Multus

🎁 Multus celebrates 4 years! Our journey so far ⬇️ 🟦 In 2020, Multus was created to make media that scales. 👥 Kevin Pan, Réka Trón and Cai Linton started Multus because they saw the need for a more sustainable food system and the potential of cultivated meat to help make that vision a reality. 🌎 They also saw the potential for engineering biology to overcome the core challenges in this emerging sector - which are: 🔒 Existing media formulations are too expensive as an input to food production. 🔒 Developing new media formulations is slow and expensive. 🔒 Inefficient approaches to media optimisation. 🔒 The limited availability of suitable ingredients. ⚠️ These problems put cultivated meat companies at risk of stalling at lab scale. 🟦 Today, Multus provides solutions that address all of these core challenges: 🔑 Our technology platform screens thousands of formulations in parallel to make media development cheaper and faster. 🔑 We use machine learning tools to handle complex optimisation. 🔑 We develop novel ingredients that can reduce food waste while making cultivated meat affordable. 🎂 As we celebrate 4 years into our journey, we are encouraged to see how far the industry has come globally as it strives to make a more sustainable food system. 📖 Read about our most recent company milestone: https://lnkd.in/erZAXKhx #AlternativeProtein #CultivatedMeat #CellularAgriculture #SustainableFoodSystems 

What’s happened in cultivated meat in 2024? ❄️ January Aleph Farms received the world-first regulatory approval for cultivated beef. 🌨️ February Simple Planet secured $6 million in a funding round to develop its cultivated meat ingredients. Vow and ORF Genetics hosted Europe’s first official tasting of cultivated meat, showcasing Vow’s cultivated quail. 🌱 March Orbillion Bio (YC W21) raised funds to develop its predictive model for cultivated meat and scale products. Innocent Meat secured €3 million to develop a simplified solution for cultivated meat production. 🌦️ April Vow obtained regulatory approval to produce and sell the world's first cultivated quail product. Mosa Meat raised €40 million from multiple investors to further develop its cultivated meat. Meatable hosted the first officially approved tasting event for cultivated meat in the European Union. 🌼 May GOOD Meat announced the world's first retail sales of cultivated meat in Singapore. VITAL MEAT filed for regulatory approval to market its cultivated chicken in Singapore and the UK. ☀️ June Cellivate Technologies secured $3.3 million on a business reality TV show to advance its cultivated meat solutions. Ever After Foods raised $10 million to develop a highly cost-efficient bioreactor platform for cultivated meat. UPSIDE Foods held a free tasting event for cultivated chicken just before Florida’s ban. Bezos Centre for Sustainable Protein launched at Imperial College London with $30m funding. 🌱 August: The UK Research and Innovation Biotechnology and Biological Sciences Research Council and Innovate UK have invested £15 million in the new National Alternative Protein Innovation Centre (NAPIC). A huge congratulations to the companies mentioned for accelerating the transition towards a healthy and sustainable food system! So what’s next? ❗ With some clear successes, this year is the crunch point for cultivated meat companies to reach key R&D goals and showcase traction to their investors. Major barriers like the cost of growth media and its performance at scale still need to be overcome. 🟦 At Multus, we use AI to make optimising growth media easier, quicker and cheaper. 💶 This saves time and money in media development so that cultivated meat companies can scale more quickly. More on how we do this: https://www.multus.bio/ #CultivatedMeat #CellbasedMeat #Biotechnology #Biotech

Next month September 22-29th, Undaunted & Imperial Enterprise Lab from Imperial College London will be attending New York Climate Week! 🇺🇸 We will be there to get involved in all aspects of the conference, to make new connections and spread the word about the climate innovation activities and impact we and our start-up alumni are having. We will be showcasing 5 climatetech start-ups as part of the venture: Notpla – a London-based sustainable packaging startup that creates seaweed and plant-based alternatives to single-use plastics. Their technology has reached full industrialization, with millions of units sold across nine EU countries and the US. ToffeeX – is the leader in physics-driven generative design used by the world’s leading engineering organizations to accelerate their path to sustainability Team Repair – are on a mission to give all children the confidence to pursue a career in STEM whilst also tackling the e-waste crisis by teaching electronics repair Cyanoskin – is an innovative living paint designed to transform buildings into carbon dioxide-absorbing structures, reducing emissions and addressing urban pollution Multus – stands at the forefront of a transformative movement in food production. Dedicated to revolutionizing the way we nourish ourselves for a sustainable future, their primary objective is to make cultivated meat—an environmentally friendly choice—accessible to all.  Will you be in New York for Climate week? Or have a connection we or our start-ups should meet? If so, please reach out to us if so directly on LinkedIn or at [email protected]

