-
Acute nicotine activates orectic and inhibits anorectic brain regions in rats exposed to chronic nicotine. Neuropharmacology. 2024 Aug 01; 253:109959.
Shankar K, Bonnet-Zahedi S, Milan K, D'argence AR, Sneddon E, Qiao R, Chonwattangul S, Carrette LLG, Kallupi M, George O. PMID: 38648925.
View in:
PubMed Mentions: Fields:
Translation:
AnimalsCells
-
High quality, high throughput, and low-cost simultaneous video recording of 60 animals in operant chambers using PiRATeMC. bioRxiv. 2023 Dec 04.
Ramborger J, Kalra S, Smith ACW, George O. PMID: 38014265; PMCID: PMC10680677.
View in:
PubMed Mentions:
-
Acute nicotine intake increases feeding behavior through decreasing glucagon signaling in dependent male and female rats. Horm Behav. 2024 Mar; 159:105447.
Shankar K, Ramborger J, Bonnet-Zahedi S, Carrette LLG, George O. PMID: 37926623.
View in:
PubMed Mentions: Fields:
Translation:
Animals
-
Author Correction: Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. Nat Neurosci. 2023 Nov; 26(11):2035.
Zhou JL, de Guglielmo G, Ho AJ, Kallupi M, Pokhrel N, Li HR, Chitre AS, Munro D, Mohammadi P, Carrette LLG, George O, Palmer AA, McVicker G, Telese F. PMID: 37845545; PMCID: PMC10620070.
View in:
PubMed Mentions: Fields:
-
Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. Nat Neurosci. 2023 Nov; 26(11):1868-1879.
Zhou JL, de Guglielmo G, Ho AJ, Kallupi M, Pokhrel N, Li HR, Chitre AS, Munro D, Mohammadi P, Carrette LLG, George O, Palmer AA, McVicker G, Telese F. PMID: 37798411; PMCID: PMC10620093.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
-
Hyperconnectivity of Two Separate Long-Range Cholinergic Systems Contributes to the Reorganization of the Brain Functional Connectivity during Nicotine Withdrawal in Male Mice. eNeuro. 2023 06; 10(6).
Carrette LLG, Kimbrough A, Davoudian PA, Kwan AC, Collazo A, George O. PMID: 37295945; PMCID: PMC10306126.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Strain and sex-related behavioral variability of oxycodone dependence in rats. Neuropharmacology. 2023 10 01; 237:109635.
Doyle MR, Martinez AR, Qiao R, Dirik S, Di Ottavio F, Pascasio G, Martin-Fardon R, Benner C, George O, Telese F, de Guglielmo G. PMID: 37327971; PMCID: PMC10353778.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
An Ensemble Learning Approach to Improving Prediction of Case Duration for Spine Surgery: Algorithm Development and Validation. JMIR Perioper Med. 2023 Jan 26; 6:e39650.
Gabriel RA, Harjai B, Simpson S, Du AL, Tully JL, George O, Waterman R. PMID: 36701181; PMCID: PMC9912154.
View in:
PubMed Mentions:
6
-
Voluntary and forced exposure to ethanol vapor produces similar escalation of alcohol drinking but differential recruitment of brain regions related to stress, habit, and reward in male rats. Neuropharmacology. 2023 01 01; 222:109309.
de Guglielmo G, Simpson S, Kimbrough A, Conlisk D, Baker R, Cantor M, Kallupi M, George O. PMID: 36334765; PMCID: PMC10022477.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Are we compulsively chasing rainbows? Neuropsychopharmacology. 2022 Nov; 47(12):2013-2015.
George O, Ahmed SH, Gilpin NW. PMID: 35982236; PMCID: PMC9556748.
View in:
PubMed Mentions:
10 Fields:
-
Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats. Addict Neurosci. 2022 Sep; 3.
Aldridge GM, Zarin TA, Brandner AJ, George O, Gilpin NW, Repunte-Canonigo V, Sanna PP, Koob GF, Vendruscolo LF, Schmeichel BE. PMID: 35965958; PMCID: PMC9365098.
