Carbon fixation is the process by which CO2 is converted from a gas into biomass. The
Calvin–Benson–Bassham cycle (CBB) is the dominant carbon-consuming pathway on …

The nonenzymatic replication of RNA is a potential transitional stage between the prebiotic
chemistry of nucleotide synthesis and the canonical RNA world in which RNA enzymes …

Direct, amplification-free detection of RNA has the potential to transform molecular
diagnostics by enabling simple on-site analysis of human or environmental samples …

Rubisco is the primary carboxylase of the Calvin cycle, the most abundant enzyme in the
biosphere, and one of the best-characterized enzymes. On the basis of correlations between …

Achieving efficient nonenzymatic replication of RNA is an important step toward the
synthesis of self-replicating protocells that may mimic early forms of life. Despite recent …

The chemical replication of RNA inside fatty acid vesicles is a plausible step in the
emergence of cellular life. On the primitive Earth, simple protocells with the ability to import …

CO 2 is converted into biomass almost solely by the enzyme rubisco. The poor carboxylation
properties of plant rubiscos have led to efforts that made it the most kinetically characterized …

A requirement for concentrated and chemically homogeneous pools of molecular building
blocks would severely restrict plausible scenarios for the origin of life. In the case of …

Rapid nucleic acid testing is central to infectious disease surveillance. Here, we report an
assay for rapid COVID-19 testing and its implementation in a prototype microfluidic device …

Recent developments in protein design rely on large neural networks with up to 100s of
millions of parameters, yet it is unclear which residue dependencies are critical for …