About
I am currently graduating my PhD in Genetics and Neuroscience at the Hebrew University…
Activity
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Excited for the poster session today!
Excited for the poster session today!
Liked by Moria Ben Yishay
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Strategy day is an opportunity for the full team to get together, reflect on the past year’s achievements and challenges, and brainstorm on…
Strategy day is an opportunity for the full team to get together, reflect on the past year’s achievements and challenges, and brainstorm on…
Liked by Moria Ben Yishay
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***מהם החיים אם לא רצף של מפגשים עם אנשים?*** כל אדם הנקרה בדרכך מעניק לך משהו שאותו אתה לוקח להמשך הדרך שלך: 💡אחד מהם יילמד אותך על איך להגשים…
***מהם החיים אם לא רצף של מפגשים עם אנשים?*** כל אדם הנקרה בדרכך מעניק לך משהו שאותו אתה לוקח להמשך הדרך שלך: 💡אחד מהם יילמד אותך על איך להגשים…
Liked by Moria Ben Yishay
Experience
Education
Volunteer Experience
Publications
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A Neuronal GPCR is Critical for the Induction of the Heat Shock Response in the Nematode C. elegans. Moria Maman*, Filipa Carvalhal Marques*, Yuli Volovik, Tatyana Dubnikov, Michal Bejerano-Sagie and Ehud Cohen
J Neurosci.
In the nematode Caenorhabditis elegans, the heat shock response (HSR) is regulated at the organismal level by a network of thermosensory neurons that senses elevated temperatures and activates the HSR in remote tissues. Which neuronal receptors are required for this signaling mechanism and in which neurons they function are largely unanswered questions. Here we used worms that were engineered to exhibit RNA interference hypersensitivity in neurons to screen for neuronal receptors that are…
In the nematode Caenorhabditis elegans, the heat shock response (HSR) is regulated at the organismal level by a network of thermosensory neurons that senses elevated temperatures and activates the HSR in remote tissues. Which neuronal receptors are required for this signaling mechanism and in which neurons they function are largely unanswered questions. Here we used worms that were engineered to exhibit RNA interference hypersensitivity in neurons to screen for neuronal receptors that are required for the activation of the HSR and identified a putative G-protein coupled receptor (GPCR) as a novel key component of this mechanism. This gene, which we termed GPCR thermal receptor 1 (gtr-1), is expressed in chemosensory neurons and has no role in heat sensing but is critically required for the induction of genes that encode heat shock proteins in non-neural tissues upon exposure to heat. Surprisingly, the knock-down of gtr-1 by RNA interference protected worms expressing the Alzheimer's-disease-linked aggregative peptide Aβ3-42 from proteotoxicity but had no effect on lifespan. This study provides several novel insights: (1) it shows that chemosensory neurons play important roles in the nematode's HSR-regulating mechanism, (2) it shows that lifespan and heat stress resistance are separable, and (3) it strengthens the emerging notion that the ability to respond to heat comes at the expense of protein homeostasis (proteostasis).
Other authorsSee publication -
Temporal requirements of heat shock factor-1 for longevity assurance. Yuli Volovik,†, Moria Maman,†, Tatyana Dubnikov,†, Michal Bejerano-Sagie, Derek Joyce, Erik A Kapernick, Ehud Cohen, Andrew Dillin
Aging Cell
Reducing the activity of the insulin/IGF-1 signaling pathway (IIS) modifies development, elevates stress resistance, protects from toxic protein aggregation (proteotoxicity), and extends lifespan (LS) of worms, flies, and mice. In the nematode Caenorhabditis elegans, LS extension by IIS reduction is entirely dependent upon the activity of the transcription factors DAF-16 and the heat shock factor-1 (HSF-1). While DAF-16 determines LS exclusively during early adulthood, it is required for…
Reducing the activity of the insulin/IGF-1 signaling pathway (IIS) modifies development, elevates stress resistance, protects from toxic protein aggregation (proteotoxicity), and extends lifespan (LS) of worms, flies, and mice. In the nematode Caenorhabditis elegans, LS extension by IIS reduction is entirely dependent upon the activity of the transcription factors DAF-16 and the heat shock factor-1 (HSF-1). While DAF-16 determines LS exclusively during early adulthood, it is required for proteotoxicity protection also during late adulthood. In contrast, HSF-1 protects from proteotoxicity during larval development. Despite the critical requirement for HSF-1 for LS extension, the temporal requirements for this transcription factor as a LS determinant are unknown. To establish the temporal requirements of HSF-1 for longevity assurance, we conditionally knocked down hsf-1 during larval development and adulthood of C. elegans and found that unlike daf-16, hsf-1 is foremost required for LS determination during early larval development, required for a lesser extent during early adulthood and has small effect on longevity also during late adulthood. Our findings indicate that early developmental events affect LS and suggest that HSF-1 sets during development of the conditions that enable DAF-16 to promote longevity during reproductive adulthood. This study proposes a novel link between HSF-1 and the longevity functions of the IIS.
Other authorsSee publication
Honors & Awards
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First prize for Outstanding Poster
The Institute of Medical Research – Israel Canada
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Aging Cell Runner-Up Best Paper Prizes 2012
Aging Cell
Aging Cell Runner-Up Best Paper Prizes 2012 on the paper:
‘Temporal requirements of heat shock factor-1 for longevity assurance’
Y. Volovik, M. Maman, T. Dubnikov, M. Bejerano-Sagie, D. Joyce, E. A. Kapernick, E. Cohen and A. Dillin
Volume 11, Issue 3, June 2012, pp 491-499 -
M.Sc graduating with honors, cum laude
Hebrew University
Languages
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Hebrew
Native or bilingual proficiency
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English
Full professional proficiency
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Spanish
Limited working proficiency
More activity by Moria
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Come work with me! We are hiring at G+ Research Associate for cell culture. Reprogramming experience - great advantage!
Come work with me! We are hiring at G+ Research Associate for cell culture. Reprogramming experience - great advantage!
Posted by Moria Ben Yishay
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ברכות שנה טובה מקבוצת רניום Rhenium Group בכלל וברכת שנה יעילה מצוות התמיכה המדעית בפרט: שתמיד תצאו עם מסקנות מניסויים, שאף פעם לא יימרחו לכם הבנדים…
ברכות שנה טובה מקבוצת רניום Rhenium Group בכלל וברכת שנה יעילה מצוות התמיכה המדעית בפרט: שתמיד תצאו עם מסקנות מניסויים, שאף פעם לא יימרחו לכם הבנדים…
Liked by Moria Ben Yishay
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very excited to share I am currently starting a new position at Rhenium Group as a Biotech Support consultant. Can't wait to face the challenges…
very excited to share I am currently starting a new position at Rhenium Group as a Biotech Support consultant. Can't wait to face the challenges…
Liked by Moria Ben Yishay
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So excited to share with all the wonderfull people at huji and my family my PhD talk last month. I'm now ready for my next challenge💪
So excited to share with all the wonderfull people at huji and my family my PhD talk last month. I'm now ready for my next challenge💪
Shared by Moria Ben Yishay
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At the Foodtech IL conference. Hard to keep the diet😬 with Roni Cohen
At the Foodtech IL conference. Hard to keep the diet😬 with Roni Cohen
Liked by Moria Ben Yishay
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