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פיתוח ישראלי: תוכנה תזהה סיכוי ללקות בסרטן ובמחלות…
Articles by Prof. Yuval
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לחברת סטארטאפ ביואינפורמטית בתחום הפארמה דרוש ביולוג \ פרמקולוג בכיר
לחברת סטארטאפ ביואינפורמטית בתחום הפארמה דרוש ביולוג \ פרמקולוג בכיר
By Prof. Yuval Tabach
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משרת תוכניתן בכיר עם תקן מיוחד בפקולטה לרפואה של האוניברסיטה העברית.
משרת תוכניתן בכיר עם תקן מיוחד בפקולטה לרפואה של האוניברסיטה העברית.
By Prof. Yuval Tabach
Activity
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It always great to listen to smart people
It always great to listen to smart people
Shared by Prof. Yuval Tabach
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We are proud and humbled to be selected in TheMarker's list of 20 most promising Israeli startups for 2024. https://lnkd.in/dsgNMN5A
We are proud and humbled to be selected in TheMarker's list of 20 most promising Israeli startups for 2024. https://lnkd.in/dsgNMN5A
Liked by Prof. Yuval Tabach
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Thank you AMOON !!! You are doing amazing work in helping us in every step! I’m proud that our startup was chosen and I’m proud that we are part of…
Thank you AMOON !!! You are doing amazing work in helping us in every step! I’m proud that our startup was chosen and I’m proud that we are part of…
Shared by Prof. Yuval Tabach
Experience
Education
Publications
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PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles
Nucleic acids research
Proteins that function in the same pathways, protein complexes or the same
environmental conditions can show similar patterns of sequence conservation across
phylogenetic clades. In species that no longer require a specific protein complex or pathway,
these proteins, as a group, tend to be lost or diverge. Analysis of the similarity in patterns of
sequence conservation across a large set of eukaryotes can predict functional associations
between different proteins, identify…Proteins that function in the same pathways, protein complexes or the same
environmental conditions can show similar patterns of sequence conservation across
phylogenetic clades. In species that no longer require a specific protein complex or pathway,
these proteins, as a group, tend to be lost or diverge. Analysis of the similarity in patterns of
sequence conservation across a large set of eukaryotes can predict functional associations
between different proteins, identify new pathway members and reveal the function of ... -
Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans
Nature Structural and Molecular Biology
Myotonic dystrophy disorders are caused by expanded CUG repeats in noncoding regions. Here we used Caenorhabditis elegans expressing CUG repeats to identify genes that modulate the toxicity of such repeats. We identified 15 conserved genes that function as suppressors or enhancers of CUG repeat-induced toxicity and that modulate formation of nuclear foci by CUG-repeat RNA. These genes regulate CUG repeat-induced toxicity through distinct mechanisms including RNA export and clearance, thus…
Myotonic dystrophy disorders are caused by expanded CUG repeats in noncoding regions. Here we used Caenorhabditis elegans expressing CUG repeats to identify genes that modulate the toxicity of such repeats. We identified 15 conserved genes that function as suppressors or enhancers of CUG repeat-induced toxicity and that modulate formation of nuclear foci by CUG-repeat RNA. These genes regulate CUG repeat-induced toxicity through distinct mechanisms including RNA export and clearance, thus suggesting that CUG-repeat toxicity is mediated by multiple pathways. A subset of the genes are also involved in other degenerative disorders. The nonsense-mediated mRNA decay (NMD) pathway has a conserved role in regulating CUG-repeat-RNA transcript levels and toxicity, and NMD recognition of toxic RNAs depends on 3'-untranslated-region GC-nucleotide content. Our studies suggest a broader surveillance role for NMD in which variations in this pathway influence multiple degenerative diseases.
Other authorsSee publication -
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
CELL
N 6-methyladenosine (m 6 A) is the most ubiquitous mRNA base modification, but
little is known about its precise location, temporal dynamics, and regulation. Here, we
generated genomic maps of m 6 A sites in meiotic yeast transcripts at nearly single-
nucleotide resolution, identifying 1,308 putatively methylated sites within 1,183 transcripts.
We validated eight out of eight methylation sites in different genes with direct genetic
analysis, demonstrated that methylated sites…N 6-methyladenosine (m 6 A) is the most ubiquitous mRNA base modification, but
little is known about its precise location, temporal dynamics, and regulation. Here, we
generated genomic maps of m 6 A sites in meiotic yeast transcripts at nearly single-
nucleotide resolution, identifying 1,308 putatively methylated sites within 1,183 transcripts.
