NADPH diaphorase histochemistry selectively labels a number of discrete populations of
neurons throughout the nervous system. This simple and robust technique has been used in a …

In a rat model of context-induced relapse to heroin, we identified sparsely distributed ventral
medial prefrontal cortex (mPFC) neurons that were activated by the heroin-associated …

Although some aspects of drug addiction can occur relatively rapidly in response to acute
administration of a drug of abuse, most changes in brain function associated with addiction …

Using a rat model of craving and relapse, we have previously found time-dependent
increases in cue-induced cocaine seeking over the first months of withdrawal from cocaine, …

It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively
increases over the first several weeks of abstinence and remains high for extended periods. …

Ecological risk assessment has grown and evolved since the 1980s, as have new challenges
(eg global climate change, loss of habitat and biodiversity and the effects of multiple …

Thirty years ago, Thomas and Pearse discovered what they termed ‘solitary active cells’ —
neurons containing an unusually high nicotinamide adenine dinucleotide phosphate …

Following chronic cocaine treatment, we have found a long-lasting increase in AP-1 binding
in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of …

Chronic treatment of rats with cocaine leads to long-term biochemical changes in the nucleus
accumbens (NAc), a brain region implicated in mediating the reinforcing effects of cocaine …

Learned associations between effects of abused drugs and the drug administration environment
are important in drug addiction. Histochemical and electrophysiological studies suggest …