View in:
PubMed Mentions:
3
-
Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction. Front Neurosci. 2022; 16:858427.
Duttke SH, Montilla-Perez P, Chang MW, Li H, Chen H, Carrette LLG, de Guglielmo G, George O, Palmer AA, Benner C, Telese F. PMID: 35651629; PMCID: PMC9149415.
View in:
PubMed Mentions:
6
-
Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats. Front Behav Neurosci. 2022; 16:832899.
Carrette LLG, Corral C, Boomhower B, Brennan M, Crook C, Ortez C, Shankar K, Simpson S, Maturin L, Solberg Woods LC, Palmer AA, de Guglielmo G, George O. PMID: 35316955; PMCID: PMC8934439.
View in:
PubMed Mentions:
3
-
Microstructural meal pattern analysis reveals a paradoxical acute increase in food intake after nicotine despite its long-term anorexigenic effects. Psychopharmacology (Berl). 2022 Mar; 239(3):807-818.
Shankar K, Ambroggi F, George O. PMID: 35129671; PMCID: PMC8891107.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-non-dependent D1R-mediated motivational state to a nicotine-dependent-like D2R-mediated motivational state. Eur J Neurosci. 2022 02; 55(3):714-724.
Grieder TE, Yee M, Vargas-Perez H, Maal-Bared G, George S, Ting-A-Kee R, George O, van der Kooy D. PMID: 34963197.
View in:
PubMed Mentions:
2 Translation:
Animals
-
FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION. Neurosci Biobehav Rev. 2022 01; 132:730-756.
Bowen MT, George O, Muskiewicz DE, Hall FS. PMID: 34839930; PMCID: PMC8892842.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Characterization of the Brain Functional Architecture of Psychostimulant Withdrawal Using Single-Cell Whole-Brain Imaging. eNeuro. 2021 Nov-Dec; 8(6).
Kimbrough A, Kallupi M, Smith LC, Simpson S, Collazo A, George O. PMID: 34580158; PMCID: PMC8570684.
View in:
PubMed Mentions:
16 Fields:
Translation:
Animals
-
Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats. Brain Stimul. 2022 Jan-Feb; 15(1):13-22.
Kallupi M, Kononoff J, Melas PA, Qvist JS, de Guglielmo G, Kandel ER, George O. PMID: 34742997; PMCID: PMC8816878.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Drugs and Bugs: The Gut-Brain Axis and Substance Use Disorders. J Neuroimmune Pharmacol. 2022 06; 17(1-2):33-61.
Simpson S, Mclellan R, Wellmeyer E, Matalon F, George O. PMID: 34694571; PMCID: PMC9074906.
View in:
PubMed Mentions:
14 Fields:
Translation:
Humans
-
How nicotine withdrawal symptoms fight each other: interpeduncular GABA neuron activity dynamically controls negative affect vs. coping behavior. Neuropsychopharmacology. 2022 02; 47(3):617-618.
Avelar AJ, George O. PMID: 34593977; PMCID: PMC8783007.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
Individual differences in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock rats. Psychopharmacology (Berl). 2021 Dec; 238(12):3423-3433.
Sedighim S, Carrette LL, Venniro M, Shaham Y, de Guglielmo G, George O. PMID: 34415376; PMCID: PMC8889911.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction. eNeuro. 2021 May-Jun; 8(3).
Carrette LLG, de Guglielmo G, Kallupi M, Maturin L, Brennan M, Boomhower B, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Velarde N, Martinez AR, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Ramirez FJ, Chitre AS, Lin B, Polesskaya O, Solberg Woods LC, Palmer AA, George O. PMID: 33875455; PMCID: PMC8213442.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
Cannabidiol reduces withdrawal symptoms in nicotine-dependent rats. Psychopharmacology (Berl). 2021 Aug; 238(8):2201-2211.
