Brian Keogh

Brian Keogh

Ireland
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Publications

  • Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease.

    McDonald CL, Hennessy E, Rubio-Araiz A, Keogh B, McCormack W, McGuirk P, Reilly M, Lynch MA. Brain Behav Immun. 2016 Nov ; 58:191-200

  • A conjugated linoleic acid enriched beef diet attenuates lipopolysaccharide- induced inflammation in mice in part through peroxisome proliferator-activated receptor gamma mediated suppression of toll-like receptor 4

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    Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KHG, Loscher CE, Roche H.
    Journal of Nutrition, 2009, 139, 2351-2357

  • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

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    Sutton C, Brereton C, Keogh B, Mills KHG, Lavelle EC.
    Journal of Experimental Medicine 2006 Jul 10;203(7):1685-91.

  • A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors.

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    Marquez Ruiz JF, Kedziora K, Keogh B, Maguire J, Reilly M, Windle H, Kelleher DP, Gilmer JF.
    Bioorg Med Chem Lett. 2011 Nov 15;21(22):6636-40

  • A nitrophenyl-based prodrug type for colorectal targeting of prednisolone, budesonide and celecoxib.

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    Marquez Ruiz JF, Kedziora K, Pigott M, Keogh B, Windle H, Gavin J, Kelleher DP, Gilmer JF.
    Bioorg Med Chem Lett. 2013 Mar 15;23(6):1693-8.

  • A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.

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    Ryan A, Lynch M, Smith S, Amu S, Nel HJ, McCoy C, Dowling JK, Draper E, O’Reilly V, McCarthy C, O’Brien J, Ní Eidhin D, O’Connell MJ, Keogh B, Morton CO, Rogers TR, Fallon PG, O’Neill LA, Kelleher D & Loscher CE.
    PLOS Pathogens. 2011, 7 (6).

  • An Artificial Intelligence Characterised Functional Ingredient, Derived from Rice, Inhibits TNF-α and Significantly Improves Physical Strength in an Inflammaging Population

    Kennedy K., Keogh B., Lopez C., Adelfio A., Molloy B., Kerr A., Wall A., Jalowicki G.,Holton T., Khaldi N. Foods 2020 Aug 20;9(9):E1147

  • An Artificial Intelligence discovered functional ingredient, NRT_N0G5IJ, derived from Pisum savitum, decreases HbA1c in a prediabetic population

    Chauhan S., Kerr A., Keogh B., Nolan S., Murphy N., Doherty A., Davis H., Wall A., and Khaldi N. Nutrients 2021., 13, 1635.

  • Avirulent Semliki Forest Virus Replication and Pathology in the Central Nervous System is Enhanced in IL-12 Defective and Reduced in IL-4 Defective Mice: A Role For Th1 Cells in the Protective Immunity.

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    Keogh, B., Atkins, G.J., Mills, K.H.G., Sheahan, B.J.
    Journal of Neuroimmunology 2002 Apr;125(1-2):15-22.

  • Azo-reductase activated budesodine prodrugs for colon targeting.

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    Marquez Ruiz JF, Kedziora K, O'Reilly M, Maguire J, Keogh B, Windle H, Kelleher DP, Gilmer JF.
    Bioorg Med Chem Lett. 2012 Dec 15;22(24):7573-7.

  • Blockade of TLR2 prevents spontaneous and induced cytokine release from Rheumatoid Arthritis ex vivo synovial explant cultures

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    Nic an Ultaigh S, Fearon U, Saber T, Dellacasagrande J, Keogh B, Reilly M, O’ Neill LA, McGuirk P, Veale DJ.
    Arthritis Research & Therapy, 2011 Feb 23;13(1):R33

  • Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses

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    Draper E, Decourcey J, Higgins S, Canavan M, McEvoy F, Keogh B, Reynolds C, Roche HM, Mills KHG, Loscher CE.
    J Nutr Biochem. 2014 Jul;25(7):741-9

  • HMGB1-mediates TLR2 inflammatory pathways during development of oesophageal adenocarcinoma

    Flis E., Barber G., Keogh B., McGuirk P., Anand A., O’Sullivan J., Quante M., Creagh E. Cancers 2021., 25; 13(9):2065

  • Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer.

