es/iode

🚀 Announcing the Deployment of ES/IODE New Version: 3.4.9 🎉 We are excited to inform you that ES/IODE, the leading online scientific research platform, has released version 3.4.9, now available as of August 20, 2024! This update brings significant enhancements to improve your research experience. What's New in This Version: 1️⃣ Science Image Feature: We've optimized the layout by centering the image area and seamlessly integrating the descriptive text within the image itself, offering better readability and a more polished presentation. 2️⃣ Scientific Review Feature: We've expanded our daily study selections with a new category focusing on Respiratory Medicine, Immuno-Allergology, and Dermatology. This addition provides access to the latest and most relevant studies in these rapidly evolving fields. We invite you to explore these new features today and continue leveraging the wealth of resources available on ES/IODE. For any questions or assistance, our support team is here to help. Thank you for your continued trust, and happy researching! 🧬🔬 ES/IODE - Innovating for Science.

📃Scientific paper: The Influence of Rapid Influenza Diagnostic Testing on Clinician Decision-Making for Patients With Acute Respiratory Infection in Urgent Care Abstract: BACKGROUND: The potential benefits of using rapid influenza diagnostic tests (RIDTs) in urgent care facilities for clinical care and prescribing practices are understudied. We compared antiviral and antibiotic prescribing, imaging, and laboratory ordering in clinical encounters with and without RIDT results. METHODS: We compared patients with acute respiratory infection (ARI) symptoms who received an RIDT and patients who did not at 2 urgent care facilities. Primary analysis using 1-to-1 exact matching resulted in 1145 matched pairs to which McNemar 2 × 2 tests were used to assess the association between the likelihood of prescribing, imaging/laboratory ordering, and RIDT use. Secondary analysis compared the same outcomes using logistic regression among the RIDT-tested population between participants who tested negative (RIDT(−)) and positive (RIDT(+)). RESULTS: Primary analysis revealed that compared to the non-RIDT-tested population, RIDT(+) patients were more likely to be prescribed antivirals (OR, 10.23; 95% CI, 5.78–19.72) and less likely to be prescribed antibiotics (OR, 0.15; 95% CI, .08–.27). Comparing RIDT-tested to non-RIDT-tested participants, RIDT use increased antiviral prescribing odds (OR, 3.07; 95% CI, 2.25–4.26) and reduced antibiotic prescribing odds (OR, 0.52; 95% CI, .43–.63). Secondary analysis identified increased odds of prescribing antivirals (OR, 28.21; 95% CI, 18.15–43.86) and decreased odds of prescribing antibiotics (OR, 0.20; 95% CI, .13–... Continued on ES/IODE ➡️ https://etcse.fr/8ZzSN ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Integrative metagenomic analysis reveals distinct gut microbial signatures related to obesity Abstract: Obesity is a metabolic disorder closely associated with profound alterations in gut microbial composition. However, the dynamics of species composition and functional changes in the gut microbiome in obesity remain to be comprehensively investigated. In this study, we conducted a meta-analysis of metagenomic sequencing data from both obese and non-obese individuals across multiple cohorts, totaling 1351 fecal metagenomes. Our results demonstrate a significant decrease in both the richness and diversity of the gut bacteriome and virome in obese patients. We identified 38 bacterial species including Eubacterium sp. CAG:274, Ruminococcus gnavus , Eubacterium eligens and Akkermansia muciniphila, and 1 archaeal species, Methanobrevibacter smithii , that were significantly altered in obesity. Additionally, we observed altered abundance of five viral families: Mesyanzhinovviridae , Chaseviridae , Salasmaviridae , Drexlerviridae , and Casjensviridae . Functional analysis of the gut microbiome indicated distinct signatures associated to obesity and identified Ruminococcus gnavus as the primary driver for function enrichment in obesity, and Methanobrevibacter smithii , Akkermansia muciniphila , Ruminococcus bicirculans , and Eubacterium siraeum as functional drivers in the healthy control group. Additionally, our results suggest that antibiotic resistance genes and bacterial virulence factors may influence the development of obesity. Finally, we demonstrated that gut vOTUs a... Continued on ES/IODE ➡️ https://etcse.fr/rfhO ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Better Fit: Accommodate Variations in Clothing Types for Virtual Try-on Abstract: Image-based virtual try-on aims to transfer target in-shop clothing to a dressed model image, the objectives of which are totally taking off original clothing while preserving the contents outside of the try-on area, naturally wearing target clothing and correctly inpainting the gap between target clothing and original clothing. Tremendous efforts have been made to facilitate this popular research area, but cannot keep the type of target clothing with the try-on area affected by original clothing. In this paper, we focus on the unpaired virtual try-on situation where target clothing and original clothing on the model are different, i.e., the practical scenario. To break the correlation between the try-on area and the original clothing