Fibroblast growth factor 23 null mice (Fgf-23−/−) have a short lifespan and show numerous
biochemical and morphological features consistent with premature aging-like phenotypes, …

Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine
fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis. …

Normal mineral ion homeostasis is tightly controlled by numerous endocrine factors that
coordinately exert effects on intestine, kidney, and bone to maintain physiological balance. The …

Fibroblast growth factor-23 (FGF-23), a recently identified molecule that is mutated in patients
with autosomal dominant hypophosphatemic rickets (ADHR), appears to be involved in the …

Nutrients usually act in a coordinated manner in the body. Intestinal absorption and subsequent
metabolism of a particular nutrient, to a certain extent, is dependent on the availability of …

Connective tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic
process associated with both physiological responses, such as wound healing, and …

Fibroblast growth factor (FGF) 23 inhibits renal phosphate reabsorption by activating FGF
receptor (FGFR) 1c in a Klotho-dependent fashion. The phosphaturic activity of FGF23 is …

Cisplatin (cis-diamminedichloroplatinum(II)) is an effective chemotherapeutic agent, and is
successfully used in the treatment of a wide range of tumors. Despite its effectiveness as an …

Indian hedgehog (Ihh) is actively involved in endochondral bone formation. Although
expression of Ihh is mostly restricted to pre‐hypertrophic chondrocytes, the role of chondrocyte‐…

Connective tissue remodeling of the interstitium is an important feature of chronic lung
diseases encompassing interstitial inflammatory changes and subsequent pulmonary fibrosis. …