LUMICKS

The tumor microenvironment remains a significant barrier, limiting the effectiveness of cell therapies through several immunosuppressive mechanisms such as upregulating immune checkpoints that inhibit T-cell activity. The BTLA-HVEM axis has emerged as a critical factor in T cell inhibition and exhaustion, particularly in Hodgkin lymphoma, and in other cancers. Crucially, by integrating cell avidity analysis, the team at UPenn demonstrated that BTLA-deficient CAR-T cells exhibited increased binding to tumor targets, thereby enhancing potency. Click through to discover more https://lnkd.in/eXWmcscK

Registration is now open! Don’t miss your chance to join Prof. David Rueda for an insightful webcast on the latest advances in DNA repair research, hosted by #Nature Custom Media. Secure your spot today and be part of this groundbreaking discussion! https://lnkd.in/d3uYf-W7

Happy to see Anastassis Perrakis and his team at The Netherlands Cancer Institute in new adventures with their shiny new C-Trap! Can’t wait to see what amazing discoveries are just around the corner! Pioneer the future of cancer research with dynamic single-molecule technology! 🤝 #cancerresearch #CTrap #LUMICKS

🌟 Join Us at the Single Molecule Biology Symposium 2024! 🌟 Dive deep into the latest advancements and innovations in single-molecule research. This symposium brings together leading scientists to discuss groundbreaking techniques and discoveries. Don’t miss out on this unique opportunity to advance your knowledge and network with peers! 📅 Oct 17-18, 2024 📍 The Rockefeller University, New York 🔗 Learn more and register now: https://lnkd.in/dPhsb_kJ #SMB2024 #SingleMoleculeBiology #ScienceSymposium

Have you read the recent #Nature publication showcasing how the C-Trap technology is transforming our understanding of DNA-protein interactions? "The C-Trap lowers the barrier for accessing single-molecule imaging, making it possible to understand dynamics.” says Dr. Lori Passmore. Check out our digest of the publication here: https://lnkd.in/dy5AU4BY

Want to find out more about how we can support your grant applications? Checkout our new Grant Expeditor webpage. here: https://lnkd.in/eeqGC7Wu We conduct a step by step process to help you navigate your grant writing journey as follows: 👉 Step 1: Lunch-and-learn seminars 👉 Step 2: Expert consultation 👉 Step 3: Supporting data (proof of concept) 👉 Step 4: Supporting Grant optimization 👉 Step 5: Budget planning & final review

Ever wondered about the mechanics of DNA replication? Join Prof. Nynke Dekker in our on-demand webinar and learn about the pivotal roles of nucleosomes, ORC, and MCM in maintaining genome integrity. Get a deep dive into how single-molecule methods are revolutionizing our understanding of molecular interactions. https://lnkd.in/ebY-FMfu

Check out this beautiful review by Gabriella Chua and Shixin Liu to see how advanced single-molecule techniques are unlocking the secrets of DNA-binding proteins. Learn about the powerful combination of fluorescence microscopy and optical tweezers, providing unprecedented insights into cellular mechanisms. Perfect for researchers and science enthusiasts eager to understand the building blocks of life! https://lnkd.in/eQUfEa7a

“It’s probably the only way!“ Prof. David Rueda from Imperial shared with us his thoughts on the dynamic single-molecule technique. Check how you can get unique insights studying DNA protein interactions: https://lnkd.in/e7nw6-7A

🚀 We are excited to announce our cell avidity Grant Expeditor Package to help Academic researchers fast-track successful grant writing proposals! 📝 As a scientific researcher, you have many innovative ideas and pressing questions, but securing funding is often the biggest hurdle. Crafting a detailed and compelling grant proposal is key to acquiring the cutting-edge scientific instrumentation that can enhance your research. To support you in this journey, we’re excited to introduce our Grant Expeditor Package ( https://lnkd.in/eG3-GzyH) a comprehensive solution designed to streamline your grant writing process and enhance your chances of securing funding. Whether you’re aiming to bring advanced Cell Avidity analysis to your lab or need support with other cell binding research initiatives, our package is here to accelerate your success. Let us help you transform your groundbreaking ideas into funded research projects! 💡🔬 #GrantWriting #ResearchFunding #CellAvidity #LabTools #ResearchSupport