and make the model learn the correct information to inpaint, we propose an adaptive mask training paradigm that dynamically adjusts training masks. It not only improves the alignment and fit of clothing but also significantly enhances the fidelity of virtual try-on experience. Furthermore, we for the first time propose two metrics for unpaired try-on evaluation, the Semantic-Densepose-Ratio (SDR) and Skeleton-LPIPS (S-LPIPS), to evaluate the correctness of clothing type and the accuracy of clothing texture. For unpaired try-on validation, we construct a comprehensive cross-try-on benchmark (Cross-27) with distinctive clothing items and model physiques, covering a broad try-on scenarios. Experiments demonstrate the effectiveness of the p... Continued on ES/IODE ➡️ https://etcse.fr/hgUnY ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Personality Assessment with Temperament and Character Inventory in Parkinson's Disease. Abstract: International audience; INTRODUCTION: There is a growing interest in personality evaluation in Parkinson's disease (PD), following observations of specific temperaments in PD patients. Therefore, our objective was to evaluate personality dimensions from the Temperament and Character Inventory (TCI) in a cohort of fluctuating PD patients considered for deep brain stimulation. METHODS: Fluctuating PD patients from the PREDISTIM cohort were included. Description of TCI dimensions and comparison with a French normative cohort were performed. Pearson correlations between TCI dimensions and motor, behavioral and cognitive variables were investigated. Structural and internal consistency analysis of the TCI were further assessed. RESULTS: The 570 PD patients presented significant higher scores in Harm Avoidance, Reward Dependence, Persistence, Self-Directedness and Cooperativeness and significant lower scores in Self-Transcendence compared to the French normative cohort; only Novelty Seeking scores were not different. Harm Avoidance and Self-directedness scores were correlated with PDQ-39 total, HAMD, HAMA scores, and anxiolytic/antidepressant treatment. Novelty Seeking scores were correlated with impulsivity. Pearson correlations between TCI dimensions, principal component analysis of TCI sub-dimensions and Cronbach's alpha coefficients showed adequate psychometric proprieties. CONCLUSION: The TCI seems to be an adequate tool to evaluate personality dimensi... Continued on ES/IODE ➡️ https://etcse.fr/RdY ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Role of serum cathelicidin in diagnosis of patient with prostatitis and prostate carcinoma Abstract: Background This study investigated the diagnostic role of 75 levels measured in serum prostatitis and prostate carcinoma and in the differentiation of these two conditions. Methods The study was conducted with 75 patients histopathologically diagnosed with prostate carcinoma or prostatitis and followed up at the Departments of Urology and Medical Oncology and 21 healthy male subjects. Serum cathelicidin levels were investigated using the ELISA method. Statistical analyses were performed using the SPSS for Windows 22.0 package software. Compliance of the variables to normal distribution was examined using visual and analytic methods. In the Kolmogorov–Smirnov test, cases with a p value of greater than 0.05 were accepted as normal distribution. Results A total of 75 patients including 45 diagnosed with prostate carcinoma and 30 diagnosed with prostatitis, as well as 21 healthy control subjects were included in the study. Prostate-specific antigen (PSA) was detected as 23 (4–1200) ng/mL in the patients with prostate carcinoma and as 9.85 (3.9–405 ng/mL) in the patients with prostatitis. The cathelicidin levels were diagnostically significant when assessed by ROC analysis in the prostate cancer, prostatitis and control groups ( p  = 0.005). The cutoff values derived from the ROC curve analysis were 3.5151 ng/mL for distinguishing prostate cancer from prostatitis, 2.2620 ng/mL for prostate cancer versus control group and 1.2340 ng/mL for prostatitis versus control group... Continued on ES/IODE ➡️ https://etcse.fr/lsUce ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Using GANs for De Novo Protein Design Targeting Microglial IL-3R$\alpha$ to Inhibit Alzheimer's Progression Abstract: IL-3 is a hemopoietic growth factor that usually targets blood cell precursors; IL-3R is a cytokine receptor that binds to IL-3. However, IL-3 takes on a different role in the context of glial cells in the nervous system, where studies show that the protein IL-3 protects against Alzheimer's disease by activating microglia at their IL-3R receptors, causing the microglia to clear out the tangles caused by the build-up of misfolded Tau proteins. In this study, we seek to ascertain what role the secondary structure of IL-3 plays in its binding with the receptor. The motivation behind this study is to learn more about the mechanism and identify possible drugs that might be able to activate it, in hopes of inhibiting the spread of Alzheimer's Disease. From a preliminary analysis of complexes containing IL-3 and IL-3R, we hypothesized that the binding is largely due to the interactions of three alpha helix structures stretching towards the active site on the receptor. The original Il-3 protein serves as the control in this experiment; the other proteins