Microbiota modulation of the gut-lung axis in COVID-19

GLV de Oliveira, CNS Oliveira, CF Pinzan… - Frontiers in …, 2021 - frontiersin.org
COVID-19 is an infectious disease caused by the Severe Acute Respiratory Syndrome
Coronavirus-2 (SARS-CoV-2), and according to the World Health Organization (WHO), to date, …

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

…, PA De Castro, RW Bastos, CF Pinzan… - Nature …, 2023 - nature.com
Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal drug
resistance, novel strategies are urgently needed to combat life-threatening fungal diseases…

Immunological Basis for the Gender Differences in Murine Paracoccidioides brasiliensis Infection

CF Pinzan, LP Ruas, AS Casabona-Fortunato… - PloS one, 2010 - journals.plos.org
This study aimed to investigate the immunological mechanisms involved in the gender
distinct incidence of paracoccidioidomycosis (pcm), an endemic systemic mycosis in Latin …

Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection

P Alves de Castro, C Figueiredo Pinzan… - Nature …, 2024 - nature.com
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …

Vaccination with recombinant microneme proteins confers protection against experimental toxoplasmosis in mice

CF Pinzan, A Sardinha-Silva, F Almeida, L Lai… - PloS one, 2015 - journals.plos.org
Toxoplasmosis, a zoonotic disease caused by Toxoplasma gondii, is an important public
health problem and veterinary concern. Although there is no vaccine for human toxoplasmosis, …

Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation

CF Pinzan, C Valero, PA de Castro, JL da Silva… - Nature …, 2024 - nature.com
Aspergillus fumigatus causes aspergillosis and relies on asexual spores (conidia) for initiating
host infection. There is scarce information about A. fumigatus proteins involved in fungal …

Brilacidin, a novel antifungal agent against Cryptococcus neoformans

C Diehl, CF Pinzan, PA de Castro, E Delbaje… - Mbio, 2024 - journals.asm.org
Invasive fungal infections have a high mortality rate causing more deaths annually than
tuberculosis or malaria. Cryptococcosis, one of the most prevalent fungal diseases, is generally …

The microbiota-dependent worsening effects of melatonin on gut inflammation

JL da Silva, LV Barbosa, CF Pinzan, V Nardini, IS Brigo… - Microorganisms, 2023 - mdpi.com
Dysbiosis and disturbances in gut homeostasis may result in dysregulated responses, which
are common in inflammatory bowel diseases (IBD). These conditions may be refractory to …

[HTML][HTML] Strain heterogeneity in a non-pathogenic Aspergillus fungus highlights factors associated with virulence

…, HA Raja, M Rangel-Grimaldo, CF Pinzan… - Communications …, 2024 - nature.com
Fungal pathogens exhibit extensive strain heterogeneity, including variation in virulence.
Whether closely related non-pathogenic species also exhibit strain heterogeneity remains …

Milteforan, a promising veterinary commercial product against feline sporotrichosis

LC García Carnero, CF Pinzan, C Diehl… - Microbiology …, 2024 - journals.asm.org
Sporotrichosis is an endemic disease in Latin America caused by different species of
Sporothrix. This fungus can infect domestic animals, mainly cats and eventually dogs, as well as …