EV Biotech

🚀 What's Your Biggest Challenge in Metabolic Engineering? 🚀 At EV Biotech, we're all about pushing the boundaries of what's possible in metabolic engineering. With the upcoming launch of OptiStrain, our revolutionary Virtual Strain Engineering Assistant, we're excited to help researchers like you overcome the toughest obstacles in strain engineering. But first, we want to hear from YOU! 💬 Vote in our poll below and share your specific challenges in the comments! 🔍 Question for the Experts: Drew Endy, George Church, Christina Smolke, Edward Shenderovich, Claire Skentelbery, Roel Bovenberg, Prateek M., Joshua Britton, Emily Leproust, Stef van Grieken, John Cumbers, Jay Keasling, Damien Perriman, Arvind Gupta — How do you see digital tools shaping the future of metabolic engineering? We'd love to hear your thoughts on the evolving landscape! Your insights will help us tailor our future content and demonstrate how OptiStrain can address your needs. OptiStrain is designed to tackle these challenges head-on, giving you the tools you need to optimize strain designs, save valuable time, and reduce costs. Don’t miss out on the future of metabolic modeling—Pre-Register Now at www.evbio.tech to be among the first to access OptiStrain! Let's shape the future of metabolic engineering together! 💡 #MetabolicEngineering #SynBio #Biotech #StrainEngineering #OptiStrain

Last month, we explored the critical role of strain engineering in bringing bioproducts to scale and to market in an insightful webinar hosted by Synonym on ‘Optimizing Strain Performance for Commercialization.’ Together with Vectron Biosolutions AS, SynBioBeta, and Enduro. Our discussion underscored the significance of strain development and stability in scaling biomanufacturing. It became clear that achieving economies of scale isn’t enough; optimized strains tailored for large-scale production are key to unlocking the full potential of biomanufacturing in the years ahead. Our expert panel highlighted how strain optimization can drive productivity, enhance process stability, and reduce costs in biomanufacturing. 🎥 Missed the live session? No problem! Comment below or email us at [email protected] to get access to the webinar recording and discover valuable insights into the future of biomanufacturing. A big thank you to everyone who participated live! Let’s keep pushing the boundaries of biomanufacturing together. #bioeconomy #biomanufacturing #sustainability #innovation #webinar #strainengineering #strainoptimization #fermentation #precisionfermentation #bioproductionatscale #synbio

Topic of the day: Phenotypic instability 💔 Try as we might, microorganisms don’t always do what we design them to do. In a recent mini-review published by our very own Max Guillaume, titled “Assessing and Reducing Phenotypic Instability in Cyanobacteria,” Max discusses a rather insidious obstacle when it comes to the scale-up process of production fermentation: phenotypic instability. Phenotypic instability is a phenomenon where your production culture gradually stops producing over time, and production cannot be rescued from the same culture. The paper outlines how this can be due to the metabolic burden of production itself! But fear not! Max also discusses how we can use genome-scale modelling and various modelling techniques, precisely what we do here at EV Biotech, to tackle and/or mitigate this challenge. Although this review is primarily focused on cyanobacteria, phenotypic instability has been observed in a variety of different organisms and the underlying principles for solving this puzzle are not inherent to one organism. This paper is also closely related to the work of our colleague Anne Hensen, who is currently focusing on modelling strain degeneration during the scale-up process. Phenotypic instability often goes overlooked at the laboratory scale because it is usually only detectable in continuous or large-scale bioreactors, like those you see at the industrial scale. It is important to be cognizant of this phenomenon and to address it early on, because if you don’t, well, in the immortal words of Dr Ian Malcolm, “Life, uh, finds a way.” Read the whole review here: https://lnkd.in/eck8U7TP Curious to know more? Check out our website (https://evbio.tech/) on how EV Biotech's no-nonsense, modelling-driven DBTL approach can help you out, and reach out to us with your questions. #biotechnology #microorganisms #scaleup #fermentation #degeneration #productivity #DBTL #modelling #CRO #industrial

