Estimulação Vagal e Depressão
Estimulação Vagal e Depressão
INTRODUÇÃO
OBJETIVO
DÚVIDA CLÍNICA
PERGUNTA ESTRUTURADA
PUBMED-MEDLINE
Busca 1: (Vagus nerve stimulation OR (Vagus Nerve AND Electric Stimulation Therapy)
OR (Vagus Nerve AND Electric Stimulation)) AND Random*
Busca 2: (Epilepsy OR depressive disorder OR depression OR seizure OR Lennox-
Gastaut syndrome OR epileptogenic disorder OR pain OR Bipolar Disorder OR Epilepsies,
Partial OR Seizures OR Epilepsy, Complex Partial) AND (Vagus nerve stimulation OR
(Vagus Nerve AND Electric Stimulation Therapy) OR (Vagus Nerve AND Electric
Stimulation)) AND Random*
Busca 3: (epilepsy OR depressive disorder OR depression OR seizure OR lennox-gastaut
syndrome OR epileptogenic disorder OR pain OR bipolar disorder OR epilepsies, partial
OR seizures OR epilepsy, complex partial) AND (vagus nerve stimulation OR (vagus nerve
AND electric stimulation therapy) OR (vagus nerve AND electric stimulation)) AND
(Therapy/broad[filter] OR Comparative study OR Comparative studies)
2013
EMBASE/ COCHRANE
(Epilepsy OR depressive disorder OR depression) AND (Vagus nerve stimulation)
TRABALHOS RECUPERADOS
Paciente
Pacientes com epilepsia ou depressão
Intervenção
Estimulação do Nervo Vago
Comparação
Simulação de estimulação do Nervo Vago ou tratamento clínico
“Outcome” (Desfecho)
Desfechos clínicos
Segundo o idioma
2013
Segundo a publicação
RESULTADOS
QUESTÃO CLÍNICA 1
Pacientes com epilepsia podem se beneficiar da estimulação do nervo vago?
Ben-Menachem E, 199416
Outros efeitos adversos são relatados tais como dor abdominal, náusea,
restrição da respiração e dor no peito, e estão associados com a alta
intensidade do estímulo, porém sem diferença significativa 17(B).
2013
Handforth A, 19983
QUESTÃO CLÍNICA 2
Pacientes com depressão podem se beneficiar da estimulação do nervo vago?
2013
A estimulação vagal, com níveis de baixo, médio ou alto estímulo (Tabela 11),
pode ser utilizada em pacientes > 18 anos, com as seguintes características:
a) diagnóstico de Transtorno Depressivo Maior crônico ( > 2 anos) ou
recorrente (≥ 2 episódios prévios), ou Transtorno Bipolar, com diagnóstico
atual de Episódio Depressivo Maior, definido pelo DSM.IV, e determinado
2013
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