett, W., McSharry, C. P., Melendez, A. J., Pushparaj, P. N., Tay, H. K. and Wong, W. S. F. (2007) Inhibition of FcεRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. Nature Medicine, 13(11), pp. 1375-1381. (doi: 10.1038/nm1654)
Leiper, J. et al. (2007) Disruption of methylarginine metabolism impairs vascular homeostasis. Nature Medicine, 13(2), pp. 198-203. (doi: 10.1038/nm1543) (PMID:17273169)
Tran, M. H., Pearson, M. S., Bethony, J. M., Smyth, D. J. , Jones, M. K., Duke, M., Don, T. A., McManus, D. P., Correa-Oliveira, R. and Loukas, A. (2006) Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis. Nature Medicine, 12(7), pp. 835-840. (doi: 10.1038/nm1430) (PMID:16783371)
Insinga, A., Monestiroli, S., Ronzoni, S., Gelmetti, V., Marchesi, F. , Viale, A., Altucci, L., Nervi, C., Minucci, S. and Pelicci, P.G. (2005) Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nature Medicine, 11(1), pp. 71-76. (doi: 10.1038/nm1160)
Liew, F. and McInnes, I. (2005) A fork in the pathway to inflammation and arthritis. Nature Medicine, 11(6), pp. 601-602. (doi: 10.1038/nm0605-601) (PMID:15937470)
Bensaad, K. and Vousden, K. (2005) Savior and slayer: the two faces of p53. Nature Medicine, 11(12), pp. 1278-1279. (doi: 10.1038/nm1205-1278)
Qi, J., Ebrahem, Q., Moore, N., Murphy, G., Claesson-Welsh, L., Bond, M., Baker, A. and Anand-Apte, B. (2003) A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nature Medicine, 9, pp. 407-415. (doi: 10.1038/nm846)
Binder, C., Horkko, S., Dewan, A., Chang, M., Kieu, E., Goodyear, C. , Shaw, P., Palinski, W., Witztum, J. and Silverman, G. (2003) Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nature Medicine, 9(6), pp. 736-743.
Young, J. D., Lawrence, A. J., MacLean, A. G., Leung, B. P., McInnes, I. B. , Canas, B., Pappin, D. J. C. and Stevenson, R. D. (1999) Thymosin β 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids. Nature Medicine, 5(12), pp. 1424-1427. (doi: 10.1038/71002) (PMID:10581087)
McInnes, I. B. , Leung, B. P., Sturrock, R. D., Field, M. and Liew, F. Y. (1997) Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis. Nature Medicine, 3(2), pp. 189-195. (doi: 10.1038/nm0297-189) (PMID:9018238)
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