Dr. Vinod Jyothikumar
Strategic Alliance Architect for Business Growth | Sustainability Strategist | SMART & Digital Mfg Advocate | Pharmaceutical and Healthcare Sector
Bengaluru, Karnataka, India
2K followers
500+ connections
About
Quality at the helm, leading transformation to set new standards of excellence, Dr. Vinod Jyothikumar stands as a paragon of innovation and strategic leadership in operations management. With a comprehensive portfolio that spans C-suite management, alliance governance, and client relationship management, he adeptly navigates the complexities of global business environments.
His robust background in life sciences, biotechnology, and pharmaceuticals has propelled substantial growth and performance enhancements across numerous organizations. An expert in quality management (GxP) and contract research and manufacturing services (CRAMS), his influence extends into the agrochemical and chemical sectors. Moreover, his expertise in digital manufacturing, SMART factories, Industry 4.0, and ESG investing seamlessly integrates with his broad industry knowledge, fostering environments where businesses can thrive and innovate.
Vinod’s reputation for leadership is anchored in his ability to drive projects to success, boost profitability, and elevate customer satisfaction. His strategic acumen, coupled with outstanding business development capabilities, consistently delivers impactful solutions in dynamic markets. An effective communicator, he excels in distilling complex concepts into actionable strategies, making him a valued leader in the field.
Known for his visionary approach, Vinod provides clear guidance and motivates teams to exceed their objectives. His interpersonal skills help forge enduring relationships with clients and foster cooperative work environments. As a forward-thinking strategist, he remains updated on industry trends, injecting fresh ideas and innovative methods into each project.
Vinod's commitment to corporate social responsibility underscores his leadership, with a strong emphasis on contributing positively to society. This commitment is evident in his support for the less fortunate and his dedication to sustainable and ethical practices. Dr. Vinod Jyothikumar embodies modern executive leadership, driving operational success while positively impacting society.
Articles by Dr. Vinod
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Navigating the Curves: Mastering Project Risk Management
Navigating the Curves: Mastering Project Risk Management
By Dr. Vinod Jyothikumar
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The Strategic Power of Portfolio Management in Life Sciences R&D
The Strategic Power of Portfolio Management in Life Sciences R&D
By Dr. Vinod Jyothikumar
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Bacteriophages: Nature's Weapon Against Antibiotic-Resistant Superbugs
Bacteriophages: Nature's Weapon Against Antibiotic-Resistant Superbugs
By Dr. Vinod Jyothikumar
Contributions
Activity
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𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞 𝐓𝐨𝐠𝐞𝐭𝐡𝐞𝐫: 𝐓𝐡𝐞 𝐒𝐭𝐫𝐚𝐭𝐞𝐠𝐢𝐜 𝐏𝐨𝐰𝐞𝐫 𝐨𝐟 𝐁𝐮𝐬𝐢𝐧𝐞𝐬𝐬 𝐀𝐥𝐥𝐢𝐚𝐧𝐜𝐞𝐬 𝐢𝐧 𝐏𝐫𝐨𝐠𝐫𝐚𝐦…
𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞 𝐓𝐨𝐠𝐞𝐭𝐡𝐞𝐫: 𝐓𝐡𝐞 𝐒𝐭𝐫𝐚𝐭𝐞𝐠𝐢𝐜 𝐏𝐨𝐰𝐞𝐫 𝐨𝐟 𝐁𝐮𝐬𝐢𝐧𝐞𝐬𝐬 𝐀𝐥𝐥𝐢𝐚𝐧𝐜𝐞𝐬 𝐢𝐧 𝐏𝐫𝐨𝐠𝐫𝐚𝐦…
Shared by Dr. Vinod Jyothikumar
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𝐓𝐆𝐈𝐅: 𝐄𝐯𝐞𝐧 𝐋𝐞𝐚𝐝𝐞𝐫𝐬 𝐍𝐞𝐞𝐝 𝐚 𝐏𝐫𝐢𝐨𝐫𝐢𝐭𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐏𝐥𝐚𝐧!☕ Raise your hand if your to-do list sometimes feels like an…
𝐓𝐆𝐈𝐅: 𝐄𝐯𝐞𝐧 𝐋𝐞𝐚𝐝𝐞𝐫𝐬 𝐍𝐞𝐞𝐝 𝐚 𝐏𝐫𝐢𝐨𝐫𝐢𝐭𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐏𝐥𝐚𝐧!☕ Raise your hand if your to-do list sometimes feels like an…
Shared by Dr. Vinod Jyothikumar
Experience
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Syngene International Limited
