University College London Hospitals NHS Foundation Trust

A research team involving UCLH clinicians have found a way to reduce the side effects of treatment for a disorder of the #adrenal glands. In the research trial, published in the NEJM Group, the team found that use of the drug #crinecerfont enabled patients with congenital adrenal hyperplasia (CAH) to safely reduce their dose of glucocorticoids, which can lead to immunosuppression, bone loss and metabolic complications. Often patients with CAH have to take higher doses of glucocorticoids than are naturally present in the body – so-called supraphysiologic doses. Long term use of glucocorticoids – particularly at supraphysiologic doses can lead to side effects and is a cause of safety concerns for patients. Data from the first 24 weeks of the trial was reported. All patients took glucocorticoids. One group took crinecerfont alongside their glucocorticoids and the other group did not. Participants did not know which group they were in. Dr Umasuthan Srirangalingam (pictured), who is a trial principal investigator at UCLH, said: “We are pleased to be able to report that crinecerfont could be used to safely reduce the glucocorticoids patients need, while still maintaining CAH control. In the longer term this should reduce side effects they may face and make long-term treatment for patients safer. This is an important step forward.” The study was supported by the National Institute for Health and Care Research (NIHR) Biomedical Research Centre at UCLH and ran at the NIHR UCLH Clinical Research Facility. Learn more about the research trial: https://buff.ly/471wxge #uclh #research #trial #oneteam #nhsstaff #healthcare #nhs #london #health #CAH

A lung cancer patient at UCLH is the first to receive a novel cancer vaccine designed to prime the immune system to recognise and fight cancer cells. It is the first time this immunotherapy made by BioNTech SE, will be studied in a clinical trial for lung cancer in the UK, where the NIHR UCLH Clinical Research Facility is the lead research site. Approximately 130 participants will be enrolled in the study across 34 research sites in seven countries, with six UK sites selected. This is early stage research which will only recruit 20 patients across the UK so the drug will not be widely available. UCLH consultant medical oncologist Siow Ming Lee, who leads the national study said: “Lung cancer remains the leading cause of cancer deaths worldwide, with an estimated 1.8 million deaths in 2020. “We are now entering this very exciting new era of mRNA-based immunotherapy clinical trials to investigate the treatment of lung cancer, thanks to the foundation laid by the Government’s Office for Life Sciences.” Dr Sarah Benafif is the principal investigator at UCLH of the study, which is supported by the National Institute of Health and Care Research (NIHR) Biomedical Research Centre at UCLH. Prof Lee is also Professor of Medical Oncology at UCL Read more about the lung cancer vaccine: https://buff.ly/3YWvqwu #LungCancer #Research #Trial #NHS #London NIHR (National Institute for Health and Care Research) Department of Health and Social Care Department for Science, Innovation and Technology NHS England Cambridge University Hospitals NHS Foundation Trust The Clatterbridge Cancer Centre NHS Foundation Trust Guy's and St Thomas' NHS Foundation Trust The Newcastle Upon Tyne Hospitals NHS Foundation Trust Photos and captions: Aaron Chown/PA

At the age of 10, Jacob has already been through several major surgeries and aggressive treatments for brain tumours. Although regular MRI monitoring shows there’s still something there, he’s currently stable. Today, we’re sharing Jacob’s wish, and why it was so important for him ✨ When Jacob started intensive treatments, it was difficult for him to adjust. Mum told us: “Jacob is autistic, so he loves routine. He really struggled when we first got to London with all the change. But once we found our routine he loved it so much that he has his hospital gown and mask up on his bedroom wall at home. It’s a testament to the people on the ward, they were brilliant and made his time there so much fun.” Jacob received treatment from a specialist team in the Proton Beam Therapy Department at University College London Hospitals NHS Foundation Trust. 🏥 When talking to our Wishgranters about what he might want as his wish, Jacob and mum mentioned about revisiting London. “He wanted to do the whole day again, be in the same hotel we stayed in whilst he was in hospital, go to the same bus stop and go on the same bus. He loved that routine. He wanted to go back to his hospital room and look out the window at the BT tower. He wanted to listen to the tune that the hotel we were staying at had. All the details meant so much to him.” On the day of his wish, Jacob and his family headed back to London to explore. They rode on the London Eye, cruised down the Thames on a boat tour and much more! Importantly, he also returned to the ward and had a party with all of the team who had been by his side throughout his treatment. 💙 “The whole wish was incredible. When we were there before he wasn't in a fit state to do anything. Out of the window there was a little park that he couldn't even go to. So being able to do all those things meant so much to Jacob. Doing it all one last time and taking pictures with the radiographers, nurses and doctors has given us some lovely memories of the department. I couldn't make that happen for him by myself, so the fact that Make-A-Wish was able to do it is incredible.” ⭐ #MakeAWishUK #UCLH #NHSEngland NHS England