Smith LC, Tieu L, Suhandynata RT, Boomhower B, Hoffman M, Sepulveda Y, Carrette LLG, Momper JD, Fitzgerald RL, Hanham K, Dowling J, Kallupi M, George O. PMID: 33909102; PMCID: PMC8295227.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
The Hidden Brain: Uncovering Previously Overlooked Brain Regions by Employing Novel Preclinical Unbiased Network Approaches. Front Syst Neurosci. 2021; 15:595507.
Simpson S, Chen Y, Wellmeyer E, Smith LC, Aragon Montes B, George O, Kimbrough A. PMID: 33967705; PMCID: PMC8097000.
View in:
PubMed Mentions:
6
-
Glucocorticoid receptor modulators decrease alcohol self-administration in male rats. Neuropharmacology. 2021 05 01; 188:108510.
McGinn MA, Tunstall BJ, Schlosburg JE, Gregory-Flores A, George O, de Guglielmo G, Mason BJ, Hunt HJ, Koob GF, Vendruscolo LF. PMID: 33647278; PMCID: PMC8099171.
View in:
PubMed Mentions:
13 Fields:
Translation:
Animals
-
Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models. Neuropharmacology. 2020 11 01; 178:108225.
Smith LC, George O. PMID: 32758566; PMCID: PMC8344403.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
-
Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use. Neuropsychopharmacology. 2020 10; 45(11):1909-1919.
Smith LC, Kallupi M, Tieu L, Shankar K, Jaquish A, Barr J, Su Y, Velarde N, Sedighim S, Carrette LLG, Klodnicki M, Sun X, de Guglielmo G, George O. PMID: 32544927; PMCID: PMC7608444.
View in:
PubMed Mentions:
24 Fields:
Translation:
Animals
-
Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal. eNeuro. 2020 May/Jun; 7(3).
Simpson S, Kimbrough A, Boomhower B, McLellan R, Hughes M, Shankar K, de Guglielmo G, George O. PMID: 32341122; PMCID: PMC7242819.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
-
Role of corticotropin-releasing factor in alcohol and nicotine addiction. Brain Res. 2020 08 01; 1740:146850.
Simpson S, Shankar K, Kimbrough A, George O. PMID: 32330519; PMCID: PMC7869920.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
-
Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats. Psychopharmacology (Berl). 2020 May; 237(5):1545-1555.
Kimbrough A, Kononoff J, Simpson S, Kallupi M, Sedighim S, Palomino K, Conlisk D, Momper JD, de Guglielmo G, George O. PMID: 32114633; PMCID: PMC7269712.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior. Pharmacol Biochem Behav. 2020 04; 191:172880.
Lee CH, George O, Kimbrough A. PMID: 32105663; PMCID: PMC7269711.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Brain-wide functional architecture remodeling by alcohol dependence and abstinence. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2149-2159.
Kimbrough A, Lurie DJ, Collazo A, Kreifeldt M, Sidhu H, Macedo GC, D'Esposito M, Contet C, George O. PMID: 31937658; PMCID: PMC6994986.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimals
-
Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. Front Behav Neurosci. 2019; 13:292.
de Guglielmo G, Kallupi M, Sedighim S, Newman AH, George O. PMID: 31992976; PMCID: PMC6971096.
View in:
PubMed Mentions:
16
-
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
-
Increases in compulsivity, inflammation, and neural injury in HIV transgenic rats with escalated methamphetamine self-administration under extended-access conditions. Brain Res. 2020 01 01; 1726:146502.
de Guglielmo G, Fu Y, Chen J, Larrosa E, Hoang I, Kawamura T, Lorrai I, Zorman B, Bryant J, George O, Sumazin P, Lefebvre C, Repunte-Canonigo V, Sanna PP. PMID: 31605699; PMCID: PMC7195807.
View in:
PubMed Mentions:
14 Fields:
Translation:
Animals
-
Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology. 2020 03; 45(4):579-588.
Spierling S, de Guglielmo G, Kirson D, Kreisler A, Roberto M, George O, Zorrilla EP. PMID: 31593982; PMCID: PMC7021713.
View in:
PubMed Mentions:
20 Fields:
Translation:
Animals
-
Systemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats. Alcohol Clin Exp Res. 2019 10; 43(10):2079-2089.
Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C. PMID: 31403700; PMCID: PMC6779498.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Exposure to passive nicotine vapor in male adolescent rats produces a withdrawal-like state and facilitates nicotine self-administration during adulthood. Eur Neuropsychopharmacol. 2019 11; 29(11):1227-1234.
Kallupi M, de Guglielmo G, Larrosa E, George O. PMID: 31462388; PMCID: PMC7899081.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 03 18; 10(1):1238.
de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. PMID: 30886240; PMCID: PMC6423296.
View in:
PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
-
An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. Sci Adv. 2018 10; 4(10):eaat4751.
Kallupi M, Xue S, Zhou B, Janda KD, George O. PMID: 30345354; PMCID: PMC6192681.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep. 2018 09 17; 8(1):13893.
Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O. PMID: 30224774; PMCID: PMC6141462.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
-
Negative Reinforcement Mechanisms in Addiction. 2018.
Olivier George. . View Publication.
-
Voluntary urination control by brainstem neurons that relax the urethral sphincter. Nat Neurosci. 2018 09; 21(9):1229-1238.
Keller JA, Chen J, Simpson S, Wang EH, Lilascharoen V, George O, Lim BK, Stowers L. PMID: 30104734; PMCID: PMC6119086.
View in:
PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
-
Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. eNeuro. 2018 May-Jun; 5(3).
Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. PMID: 29971251; PMCID: PMC6027959.
View in:
PubMed Mentions:
22 Fields:
Translation:
Animals
-
Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. Mol Psychiatry. 2018 12; 23(12):2266-2276.
Pelloux Y, Degoulet M, Tiran-Cappello A, Cohen C, Lardeux S, George O, Koob GF, Ahmed SH, Baunez C. PMID: 29880881; PMCID: PMC8276917.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. Pharmacol Biochem Behav. 2018 04; 167:36-41.
de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O. PMID: 29505808; PMCID: PMC5866249.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
An enzymatic advance in nicotine cessation therapy. Chem Commun (Camb). 2018 Feb 13; 54(14):1686-1689.
Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD. PMID: 29308799; PMCID: PMC6231713.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology (Berl). 2018 04; 235(4):1131-1140.
Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF. PMID: 29354872; PMCID: PMC8162771.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biol Psychiatry. 2018 06 15; 83(12):1024-1035.
Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR. PMID: 29357981; PMCID: PMC5960600.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence. Neuropsychopharmacology. 2018 04; 43(5):1010-1020.
Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R. PMID: 29052613; PMCID: PMC5854806.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res. 2017 Nov; 41(11):1886-1895.
Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O. PMID: 28833238; PMCID: PMC5659873.
View in:
PubMed Mentions:
29 Fields:
Translation:
Animals
-
Individual differences in the neuropsychopathology of addiction. Dialogues Clin Neurosci. 2017 09; 19(3):217-229.
George O, Koob GF. PMID: 29302219; PMCID: PMC5741105.
View in:
PubMed Mentions:
51 Fields:
Translation:
Humans
-
Compulsive-Like Sufentanil Vapor Self-Administration in Rats. Neuropsychopharmacology. 2018 03; 43(4):801-809.
Vendruscolo JCM, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater SA, Taffe MA, Koob GF, Vendruscolo LF. PMID: 28812595; PMCID: PMC5809787.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
-
Intermittent Access to Ethanol Drinking Facilitates the Transition to Excessive Drinking After Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res. 2017 Aug; 41(8):1502-1509.
Kimbrough A, Kim S, Cole M, Brennan M, George O. PMID: 28679148; PMCID: PMC5531063.
View in:
PubMed Mentions:
29 Fields:
Translation:
Animals
-
Nicotine Vapor Method to Induce Nicotine Dependence in Rodents. Curr Protoc Neurosci. 2017 Jul 05; 80:8.41.1-8.41.10.
Kallupi M, George O. PMID: 28678400; PMCID: PMC5572764.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats. J Pharmacol Exp Ther. 2017 09; 362(3):378-384.
de Guglielmo G, Matzeu A, Kononoff J, Mattioni J, Martin-Fardon R, George O. PMID: 28645915; PMCID: PMC5539589.
