User profiles for Bruce Hope
![]() | Bruce HopeSenior Investigator/PI, Chief of Neuronal Ensembles in Addiction Section, NIDA IRP, NIH Verified email at intra.nida.nih.gov Cited by 21496 |
Neuronal NADPH diaphorase is a nitric oxide synthase.
BT Hope, GJ Michael, KM Knigge… - Proceedings of the …, 1991 - National Acad Sciences
NADPH diaphorase histochemistry selectively labels a number of discrete populations of
neurons throughout the nervous system. This simple and robust technique has been used in a …
neurons throughout the nervous system. This simple and robust technique has been used in a …
Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin
In a rat model of context-induced relapse to heroin, we identified sparsely distributed ventral
medial prefrontal cortex (mPFC) neurons that were activated by the heroin-associated …
medial prefrontal cortex (mPFC) neurons that were activated by the heroin-associated …
Drug addiction: a model for the molecular basis of neural plasticity
EJ Nestler, BT Hope, KL Widnell - Neuron, 1993 - Elsevier
Although some aspects of drug addiction can occur relatively rapidly in response to acute
administration of a drug of abuse, most changes in brain function associated with addiction …
administration of a drug of abuse, most changes in brain function associated with addiction …
Central amygdala ERK signaling pathway is critical to incubation of cocaine craving
Using a rat model of craving and relapse, we have previously found time-dependent
increases in cue-induced cocaine seeking over the first months of withdrawal from cocaine, …
increases in cue-induced cocaine seeking over the first months of withdrawal from cocaine, …
Neurobiology of the incubation of drug craving
…, M Airavaara, F Theberge, S Fanous, BT Hope… - Trends in …, 2011 - cell.com
It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively
increases over the first several weeks of abstinence and remains high for extended periods. …
increases over the first several weeks of abstinence and remains high for extended periods. …
An examination of ecological risk assessment and management practices
BK Hope - Environment International, 2006 - Elsevier
Ecological risk assessment has grown and evolved since the 1980s, as have new challenges
(eg global climate change, loss of habitat and biodiversity and the effects of multiple …
(eg global climate change, loss of habitat and biodiversity and the effects of multiple …
Neurons that say NO
SR Vincent, BT Hope - Trends in neurosciences, 1992 - Elsevier
Thirty years ago, Thomas and Pearse discovered what they termed ‘solitary active cells’ —
neurons containing an unusually high nicotinamide adenine dinucleotide phosphate …
neurons containing an unusually high nicotinamide adenine dinucleotide phosphate …
Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments
Following chronic cocaine treatment, we have found a long-lasting increase in AP-1 binding
in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of …
in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of …
Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine.
Chronic treatment of rats with cocaine leads to long-term biochemical changes in the nucleus
accumbens (NAc), a brain region implicated in mediating the reinforcing effects of cocaine …
accumbens (NAc), a brain region implicated in mediating the reinforcing effects of cocaine …
Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization
…, D Farquhar, SC Ghosh, BJ Mattson, BT Hope - Nature …, 2009 - nature.com
Learned associations between effects of abused drugs and the drug administration environment
are important in drug addiction. Histochemical and electrophysiological studies suggest …
are important in drug addiction. Histochemical and electrophysiological studies suggest …