Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis
Importance Blockade of small GTPase-RhoA signaling pathway is considered a candidate
translational strategy to improve functional outcome after spinal cord injury (SCI) in humans.
Pooling preclinical evidence by orthodox meta-analysis is confounded by missing data
(publication bias). Objective To conduct a systematic review and meta-analysis of RhoA/Rho-
associated coiled-coil containing protein kinase (ROCK) blocking approaches to (1) analyze
the impact of bias that may lead to inflated effect sizes and (2) determine the normalized …
translational strategy to improve functional outcome after spinal cord injury (SCI) in humans.
Pooling preclinical evidence by orthodox meta-analysis is confounded by missing data
(publication bias). Objective To conduct a systematic review and meta-analysis of RhoA/Rho-
associated coiled-coil containing protein kinase (ROCK) blocking approaches to (1) analyze
the impact of bias that may lead to inflated effect sizes and (2) determine the normalized …
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