View in:
PubMed Mentions:
23 Fields:
Translation:
Animals
-
Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism. Eur J Neurosci. 2017 Jul; 46(1):1673-1681.
Grieder TE, George O, Yee M, Bergamini MA, Chwalek M, Maal-Bared G, Vargas-Perez H, van der Kooy D. PMID: 28498560; PMCID: PMC8162765.
View in:
PubMed Mentions:
6 Translation:
Animals
-
Cortical and amygdalar neuronal ensembles in alcohol seeking, drinking and withdrawal. Neuropharmacology. 2017 Aug 01; 122:107-114.
George O, Hope BT. PMID: 28435008; PMCID: PMC5512851.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. J Neurosci. 2017 04 26; 37(17):4593-4603.
Varodayan FP, de Guglielmo G, Logrip ML, George O, Roberto M. PMID: 28363981; PMCID: PMC5413190.
View in:
PubMed Mentions:
29 Fields:
Translation:
Animals
-
Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration. Psychopharmacology (Berl). 2017 Jul; 234(13):2009-2018.
de Guglielmo G, Kallupi M, Cole MD, George O. PMID: 28342089; PMCID: PMC5658208.
View in:
PubMed Mentions:
21 Fields:
Translation:
Animals
-
Negative Affective States and Cognitive Impairments in Nicotine Dependence. Overview of Nicotine Withdrawal and Negative Reinforcement (Preclinical). 2017.
Olivier George and G.F. Koob. . View Publication.
-
Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. J Neurosci. 2017 02 01; 37(5):1139-1155.
Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE. PMID: 27986929; PMCID: PMC5296793.
View in:
PubMed Mentions:
48 Fields:
Translation:
Animals
-
High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology. 2017 Aug; 42(9):1850-1859.
Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. PMID: 27917870; PMCID: PMC5520777.
View in:
PubMed Mentions:
19 Fields:
Translation:
Animals
-
Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. J Neurosci. 2016 09 07; 36(36):9446-53.
de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. PMID: 27605618; PMCID: PMC5013191.
View in:
PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
-
A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci. 2015; 9:487.
Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO. PMID: 26733798; PMCID: PMC4689854.
View in:
PubMed Mentions:
72
-
Corrigendum: Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Jul 02; 6:7625.
Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. PMID: 26133887.
View in:
PubMed Mentions:
2 Fields:
-
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. J Clin Invest. 2015 Aug 03; 125(8):3193-7.
Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. PMID: 26121746; PMCID: PMC4563748.
View in:
PubMed Mentions:
119 Fields:
Translation:
HumansAnimals
-
Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Apr 21; 6:6770.
Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. PMID: 25898242; PMCID: PMC4405813.
View in:
PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
-
Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. J Neurosci. 2015 Apr 15; 35(15):6241-53.
Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. PMID: 25878294; PMCID: PMC4397613.
View in:
PubMed Mentions:
42 Fields:
Translation:
Animals
-
κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci. 2015 Mar 11; 35(10):4296-305.
Whitfield TW, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. PMID: 25762676; PMCID: PMC4355200.
View in:
PubMed Mentions:
44 Fields:
Translation:
Animals
-
VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nat Neurosci. 2014 Dec; 17(12):1751-8.
Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. PMID: 25402857; PMCID: PMC4241147.
View in:
PubMed Mentions:
75 Fields:
Translation:
HumansAnimalsCells
-
Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology (Berl). 2015 Jan; 232(2):453-63.
Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. PMID: 25059540; PMCID: PMC4297709.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
-
Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Mol Neurodegener. 2014 Jul 01; 9:26.
Repunte-Canonigo V, Lefebvre C, George O, Kawamura T, Morales M, Koob GF, Califano A, Masliah E, Sanna PP. PMID: 24980976; PMCID: PMC4107468.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
-
Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. Psychopharmacology (Berl). 2014 Oct; 231(19):3911-7.
George O, Koob GF, Vendruscolo LF. PMID: 24923982; PMCID: PMC8278497.