We've come top in England in the annual CQC Adult Inpatient Survey for the second year running. Well done to everyone who works at UCLH! Read more: https://buff.ly/3ABbCEH #oneteam

UCLH and Whittington Health have a long history of working together to benefit our patients and staff. Our joint #tuberculosis (TB) service is just one of many cases where our teams have collaborated together to positively impact our community. Based at Whittington Health, the service offers outpatient and inpatient services for TB patients including those with complex medical needs, such as children, prisoners, HIV and TB infections together, homeless people and multi-drug resistant TB. Since 2019, the team has held over 23,000 patient consultations and treated over 1,300 people with TB, including those with latent TB who have the infection but don’t have any symptoms. Dr Mike Brown, divisional clinical director for infectious diseases, said: “The TB service is a fantastic example of partnership working in practice for the benefit of staff and patients. "As one service, we bring together expertise from across UCLH and Whittington Health and, crucially, we have enabled many more patients to be involved in research studies to improve treatments." Learn more about the TB service here: https://buff.ly/3M8O10G #oneteam #teamwork #nhs #healthcare

Congratulations to UCLH doctor Chris van Tulleken who will give The Royal Institution Christmas Lecture on what happens in our bodies when we eat. Chris said: “The food we eat, how its produced, and the process through which we derive energy from it is not only deeply fascinating scientifically, it’s also fundamental to human and planetary health. “I’m really looking forward to revealing that fascinating science to our young audience, with the help of special expert guests and the Lectures’ trademark demonstrations developed by the Ri team. Along the way we’ll ask some challenging questions that we all need to consider, about the future of food and the health of our planet.” We look forward to hearing the broadcast! Find out more: https://buff.ly/4dNBzPB #XmasLectures

Two of our amazing teams have made the shortlist for this year’s Health Service Journal Awards! ⭐️Perioperative Medicine Service for the Acute Sector Innovation of the Year Award ⭐️Staff Experience Team for the Staff Wellbeing Award Congratulations to them both! #oneteam

A very warm welcome to the doctors in training who are joining UCLH today! We look forward to working with you and hope you’ll enjoy your time here with us. #oneteam💙

We are proud to be part of the North Central London Integrated Care System (NCL ICS), improving the health and wellbeing of residents from Barnet, Camden, Enfield, Haringey and Islington. Our patients/service users/residents are at the heart of what we do. We want to make sure they’re able to play an active role in their own health and wellbeing, working with them to get the best possible start in life, and manage any health problems they have, particularly as they get older. But better still, we want to collectively prevent health problems from happening at all. We need to look at the bigger picture, focussing on the environments, habits and situations that can gradually affect people’s health. By working as one system, we are committed to tackling some of the root causes of ill health, whether that’s things like air quality, employment, financial hardship or social connections. Find out more about the Integrated Care System, our joint purpose, and how we’re improving the health of our patients and residents: https://buff.ly/4fmLhdg

Our patient app MyCare UCLH is already being used by over 250,000 patients. Whether this be to check appointment details, receive test results and clinic letters, or to prepare for appointments by providing information in advance. Activate your account and start managing information about your health and care at UCLH: https://lnkd.in/erVXz6mb