About
Experienced strategy and operational professional, focusing on healthcare and…
Activity
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Was fun to sign copies at B&N today….being there with Charu made it even more special. Thank you Amir and Anitha for being there…
Was fun to sign copies at B&N today….being there with Charu made it even more special. Thank you Amir and Anitha for being there…
Liked by Bihe Chen
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“Are you ready for Nordic Life Science Days 2024 in Malmo? Will Bromley is excited to hear from Nordic Stars 🌟, Pharma execs, investors and…
“Are you ready for Nordic Life Science Days 2024 in Malmo? Will Bromley is excited to hear from Nordic Stars 🌟, Pharma execs, investors and…
Liked by Bihe Chen
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Ironmind 15: 5 down 10 to go ___________ One third of the challenge complete - 10 full distances remaining. Difficult session today especially on…
Ironmind 15: 5 down 10 to go ___________ One third of the challenge complete - 10 full distances remaining. Difficult session today especially on…
Liked by Bihe Chen
Experience
Education
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Activities and Societies: Guild of Students International Students' Officer; International Students' Association Co-Chair; Toastmaster's Club Vice President
Received Dean's Scholarship to attend UoB as part of Fudan-Birmingham dual degree program.
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Activities and Societies: Class leader for 3 years; Model United Nations
Publications
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Environmental T4-Family Bacteriophages Evolve to Escape Abortive Infection via Multiple Routes in a Bacterial Host Employing “Altruistic Suicide” through Type III Toxin-Antitoxin Systems
Frontiers in Microbiology
Abortive infection is an anti-phage mechanism employed by a bacterium to initiate its own death upon phage infection. This reduces, or eliminates, production of viral progeny and protects clonal siblings in the bacterial population by an act akin to an “altruistic suicide.” Abortive infection can be mediated by a Type III toxin-antitoxin system called ToxINPa consisting of an endoribonuclease toxin and RNA antitoxin. ToxINPa is a heterohexameric quaternary complex in which pseudoknotted RNA…
Abortive infection is an anti-phage mechanism employed by a bacterium to initiate its own death upon phage infection. This reduces, or eliminates, production of viral progeny and protects clonal siblings in the bacterial population by an act akin to an “altruistic suicide.” Abortive infection can be mediated by a Type III toxin-antitoxin system called ToxINPa consisting of an endoribonuclease toxin and RNA antitoxin. ToxINPa is a heterohexameric quaternary complex in which pseudoknotted RNA inhibits the toxicity of the toxin until infection by certain phages causes destabilization of ToxINPa, leading to bacteriostasis and, eventually, lethality. However, it is still unknown why only certain phages are able to activate ToxINPa. To try to address this issue we first introduced ToxINPa into the Gram-negative enterobacterium, Serratia sp. ATCC 39006 (S 39006) and then isolated new environmental S 39006 phages that were scored for activation of ToxINPa and abortive infection capacity. We isolated three T4-like phages from a sewage treatment outflow point into the River Cam, each phage being isolated at least a year apart. These phages were susceptible to ToxINPa-mediated abortive infection but produced spontaneous “escape” mutants that were insensitive to ToxINPa. Analysis of these resistant mutants revealed three different routes of escaping ToxINPa, namely by mutating asiA (the product of which is a phage transcriptional co-activator); by mutating a conserved, yet functionally unknown, orf84; or by deleting a 6.5–10 kb region of the phage genome. Analysis of these evolved escape mutants may help uncover the nature of the corresponding phage product(s) involved in activation of ToxINPa.
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Structure, Evolution, and Functions of Bacterial Type III Toxin-Antitoxin Systems
Toxins
Toxin-antitoxin (TA) systems are small genetic modules that encode a toxin (that targets an essential cellular process) and an antitoxin that neutralises or suppresses the deleterious effect of the toxin. Based on the molecular nature of the toxin and antitoxin components, TA systems are categorised into different types. Type III TA systems, the focus of this review, are composed of a toxic endoribonuclease neutralised by a non-coding RNA antitoxin in a pseudoknotted configuration…
Toxin-antitoxin (TA) systems are small genetic modules that encode a toxin (that targets an essential cellular process) and an antitoxin that neutralises or suppresses the deleterious effect of the toxin. Based on the molecular nature of the toxin and antitoxin components, TA systems are categorised into different types. Type III TA systems, the focus of this review, are composed of a toxic endoribonuclease neutralised by a non-coding RNA antitoxin in a pseudoknotted configuration. Bioinformatic analysis shows that the Type III systems can be classified into subtypes. These TA systems were originally discovered through a phage resistance phenotype arising due to a process akin to an altruistic suicide; the phenomenon of abortive infection. Some Type III TA systems are bifunctional and can stabilise plasmids during vegetative growth and sporulation. Features particular to Type III systems are explored here, emphasising some of the characteristics of the RNA antitoxin and how these may affect the co-evolutionary relationship between toxins and cognate antitoxins in their quaternary structures. Finally, an updated analysis of the distribution and diversity of these systems are presented and discussed
Honors & Awards
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Cambridge Trust International Scholarship
Cambridge Trust
£35,000/year
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Dean's Scholarship
University of Birmingham School of Biosciences
$24,000/year
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Winner of FLTRP Cup National English Speech Contest (外研社杯全国英语演讲大赛 全国总决赛亚军)
Foreign Language Teaching and Research Press
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The Britain in China Prize Essay Competition
British Consulate Shanghai; Standard Chartered Bank
Test Scores
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GRE
Score: V162+Q170+4.0
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TOEFL iBT
Score: 118
Reading: 30
Speaking: 28
Writing: 30
Listening: 30
Languages
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English
Native or bilingual proficiency
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Chinese
Native or bilingual proficiency
Organizations
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Cambridge University Consulting Society
Head of CUCS
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Gonville & Caius College MCR
International Students' Officer
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International Students' Association, University of Birmingham
co-Chair
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Guild of Students, University of Birmingham
International Students' Officer
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More activity by Bihe
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On the weekend I ordered an Uber and realised that what used to be the standard ride is now more expensive than a cab, and the new standard ride is…
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Perplexity the company turns two today! 🎂
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