We validated eight out of eight methylation sites in different genes with direct genetic
analysis, demonstrated that methylated sites are significantly conserved in a related ... -
Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling
MSB
Genes with common profiles of the presence and absence in disparate genomes tend to function in the same pathway. By mapping all human genes into about 1000 clusters of genes with similar patterns of conservation across eukaryotic phylogeny, we determined that sets of genes associated with particular diseases have similar phylogenetic profiles. By focusing on those human phylogenetic gene clusters that significantly overlap some of the thousands of human gene sets defined by their coexpression…
Genes with common profiles of the presence and absence in disparate genomes tend to function in the same pathway. By mapping all human genes into about 1000 clusters of genes with similar patterns of conservation across eukaryotic phylogeny, we determined that sets of genes associated with particular diseases have similar phylogenetic profiles. By focusing on those human phylogenetic gene clusters that significantly overlap some of the thousands of human gene sets defined by their coexpression or annotation to pathways or other molecular attributes, we reveal the evolutionary map that connects molecular pathways and human diseases. The other genes in the phylogenetic clusters enriched for particular known disease genes or molecular pathways identify candidate genes for roles in those same disorders and pathways. Focusing on proteins coevolved with the microphthalmia-associated transcription factor (MITF), we identified the Notch pathway suppressor of hairless (RBP-Jk/SuH) transcription factor, and showed that RBP-Jk functions as an MITF cofactor.
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Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence.
Nature
Genetic and biochemical analyses of RNA interference (RNAi) and microRNA (miRNA) pathways have revealed proteins such as Argonaute and Dicer as essential cofactors that process and present small RNAs to their targets. Well-validated small RNA pathway cofactors such as these show distinctive patterns of conservation or divergence in particular animal, plant, fungal and protist species. We compared 86 divergent eukaryotic genome sequences to discern sets of proteins that show similar phylogenetic…
Genetic and biochemical analyses of RNA interference (RNAi) and microRNA (miRNA) pathways have revealed proteins such as Argonaute and Dicer as essential cofactors that process and present small RNAs to their targets. Well-validated small RNA pathway cofactors such as these show distinctive patterns of conservation or divergence in particular animal, plant, fungal and protist species. We compared 86 divergent eukaryotic genome sequences to discern sets of proteins that show similar phylogenetic profiles with known small RNA cofactors. A large set of additional candidate small RNA cofactors have emerged from functional genomic screens for defects in miRNA- or short interfering RNA (siRNA)-mediated repression in Caenorhabditis elegans and Drosophila melanogaster1, 2, and from proteomic analyses of proteins co-purifying with validated small RNA pathway proteins3, 4. The phylogenetic profiles of many of these candidate small RNA pathway proteins are similar to those of known small RNA cofactor proteins. We used a Bayesian approach to integrate the phylogenetic profile analysis with predictions from diverse transcriptional coregulation and proteome interaction data sets to assign a probability for each protein for a role in a small RNA pathway. Testing high-confidence candidates from this analysis for defects in RNAi silencing, we found that about one-half of the predicted small RNA cofactors are required for RNAi silencing. Many of the newly identified small RNA pathway proteins are orthologues of proteins implicated in RNA splicing. In support of a deep connection between the mechanism of RNA splicing and small-RNA-mediated gene silencing, the presence of the Argonaute proteins and other small RNA components in the many species analysed strongly correlates with the number of introns in those species.
Other authorsSee publication -
Mutant p53R175H upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells
Nature Publishing Group
Abstract A mutation within one allele of the p53 tumor suppressor gene can inactivate the
remaining wild-type allele in a dominant-negative manner and in some cases can exert an
additional oncogenic activity, known as mutant p53 'gain of function'(GOF). To study the role
of p53 mutations in prostate cancer and to discriminate between the dominant-negative
effect and the GOF activity of mutant p53, we measured, using microarrays, the expression
profiles of three immortalized…Abstract A mutation within one allele of the p53 tumor suppressor gene can inactivate the
remaining wild-type allele in a dominant-negative manner and in some cases can exert an
additional oncogenic activity, known as mutant p53 'gain of function'(GOF). To study the role
of p53 mutations in prostate cancer and to discriminate between the dominant-negative
effect and the GOF activity of mutant p53, we measured, using microarrays, the expression
profiles of three immortalized prostate epithelial cultures expressing wild-type, inactivated . -
Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF
Molecular cell
Summary The most critical stage in initiation of melanoma metastasis is the radial to vertical
growth transition, yet the triggers of this transition remain elusive. We suggest that the
microenvironment drives melanoma metastasis independently of mutation acquisition. Here
we examined the changes in microenvironment that occur during melanoma radial growth.
We show that direct contact of melanoma cells with the remote epidermal layer triggers
vertical invasion via Notch…Summary The most critical stage in initiation of melanoma metastasis is the radial to vertical
growth transition, yet the triggers of this transition remain elusive. We suggest that the
microenvironment drives melanoma metastasis independently of mutation acquisition. Here
we examined the changes in microenvironment that occur during melanoma radial growth.