☀️ The summer is upon us and while some enjoy well-deserved holidays, our strain engineering and fermentation labs are running at full speed. Today, we want to introduce you to one of our recent products of commercial interest: Amylase. ☀️ Amylase, a crucial enzyme in various industries, is predominantly produced through the fermentation of microorganisms such as fungi, yeast or bacteria. This biotechnological approach offers a sustainable and efficient method to meet the growing demand for this versatile enzyme. 🔬 Why Amylase? Amylase catalyses the breakdown of starches into simple sugars, playing a vital role in: - Food and Beverage Industry: Enhancing bread quality, brewing beer, and producing high-fructose corn syrup. - Dairy Industry: Amylase can break down milk into monomers which are responsible for flavors in cheese - Textile Industry: Desizing fabrics. - Paper Industry: Modifying starches for coating and sizing. - Biofuel Production: Converting starches into fermentable sugars. ♻️ Circular Economy and Waste Valorization: Amylase also plays a pivotal role in the circular economy by enabling the conversion of agricultural and food waste into valuable products. Through side-stream valorisation, waste materials rich in starch can be transformed into useful sugars, reducing waste, and promoting sustainability and a circular economy. 💡 Market Insights: The global amylase market is experiencing robust growth, driven by the increasing demand for processed foods and beverages, advancements in biotechnology, and the rising trend of biofuels. In 2023, the market was valued at approximately $2.7 billion and is projected to reach $4.4 billion by 2033, growing at a CAGR of around 5.1% from 2024 to 2033 (Allied Market Research) 🔗 What else is brewing at EV Biotech? We recently announced the upcoming release of our ✨OptiStrain✨ tool, which will enable our clients to interact with our metabolic models, and design and test strain engineering strategies, before starting the work in the lab. Want to hear more? sign up here: https://lnkd.in/e5F9_tku   #Biotechnology #Enzymes #Amylase #Sustainability #CircularEconomy #Innovation #WasteValorization #MicrobialFermentation Video by: Arno de Vries

Nieuwe samenwerking EV Biotech x Researchable | Data-innovatiebureau🤝 We hebben recent de ontwerpfase met EV Biotech afgerond. In een ontwerpfase identificeren we eerst de behoeften en eisen van de organisatie en eindgebruikers, en stellen we een duidelijk en gedeeld begrip vast van wat het Minimum Viable Product omvat en wat niet (Scope van het MVP). EV Biotech produceert micro-organismen om producten zoals vanille en plastic op een duurzame manier te ontwikkelen. Zij doen dit in een digitaal laboratorium waarin alle celcombinaties worden getest voor het echte laboratoriumwerk start. Tijdens dit proces worden veel data gegenereerd zoals data van experimenten, chemische reacties en simulaties. Door de data-applicatie die wij nu mogen ontwikkelen kun je het aantal fysieke lab experimenten aanzienlijk verminderen. Via de Software-as-a-Service applicatie #OptiStrain wil EV Biotech haar klanten een virtuele assistent aanbieden die onderzoekers in staat stelt om onbeperkt digitale experimenten uit te voeren, waarbij de effecten van 'knock-outs' en verschillende koolstofbronnen op groei en productie in meer dan 10 verschillende microben worden getest. 🎯 Zeer nauwkeurig door gebruik van geavanceerde modellen 🔮 Voorspelt welke genetische aanpassingen het beste werken 👍 Makkelijk te gebruiken voor iedereen 💸 Bespaart geld en versnelt ontwikkeling 📈 Wordt regelmatig bijgewerkt met nieuwe functies Inmiddels zijn we begonnen met de ontwikkelfase en technische realisatie van deze data-innovatie. Omdat de omgang met data centraal staat in de applicaties die wij ontwikkelen, houden we rekening met de hoogste normen voor informatiebeveiliging. Ons bedrijf is #ISO27001 gecertificeerd en daarnaast hebben we ook de ISO/IEC 25010:2023 en NEN7510-normen geïmplementeerd. Aga Wegrzyn Linda Dijkshoorn Max Verbeek Frank Blaauw Reindert Visser Carmen Rozendaal Mandelo -- Wij bij Researchable | Data-innovatiebureau helpen organisaties met het bedenken, ontwerpen en realiseren van impactvolle softwareapplicaties waarin de omgang met data centraal staat. #Samenwerking #InnovatieDoorData #SoftwareOntwikkeling #Researchable #EVBiotech #DatagedrevenInnovatie

Today, we are proud to announce our collaboration with Mandelo! While EV Biotech's team is rich in strain engineering, fermentation and computational biology expertise, we know that our aesthetic sense and design skills might be below average. That is why we rely on experts from the Mandelo team, to help us visualise our scientific vision, and make our tools user-friendly, and pleasant to the eye. They are an essential part of our journey to bring the ✨OptiStrain✨ tool to the users. Do you want to learn more about ✨OptiStrain✨? Sign up here: https://lnkd.in/e5F9_tku Mandelo is a digital branding agency for brands that break the status quo with purpose. #collaboration #biotechnology #SaaS #design #modelling #derisking #strainengineering #costreduction Carmen Rozendaal Aga Wegrzyn Reindert Visser Max Guillaume

