A-listers swear them and they’ve become all the rage in wellness circles over the last few years, but some of us still don’t know much at all about the elusive NMN supplements.
Nicotinamide Mononucleotide, also known as “NMN,” is a molecule involved in the production of nicotinamide adenine dinucleotide “NAD+”, a coenzyme found in all living cells which is essential for various biological processes, including energy metabolism, DNA repair, and cell signaling.
In other words, NMN supplements have the potential to put a pause on the effects of aging, while also improving the metabolism and enhancing energy. Due to the rising interest in these supplements and recent research supporting their benefits, we’ve stitched together a guide on all you need to know about them — and how to decide which brand may be best for you.
The Post consulted Multi-Specialist Physician, Dr. Azza Halim for answers to all our NMN-related questions. Dr. Halim is a board-certified physician, with specialized training in Functional and Regenerative Medicine and Aesthetics — a major focus of her medical practices in creating customized, anti-aging treatment plans.
While research on NMN supplements is still ongoing, Dr. Halim has stressed that these supplements have gained recognition for their potential anti-aging properties: “Optimal NAD+ levels help with DNA repair, improve cellular signaling, help regulate circadian rhythm for sleep cycle, support protein synthesis, and strengthen the immune system,” she shared.
In addition to providing some additional information about the use, side effects, and potential health benefits, Dr. Halim has also inputted some of her medical analyses on the most popular NAD+ boosting brands like Wonderfeel, Elysium, Genuine Purity, and more — to help interested shoppers decide which option may be the best for them.
Below, read on for more information on the best NMN supplements for anti-aging, and be sure to consider adding other expert-backed supplements to your holistic health routine — including personalized vitamins, collagen, prebiotics, probiotics, and more.
Best overall NMN: Wonderfeel Youngr NMN
Pros:
- A patented formula combining NMN with natural ingredients (olive oil extract, emergent antioxidants, and Vitamin D3)
- Glass bottle, biodegradable refillable packaging
- Non-GMO, vegan friendly, does not contain preservatives.
- Made in America
Cons:
- Higher price point than some competitors — but a very high dose of NMN per serving (900mg) for a great value
- Effects vary from person to person (some see results within the first week, while it takes others up to a month or more)
If potency is what you’re after, try the Wonderfeel Youngr. The formula was engineered by Andrew Salzman, a prominent Harvard MD with nearly 30 years of expertise in NAD and cellular health, and it delivers a 900mg dose — which is one of the most potent on the list.
Dr. Halim noted that the price point is a bit higher for this multi-targeted solution. However, just one capsule of Wonderfeel Youngr contains a host of powerful ingredients: “The components of Wonderfeel Youngr NMN are as follows: 450 mg Nicotinamide Mononucleotide, 2 mg Ergothioneine, 50 mg Trans-Resveratrol, 25 mg Olive fruit Extract (40% hydroxytyrosol), and 10 mcg Vitamin D3.”
Is this patented solution worth a few more bucks? Considering that one serving contains two capsules, users will receive 900mg of NMN. This is a much stronger dose than what most competitors offer. The combination of quality ingredients is also unique to the brand. The blend draws from nature and science, featuring Ergo from mushrooms, hydroxytyrosol from olive fruit, and resveratrol, plus 100% of your daily Vitamin D3; which all work together to slow down biological aging at the cellular level.
Considering the balanced list of ingredients, high potency, rigorous testing, and positive customer reviews — this might just be the best NMN supplement you can find.
Dose: 900 mg NMN
Customers are saying: “After 9 weeks of use, Wonderfeel’s formula has more noticeable effects than the two other brands I dabbled with. My memory recall and thought processing is much more acute, especially after a few drinks the previous evening. Overall I feel like my body is running smoother with less fatigue.”
Best NMN for all ages: Wonderfeel NMN Capsuls 1000 mg
Pros:
- Non-GMO, vegan friendly, does not contain preservatives
- Competitive price
- Ideal dosage (stackable so you can decide your dose based on your age and needs)
- Made in America
Cons:
- Effects vary from person to person (some see results within the first week, while it takes others up to a month or more)
If you’re not quite ready to bite the bullet on the Wonderfeel Youngr NMN, then Wonderfeel’s NMN Capsuls may be a better choice. They’re not just more affordable, but also allow for more tailoring, which is something that Dr. Halim has explained is an important part of addressing specific health needs.
Much of Sr. Halim’s work as a physician is focused on “finding the best treatment plan customized for each individual, rather than the traditional cookie-cutter approach.” This can mean many things — but one factor to consider is your age and goals.
Wonderfeel NMN Capsuls were designed for wellness enthusiasts who want to create their own supplement regimen or “stack.” Younger users might start with one capsule, which contains 500 mg of pure NMN. Those over 40 can consider upping their dose to 1000 mg to more efficiently increase energy levels, restore skin elasticity, improve sleep quality and cognition, and aid in organ health.