View in:
PubMed Mentions:
38 Fields:
Translation:
Humans
-
Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behav Brain Res. 2014 Sep 01; 271:171-6.
Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. PMID: 24914463; PMCID: PMC4216724.
View in:
PubMed Mentions:
18 Fields:
Translation:
Animals
-
Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PLoS One. 2014; 9(5):e97216.
Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. PMID: 24816773; PMCID: PMC4016270.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. J Neurosci. 2013 Dec 04; 33(49):19384-92.
Schlosburg JE, Whitfield TW, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF. PMID: 24305833; PMCID: PMC3850049.
View in:
PubMed Mentions:
69 Fields:
Translation:
Animals
-
Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology (Berl). 2014 Mar; 231(5):929-37.
Buck CL, Vendruscolo LF, Koob GF, George O. PMID: 24221826; PMCID: PMC3945412.
View in:
PubMed Mentions:
18 Fields:
Translation:
Animals
-
Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addict Biol. 2015 Jan; 20(1):56-68.
Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. PMID: 23869743; PMCID: PMC3859819.
View in:
PubMed Mentions:
45 Fields:
Translation:
Animals
-
Addiction as a stress surfeit disorder. Neuropharmacology. 2014 Jan; 76 Pt B:370-82.
Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW, George O. PMID: 23747571; PMCID: PMC3830720.
View in:
PubMed Mentions:
223 Fields:
Translation:
HumansAnimals
-
Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking. Front Psychiatry. 2013; 4:41.
Cohen A, George O. PMID: 23761766; PMCID: PMC3671664.
View in:
PubMed Mentions:
27
-
Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addict Biol. 2014 Sep; 19(5):755-7.
Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. PMID: 23639035; PMCID: PMC3872251.
View in:
PubMed Mentions:
21 Fields:
Translation:
Animals
-
Control of craving by the prefrontal cortex. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4165-6.
George O, Koob GF. PMID: 23483010; PMCID: PMC3600441.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
-
Hippocampal neurogenesis protects against cocaine-primed relapse. Addict Biol. 2014 Jul; 19(4):562-74.
Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. PMID: 23278919; PMCID: PMC3620729.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Nicotine vapor inhalation escalates nicotine self-administration. Addict Biol. 2014 Jul; 19(4):587-92.
Gilpin NW, Whitaker AM, Baynes B, Abdel AY, Weil MT, George O. PMID: 23240929; PMCID: PMC4516274.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
-
Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18156-61.
George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. PMID: 23071333; PMCID: PMC3497825.
View in:
PubMed Mentions:
131 Fields:
Translation:
Animals
-
Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology. 2012 Aug; 37(9):2153-60.
Cohen A, Koob GF, George O. PMID: 22549121; PMCID: PMC3398720.
View in:
PubMed Mentions:
50 Fields:
Translation:
Animals
-
Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice. Psychopharmacology (Berl). 2012 Sep; 223(2):159-68.
Tobey KM, Walentiny DM, Wiley JL, Carroll FI, Damaj MI, Azar MR, Koob GF, George O, Harris LS, Vann RE. PMID: 22526534; PMCID: PMC3464481.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology (Berl). 2012 Sep; 223(1):17-25.
Goeders NE, Cohen A, Fox BS, Azar MR, George O, Koob GF. PMID: 22418732; PMCID: PMC3464482.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3101-6.
Grieder TE, George O, Tan H, George SR, Le Foll B, Laviolette SR, van der Kooy D. PMID: 22308372; PMCID: PMC3286981.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
-
Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology. 2012 Apr; 37(5):1275-87.
Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. PMID: 22205547; PMCID: PMC3306889.
View in:
PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
-
Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiol Behav. 2012 Apr 12; 106(1):58-64.
George O, Le Moal M, Koob GF. PMID: 22108506; PMCID: PMC3288230.
View in:
PubMed Mentions:
77 Fields:
Translation:
HumansAnimals
-
Craving, context and the cortex. Nat Neurosci. 2011 Apr; 14(4):409-10.