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Workplace wellbeing Consultant (Operations strategy, safety, SCM)
Freelance Service Provider
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University of Strathclyde
Education
Licenses & Certifications
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PG Level Advanced Certification Programme in Digital Manufacturing & SMART Industry
Indian Institute of Science (IISc)
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CII-CERTIFIED TRAINING ON CLIMATE CHANGE
CII-ITC Centre of Excellence for Sustainable Development
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Occupational Safety and Health Professional [132 hours]
OSHAcademy Safety and Health Training
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ARS-07: Bioterrorism Awareness for the Animal Health Community (ABSA Pre-conference course)
USDA ARS
Publications
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Use of Time Lapse Microscopy in the Genetic Characterisation of SCO1389 and SCO5750 in Streptomyces Coelicolor Growth and Development
Strathclyde Institute Of Pharmacy And Biomedical Sciences
In summary, this study contributes to our understanding of the complex morphogenetic program of streptomycetes, particularly regarding aerial hyphae formation and spore development. The researchers developed a time-lapse microscopy system to investigate the dynamic processes involved in streptomycete growth. Through genetic characterization, they identified the essential role of the SCO1389 gene in streptomycete growth and development, specifically related to membrane phospholipid biosynthesis.…
In summary, this study contributes to our understanding of the complex morphogenetic program of streptomycetes, particularly regarding aerial hyphae formation and spore development. The researchers developed a time-lapse microscopy system to investigate the dynamic processes involved in streptomycete growth. Through genetic characterization, they identified the essential role of the SCO1389 gene in streptomycete growth and development, specifically related to membrane phospholipid biosynthesis. Localization studies using fluorescence microscopy and specific dyes provided valuable insights into the distribution of cardiolipin-rich domains in streptomycete cells.
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Building Sustainable Biosafety & Biosecurity for Synthetic Biopharmaceuticals
Institute of Sustainability
Effective disease surveillance and diagnostics are key for controlling infectious diseases globally. A pressing issue in biopharma is the potential environmental release of genetically modified microbes, which might have unpredictable effects. To mitigate biosafety risks, strategies are employed to limit microbial cell replication and horizontal gene transfer. The rapid growth in biosafety and biosecurity interest is due to the increased handling of pathogens and new biotech applications…
Effective disease surveillance and diagnostics are key for controlling infectious diseases globally. A pressing issue in biopharma is the potential environmental release of genetically modified microbes, which might have unpredictable effects. To mitigate biosafety risks, strategies are employed to limit microbial cell replication and horizontal gene transfer. The rapid growth in biosafety and biosecurity interest is due to the increased handling of pathogens and new biotech applications. Biosafety ensures the safe use of infectious materials; biosecurity protects against unauthorized access or release. Risk assessment is crucial to establish the right containment level for biohazardous agents, recognizing that biological materials, unlike nuclear or chemical, can prompt widespread epidemics swiftly if not properly contained.
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Augmentation of CFTR maturation by S-nitrosoglutathione reductase
American Journal of Physiology
Augmentation of CFTR maturation byS-nitrosoglutathione reductase.Am J Physiol Lung Cell Mol Physiol310: L263–L270, 2016. Firstpublished December 4, 2015; doi:10.1152/ajplung.00269.2014.—S-nitrosoglutathione (GSNO) reductase regulates novel endogenousS-nitrosothiol signaling pathways, and mice deficient in GSNO reduc-tase are protected from airways hyperreactivity.S-nitrosothiols arepresent in the airway, and patients with cystic fibrosis (CF) tend tohave lowS-nitrosothiol levels that may…
Augmentation of CFTR maturation byS-nitrosoglutathione reductase.Am J Physiol Lung Cell Mol Physiol310: L263–L270, 2016. Firstpublished December 4, 2015; doi:10.1152/ajplung.00269.2014.—S-nitrosoglutathione (GSNO) reductase regulates novel endogenousS-nitrosothiol signaling pathways, and mice deficient in GSNO reduc-tase are protected from airways hyperreactivity.S-nitrosothiols arepresent in the airway, and patients with cystic fibrosis (CF) tend tohave lowS-nitrosothiol levels that may be attributed to upregulationof GSNO reductase activity. The present study demonstrates that1)GSNO reductase activity is increased in the cystic fibrosis bronchialepithelial (CFBE41o) cells expressing mutant F508del-cystic fibro-sis transmembrane regulator (CFTR) compared with the wild-typeCFBE41ocells,2) GSNO reductase expression level is increased inthe primary human bronchial epithelial cells expressing mutantF508del-CFTR compared with the wild-type cells,3) GSNO reduc-tase colocalizes with cochaperone Hsp70/Hsp90 organizing protein(Hop; Stip1) in human airway epithelial cells,4) GSNO reductaseknockdown with siRNA increases the expression and maturation ofCFTR and decreases Stip1 expression in human airway epithelialcells,5) increased levels of GSNO reductase cause a decrease inmaturation of CFTR, and6) a GSNO reductase inhibitor effectivelyreverses the effects of GSNO reductase on CFTR maturation. Thesestudies provide a novel approach to define the subcellular location ofthe interactions between Stip1 and GSNO reductase and the role ofS-nitrosothiols in these interactions.
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Hypoxia-induced changes in protein s-nitrosylation in female mouse brainstem
American Thoracic Society
Exposure to hypoxia elicits an increase in minute ventilation that diminishes during continued exposure (roll-off). Brainstem N-methyl-D-aspartate receptors (NMDARs) and neuronal nitric oxide synthase (nNOS) contribute to the initial hypoxia-induced increases in minute ventilation. Roll-off is regulated by platelet-derived growth factor receptor-β (PDGFR-β) and S-nitrosoglutathione (GSNO) reductase (GSNOR). S-nitrosylation inhibits activities of NMDAR and nNOS, but enhances GSNOR activity. The…
Exposure to hypoxia elicits an increase in minute ventilation that diminishes during continued exposure (roll-off). Brainstem N-methyl-D-aspartate receptors (NMDARs) and neuronal nitric oxide synthase (nNOS) contribute to the initial hypoxia-induced increases in minute ventilation. Roll-off is regulated by platelet-derived growth factor receptor-β (PDGFR-β) and S-nitrosoglutathione (GSNO) reductase (GSNOR). S-nitrosylation inhibits activities of NMDAR and nNOS, but enhances GSNOR activity. The importance of S-nitrosylation in the hypoxic ventilatory response is unknown. This study confirms that ventilatory roll-off is virtually absent in female GSNOR+/− and GSNO−/− mice, and evaluated the location of GSNOR in female mouse brainstem, and temporal changes in GSNOR activity, protein expression, and S-nitrosylation status of GSNOR, NMDAR (1, 2A, 2B), nNOS, and PDGFR-β during hypoxic challenge. GSNOR-positive neurons were present throughout the brainstem, including the nucleus tractus solitarius. Protein abundances for GSNOR, nNOS, all NMDAR subunits and PDGFR-β were not altered by hypoxia. GSNOR activity and S-nitrosylation status temporally increased with hypoxia. In addition, nNOS S-nitrosylation increased with 3 and 15 minutes of hypoxia. Changes in NMDAR S-nitrosylation were detected in NMDAR 2B at 15 minutes of hypoxia. No hypoxia-induced changes in PDGFR-β S-nitrosylation were detected. However, PDGFR-β phosphorylation increased in the brainstems of wild-type mice during hypoxic exposure (consistent with roll-off), whereas it did not rise in GSNOR+/− mice (consistent with lack of roll-off). These data suggest that: (1) S-nitrosylation events regulate hypoxic ventilatory response; (2) increases in S-nitrosylation of NMDAR 2B, nNOS, and GSNOR may contribute to ventilatory roll-off; and (3) GSNOR regulates PDGFR-β phosphorylation.
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Cardiolipin synthase is required for Streptomyces coelicolor morphogenesis
Blackwell Publishing Ltd
The fluid mosaic model has recently been amended to account for the existence of membrane domains enriched in certain phospholipids. In rod-shaped bacteria, the anionic phospholipid cardiolipin is enriched at the cell poles but its role in the morphogenesis of the filamentous bacterium Streptomyces coelicolor is unknown. It was impossible to delete clsA (cardiolipin synthase; SCO1389) unless complemented by a second copy of clsA elsewhere in the chromosome. When placed under the control of an…
The fluid mosaic model has recently been amended to account for the existence of membrane domains enriched in certain phospholipids. In rod-shaped bacteria, the anionic phospholipid cardiolipin is enriched at the cell poles but its role in the morphogenesis of the filamentous bacterium Streptomyces coelicolor is unknown. It was impossible to delete clsA (cardiolipin synthase; SCO1389) unless complemented by a second copy of clsA elsewhere in the chromosome. When placed under the control of an inducible promoter, clsA expression, phospholipid profile and morphogenesis became inducer dependent. TLC analysis of phospholipid showed altered profiles upon depletion of clsA expression. Analysis of cardiolipin by mass spectrometry showed two distinct cardiolipin envelopes that reflected differences in acyl chain length; the level of the larger cardiolipin envelope was reduced in concert with clsA expression. ClsA-EGFP did not localize to specific locations, but cardiolipin itself showed enrichment at hyphal tips, branch points and anucleate regions. Quantitative analysis of hyphal dimensions showed that the mycelial architecture and the erection of aerial hyphae were affected by the expression of clsA. Overexpression of clsA resulted in weakened hyphal tips, misshaped aerial hyphae and anucleate spores and demonstrates that cardiolipin synthesis is a requirement for morphogenesis in Streptomyces.
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Time-Lapse Microscopy of Streptomyces coelicolor Growth and Sporulation
ASM Journals
Bacteria from the genus Streptomyces are among the most complex of all prokaryotes; not only do they grow as a complex mycelium, they also differentiate to form aerial hyphae before developing further to form spore chains. This developmental heterogeneity of streptomycete microcolonies makes studying the dynamic processes that contribute to growth and development a challenging procedure. As a result, in order to study the mechanisms that underpin streptomycete growth, we have developed a system…
Bacteria from the genus Streptomyces are among the most complex of all prokaryotes; not only do they grow as a complex mycelium, they also differentiate to form aerial hyphae before developing further to form spore chains. This developmental heterogeneity of streptomycete microcolonies makes studying the dynamic processes that contribute to growth and development a challenging procedure. As a result, in order to study the mechanisms that underpin streptomycete growth, we have developed a system for studying hyphal extension, protein trafficking, and sporulation by time-lapse microscopy. Through the use of time-lapse microscopy we have demonstrated that Streptomyces coelicolor germ tubes undergo a temporary arrest in their growth when in close proximity to sibling extension sites. Following germination, in this system, hyphae extended at a rate of ∼20 μm h−1, which was not significantly different from the rate at which the apical ring of the cytokinetic protein FtsZ progressed along extending hyphae through a spiraling movement. Although we were able to generate movies for streptomycete sporulation, we were unable to do so for either the erection of aerial hyphae or the early stages of sporulation. Despite this, it was possible to demonstrate an arrest of aerial hyphal development that we suggest is through the depolymerization of FtsZ-enhanced green fluorescent protein (GFP). Consequently, the imaging system reported here provides a system that allows the dynamic movement of GFP-tagged proteins involved in growth and development of S. coelicolor to be tracked and their role in cytokinesis to be characterized during the streptomycete life cycle.
Honors & Awards
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CEO Business Achievement Award
Syngene International Limited
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Overseas Research Students Awards Scheme (ORAS)-http://www.orsas.ac.uk/
Secretary of State for Education and Science- The United Kingdom
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University of Strathclyde Research Scholarships
University of Strathclyde
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M.George memorial award for Best out going student in college year 2002
Alpha Arts and Science college [http://alphagroup.edu/alpha_arts/]
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