Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates

Mol Cell. 2022 Dec 15;82(24):4585-4587. doi: 10.1016/j.molcel.2022.11.013.

Abstract

Plaza-Jennings et al. applied single-nucleus RNA-seq, sorted neuronal and microglia cells for HiC, and found that chronic HIV infection in the brain induces interferon stimulation in microglia, drives chromatin reconfiguration into a transcriptionally active environment, and changes HIV integration landscape.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Chromatin / genetics
  • HIV Infections* / genetics
  • Humans
  • Inflammation / genetics
  • Interferons
  • Microglia

Substances

  • Chromatin
  • Interferons