George O, Koob GF. PMID: 21445066; PMCID: PMC3829767.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsPHPublic Health
-
Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology (Berl). 2011 Feb; 213(4):715-22.
George O, Lloyd A, Carroll FI, Damaj MI, Koob GF. PMID: 20924754; PMCID: PMC3033995.
View in:
PubMed Mentions:
42 Fields:
Translation:
Animals
-
Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev. 2010 Nov; 35(2):232-47.
George O, Koob GF. PMID: 20493211; PMCID: PMC2955797.
View in:
PubMed Mentions:
144 Fields:
Translation:
HumansAnimals
-
Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats. Biol Psychiatry. 2010 Nov 15; 68(10):956-63.
George O, Vallée M, Vitiello S, Le Moal M, Piazza PV, Mayo W. PMID: 20471631; PMCID: PMC2936666.
View in:
PubMed Mentions:
11 Fields:
Translation:
Animals
-
Exposure to chronic intermittent nicotine vapor induces nicotine dependence. Pharmacol Biochem Behav. 2010 Jul; 96(1):104-7.
George O, Grieder TE, Cole M, Koob GF. PMID: 20420848; PMCID: PMC2878929.
View in:
PubMed Mentions:
31 Fields:
Translation:
Animals
-
A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. J Neurosci. 2009 Apr 15; 29(15):4846-57.
Orio L, Edwards S, George O, Parsons LH, Koob GF. PMID: 19369553; PMCID: PMC2688678.
View in:
PubMed Mentions:
50 Fields:
Translation:
Animals
-
Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology. 2008 Sep; 33(10):2474-82.
George O, Mandyam CD, Wee S, Koob GF. PMID: 18033234; PMCID: PMC2760333.
View in:
PubMed Mentions:
92 Fields:
Translation:
AnimalsCells
-
CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17198-203.
George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. PMID: 17921249; PMCID: PMC2040467.
View in:
PubMed Mentions:
151 Fields:
Translation:
Animals
-
Motherhood-induced memory improvement persists across lifespan in rats but is abolished by a gestational stress. Eur J Neurosci. 2006 Jun; 23(12):3368-74.
Lemaire V, Billard JM, Dutar P, George O, Piazza PV, Epelbaum J, Le Moal M, Mayo W. PMID: 16820026.
View in:
PubMed Mentions:
34 Translation:
HumansAnimals
-
Chronic exposure of rats to noise: relationship between long-term memory deficits and slow wave sleep disturbances. Behav Brain Res. 2006 Aug 10; 171(2):303-12.
Rabat A, Bouyer JJ, George O, Le Moal M, Mayo W. PMID: 16716416.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsPHPublic Health
-
Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes. Psychopharmacology (Berl). 2006 Jun; 186(3):402-13.
George O, Vallée M, Le Moal M, Mayo W. PMID: 16416333.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
-
Smad-dependent alterations of PPT cholinergic neurons as a pathophysiological mechanism of age-related sleep-dependent memory impairments. Neurobiol Aging. 2006 Dec; 27(12):1848-58.
George O, Parducz A, Dupret D, Kharouby M, Le Moal M, Piazza PV, Mayo W. PMID: 16316709.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
New insights into the role of neuroactive steroids in cognitive aging. Exp Gerontol. 2004 Nov-Dec; 39(11-12):1695-704.
Vallée M, George O, Vitiello S, Le Moal M, Mayo W. PMID: 15582285.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
Sleep-wake states and cortical synchronization control by pregnenolone sulfate into the pedunculopontine nucleus. J Neurosci Res. 2004 Jun 01; 76(5):742-7.
Darbra S, George O, Bouyer JJ, Piazza PV, Le Moal M, Mayo W. PMID: 15139033.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
Individual differences in cognitive aging: implication of pregnenolone sulfate. Prog Neurobiol. 2003 Sep; 71(1):43-8.
Mayo W, George O, Darbra S, Bouyer JJ, Vallée M, Darnaudéry M, Pallarès M, Lemaire-Mayo V, Le Moal M, Piazza PV, Abrous N. PMID: 14611866.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimals