정보
As a veterinarian with more than 10 years of experience in preclinical translational…
활동
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#Immunity | #Tuberculosis | Unmasking the Hidden Impact of #Viruses on TB Risk | BREAKING OPEN ACCESS OPINION ARTICLE by Sara Suliman & Friends…
#Immunity | #Tuberculosis | Unmasking the Hidden Impact of #Viruses on TB Risk | BREAKING OPEN ACCESS OPINION ARTICLE by Sara Suliman & Friends…
추천한 사람: Donggeon Kim
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Very interesting weekend reading! Worked a little a bit on VAV (Guanine nucleotide exchange factor, GEF) more than 10 years ago (on cancer cells and…
Very interesting weekend reading! Worked a little a bit on VAV (Guanine nucleotide exchange factor, GEF) more than 10 years ago (on cancer cells and…
추천한 사람: Donggeon Kim
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국내에서 LECLAZA로 시판된 lazertinib이 대한민국에서 개발된 항암 신약 최초로 FDA에서 승인되었습니다. 미국 브랜드명은 LAZCLUZE로 저희 Brand Institute가 개발하여 “FDA 브랜드명 승인”을 받아드렸습니다. 의약품의 미국 출시를…
국내에서 LECLAZA로 시판된 lazertinib이 대한민국에서 개발된 항암 신약 최초로 FDA에서 승인되었습니다. 미국 브랜드명은 LAZCLUZE로 저희 Brand Institute가 개발하여 “FDA 브랜드명 승인”을 받아드렸습니다. 의약품의 미국 출시를…
추천한 사람: Donggeon Kim
경력
학력
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Sunkyunkwan University
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• Studied differential expression of miRNAs between primary tumor and its matched reccur tumor samples to identify a tumor promoting miRNA for a novel therapeutic target. Evaluation of anticancer effects in glioblastoma using PDX models by chemical modificated an anti-miR(ASO)
• Study was focused on miRNA expression profiling and functional validation of miR10b, miR29 in cancer
자격/수료증
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Korean Veterinary License
Ministry of Agriculture, Food and Rural Affairs of Korea
발행일:
논문·저서
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The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling
JCI Insight .
Sema3A binds to its receptor neuropilin-1 (NRP1) and facilitates an interaction between NRP1 and TGF-β receptor 1 (TGF-βR1), which in turn leads to activation of canonical TGF-β signaling in both GSCs and NPCs. TGF-β signaling enhances self-renewal and survival of GBM tumors through induction of key stem cell factors, but it evokes cytostatic responses in NPCs. Blockage of the Sema3A/NRP1 axis via shRNA-mediated knockdown of Sema3A or NRP1 impeded clonogenic growth and TGF-β pathway activity in…
Sema3A binds to its receptor neuropilin-1 (NRP1) and facilitates an interaction between NRP1 and TGF-β receptor 1 (TGF-βR1), which in turn leads to activation of canonical TGF-β signaling in both GSCs and NPCs. TGF-β signaling enhances self-renewal and survival of GBM tumors through induction of key stem cell factors, but it evokes cytostatic responses in NPCs. Blockage of the Sema3A/NRP1 axis via shRNA-mediated knockdown of Sema3A or NRP1 impeded clonogenic growth and TGF-β pathway activity in GSCs and inhibited tumor growth in vivo.
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Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma
Genome Medicine
Identified molecular characteristics associated with temozolomide (TMZ) resistance in primary isocitrate dehydrogenase wild-type glioblastoma (GBM) patients. They used patient-derived glioma stem-like cells to develop a machine learning model that predicts TMZ response from genomic and transcriptomic signatures. They validated their findings with multi-sector sequencing analysis and showed highly heterogeneous TMZ-response patterns within each GBM patient. The model was developed into a…
Identified molecular characteristics associated with temozolomide (TMZ) resistance in primary isocitrate dehydrogenase wild-type glioblastoma (GBM) patients. They used patient-derived glioma stem-like cells to develop a machine learning model that predicts TMZ response from genomic and transcriptomic signatures. They validated their findings with multi-sector sequencing analysis and showed highly heterogeneous TMZ-response patterns within each GBM patient. The model was developed into a webserver for public use. The study highlights the potential clinical value of precision medicine approaches in treating GBM.
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Fibroblast activating protein (FAP)-targeting IL-12 (anti-FAP/IL-12) TMEkine™ potentiates anti-cancer effects in preclinical cancer models
Journal for Immunotherapy of Cancer
SITC2020, Poster
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cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody−Drug Conjugate Targeting c‑Met Overexpression Tumors
ACS Omega
In the present study, site-specific drug–conjugate technology was applied to develop an ADC using the human-mouse cross-reactive c-Met antibody and a prodrug pyrrolobenzodiazepine (PBD).
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Therapeutic Efficacy of GC1118, a Novel Anti-EGFR Antibody, against Glioblastoma with High EGFR Amplification in Patient-Derived Xenografts
Cancers
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Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma
Genome biology
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Secretome analysis of patient-derived GBM tumorspheres identifies midkine as a potent therapeutic target
Exp Mol Med .
antagonizing MDK reduced the survival of GBM tumor spheres through the promotion of cell cycle arrest and the consequent apoptotic cell death caused by oxidative stress-induced DNA damage. We also identified PCBP4, a novel molecular predictor of resistance to anti-MDK treatment. Collectively, our results indicate that MDK inhibition is an important therapeutic option by suppressing GIC survival through the induction of ROS-mediated cell cycle arrest and apoptosis.
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Novel semi- and pseudotyped-retroviral replicating vector-based dual-suicide gene-transfer enhances antitumor effects in patient-derived glioblastoma platform
Cancers
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PIP4K2A as a negative regulator of PI3K in PTEN - deficient glioblastoma
Journal of Experimental Medicine
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Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
Nature Genetics
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Distinct genomic profile and specific targeted drug responses in adult cerebellar glioblastoma
Neuro-Oncology
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Identification of Genomic and Molecular Traits that Present Therapeutic Vulnerability to HGF-targeted therapy in Glioblastoma
Neuro-Oncology
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Pharmacokinetics, Biodistribution, and Toxicity Evaluation of Anti-SEMA3A (F11) in In Vivo Models
Anticancer research
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Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-κB signaling pathway
Oncogene
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Antitumor activity, pharmacokinetics, tumor-homing effect, and hepatotoxicity of a species cross-reactive c-Met antibody
Biochemical and Biophysical Research Communications
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Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain
International Journal of Molecular Sciences
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Facilitating tailored therapeutic strategies for glioblastoma through an orthotopic patient-derived xenograft platform
Histology and histopathology
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GC1118, an Anti-EGFR Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity against High-Affinity EGFR Ligands
Molecular Cancer Therapeutics
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FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2
PLoS ONE
클래스
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Laboratory animal medicine expert training
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Non-clinical expert training
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Toxicology education course , Korean society of toxicology
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단체
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Korean Society of Toxicology
Associated member
– 현재 -
The Korean Society Nonclinical Study,KSNS
Subcommittee member
– 현재 -
KCLAM, KOREAN COLLEAGE OF LABORATORY ANIMAL MEDICINE
Associated member
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KOREAN VETERINARY MEDICINE ASSOCIATION
Associated member
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CND, Center for Non-Clinical Development
Advisory Committee
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Donggeon님의 활동 더보기
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Our approach of next-gen cytokine therapy is now published online at Molecular Cancer Therapeutics. We utilized anti-FAP for TME targeting and IL-12…