⏰ We did a differentiation assay at 2 am on a Friday night… but how? ⬇️ 🥩 Understanding how cells develop and differentiate into their final cell type is a key process in creating cultivated meat. ❗However, stem cells grown in the lab are prone to differentiate spontaneously, losing their differentiation capability. 🧬 Ensuring cells maintain this ability is vital so they can be differentiated into certain cell types later when needed.  🧫 To overcome this, growth media must be developed that can preserve the ability of cells to differentiate into a broader set of cells. 🔬 Assessing the success and progress of this is traditionally a time-consuming and labour-intensive process that must be undertaken at exactly the right time. ⏰ The point in a cell’s growth cycle where an assay is needed can be reached at unpredictable times that are out of working hours. 🟦 At Multus, we demonstrated that the media fed to our cells enabled them to maintain their “stemness” and differentiation characteristics. 🕑 This took place at 2 am in the morning. ⬇️ We were able to perform this differentiation assay at the exact moment it needed to be done because we had:  🔹 Developed a detailed protocol 🔹 Automated the entire process After that, it was as simple as pushing a button! ⏩ If you want to work with us to automate your cultivated meat processes, reach out here: https://bit.ly/3PNtNM6 #CultivatedMeat #CellularAgriculture #SustainableFoodSystems #BioEngineering #Differentiation #Assay

🥩 Cultivated meat progresses to market in the UK: What this means for the sector ⬇️ 📰 News broke last month that Meatly cultivated chicken products have been approved by UK regulators. ℹ️ Read more here: https://lnkd.in/e_wJSdzz ⬇️ This is a significant step for the cultivated meat industry as it: ⚡ Places the UK at the forefront of food innovation 🤝 Signals the commitment of UK regulatory bodies to collaborate with innovative solution providers ⭐ Puts cultivated meat on the path to industrial-scale production for the first time in Europe 🌀 The next steps now will be cost reduction and increasing production on a commercial scale. ❗ However, the main input to making cultivated meat - the growth media - remains a critical challenge to enabling large-scale, affordable commercialisation. 🟦 At Multus, we use AI to make optimising growth media easier, quicker and cheaper. 💶 This saves time and money in media development so that cultivated meat companies can scale more quickly. ⏩ Reach out to learn more about our process: https://bit.ly/3PNtNM6 Congratulations to Meatly! Food Standards Agency, Department for Environment, Food and Rural Affairs, Animal and Plant Health Agency #CultivatedMeat #CellularAgriculture #SustainableFoodSystems #BioEngineering #ProteinEngineering 

⏰ We did a differentiation assay at 2 am on a Friday night… but how? ⬇️ 🥩 Understanding how cells develop and differentiate into their final cell type is a key process in creating cultivated meat. ❗However, stem cells grown in the lab are prone to differentiate spontaneously, losing their differentiation capability. 🧬 Ensuring cells maintain this ability is vital so they can be differentiated into certain cell types later when needed.  🧫 To overcome this, growth media must be developed that can preserve the ability of cells to differentiate into a broader set of cells. 🔬 Assessing the success and progress of this is traditionally a time-consuming and labour-intensive process that must be undertaken at exactly the right time. ⏰ The point in a cell’s growth cycle where an assay is needed can be reached at unpredictable times that are out of working hours. 🟦 At Multus, we demonstrated that the media fed to our cells enabled them to maintain their “stemness” and differentiation characteristics. 🕑 This took place at 2 am in the morning. ⬇️ We were able to perform this differentiation assay at the exact moment it needed to be done because we had:  🔹 Developed a detailed protocol 🔹 Automated the entire process After that, it was as simple as pushing a button! ⏩ If you want to work with us to automate your cultivated meat processes, reach out here: https://bit.ly/3PNtNM6 #CultivatedMeat #CellularAgriculture #SustainableFoodSystems #BioEngineering #Differentiation #Assay

🤖 4 ways AI can optimise bioreactor and food processing parameters for cultivated meat ⬇️ ⚡ Bioreactors are vital for producing a controlled environment for cell growth and differentiation. ⛔ However, for cultivated meat products to reach market, efficient bioprocess design and food processing steps both need optimisation. 📗 A new resource from New Harvest explores the potential that machine learning has to accelerate cultivated meat technology. ✅ The paper highlights 3 ways machine learning can improve the efficiency of bioprocessing and food processing: 1️⃣ Maintaining bioreactor homeostasis 🧪 Machine learning can unlock real-time quality assurance and process monitoring to allow for adjustments in culture conditions. 📈 This can help optimise yield, highlight potential contamination and reduce human errors. 2️⃣ Overcoming the challenges of structured products 🧩 Imposing organisation upon cells to create structured tissues can be aided by leveraging random forests, neural networks and gradient boosting. 🥩 Machine learning can help predict behaviour within bioreactor systems for harvesting of large intact tissues. 3️⃣ Real-time sensory prediction and control 👃 Machine learning models can be used to analyse and predict flavours and textures of cultivated meat. 🍽️ Reinforcement learning can also help effectively manage and adjust sensor readings to enhance compliance with food processing requirements. 🟦 At Multus, we leverage the power of AI and machine learning to ensure cultivated meat products can scale from lab to market effectively. 🔷 Work with us to enhance your development processes by reaching out to our team here: https://bit.ly/3PNtNM6  #CultivatedMeat #CellularAgriculture #SustainableFoodSystems #FoodInnovation #SustainableAgriculture #BioEngineering #AI #MachineLearning #BioEngineering 