being tested are generated through several types of computational de novo protein design, where machine learning allows for the production of entirely novel structures. The efficacy of the generated proteins is assessed through docking simulations with the IL-3R receptor, and the binding poses are also qualitatively examined to gain insight into the function of the binding. From the docking data and poses, the most successfu... Continued on ES/IODE ➡️ https://etcse.fr/b98 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: Graves’ disease after exposure to the SARS-CoV-2 vaccine: a case report and review of the literature Abstract: Background Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is characterized by immune system dysregulation after exposure to adjuvants, such as aluminum. Although cases of autoimmune thyroid diseases caused by ASIA have been reported, Graves' disease is one of the rarer diseases. There are some reports that vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause ASIA. Here, we describe a case of Graves’ disease following SARS-CoV-2 vaccination and a review of the literature. Case presentation A 41-year-old woman was admitted to our hospital because of palpitations and fatigue. Two weeks after receiving the second SARS-CoV-2 vaccine (BNT162b2, Coronavirus Modified Uridine messenger RNA (mRNA) Vaccine, Pfizer), she developed fatigue and gradually worsened. On admission, she exhibited thyrotoxicosis (thyroid-stimulating hormone (TSH) < 0.01 mIU/L (0.08–0.54), free triiodothyronine (FT3) 33.2 pmol/L (3.8–6.3), and free thyroxine (FT4) 72.1 pmol/L (11.6–19.3)) and palpitations associated with atrial fibrillation. TSH receptor antibody (TRAb) was positive (TRAb 5.0 IU/L (< 2.0)), and ^99mTc scintigraphy showed diffuse uptake in the thyroid gland, suggesting that the thyrotoxicosis in this case was caused by Graves’ disease. Thiamazole was prescribed to correct her condition, and soon after this treatment was initiated, her symptoms and thyroid hormone levels were significantly reduced. Conclusions This case report reinforces the p... Continued on ES/IODE ➡️ https://etcse.fr/7in ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Preliminary Design of Detector Assembly for DIXE Abstract: Diffuse X-ray Explorer (DIXE) is a proposed X-ray spectroscopic survey experiment for the China Space Station. Its detector assembly (DA) contains the transition edge sensor (TES) microcalorimeter and readout electronics based on the superconducting quantum interference device (SQUID) on the cold stage. The cold stage is thermally connected to the ADR stage, and a Kevlar suspension is used to stabilize and isolate it from the 4 K environment. TES and SQUID are both sensitive to the magnetic field, so a hybrid shielding structure consisting of an outer Cryoperm shield and an inner niobium shield is used to attenuate the magnetic field. In addition, IR/optical/UV photons can produce shot noise and thus degrade the energy resolution of the TES microcalorimeter. A blocking filter assembly is designed to minimize the effects. In it, five filters are mounted at different temperature stages, reducing the probability of IR/optical/UV photons reaching the detector through multiple reflections between filters and absorption. This paper will describe the preliminary design of the detector assembly and its optimization. ;Comment: 13 pages, 6 figures. Submitted version, the full version is published by Journal of Low Temperature Physics Continued on ES/IODE ➡️ https://etcse.fr/agB ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: A New Nonlinear Autoregressive Exogenous (NARX)-based Intra-spinal Stimulation Approach to Decode Brain Electrical Activity for Restoration of Leg Movement in Spinally-injured Rabbits Abstract: INTRODUCTION: This study aimed at investigating the stimulation by intra-spinal signals decoded from electrocorticography (ECoG) assessments to restore the movements of the leg in an animal model of spinal cord injury (SCI). METHODS: The present work is comprised of three steps. First, ECoG signals and the associated leg joint changes (hip, knee, and ankle) in sedated healthy rabbits were recorded in different trials. Second, an appropriate set of intra-spinal electric stimuli was discovered to restore natural leg movements, using the three leg joint movements under a fuzzy-controlled strategy in spinally-injured rabbits under anesthesia. Third, a nonlinear autoregressive exogenous (NARX) neural network model was developed to produce appropriate intra-spinal stimulation developed from decoded ECoG information. The model was able to correlate the ECoG signal data to the intra-spinal stimulation data and finally, induced desired leg movements. In this study, leg movements were also developed from offline ECoG signals (deciphered from rabbits that were not injured) as well as online ECoG data (extracted from the same rabbit after SCI induction). RESULTS: Based on our data, the correlation coefficient was 0.74±0.15 and the normalized root means square error of the brain-spine interface was 0.22±0.10. CONCLUSION: Overall, we found that using NARX, appropriate information from ECoG recordings can be extracted and used for the generation of proper intra-spinal electric sti... Continued on ES/IODE ➡️ https://etcse.fr/HriWh ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.