Our approach of next-gen cytokine therapy is now published online at Molecular Cancer Therapeutics. We utilized anti-FAP for TME targeting and IL-12…
추천한 사람: Donggeon Kim
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#Immunity | Advances in the #Development of #mRNA-based #Vaccines for Respiratory #Viruses | Free Access Review from Alexis Kalergis & Co. breaking…
#Immunity | Advances in the #Development of #mRNA-based #Vaccines for Respiratory #Viruses | Free Access Review from Alexis Kalergis & Co. breaking…
추천한 사람: Donggeon Kim
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We’re looking forward to sharing new data tomorrow on our PROTAb platform at the ADC Linker and Conjugation Summit in Boston. Our Principal…
We’re looking forward to sharing new data tomorrow on our PROTAb platform at the ADC Linker and Conjugation Summit in Boston. Our Principal…
추천한 사람: Donggeon Kim
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현 직장에 부임하고부터 습관이 생겼다. 출근 즉시 셀카를 찍고 하루 일정을 소화한다. 누군가는 관종이냐고 히지만, 내겐 어느덧 루틴이 되었다. 나를 최대한 객관적으로 보고 표정 기반으로 내 자신의 심리 상태를 체크한다. 그리고, 이 모습을 울 연구소원분들이 하루…
현 직장에 부임하고부터 습관이 생겼다. 출근 즉시 셀카를 찍고 하루 일정을 소화한다. 누군가는 관종이냐고 히지만, 내겐 어느덧 루틴이 되었다. 나를 최대한 객관적으로 보고 표정 기반으로 내 자신의 심리 상태를 체크한다. 그리고, 이 모습을 울 연구소원분들이 하루…
추천한 사람: Donggeon Kim
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Enjoy reading, nice work from Rezvani laboratory (again), IL-21 armed NK cells in solid tumor, "Interleukin-21 engineering enhances NK cell activity…
Enjoy reading, nice work from Rezvani laboratory (again), IL-21 armed NK cells in solid tumor, "Interleukin-21 engineering enhances NK cell activity…
추천한 사람: Donggeon Kim
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https://lnkd.in/erUCnNp8
https://lnkd.in/erUCnNp8
추천한 사람: Donggeon Kim
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CDK9 inhibitor https://lnkd.in/dNP6ryYU
CDK9 inhibitor https://lnkd.in/dNP6ryYU
공유한 사람: Donggeon Kim
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#Immunity | "Foreboding #Antibodies" | How #ADE aids #Infection | Mechanisms of #AntibodyDependentEnhancement of #InfectiousDisease | Breaking online…
#Immunity | "Foreboding #Antibodies" | How #ADE aids #Infection | Mechanisms of #AntibodyDependentEnhancement of #InfectiousDisease | Breaking online…
추천한 사람: Donggeon Kim
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The #Pathogenic Role of #Retinoid Signaling | A "Carrot" or "Stick" Approach to #Therapy in #Cancer & #MetabolicSyndromes 🤔 | Open Access Critique…
The #Pathogenic Role of #Retinoid Signaling | A "Carrot" or "Stick" Approach to #Therapy in #Cancer & #MetabolicSyndromes 🤔 | Open Access Critique…
추천한 사람: Donggeon Kim
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The "Natural Killer Cell Engager" field is booming. Let's break it down. By now, I'm sure you've heard of bispecific T cell engagers (BiTEs) -…
The "Natural Killer Cell Engager" field is booming. Let's break it down. By now, I'm sure you've heard of bispecific T cell engagers (BiTEs) -…
추천한 사람: Donggeon Kim
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#Macrophage-mediated #Myelin recycling fuels #BrainCancer #Malignancy | "Chewing the Fat" in the #Glioblastoma #TumorMicroEnvironment | Breaking Open…
#Macrophage-mediated #Myelin recycling fuels #BrainCancer #Malignancy | "Chewing the Fat" in the #Glioblastoma #TumorMicroEnvironment | Breaking Open…
추천한 사람: Donggeon Kim
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Colorectal cancer is not a single disease but a complex collection of subtypes with unique genomic landscapes. Whole-genome sequencing of 2,023…
Colorectal cancer is not a single disease but a complex collection of subtypes with unique genomic landscapes. Whole-genome sequencing of 2,023…
추천한 사람: Donggeon Kim
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Enjoy weekend reading—this is really cool work! C-Kit (CD117) high hematopoietic stem cells (HSCs) utilize the process of trogocytosis (TROG⁺ HSCs)…
Enjoy weekend reading—this is really cool work! C-Kit (CD117) high hematopoietic stem cells (HSCs) utilize the process of trogocytosis (TROG⁺ HSCs)…
추천한 사람: Donggeon Kim
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https://lnkd.in/gUsmkPZ4
https://lnkd.in/gUsmkPZ4
추천한 사람: Donggeon Kim
다른 비슷한 프로필
대한민국 Donggeon Kim님의 동명이인
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Donggeon Kim
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DongGeon Kim
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DongGeon Kim
Clinical Research Associate(CRA)
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DONGGEON kim
Management Planning Dep.
LinkedIn에 가입한 대한민국 내 Donggeon Kim님의 동명이인 20명
Donggeon Kim님의 동명이인