About
My overarching career goal is to translate my research into novel therapeutics to treat…
Activity
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Its been 3 years since the Form an Formulation team at Sygnature kicked off! Time has flown by. The number of compounds we have helped move forward…
Its been 3 years since the Form an Formulation team at Sygnature kicked off! Time has flown by. The number of compounds we have helped move forward…
Liked by Alan Richardson
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Delighted to be joining a new Biotech with a great vision for the future I look forward to exploring the new horizon with Copner Biotech.
Delighted to be joining a new Biotech with a great vision for the future I look forward to exploring the new horizon with Copner Biotech.
Liked by Alan Richardson
Experience
Education
Publications
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The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models
Frontiers in Pharmacology
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to measure the dimerization of angiotensin-converting enzyme 2 (ACE2), the primary receptor for the virus. This screen identified fenofibric acid, the active metabolite of fenofibrate. Fenofibric acid also destabilized the receptor-binding domain (RBD) of the viral…
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to measure the dimerization of angiotensin-converting enzyme 2 (ACE2), the primary receptor for the virus. This screen identified fenofibric acid, the active metabolite of fenofibrate. Fenofibric acid also destabilized the receptor-binding domain (RBD) of the viral spike protein and inhibited RBD binding to ACE2 in enzyme-linked immunosorbent assay (ELISA) and whole cell-binding assays. Fenofibrate and fenofibric acid were tested by two independent laboratories measuring infection of cultured Vero cells using two different SARS-CoV-2 isolates. In both settings at drug concentrations, which are clinically achievable, fenofibrate and fenofibric acid reduced viral infection by up to 70%. Together with its extensive history of clinical use and its relatively good safety profile, this study identifies fenofibrate as a potential therapeutic agent requiring an urgent clinical evaluation to treat SARS-CoV-2 infection
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Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions
American Journal of Pharmaceutical Education
Objective. To determine whether using 3-dimensional (3D) technology to teach pharmacy students about the molecular basis of the interactions between drugs and their targets is more effective than traditional lecture using 2-dimensional (2D) graphics.
Design. Second-year students enrolled in a 4-year masters of pharmacy program in the United Kingdom were randomly assigned to attend either a 3D or 2D presentation on 3 drug targets, the β-adrenoceptor, the Na+-K+ ATPase, and the nicotinic…Objective. To determine whether using 3-dimensional (3D) technology to teach pharmacy students about the molecular basis of the interactions between drugs and their targets is more effective than traditional lecture using 2-dimensional (2D) graphics.
Design. Second-year students enrolled in a 4-year masters of pharmacy program in the United Kingdom were randomly assigned to attend either a 3D or 2D presentation on 3 drug targets, the β-adrenoceptor, the Na+-K+ ATPase, and the nicotinic acetylcholine receptor.
Assessment. A test was administered to assess the ability of both groups of students to solve problems that required analysis of molecular interactions in 3D space. The group that participated in the 3D teaching presentation performed significantly better on the test than the group who attended the traditional lecture with 2D graphics. A questionnaire was also administered to solicit students’ perceptions about the 3D experience. The majority of students enjoyed the 3D session and agreed that the experience increased their enthusiasm for the course.
Conclusions. Viewing a 3D presentation of drug-receptor interactions improved student learning compared to learning from a traditional lecture and 2D graphics.Other authors -
Projects
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KUiz
- Present
Educational software to rapidly create quizzes for students using teaching material that you have already prepared. And it can be viewed by students using a smartphone!
http://www.kuiz.co.ukOther creators -
More activity by Alan
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Very happy to share that I have been awarded Senior Fellowship of the Higher Education Academy
Very happy to share that I have been awarded Senior Fellowship of the Higher Education Academy
Liked by Alan Richardson
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Thursday 26th July is my last full working day as the Head of the School of Pharmacy and Bioengineering at Keele. Officially my term of office comes…
Thursday 26th July is my last full working day as the Head of the School of Pharmacy and Bioengineering at Keele. Officially my term of office comes…
Liked by Alan Richardson
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Congratulations Will and excellent cellcentric team for huge effort in generating exciting and compelling data in myeloma patients.
Congratulations Will and excellent cellcentric team for huge effort in generating exciting and compelling data in myeloma patients.
Liked by Alan Richardson
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Meet-up with my PhD supervisor, Guido Bugmann in Plymouth after more than 20 years. The man who started it all and to whom I am very grateful!
Meet-up with my PhD supervisor, Guido Bugmann in Plymouth after more than 20 years. The man who started it all and to whom I am very grateful!
Liked by Alan Richardson
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CellCentric at #EHA2024. Inobrodib, our Phase II, first-in-class oral p300/CBP inhibitor drug, to treat multiple myeloma. Despite great progress…
CellCentric at #EHA2024. Inobrodib, our Phase II, first-in-class oral p300/CBP inhibitor drug, to treat multiple myeloma. Despite great progress…
Liked by Alan Richardson
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Great to present STORM Therapeutics Limited exciting METTL3 preclinical and clinical data at the excellent #BioBabrahamSymposium!
Great to present STORM Therapeutics Limited exciting METTL3 preclinical and clinical data at the excellent #BioBabrahamSymposium!
Liked by Alan Richardson
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Fantastic experience at ISTH2024 in Bangkok. Thanks to the ISTH for giving me the opportunity to deliver an oral communication. International…
Fantastic experience at ISTH2024 in Bangkok. Thanks to the ISTH for giving me the opportunity to deliver an oral communication. International…
Liked by Alan Richardson
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Proud supervisor moment! My PhD student Arjan Atwal has received the best #TCES Oral presentation award for the second year in a row. 👏 👏 Special…
Proud supervisor moment! My PhD student Arjan Atwal has received the best #TCES Oral presentation award for the second year in a row. 👏 👏 Special…
Liked by Alan Richardson
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We have today announced that our lead asset, dencatistat (STP938), has cleared an investigational new drug application by the US Food and Drug…
We have today announced that our lead asset, dencatistat (STP938), has cleared an investigational new drug application by the US Food and Drug…
Liked by Alan Richardson
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Targeting p300/CBP with a well tolerated small molecule drug, is a new way to treat relapsed refractory multiple myeloma. Clear potential as an all…
Targeting p300/CBP with a well tolerated small molecule drug, is a new way to treat relapsed refractory multiple myeloma. Clear potential as an all…
Liked by Alan Richardson
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