    West AC, Tang K, Tye H, Yu L, Deng N, Najdovska M, Lin SJ, Balic JJ, Okochi-Takada E, McGuirk P, Keogh B, McCormack W, Bhathal PS, Reilly M, Oshima M, Ushijima T, Tan P, Jenkins BJ. Oncogene. 2017 May 8.

  • IL-10 production through TLR4 regulates the inflammatory Th1 response to Bordetella pertussis in the lungs.

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    Higgins, S., McCann, C., Lavelle, E., Keogh, B., McGuirk, P., Mills, K.H.G.
    Journal of Immunology. 2003 Sep 15;171(6):3119-27.

  • Inhibition of matrix metalloproteinases ameliorates blood-brain-barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection.

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    Keogh, B., Sheahan, B.J., Atkins, G.J., Mills, K.H.G.
    Veterinary Immunology and Immunopathology 2003, 94, 3/4 , 185-190.

  • Monoclonal antibody inhibition of TLR2 promotes graft function in a murine model of renal transplantation

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    Farrar CA., Keogh B., McCormack W., O’Shaughnessy A., Parker A, Reilly M., Sacks SH.
    FASEB., 2012 Feb;26(2):799-807

  • Myocardial ischemia/reperfusion injury is mediated by leukocytic TLR2 and reduced by systemic administration of a novel anti-TLR2 antibody

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    Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L, C Tersteeg, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP
    Circulation 2010, 121, 80-90.

  • Randomized, double-blind, placebo controlled, dose-escalating Phase I, healthy subjects study of intravenous OPN-305, a humanized anti-TLR-2 antibody.

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    Reilly M, Miller RM, Thomson MH, Patris V, Ryle P, McLoughlin L, Mutch P, Gilboy P, Miller C, Broekema M, Keogh B, McCormack W, van de Wetering de Rooij J.
    Clin Pharmacol Ther. 2013 Jul 23

  • Role of Interferon-gamma and nitric oxide in the neuropathogenesis of avirulent Semliki Forest virus infection.

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    Keogh, B., Atkins, G.J., Mills, K.H.G., Sheahan, B.J.
    Neuropathology & Applied Neurobiology. 2003 Dec;29(6):553-562.

  • TLR2 and TLR4 in ischemia reperfusion injury

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    Arslan F., Keogh B., Mcguirk P., Parker A.
    Mediators of Inflammation, 2010, 2010; 2010: 704202

  • Toll-like receptors as targets for immune disorders.

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    Keogh B, Parker AE.
    Trends Pharmacol Sci. 2011 Apr 27.

  • Treatment with OPN-305, a humanized anti-Toll-like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs

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    Arslan F, Houtgraaf JH, Keogh B, Kazemi K, O’Neill LA, de Jong R, Timmers L, Smeets MB, Akeroyd L, Doevendans PA, Pasterkamp G & de Kleijn DVP.
    Circ Cardiovasc Interv. 2012 Feb 21

  • VIPER, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting Mal and TRAM

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    Lysakova-Devine T., Keogh B., Harrington B., Nagpal K., Halle A., Golenbock DT., Monie T., & Bowie AG.
    Journal of Immunology, 2010 Oct 1;185(7):4261-71

Patents

  • A Vaccinia Virus Protein A46 Peptide and Use Thereof

    US US8722052B2

    Bowie Andrew Graham; Harrington Barry Noel; Lysakova Tatynan Sergeevna; Keogh Brian

  • Composition and Method for Treatment of Reperfusion Injury and Tissue Damage

    US US8734788B2

    Heffernan Mark; O'Neill Luke; McGuirk Peter; Keogh Brian; Locher Christopher; De Kleijn Dominique; Arslan Fatih; Pasterkamp Gerard

  • Composition and Method for Treatment of Rheumatoid Arthritis

    AU 2008267151B2

    Heffernan Mark; O'Neill Luke; McGuirk Peter, Locher Christopher; Keogh Brian

  • Compounds and Methods for the Treatment of Renal Disease

    AU 2008270218B2

    Heffernan Mark; O'Neill Luke; McGuirk Peter; Keogh Brian; Locher Christopher;

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