Join Multus as Our New Lab Manager! 🧬🌿 Are you driven by making a lasting positive impact on people and the planet? Multus is seeking a tenacious and experienced Lab Manager to lead the safe and smooth operation of our R&D and production bio-laboratories. 🔬 About Multus : Our mission is to enable cultivated meat to be the sustainable and affordable choice, for everyone. We do that by developing growth media for cultivated meat production. We make it faster and cheaper to get media that scales, helping cultivated meat get from lab to market. 🧪 Position: As our Lab Manager, you will play a crucial role in managing and optimising our laboratory operations. You will lead a team of talented scientists, ensuring the highest standards of safety, efficiency, and productivity. Your contributions will be vital in advancing our research and development efforts and bringing new products to market. See the full job role description in the link below. Why Join Us? 💸 Highly Competitive salary 🏝️ 25 days' holiday + flexible bank holidays 🏥 Private health insurance 🏡 Pension plan 👐 Collaborative, dynamic and driven team If you are excited by this challenge, we want to hear from you! Let's make a difference together. Join Multus and drive the food system towards sustainability! #Biotechnology #LabManager #SustainableFood #CultivatedMeat #Innovation #JoinOurTeam #ClimateJobs #Startups #hiring

🤖 4 ways AI can optimise cell culture media design for cultivated meat ⤵️ 🔽 Existing cell culture media formulations are: ❗ Expensive,  ❗ Not designed for cultivated meat species,  ❗ Often include animal-derived ingredients. 📈 Media design for cultivated meat requires optimisations to address these limitations. However, this is a complex and resource-intensive process. 📔 A new resource from New Harvest explores the potential that machine learning has to accelerate cultivated meat technology. ⚡ The resource emphasises that machine learning is well suited to address the optimisation problem that culture media development presents. Four specific ways it can do this include: ⬇️ 1️⃣ Interpreting how cells respond to media conditions. 🔍 Machine learning-guided network analysis can assess changes to the inner state of cells when performing media design or other optimisations.  2️⃣ Predicting protein stability. 📊 To overcome differential folding between species, transformer-based models can be used to predict thermal protein stability. 3️⃣ Engineering proteins to optimise their stability. 🧫 Machine learning can be leveraged to improve stability in culture, reducing the amount of protein needed for cultivated meat production. 4️⃣ Provide protein structure alignment. 🦠 Proteins used in high concentrations may benefit from replacement with lower-cost alternatives. 🧬 Machine learning can help screen plants or microbes for sequence homology to proteins of interest. 🟦 At Multus, we use AI to make optimising growth media easier, quicker and cheaper. ⏩ Learn more here: https://lnkd.in/dmYJaPHv  #CultivatedMeat #CellularAgriculture #SustainableFoodSystems #FoodInnovation #SustainableAgriculture #BioEngineering #AI #MachineLearning #BioEngineering 

✴️ We were delighted to welcome the INNOVACC delegation from Catalonia to the White City Innovation District and show them around the Multus HQ. ⚡ Representatives from the Catalan cluster of meat and alternative protein sector joined us at Scale Space with other pioneering companies from the UK-cultivated meat ecosystem. 💬 The day featured insights from Linus Pardoe of The Good Food Institute and discussions about the technical challenges and opportunities for partnerships. 👤 Charlie Taylor, our Head of Business Development, gave a presentation on our iterative closed-loop media design process that makes development cheaper, faster and scalable. 🔬 Charlie and Soraya Padilla Lopategui also gave the Catalonia group a tour of our lab facilities, where we are advancing the affordable scale-up of cellular agriculture. ⏩ For more information on working with us, reach out here: https://bit.ly/3PNtNM6 🟧 A huge thank you to Catalonia Trade & Investment,  INNOVACC Clúster català de la carn i la proteïna alternativa and ACCIÓ  for organising this collaborative event. 🔸 The Catalan delegation included Katherine Gil, PhD, Massimo Castellari, Montse Jorba, ANTONIO CRUZ BAÑERES, Esteve Espuña, Marta Xargayo, Xavier Rúbies Feijóo, Simone Salza, Jaume Planella, Guillem Alvarez, Encarni Avilés, Júlia Strubell i Prats, Saskia van Brakel, Oscar Martí, Marta Plana and Marta Pujolar. ⭐ It was great to see such a strong representation of the UK-cultivated meat ecosystem with people from groundbreaking companies such as Tom Phillips of Roslin Technologies, Nico Hutton of Extracellular, Annie Conde of Hoxton Farms, Artun Sukan of Uncommon and Helder Cruz of Meatly. #CultivatedMeat #CellularAgriculture #SustainableFoodSystems #BioEngineering #ProteinEngineering