We show that direct contact of melanoma cells with the remote epidermal layer triggers
vertical invasion via Notch signaling activation, the latter serving to inhibit MITF function. .. -
Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53
Cancer cell
The p53 gene is mutated in many human tumors. Cells of such tumors often contain
abundant mutant p53 (mutp53) protein, which may contribute actively to tumor progression
via a gain-of-function mechanism. We applied ChIP-on-chip analysis and identified the
vitamin D receptor (VDR) response element as overrepresented in promoter sequences
bound by mutp53. We report that mutp53 can interact functionally and physically with VDR.
Mutp53 is recruited to VDR-regulated genes and…The p53 gene is mutated in many human tumors. Cells of such tumors often contain
abundant mutant p53 (mutp53) protein, which may contribute actively to tumor progression
via a gain-of-function mechanism. We applied ChIP-on-chip analysis and identified the
vitamin D receptor (VDR) response element as overrepresented in promoter sequences
bound by mutp53. We report that mutp53 can interact functionally and physically with VDR.
Mutp53 is recruited to VDR-regulated genes and modulates their expression, augmenting ... -
The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation
Nature - EMBO
Whole-genome mRNA expression data obtained during in-vitro cancerous transformation allowed us to decipherer key molecular events in tumorigenesis
We focused on a cluster of cell cycle genes that appear to derive the process and uncovered the transcriptional control of the genes in the cluster
We found promoter elements that couple the genes activity with the activity of two prime up-stream tumor suppressors, p53 and p21.
The transcription factors that control the cluster appear to…Whole-genome mRNA expression data obtained during in-vitro cancerous transformation allowed us to decipherer key molecular events in tumorigenesis
We focused on a cluster of cell cycle genes that appear to derive the process and uncovered the transcriptional control of the genes in the cluster
We found promoter elements that couple the genes activity with the activity of two prime up-stream tumor suppressors, p53 and p21.
The transcription factors that control the cluster appear to sum-up the activity of the two tumor suppressive channels and produce an expression level that is analogous to it. This expression pattern appears to determine proliferation rates, and potentially also, tumorigenesis.
Our findings provide for the first time a 3-way connection between gene expression, promoter architecture and activity of up-stream signaling pathways in mammalian cells.
Honors & Awards
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Prusiner-Abramsky Research Prize for 2016
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https://medicine.ekmd.huji.ac.il/En/Home/News/Pages/Prusiner_Abramsky_2016.aspx
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Golda Meir Fellowship Lectureship Awards
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BEST POSTER AWARD - Genetics Retreat, Harvard Medical School,
Department of Genetics Harvard Medical School
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BEST POSTER AWARD - IBS conference
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BEST POSTER AWARD - ISMB
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Languages
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Hebrew
Native or bilingual proficiency
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English
Full professional proficiency
More activity by Prof. Yuval
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תלמידות לתואר שני נשמח שתגישו מועמדות קול הקורא לתכנית מלגות ות"ת המיועדות לתלמידות תואר שני במדעי הנתונים וביו-אינפורמטיקה (הייטק)…
תלמידות לתואר שני נשמח שתגישו מועמדות קול הקורא לתכנית מלגות ות"ת המיועדות לתלמידות תואר שני במדעי הנתונים וביו-אינפורמטיקה (הייטק)…
Posted by Prof. Yuval Tabach
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It was a such a great pleasure to preset and talk in Novartis conference
It was a such a great pleasure to preset and talk in Novartis conference
Shared by Prof. Yuval Tabach
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#חודשהגאווה ***מיתוס מבנה המשפחה*** אני מניחה שהפוסט הזה לא יפתיע רבים מכם, אבל עדיין חשוב לכתוב אותו, גם כדי שתוכלו לשתף עם מי שצריך שכנוע. יש…
#חודשהגאווה ***מיתוס מבנה המשפחה*** אני מניחה שהפוסט הזה לא יפתיע רבים מכם, אבל עדיין חשוב לכתוב אותו, גם כדי שתוכלו לשתף עם מי שצריך שכנוע. יש…
Liked by Prof. Yuval Tabach
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You are welcome to join us at the Novartis- Israel meeting
You are welcome to join us at the Novartis- Israel meeting
Posted by Prof. Yuval Tabach
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It was such a pleasure to give a keynote In biomed Thank you Yael Gruenbaum-Cohen for inviting me You are amazing and love to work with you !!!
It was such a pleasure to give a keynote In biomed Thank you Yael Gruenbaum-Cohen for inviting me You are amazing and love to work with you !!!
Shared by Prof. Yuval Tabach
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