We are very excited to work again with Researchable | Data-innovatiebureau! In the past, Researchable | Data-innovatiebureau assisted us with setting up a safe internal database to handle all our data and knowledge. This time, they are working with us to ensure that our new offer, ✨OptiStrain✨ , handles our client's data with the utmost care, and adheres to the data safety certifications! Do you want to learn more about ✨OptiStrain✨? Sign up here: https://lnkd.in/e5F9_tku Researchable | Data-innovatiebureau, helps organizations devise, design and realize impactful software applications that focus on the handling of data. #collaboration #biotechnology #SaaS #datasafety #modelling #derisking #strainengineering #costreduction Ando Emerencia Fionneke Bos Frank Blaauw Max Verbeek Reindert Visser Max Guillaume Aga Wegrzyn Linda Dijkshoorn

🚀🚀Prelaunch announcement - SIGN UP for the launch!! 🚀🚀 Yesterday during the webinar with Synonym Enduro Vectron Biosolutions AS SynBioBeta we made a big announcement! EV Biotech is thrilled to introduce OptiStrain, our cutting-edge SaaS solution designed to revolutionize the way you approach strain engineering. This digital toolbox/suite is crafted to accelerate strain engineering by integrating advanced computational tools and genome-scale modeling, providing unparalleled precision and speed in your research. What is OptiStrain? Optistrain is a cloud-based, user-friendly platform that serves as your virtual strain engineering assistant. It enables researchers to perform unlimited digital experiments, testing the effects of knockouts and different carbon sources on growth and production in over 10+ microbes. How Does It Work? Our platform simulates years’ worth of lab work at the click of a button, allowing you to test hypotheses, optimize strain designs, and identify the best knockouts to enhance production. By using OptiStrain, you can significantly limit the number of physical experiments needed, saving both time and costs. Why Choose OptiStrain? 🎯 Unmatched Accuracy: Leverage genome-scale modeling for precise insights. 🔮 Predictive Power: Identify the most effective genetic modifications to boost molecule production. 👍 User-Friendly Interface: Our intuitive design makes advanced modeling accessible to everyone. 💸 Cost-Effective: Reduce experimental costs and streamline your development process. 📈 Future-Proof: StrainOptimizer is not a static tool; it evolves with continuous updates and new features to meet your growing needs. Key Benefits: ⏩ Accelerate Your Research: Save years of lab work with our digital solutions. 🔬 Unlimited Experimentation: Test countless hypotheses to find the best strategies. 🚀 Fast and Reliable: Achieve your research goals quicker with high precision and reliability. 👩💻 Secure and IP Safe: Your experimental work remains confidential and protected. Join the Revolution! Pre-Register Today at www.evbio.tech ! Be among the first to experience the future of metabolic modeling. Pre-register now for our exclusive launch and get a head start on transforming your research and production capabilities. Smart strain engineering can lead us to reach cost parity according to Boston Consulting Group (BCG)

Final call to sign up for tomorrow's webinar. Besides an interesting discussion on the state and state-of-the-art in strain engineering, we will announce something special that will change how you approach strain engineering! 📅 Date: July 17, 2024 🕒 Time: 4pm to 5pm CET 📍 Register here: https://lnkd.in/gdQ8UMgS #synbio #bioeconomy #scaleup #sustainability #biotech #fermentation Synonym EV Biotech Vectron Biosolutions AS Enduro SynBioBeta

🚀 Special Announcement Coming Soon from EV Biotech! 🚀 EV Biotech will be unveiling something special that will change the way you engineer your strains!! Join us at our upcoming webinar to be the first to hear about this exciting development! 🗓️ Date: July 17, 2024 ⏰ Time: 4pm to 5pm CET (10am to 11am EDT) 🔗 Register here: https://lnkd.in/ey4VDbzA Hosted by Synonym in collaboration with EV Biotech, Vectron Biosolutions AS, SynBioBeta, and Enduro Genetics, this webinar will feature an insightful discussion on the critical role of strain engineering in the commercialization of bioproducts. Why Attend? Discover the latest in strain engineering and its impact on productivity, product quality, and cost efficiency. Be the first to hear about a revolutionary development from EV Biotech  Don't miss out on this opportunity to shape the future of sustainable development through biomanufacturing. We look forward to seeing you there! #Webinar #Biotech #StrainEngineering #Biomanufacturing #Innovation #EVBiotech #Synonym #VectronBiosolutions #SynBioBeta #EnduroGenetics