Having choices is what sets this formula apart.
Dose: 1000 mg NMN
Customers are saying: “I love this product! I’m 56 and a former Marine. Since taking this I have noticed more focus and quicker recovery time after workouts. Enjoy it…it’s Outstanding!”
Best natural NMN: Codeage Liposomal NMN Supplement
Pros:
- Includes polyphenol extracted from Japanese knotweed’s root
- Provides Vitamin B2, vitamin B12 , and quercetin anhydrous
- Contains phosphatidylcholine to help support the delivery and bioavailability of its ingredients
- Free from dairy, soy, and gluten
Cons:
- Recommended to spread doses three times throughout the day
- One of the most expensive options
- Not made in America
Dr. Halim has recommended looking for “NMN derived from natural sources, such as fermentation or plant extracts, rather than synthetic NMN.” There are plenty of chemical compounds behind NAD+ supplements, but there are also a handful of ingredients sourced straight from the planet that have abundant health benefits.
The Codeage Liposomal NMN Supplement reaches beyond the lab, for ingredients that are handpicked from across the globe. The formula pairs NMN with resveratrol, a polyphenol extracted from Japanese knotweed’s root, as well as betaine — which usually consists of an amino acid derived from plants and sugar beets.
While reviewers enjoy the diverse array of ingredients and have noted improvements in memory and energy levels, they’re less enthused about the fact that the brand suggests taking one capsule three times a day. Some have mentioned the pills are on the bigger side, which might make them more difficult to swallow. While the NMN supplement price point has a wide range, this formula is also much pricier than competitors.
Dose: 500 mg NMN
Customers are saying: “My memory feels sharper, and those forgetful moments have become fewer and farther between. Alongside the memory enhancement, I’ve also experienced a significant uptick in my energy levels. It’s like a fog has lifted from my mind, and I’m able to tackle the day with newfound vigor and clarity. Tasks that once felt daunting now seem more manageable, and I find myself powering through my to-do list with ease.”
Best lower-dose NMN: with Cymbiotika NMN Trans-Resveratrol
Pros:
- Made in USA
- Incorporates Green Coffee Beans and antioxidants
- Reviewers notice major improvements in energy
Cons:
- Reviewers mention it may take a while to begin noticing results
Dr. Halim has pointed out that Cymbiotika NMN Trans-Resveratrol is another well-known NMN brand, which makes sense considering it’s currently sold out and requires pre-ordering. Customers mention it may take time to see results, but consistency pays off.
“Cymbiotika NMN is made with added polyphenols and antioxidants that can significantly boost NAD levels throughout the body,” said Dr. Halim. “NAD plays an important role in energy, metabolism, and maintenance of healthy gene expression.”
The Cymbiotika formula brings together a handful of natural ingredients for further health benefits. According to the brand, green coffee contains high levels of antioxidants that regulate healthy blood pressure, blood sugar, and metabolism. The addition of Apigenin, a flavonoid found in plants, may improve insomnia and assist in reducing anxiety and depression, as well as lowering inflammation.
Dose: 400 mg NMN
Customers are saying: “I love this product! I’m 35 and I’ve narrowed down the supplements that I take daily to just a few essentials and this is one of them. I take this daily and have been doing so for about six months! I feel great overall and will continue taking this product for healthy cell support.”
More NAD+ supplements
Best budget-friendly NAD+: Life Extension NAD+ Cell Regenerator
Pros:
- Very competitive pricing
- Many reviewers suggest this improves energy levels
- About 98% of our customers recommend the product
- Gluten free, Non-GMO, Vegetarian
Cons:
- Only 30 capsules per bottle (shorter supply than some competitors)
- Only 100 mg of Niagen per serving
Looking for a solution on a budget? Life Extention isn’t playing around — the name on the bottle says it all. At just $16.50 a bottle, the brand promises an array of physical results, however, it’s important to note that it works a bit differently than some other NMN formulas, and it is offered in a lower dose.
Life Extension does not use NMN to increase NAD+ but incorporates Niagen (NR). These two compounds are very similar from a structural comparison, however, NMN includes a phosphate group which makes this precursor larger than NR. Studies have shown that NMN can improve cardiac function, while NR can improve mitochondrial function in muscle, liver, and brown adipose tissue.
“Life Extension uses Niagen Nicotinamide Riboside to fight general fatigue on a cellular level,” explained Dr. Halim. She added that the blend contains resveratrol to modulate the expression of genes associated with some aspects of aging, as well as promoting “mitochondrial health and youthful cellular energy production.” It could also help inhibit oxidative stress and improve cardiovascular health.
Dose:100 mg NR
Customers are saying: “Soon after taking the NAD+, my energy levels started coming back and my thinking faculties became strong again. It was really amazing. I’m aware that not every supplement has the same result for different people, but this one certainly worked for me.”
Best low-dose NAD+: Elysium Basis Celluar Health and Optimization
Pros:
- Vegetarian, vegan, gluten-free, nut-free, and contains no artificial colors or flavors
- Includes Pterostilbene; powerful polyphenols to protect against internal and external stress
- Many subscription options are available
Cons:
- High price point
- The lower-dose is not ideal for everyone
“Elysium Basis is created for long-term use in adults of all ages,” shared Dr. Halim. The formula was developed by Elysium chief scientist and renowned aging researcher Leonard Guarente, and tests have shown the formula has the power to increase and sustain NAD+ levels by 40%. Dr. Hadim has highlighted two ingredients that boost its efficiency.
“The ingredients are all FDA-approved, but there are two main ingredients in Basis supplement that can provide potential health benefits. One is pterostilbene, which is plant-based and can protect the body against stress. The other ingredient is nicotinamide, which is a ‘direct precursor’ to NAD and helps power the body’s metabolic system.”
While this is another one of the more expensive brands, reviewers like Elysium for the addition of pterostilbene and the moderate dosage level, and note that results are worth waiting for. Many have commented that people don’t believe how old they are after sticking to these supplements.
Dose: 250 mg NR
Customers are saying: “I’ve been taking Basis for a long term, guessing nearly a decade. (And I only take a half dose because it’s all I can afford AND I usually only need small doses of ANY drug I take).
A year or so ago, I did the Index biological age test. It came back as 15 years YOUNGER than my chronological age… the test results speak for themself and the literature certainly supports taking it. I’m more of a believer in the efficacy of Basis than I am in mere coincidence.”
Best Liposomal NAD+: Liposomal NR 300mg Nicotinamide Riboside Supplement
Pros:
- Organic and non-GMO ingredients
- Capsules are small and easy to swallow
- 99% pure spermidine naturally sourced from wheat germ
- Made in America
Cons:
- Only 30 capsules per bottle (shorter supply than some competitors)
- Purity is not the highest
- Differing opinions on liposomal delivery
Dr. Halim has emphasized that Genuine Purity’s NR formula distinguishes itself due to unique liposomal delivery. According to the brand, some active ingredients in supplements can get destroyed in the digestive tract. Genuine Purity has claimed that Liposomal Technology protects nutrients with a “bubble” that helps them reach the bloodstream for 80% more absorption. The brand also says it’s gentler on the stomach.
“Genuine Purity comes in a liposomal form for better absorption and has minimal ingredients,” explained Dr. Halim. “According to some reviews and testing, purity is not the highest and pricing is moderate to expensive range. But, it’s considered a good quality product with good absorption given the liposomal delivery, although some beg to differ on absorption method with supplements.”
In addition to highlighting the Liposomal Technology, reviewers have also pointed out that this formula has helped boost their mood and energy levels a bit faster than they expected. While it may not give you an “explosion” of energy, consistent users may experience more vitality throughout the day and better quality sleep at night.
Dose: 300 mg NR
Customers are saying: “NAD has been an open secret in Hollywood for a while to maintain a good collagen level and elasticity in the skin from what I understand. This product has a few more ingredients in it which definitely can’t hurt. But you have to understand that you gotta be committed to making this a long-term deal if you want to be able to figure the effects out for yourself!”
Best NAD+ for sleep: TRU NIAGEN Patented NAD+ Supplement for Anti-Aging and Cell Regeneration
Pros:
- Competitive pricing
- Made in America
- Vegetarian, gluten-free, nut-free, caffeine-free, and have no artificial flavors or colors
- Reviewers note improvements in sleep
Cons:
- Some negative reviewers regarding excessive packaging
Dr. Halim has described Tru Niagen as another budget-friendly option for those seeking an NR-based solution to boosting NAD+ levels. “Tru Niagen not as expensive,” she said. “It uses NR as a precursor, ingredients are considered safe.”
According to the brand, Tru Niagen is clinically proven to be one of the safest and most efficient boosters of NAD+ levels, with an average increase of over 50% in two weeks with daily use. The brand is backed by two Nobel Peace prize winners, and developed from over 50 years of scientific research and testing.
The dosage is on the moderate side, so it could be a good option for people starting to take the supplement in their 30s. Another plus — you’ll only need to take one capsule per serving, which makes it a good option for the pill-averse. Reviewers have reported better sleep, less brain fog, and improved focus with this supplement.
Dose: 300 mg NR
Customers are saying: “The first week that I took Tru Niagen, I felt that the quality of my sleep improved in a major way. It seemed to me that I was dreaming more vividly, and getting to a deeper level of sleep. By the second week, I noticed that my skin was clearing up. I have taken Niagen vitamin B3 for about 2 years now. It’s the best vitamin supplement I have ever taken. I have better sleep quality, better skin, stronger nails, better eyesight, less gray hair, better liver/kidney/cholesterol numbers on lab tests, and less brain fog.”
How to incorporate NMN into your routine
What is the recommended NMN supplement dosage?
According to Healthline, there still isn’t enough research on NMN supplements to determine the ideal dose. Some studies have found benefits associated with doses as low as 250 mg per day and up to a maximum of 1200 mg a day.
In another study involving amateur runners, aerobic improvements were greater with higher doses of NMN (1200 mg) compared with lower doses (300 mg). There was no difference observed between those given a high dose compared with a medium dose (600 mg).
When is the best time to take NMN supplements?
Most brands suggest taking NMN supplements in the morning due to the natural increase in cellular NAD+ production that happens after waking up. Others say that timing does not matter.
Were NMN supplements banned in the United States?
The Food and Drug Administration banned the sale and marketing of NMN as a “dietary supplement” in the United States in 2022, according to a report by Forbes.
The decision was based on the fact that NMN’s authorized investigation as a “new drug” happened before it was lawfully marketed as a “dietary supplement.” The FDA concluded that it should be excluded from the dietary supplement category until further notice.
Due to the amount of MNM research that has already been done, various manufacturers have continued making and marketing MNM products. There are still plenty of NMN supplements available for purchase in the United States.
Are there any NMN supplement side effects?
Research in humans has shown that doses of up to 1200 mg NMN daily are safe to consume. Both human and animal studies have shown that the supplement is well-tolerated and has minimal side effects.
Can everyone benefit from NMN supplements?
People of all ages can use NMN supplements, but some groups may reap more benefits from consistent use. People over the age of 35 may be more likely to take NMN supplements because NAD+ levels begin to decline around this time.
Some animal studies have also shown that MNM supplements can improve cognitive functions, and help people with insulin sensitivity, fatigue, and depression, and inflammation.
How long does it take to see results?
Each supplement is different, but most brands suggest users start looking for short-term results around one week, and longer-term results after three months.
The popular Wonderfeel brand says you may notice more energy after one to three weeks, but more profound changes should happen around three to four months.
Are there natural sources of NMN?
According to the National Library of Medicine, traces of NMN are found in a variety of foods, including:
- avocados — 0.36 to 1.60 mg per 100 grams
- broccoli — 0.25 to 1.12 mg per 100 grams
- cabbage — up to 0.9 mg per 100 grams
- tomatoes — 0.26 to 0.30 mg per 100 grams
- raw beef — 0.06 to 0.42 mg per 100 grams
More FAQs with Dr. Halim
What is an NMN anti-aging supplement and how do they work?
“NMN is Nicotinamide Mononucleotide, which is the molecule that is involved in the production of nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells which is essential for various biological processes, including energy metabolism, DNA repair, and cell signaling,” shared Dr. Halim.
Are NMN supplements the best for anti-aging?
NMN has gained attention for its potential anti-aging properties especially as we do know that with the aging process, our levels of NAD+ decline thereby leading to various health issues.
“Research Studies in animals suggest that NMN supplementation can improve metabolic health, enhance physical endurance, and protect against age-related decline,” noted Dr. Halim.
She has added that human studies are still in their early stages, but results are promising for improving health and longevity.
“Current research indicates that NMN is generally well-tolerated in humans, but long-term safety data is limited,” she said. “Whenever starting any new supplement it is always best to consult a healthcare provider for proper management and safety.”`
Will NMN supplements make you look younger?
“Although NMN shows promise in the field of aging and health, we definitely need more research to fully understand its effects and optimal usage in humans as well as safety profile and optimal method of supplementation,” said Dr. Halim.
She has added that Optimal NAD+ levels help with DNA repair, improve Cellular Signaling, help regulate Circadian Rhythm for the sleep cycle, support Protein Synthesis, and strengthen the Immune System.
What is the difference between NMN and NR supplements?
Nicotinamide Mononucleotide (NMN) and Niagen (NR) are very similar in a structural comparison. The main difference is that NMN includes a phosphate group which makes this precursor larger than NR.
Studies have shown that NMN can improve cardiac function, while NR can improve mitochondrial function in muscle, liver, and brown adipose tissue.
Dr. Halim has pointed out that some people may choose to supplement NMN with HR for further health benefits: “Supplementation with its precursor NR shows great benefits, hence some combine both NMN and NR.”
What should you look for when choosing an NMN supplement?
Dr. Halim has suggested looking for NMN derived from natural sources, such as fermentation or plant extracts, rather than synthetic NMN.
“Avoid unnecessary additives, fillers, or other ingredients that may not be necessary or beneficial,” she added. “Always research the manufacturer and source of the NMN supplement to ensure its high quality and purity. Look for NMN supplements that have been third-party tested for purity, potency, and quality.”
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