Charles Large
St Albans, England, United Kingdom
981 followers
500+ connections
About
Charles Large is a founder of Autifony Therapeutics, with over 30 years of experience of…
Activity
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New news item on the Autifony website! https://lnkd.in/ePKYm82H
New news item on the Autifony website! https://lnkd.in/ePKYm82H
Liked by Charles Large
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An amazing Day 1 at #aes2023 in the Scientific Symposium - New Insights on Epileptogenesis and Therapeutic Discovery from Encephalitis-induced…
An amazing Day 1 at #aes2023 in the Scientific Symposium - New Insights on Epileptogenesis and Therapeutic Discovery from Encephalitis-induced…
Liked by Charles Large
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Teitur is happy to announce the addition of Sanne Nordestgaard Andersen to the Teitur R&D team in the role as Laboratory Technician. With nearly 20…
Teitur is happy to announce the addition of Sanne Nordestgaard Andersen to the Teitur R&D team in the role as Laboratory Technician. With nearly 20…
Liked by Charles Large
Experience
Education
Publications
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Mechanisms contributing to central excitability changes during hearing loss
Proc Natl Acad Sci U S A.
Pilati N, Ison MJ, Barker M, Mulheran M, Large CH, Forsythe ID, Matthias J, Hamann M.
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Acoustic over-exposure triggers burst firing in dorsal cochlear nucleus fusiform cells.
Hearing Research
Pilati N, Large CH, Forsythe ID, Hamann M
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The efficacy of sodium channel blockers to prevent PCP-induced cognitive dysfunction in the rat: Potential for novel treatments for schizophrenia.
J Pharmacol Exp Ther.
Large CH, Bison S, Sartori I, Read KD, Gozzi A, Quarta D, Antolini M, Gill CH, Hollands E, Gunthorpe MJ, Idris N, Neill J, Alvaro GS.
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Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist
Epilepsia
Kalinichev M, Bradford A, Bison S, Lucas A, Sartori I, Garbati N, Andreetta F, Bate S, Austin NE, Jones DN, Read KD, Alvaro G, Large CH
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Interleaved transcranial magnetic stimulation and fMRI suggests that lamotrigine and valproic acid have different effects on corticolimbic activity.
Psychopharmacology
Li X, Ricci R, Large CH, Anderson B, Nahas Z, Bohning DE, George MS.
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Neural network dysfunction in bipolar depression: clues from the efficacy of lamotrigine
Biochemical Society Transactions
Large CH, Di Daniel E, Li X, George MS.
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The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure
Epilepsy Research
Large CH, Kalinichev M, Lucas A, Carignani C, Bradford A, Garbati N, Sartori I, Austin NE, Ruffo A, Jones DN, Alvaro G, Read KD
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The relationship between lamotrigine concentration and change in resting motor threshold in a model of motor cortex stimulation
Epilepsy Research
Sokal DM, Girlanda E, Sabattini G, Large CH
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Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?
Journal of Psychopharmacology
Large CH
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The potential role of lamotrigine in schizophrenia
Psychopharmacology
Large CH, Webster EL, Goff DC
Languages
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English
Native or bilingual proficiency
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Italian
Full professional proficiency
More activity by Charles
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I’m happy to share that I’ve been promoted to CFO at Autifony Therapeutics Limited
I’m happy to share that I’ve been promoted to CFO at Autifony Therapeutics Limited
Liked by Charles Large
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We’re delighted to be hosting the 2023 Hearing Therapeutics Summit in London today, with UCL Ear Institute and NIHR (National Institute for Health…
We’re delighted to be hosting the 2023 Hearing Therapeutics Summit in London today, with UCL Ear Institute and NIHR (National Institute for Health…
Liked by Charles Large
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We are thrilled to announce the successful completion of a €28M #SeriesA financing, co-led by Sunstone Life Science Ventures and Sound…
We are thrilled to announce the successful completion of a €28M #SeriesA financing, co-led by Sunstone Life Science Ventures and Sound…
Liked by Charles Large
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